Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells (original) (raw)
Smale, S.T. & Fisher, A.G. Chromatin structure and gene regulation in the immune system. Annu. Rev. Immunol.20, 427–462 (2002). ArticleCASPubMed Google Scholar
Murphy, K.M. & Reiner, S.L. The lineage decisions of helper T cells. Nat. Rev. Immunol.2, 933–944 (2002). ArticleCASPubMed Google Scholar
Ho, I.C. & Glimcher, L.H. Transcription: tantalizing times for T cells. Cell109, S109–120 (2002). ArticleCASPubMed Google Scholar
Ansel, K.M., Lee, D.U. & Rao, A. An epigenetic view of helper T cell differentiation. Nat. Immunol.4, 616–623 (2003). ArticleCASPubMed Google Scholar
Asnagli, H. & Murphy, K.M. Stability and commitment in T helper cell development. Curr. Opin. Immunol.13, 242–247 (2001). ArticleCASPubMed Google Scholar
Avni, O. et al. TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol.3, 643–651 (2002). ArticleCASPubMed Google Scholar
Guo, L. et al. In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production. Proc. Natl. Acad. Sci. USA99, 10623–10628 (2002). ArticleCASPubMedPubMed Central Google Scholar
Lee, D.U., Agarwal, S. & Rao, A. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the Il4 gene. Immunity16, 649–660 (2002). ArticleCASPubMed Google Scholar
Santangelo, S., Cousins, D.J., Winkelmann, N.E. & Staynov, D.Z. DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4+ T cell differentiation. J. Immunol.169, 1893–1903 (2002). ArticleCASPubMed Google Scholar
Fields, P.E., Kim, S.T. & Flavell, R.A. Cutting edge: changes in histone acetylation at the Il4 and Ifng loci accompany Th1/Th2 differentiation. J. Immunol.169, 647–650 (2002). ArticleCASPubMed Google Scholar
Hutchins, A.S. et al. Gene silencing quantitatively controls the function of a developmental trans-activator. Mol. Cell10, 81–91 (2002). ArticleCASPubMed Google Scholar
Bird, A.P. & Wolffe, A.P. Methylation-induced repression—belts, braces, and chromatin. Cell99, 451–454 (1999). ArticleCASPubMed Google Scholar
Jones, P.A. & Takai, D. The role of DNA methylation in mammalian epigenetics. Science293, 1068–1070 (2001). ArticleCASPubMed Google Scholar
Li, E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat. Rev. Genet.3, 662–673 (2002). ArticleCASPubMed Google Scholar
Lee, P.P. et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity15, 763–774 (2001). ArticleCASPubMed Google Scholar
Lee, H.J. et al. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J. Exp. Med.192, 105–115 (2000). ArticleCASPubMedPubMed Central Google Scholar
Lee, G.R., Fields, P.E. & Flavell, R.A. Regulation of Il4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity14, 447–459 (2001). ArticleCASPubMed Google Scholar
Ranganath, S. et al. GATA-3-dependent enhancer activity in Il4 gene regulation. J. Immunol.161, 3822–3826 (1998). CASPubMed Google Scholar
Murphy, K.M. et al. Signaling and transcription in T helper development. Annu. Rev. Immunol.18, 451–494 (2000). ArticleCASPubMed Google Scholar
Avni, O. & Rao, A. T cell differentiation: a mechanistic view. Curr. Opin. Immunol.12, 654–659 (2000). ArticleCASPubMed Google Scholar
Takemoto, N. et al. Th2-specific DNase I-hypersensitive sites in the murine Il13 and Il4 intergenic region. Int. Immunol.10, 1981–1985 (1998). ArticleCASPubMed Google Scholar
Richards, E.J. & Elgin, S.C. Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. Cell108, 489–500 (2002). ArticleCASPubMed Google Scholar
Kouzarides, T. Histone methylation in transcriptional control. Curr. Opin. Genet. Dev.12, 198–209 (2002). ArticleCASPubMed Google Scholar
Zegerman, P., Canas, B., Pappin, D. & Kouzarides, T. Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex. J. Biol. Chem.277, 11621–11624 (2002). ArticleCASPubMed Google Scholar
Lachner, M., O'Sullivan, R.J. & Jenuwein, T. An epigenetic road map for histone lysine methylation. J. Cell Sci.116, 2117–2124 (2003). ArticleCASPubMed Google Scholar
Kim, G.D., Ni, J., Kelesoglu, N., Roberts, R.J. & Pradhan, S. Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. EMBO J.21, 4183–4195 (2002). ArticleCASPubMedPubMed Central Google Scholar
Leonhardt, H., Page, A.W., Weier, H.U. & Bestor, T.H. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell71, 865–873 (1992). ArticleCASPubMed Google Scholar
Bachman, K.E., Rountree, M.R. & Baylin, S.B. Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J. Biol. Chem.276, 32282–32287 (2001). ArticleCASPubMed Google Scholar
Agarwal, S. & Rao, A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity9, 765–775 (1998). ArticleCASPubMed Google Scholar
Glimcher, L.H. & Murphy, K.M. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev.14, 1693–1711 (2000). CASPubMed Google Scholar
Szabo, S.J. et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell100, 655–669 (2000). ArticleCASPubMed Google Scholar
Ouyang, W. et al. Inhibition of Th1 development mediated by GATA-3 through an Il4-independent mechanism. Immunity9, 745–755 (1998). ArticleCASPubMed Google Scholar
Ho, I.C., Hodge, M.R., Rooney, J.W. & Glimcher, L.H. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell85, 973–983 (1996). ArticleCASPubMed Google Scholar
Reiner, S.L. Helper T cell differentiation, inside and out. Curr Opin Immunol13, 351–355 (2001). ArticleCASPubMed Google Scholar
Lyko, F. et al. Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila. Nat. Genet.23, 363–366 (1999). ArticleCASPubMed Google Scholar
Rhee, I. et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature416, 552–556 (2002). ArticleCASPubMed Google Scholar
Bruniquel, D. & Schwartz, R.H. Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat. Immunol.4, 235–240 (2003). ArticleCASPubMed Google Scholar
Fuks, F. et al. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J. Biol. Chem.278, 4035–4040 (2003). ArticleCASPubMed Google Scholar
Fuks, F., Burgers, W.A., Brehm, A., Hughes-Davies, L. & Kouzarides, T. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat. Genet.24, 88–91 (2000). ArticleCASPubMed Google Scholar
Robertson, K.D. et al. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat. Genet.25, 338–342 (2000). ArticleCASPubMed Google Scholar
Rountree, M.R., Bachman, K.E. & Baylin, S.B. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet.25, 269–277 (2000). ArticleCASPubMed Google Scholar
Fuks, F., Hurd, P.J., Deplus, R. & Kouzarides, T. The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res.31, 2305–2312 (2003). ArticleCASPubMedPubMed Central Google Scholar
Goll, M.G. & Bestor, T.H. Histone modification and replacement in chromatin activation. Genes Dev.16, 1739–1742 (2002). ArticleCASPubMed Google Scholar
Ayyanathan, K. et al. Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation. Genes Dev.17, 1855–1869 (2003). ArticleCASPubMedPubMed Central Google Scholar
Grogan, J.L. et al. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity14, 205–215 (2001). