Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair (original) (raw)

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Acknowledgements

For full acknowledgments, see the Supplementary Note.

Author information

Author notes

1. Felix R Day, Katherine S Ruth, Deborah J Thompson and Joanne M Murabito: These authors contributed equally to this work.
2. Joanne M Murabito, John R B Perry and Anna Murray: These authors jointly supervised this work.

Authors and Affiliations

1. Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK
   Felix R Day, Cathy E Elks, Claudia Langenberg, Jian'an Luan, Robert A Scott, Nicholas J Wareham, Ken K Ong & John R B Perry
2. Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK
   Katherine S Ruth, Samuel E Jones & Anna Murray
3. Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
   Deborah J Thompson, Antonis C Antoniou, Manjeet K Bolla, Joe Dennis, Kyriaki Michailidou, Paul D P Pharoah, Ailith Pirie, Qin Wang & Douglas F Easton
4. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
   Kathryn L Lunetta
5. National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA
   Kathryn L Lunetta, Andrew D Johnson, Jennifer E Huffman, John D Eicher & Joanne M Murabito
6. Estonian Genome Center, University of Tartu, Tartu, Estonia
   Natalia Pervjakova, Tõnu Esko, Reedik Mägi, Evelin Mihailov, Lili Milani & Andres Metspalu
7. Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
   Natalia Pervjakova
8. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
   Daniel I Chasman, Lynda M Rose, Julie E Buring & Paul M Ridker
9. Harvard Medical School, Boston, Massachusetts, USA
   Daniel I Chasman, David Karasik, Julie E Buring & Paul M Ridker
10. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands
    Lisette Stolk, Fernando Rivadeneira, André G Uitterlinden & Jenny A Visser
11. Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands
    Lisette Stolk, Fernando Rivadeneira & André G Uitterlinden
12. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Hilary K Finucane, Immaculata De Vivo, Frank B Hu, David J Hunter, Xin Li, Sara Lindström, Peter Kraft & Alkes L Price
13. Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Hilary K Finucane
14. deCODE Genetics/Amgen, Inc., Reykjavik, Iceland
    Patrick Sulem, Daniel F Gudbjartsson, Unnur Thorsteinsdottir & Kari Stefansson
15. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Brendan Bulik-Sullivan & Benjamin M Neale
16. Department of Medicine, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Brendan Bulik-Sullivan & Benjamin M Neale
17. Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Brendan Bulik-Sullivan & Benjamin M Neale
18. Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA
    Tõnu Esko
19. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Tõnu Esko
20. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Tõnu Esko & David J Hunter
21. Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Nora Franceschini
22. Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana, USA
    Chunyan He
23. Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, USA
    Chunyan He
24. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
    Elisabeth Altmaier, Jennifer Kriebel, Judith Manz & Christian Gieger
25. Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
    Elisabeth Altmaier, Eva Albrecht, Martina Müller-Nurasyid, Konstantin Strauch & Christian Gieger
26. Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
    Elisabeth Altmaier, Jennifer Kriebel, Judith Manz, Doris Stöckl & Christian Gieger
27. Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Jennifer A Brody & Bruce M Psaty
28. Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands
    Lude L Franke
29. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Jennifer E Huffman, Thibaud S Boutin, Jonathan Marten, James F Wilson, Alan F Wright & Caroline Hayward
30. Merck Pharmaceuticals, Boston, Massachusetts, USA
    Margaux F Keller
31. Division of Endocrinology, Program in Personalized Medicine, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Patrick F McArdle & Laura M Yerges-Armstrong
32. Institute of Genetics and Biophysics, National Research Council, Naples, Italy
    Teresa Nutile, Daniela Ruggiero, Rossella Sorice & Marina Ciullo
33. Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy
    Eleonora Porcu, Giorgio Pistis, Serena Sanna & Laura Crisponi
34. Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    Eleonora Porcu & Giorgio Pistis
35. Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
    Eleonora Porcu, Gonçalo R Abecasis & Giorgio Pistis
36. Institute for Maternal and Child Health, Scientific Institute for Research, Hospitalisation and Health Care 'Burlo Garofolo', Trieste, Italy
    Antonietta Robino, Dragana Vuckovic, Caterina Barbieri, Ilaria Gandin, Nicola N Pirastu, Diego Vozzi, Paolo P Gasparini & Sheila Ulivi
37. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Ursula M Schick, Charles Kooperberg, Ulrike Peters & Alex P Reiner
38. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA
    Jennifer A Smith, Wei Zhao & Sharon L R Kardia
39. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
    Alexander Teumer & Henry Völzke
40. Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy
    Michela Traglia, Caterina Barbieri, Corrado Masciullo, Cinzia F Sala & Daniela Toniolo
41. Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste, Italy
    Dragana Vuckovic, Ilaria Gandin, Giorgia G Girotto, Nicola N Pirastu & Paolo P Gasparini
42. Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA
    Jie Yao, Yii-Der Ida Chen, Xiuqing Guo, Kent D Taylor & Jerome I Rotter
43. Department of Epidemiology, Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, the Netherlands
    Najaf Amin, Albert Hofman, Fernando Rivadeneira, Cornelia M van Duijn & André G Uitterlinden
44. Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
    Tanguy Corre & Sven Bergmann
45. Swiss Institute of Bioinformatics, Lausanne, Switzerland
    Tanguy Corre & Sven Bergmann
46. Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands
    Jouke-Jan Hottenga, Gonneke Willemsen & Dorret I Boomsma
47. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
    Massimo Mangino & Tim D Spector
48. National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK
    Massimo Mangino
49. Icelandic Heart Association, Kopavogur, Iceland
    Albert V Smith & Vilmundur Gudnason
50. Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Albert V Smith, Unnur Thorsteinsdottir, Vilmundur Gudnason & Kari Stefansson
51. Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA
    Toshiko Tanaka & Luigi Ferrucci
52. Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada
    Irene L Andrulis
53. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Irene L Andrulis
54. Department of Epidemiology, University of California–Irvine, Irvine, California, USA
    Hoda Anton-Culver
55. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
    Volker Arndt & Hermann Brenner
56. Department of Biostatistics, University of Washington, Seattle, Washington, USA
    Alice M Arnold & Barbara McKnight
57. Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany
    Matthias W Beckmann & Peter A Fasching
58. Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Alicia Beeghly-Fadiel & Wei Zheng
59. Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
    Javier Benitez & Anna González-Neira
60. Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain
    Javier Benitez
61. Beckman Research Institute of City of Hope, Duarte, California, USA
    Leslie Bernstein
62. Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA
    Suzette J Bielinski & Janet E Olson
63. Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Carl Blomqvist
64. Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Eric Boerwinkle, Megan L Grove & Alanna C Morrison
65. Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA
    Eric Boerwinkle
66. Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Natalia V Bogdanova
67. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Stig E Bojesen & Børge G Nordestgaard
68. Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Stig E Bojesen & Børge G Nordestgaard
69. Department of Genetics, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo, Norway
    Anne-Lise Borresen-Dale & Vessela Kristensen
70. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    Anne-Lise Borresen-Dale & Vessela Kristensen
71. Dr. Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Hiltrud Brauch
72. Institute of Clinical Pharmacology, University of Tübingen, Tübingen, Germany
    Hiltrud Brauch
73. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
    Hiltrud Brauch & Hermann Brenner
74. Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany
    Hermann Brenner
75. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance Institute of Ruhr University Bochum (IPA), Bochum, Germany
    Thomas Brüning
76. Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
    Barbara Burwinkel
77. Department of Obstetrics and Gynecology, Molecular Biology of Breast Cancer, University of Heidelberg, Heidelberg, Germany
    Barbara Burwinkel
78. Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Archie Campbell & David Porteous
79. Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
    Harry Campbell, Igor Rudan & James F Wilson
80. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Stephen J Chanock
81. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Ross Chapman & Ian Tomlinson
82. Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
    Georgia Chenevix-Trench
83. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Fergus J Couch
84. Department of Medicine, Section of Preventive Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Andrea D Coviello
85. Department of Medicine, Section of Endocrinology, Boston University School of Medicine, Boston, Massachusetts, USA
    Andrea D Coviello
86. Department of Oncology, Sheffield Cancer Research, University of Sheffield, Sheffield, UK
    Angela Cox
87. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Kamila Czene, Hatef Darabi, Per Hall, Keith Humphreys & Jingmei Li
88. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Immaculata De Vivo, Frank B Hu & David J Hunter
89. Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Ellen W Demerath
90. Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands
    Peter Devilee
91. Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands
    Peter Devilee
92. Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
    Thilo Dörk
93. Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK
    Isabel dos-Santos-Silva & Julian Peto
94. Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
    Alison M Dunning, Paul D P Pharoah & Douglas F Easton
95. Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.,
    Peter A Fasching
96. Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA
    Jessica D Faul & David R Weir
97. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Jonine Figueroa
98. Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany
    Dieter Flesch-Janys
99. Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany
    Dieter Flesch-Janys
100. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA
     Melissa E Garcia & Tamara B Harris
101. Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK
     Montserrat García-Closas, Minouk J Schoemaker & Anthony Swerdlow
102. Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
     Montserrat García-Closas
103. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
     Graham G Giles, John L Hopper & Roger L Milne
104. Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia
     Graham G Giles & Roger L Milne
105. Department of Medicine, McGill University, Montreal, Quebec, Canada
     Mark S Goldberg
106. Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
     Mark S Goldberg
107. Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California, USA
     Mark O Goodarzi
108. School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
     Daniel F Gudbjartsson
109. Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France
     Pascal Guénel & Thérèse Truong
110. University Paris–Sud, UMRS 1018, Villejuif, France
     Pascal Guénel & Thérèse Truong
111. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
     Christopher A Haiman & Brian E Henderson
112. Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany
     Ute Hamann & Maria Kabisch
113. Division of Applied Medicine, Musculoskeletal Research Programme, University of Aberdeen, Aberdeen, UK
     Lynne J Hocking
114. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
     Georg Homuth & Frank Schmidt
115. Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands
     Maartje J Hooning & Caroline M Seynaeve
116. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
     Frank B Hu & David J Hunter
117. State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
     Jinyan Huang
118. Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
     Anna Jakubowska & Jan Lubinski
119. Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts, USA
     David Karasik
120. Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada
     Julia A Knight
121. Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
     Julia A Knight
122. Faculty of Medicine, University of Split, Split, Croatia
     Ivana Kolcic, Ozren Polasek & Tatijana Zemunik
123. Cancer Center, Kuopio University Hospital, Kuopio, Finland
     Veli-Matti Kosma & Arto Mannermaa
124. School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland
     Veli-Matti Kosma & Arto Mannermaa
125. Department of Clinical Pathology, Imaging Center, Kuopio University Hospital, Kuopio, Finland
     Veli-Matti Kosma & Arto Mannermaa
126. German Center for Diabetes Research, Neuherberg, Germany
     Jennifer Kriebel
127. Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway
     Vessela Kristensen
128. Vesalius Research Center (VRC), VIB, Leuven, Belgium
     Diether Lambrechts
129. Department of Oncology, Laboratory for Translational Genetics, University of Leuven, Leuven, Belgium
     Diether Lambrechts
130. Division of Public Health Sciences, Center for Human Genetics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
     Yongmei Liu
131. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
     Sara Margolin
132. QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
     Nicholas G Martin & Grant W Montgomery
133. Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany
     Alfons Meindl
134. Department of Medicine I, Ludwig Maximilians University Munich, Munich, Germany
     Martina Müller-Nurasyid
135. German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany
     Martina Müller-Nurasyid
136. Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA
     Michael Nalls
137. Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
     Heli Nevanlinna
138. Department of Oncology, University Hospitals Leuven, Leuven, Belgium
     Patrick Neven
139. Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
     Anne B Newman
140. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
     Anne B Newman
141. Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
     Anne B Newman
142. British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
     Sandosh Padmanabhan
143. Fondazione Istituto FIRC di Oncologia Molecolare (IFOM), Milan, Italy
     Paolo Peterlongo
144. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald,, Greifswald, Germany
     Astrid Petersmann
145. Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
     Bruce M Psaty & Alex P Reiner
146. Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA
     Bruce M Psaty
147. Department of Health Services, University of Washington, Seattle, Washington, USA
     Bruce M Psaty
148. Department of Clinical Chemistry, Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, Oulu, Finland
     Katri Pylkäs & Robert Winqvist
149. Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland
     Katri Pylkäs & Robert Winqvist
150. Department of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy
     Paolo Radice
151. Medical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
     Leslie J Raffel
152. UCLA Clinical and Translational Science Institute, Cedars-Sinai Medical Center,, Los Angeles, California, USA
     Leslie J Raffel
153. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
     Anja Rudolph & Jenny Chang-Claude
154. Research Oncology, Guy's Hospital, King's College London, London, UK
     Elinor J Sawyer
155. National Institute on Aging, Intramural Research Program, Baltimore, Maryland, USA
     David Schlessinger
156. Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands
     Marjanka K Schmidt
157. Division of Molecular Gyneco-Oncology, Department of Gynecology and Obstetrics, University Hospital of Cologne, Cologne, Germany
     Rita K Schmutzler
158. Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany
     Rita K Schmutzler
159. Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany
     Rita K Schmutzler
160. Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec City, Quebec, Canada
     Jacques Simard
161. Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia
     Melissa C Southey
162. Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität, Munich, Germany
     Konstantin Strauch
163. Division of Breast Cancer Research, The Institute of Cancer Research, London, UK
     Anthony Swerdlow
164. Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
     Amanda E Toland
165. NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK
     Ian Tomlinson
166. Icelandic Cancer Registry, Reykjavik, Iceland
     Laufey Tryggvadottir
167. Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
     Stephen T Turner
168. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
     Melissa Wellons
169. Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands
     Bruce B H R Wolffenbuttel
170. LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
     Bruce B H R Wolffenbuttel
171. Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research 'Demokritos', Athens, Greece
     Drakoulis Yannoukakos
172. Department of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald, Germany
     Marek Zygmunt
173. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
     Behrooz Z Alizadeh
174. Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
     Peter Kraft
175. Department of Paediatrics, University of Cambridge, Cambridge, UK
     Ken K Ong
176. Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
     Joanne M Murabito

Authors

1. Felix R Day
2. Katherine S Ruth
3. Deborah J Thompson
4. Kathryn L Lunetta
5. Natalia Pervjakova
6. Daniel I Chasman
7. Lisette Stolk
8. Hilary K Finucane
9. Patrick Sulem
10. Brendan Bulik-Sullivan
11. Tõnu Esko
12. Andrew D Johnson
13. Cathy E Elks
14. Nora Franceschini
15. Chunyan He
16. Elisabeth Altmaier
17. Jennifer A Brody
18. Lude L Franke
19. Jennifer E Huffman
20. Margaux F Keller
21. Patrick F McArdle
22. Teresa Nutile
23. Eleonora Porcu
24. Antonietta Robino
25. Lynda M Rose
26. Ursula M Schick
27. Jennifer A Smith
28. Alexander Teumer
29. Michela Traglia
30. Dragana Vuckovic
31. Jie Yao
32. Wei Zhao
33. Eva Albrecht
34. Najaf Amin
35. Tanguy Corre
36. Jouke-Jan Hottenga
37. Massimo Mangino
38. Albert V Smith
39. Toshiko Tanaka
40. Gonçalo R Abecasis
41. Irene L Andrulis
42. Hoda Anton-Culver
43. Antonis C Antoniou
44. Volker Arndt
45. Alice M Arnold
46. Caterina Barbieri
47. Matthias W Beckmann
48. Alicia Beeghly-Fadiel
49. Javier Benitez
50. Leslie Bernstein
51. Suzette J Bielinski
52. Carl Blomqvist
53. Eric Boerwinkle
54. Natalia V Bogdanova
55. Stig E Bojesen
56. Manjeet K Bolla
57. Anne-Lise Borresen-Dale
58. Thibaud S Boutin
59. Hiltrud Brauch
60. Hermann Brenner
61. Thomas Brüning
62. Barbara Burwinkel
63. Archie Campbell
64. Harry Campbell
65. Stephen J Chanock
66. J Ross Chapman
67. Yii-Der Ida Chen
68. Georgia Chenevix-Trench
69. Fergus J Couch
70. Andrea D Coviello
71. Angela Cox
72. Kamila Czene
73. Hatef Darabi
74. Immaculata De Vivo
75. Ellen W Demerath
76. Joe Dennis
77. Peter Devilee
78. Thilo Dörk
79. Isabel dos-Santos-Silva
80. Alison M Dunning
81. John D Eicher
82. Peter A Fasching
83. Jessica D Faul
84. Jonine Figueroa
85. Dieter Flesch-Janys
86. Ilaria Gandin
87. Melissa E Garcia
88. Montserrat García-Closas
89. Graham G Giles
90. Giorgia G Girotto
91. Mark S Goldberg
92. Anna González-Neira
93. Mark O Goodarzi
94. Megan L Grove
95. Daniel F Gudbjartsson
96. Pascal Guénel
97. Xiuqing Guo
98. Christopher A Haiman
99. Per Hall
100. Ute Hamann
101. Brian E Henderson
102. Lynne J Hocking
103. Albert Hofman
104. Georg Homuth
105. Maartje J Hooning
106. John L Hopper
107. Frank B Hu
108. Jinyan Huang
109. Keith Humphreys
110. David J Hunter
111. Anna Jakubowska
112. Samuel E Jones
113. Maria Kabisch
114. David Karasik
115. Julia A Knight
116. Ivana Kolcic
117. Charles Kooperberg
118. Veli-Matti Kosma
119. Jennifer Kriebel
120. Vessela Kristensen
121. Diether Lambrechts
122. Claudia Langenberg
123. Jingmei Li
124. Xin Li
125. Sara Lindström
126. Yongmei Liu
127. Jian'an Luan
128. Jan Lubinski
129. Reedik Mägi
130. Arto Mannermaa
131. Judith Manz
132. Sara Margolin
133. Jonathan Marten
134. Nicholas G Martin
135. Corrado Masciullo
136. Alfons Meindl
137. Kyriaki Michailidou
138. Evelin Mihailov
139. Lili Milani
140. Roger L Milne
141. Martina Müller-Nurasyid
142. Michael Nalls
143. Benjamin M Neale
144. Heli Nevanlinna
145. Patrick Neven
146. Anne B Newman
147. Børge G Nordestgaard
148. Janet E Olson
149. Sandosh Padmanabhan
150. Paolo Peterlongo
151. Ulrike Peters
152. Astrid Petersmann
153. Julian Peto
154. Paul D P Pharoah
155. Nicola N Pirastu
156. Ailith Pirie
157. Giorgio Pistis
158. Ozren Polasek
159. David Porteous
160. Bruce M Psaty
161. Katri Pylkäs
162. Paolo Radice
163. Leslie J Raffel
164. Fernando Rivadeneira
165. Igor Rudan
166. Anja Rudolph
167. Daniela Ruggiero
168. Cinzia F Sala
169. Serena Sanna
170. Elinor J Sawyer
171. David Schlessinger
172. Marjanka K Schmidt
173. Frank Schmidt
174. Rita K Schmutzler
175. Minouk J Schoemaker
176. Robert A Scott
177. Caroline M Seynaeve
178. Jacques Simard
179. Rossella Sorice
180. Melissa C Southey
181. Doris Stöckl
182. Konstantin Strauch
183. Anthony Swerdlow
184. Kent D Taylor
185. Unnur Thorsteinsdottir
186. Amanda E Toland
187. Ian Tomlinson
188. Thérèse Truong
189. Laufey Tryggvadottir
190. Stephen T Turner
191. Diego Vozzi
192. Qin Wang
193. Melissa Wellons
194. Gonneke Willemsen
195. James F Wilson
196. Robert Winqvist
197. Bruce B H R Wolffenbuttel
198. Alan F Wright
199. Drakoulis Yannoukakos
200. Tatijana Zemunik
201. Wei Zheng
202. Marek Zygmunt
203. Sven Bergmann
204. Dorret I Boomsma
205. Julie E Buring
206. Luigi Ferrucci
207. Grant W Montgomery
208. Vilmundur Gudnason
209. Tim D Spector
210. Cornelia M van Duijn
211. Behrooz Z Alizadeh
212. Marina Ciullo
213. Laura Crisponi
214. Douglas F Easton
215. Paolo P Gasparini
216. Christian Gieger
217. Tamara B Harris
218. Caroline Hayward
219. Sharon L R Kardia
220. Peter Kraft
221. Barbara McKnight
222. Andres Metspalu
223. Alanna C Morrison
224. Alex P Reiner
225. Paul M Ridker
226. Jerome I Rotter
227. Daniela Toniolo
228. André G Uitterlinden
229. Sheila Ulivi
230. Henry Völzke
231. Nicholas J Wareham
232. David R Weir
233. Laura M Yerges-Armstrong
234. Alkes L Price
235. Kari Stefansson
236. Jenny A Visser
237. Ken K Ong
238. Jenny Chang-Claude
239. Joanne M Murabito
240. John R B Perry
241. Anna Murray

Consortia

The PRACTICAL Consortium

kConFab Investigators

AOCS Investigators

Generation Scotland

EPIC-InterAct Consortium

LifeLines Cohort Study

Contributions

All authors reviewed the original and revised manuscripts. Statistical analysis: F.R.D., K.S.R., D.J.T., K.L.L., N.P., D.I.C., L.S., H.K.F., P.S., B.B.-S., T.E., A.D.J., C.E.E., N.F., C. He, E. Altmaier, J.A.B., L.L.F., J.E.H., S.E.J., M.F.K., P.F.M., T.N., E.P., A. Robino, L.M.R., U.M.S., J.A.S., A.T., M.T., D. Vuckovic, J.Y., W. Zhao, E. Albrecht, N.A., T.C., J.-J.H., M.M., A.V.S., T. Tanaka, J.R.B.P. Sample collection, genotyping and phenotyping: G.R.A., I.L.A., H.A.-C., A.C.A., V.A., A.M.A., C. Barbieri, M.W.B., A.B.-F., J.B., L.B., S.J.B., C. Blomqvist, E.B., N.V.B., S.E.B., M.K.B., A.-L.B.-D., T.S.B., H. Brauch, H. Brenner, T.B., B.B., A. Campbell, H.C., S.J.C., J.R.C., Y.-D.I.C., G.C.-T., F.J.C., A.D.C., A. Cox, K.C., H.D., I.D.V., E.W.D., J.D., P.D., T.D., I.d.-S.-S., A.M.D., J.D.E., P.A.F., J.D.F., J.F., D.F.-J., I.G., M.E.G., M.G.-C., G.G. Giles, G.G. Girotto, M.S.G., A.G.-N., M.O.G., M.L.G., D.F.G., P.G., X.G., C.A.H., P.H., U.H., B.E.H., L.J.H., A.H., G.H., M.J.H., J.L.H., F.B.H., J.H., K.H., D.J.H., A.J., M.K., D.K., J.A.K., I.K., C.K., V.-M.K., J.K., V.K., D.L., C.L., J. Li, X.L., S.L., Y.L., J. Luan, J. Lubinski, R.M., A. Mannermaa, J. Manz, S.M., J. Marten, N.G.M., C.M., A. Meindl, K.M., E.M., L.M., R.L.M., M.M.-N., M.N., B.M.N., H.N., P.N., A.B.N., B.G.N., J.E.O., S.P., P.P., U.P., A. Petersmann, J.P., P.D.P.P., N.N.P., A. Pirie, G.P., O.P., D.P., B.M.P., K.P., P.R., L.J.R., F.R., I.R., A. Rudolph, D.R., C.F.S., S.S., E.J.S., D. Schlessinger, M.K.S., F.S., R.K.S., M.J.S., R.A.S., C.M.S., J.S., R.S., M.C.S., D. Stöckl, K. Strauch, A.S., K.D.T., U.T., A.E.T., I.T., T. Truong, L.T., S.T.T., D. Vozzi, Q.W., M.W., G.W., J.F.W., R.W., B.B.H.R.W., A.F.W., D.Y., T.Z., W. Zheng, M.Z. Individual study principal investigators: S.B., D.I.B., J.E.B., L.F., G.W.M., V.G., T.D.S., C.M.v.D., B.Z.A., M.C., L.C., D.F.E., P.P.G., C.G., T.B.H., C. Hayward, S.L.R.K., P.K., B.M., A. Metspalu, A.C.M., A.P.R., P.M.R., J.I.R., D.T., A.G.U., S.U., H.V., N.J.W., D.R.W., L.M.Y.-A., A.L.P., K. Stefansson, J.A.V., K.K.O., J.C.-C., J.M.M., A. Murray. Working group: F.R.D., K.S.R., D.J.T., K.L.L., N.P., D.I.C., L.S., H.K.F., P.S., B.B.-S., T.E., A.D.J., C.E.E., N.F., C. He, A.L.P., K. Stefansson, J.A.V., K.K.O., J.C.-C., J.M.M., J.R.B.P., A. Murray.

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Correspondence toJohn R B Perry.

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The authors declare no competing financial interests.

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A full list of members and affiliations appears in the Supplementary Note.

A full list of members and affiliations appears in the Supplementary Note.

A full list of members and affiliations appears in the Supplementary Note.

A full list of members and affiliations appears in the Supplementary Note.

A full list of members and affiliations appears in the Supplementary Note.

A full list of members and affiliations appears in the Supplementary Note.

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Day, F., Ruth, K., Thompson, D. et al. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.Nat Genet 47, 1294–1303 (2015). https://doi.org/10.1038/ng.3412

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• Received: 17 February 2015
• Accepted: 02 September 2015
• Published: 28 September 2015
• Issue date: November 2015
• DOI: https://doi.org/10.1038/ng.3412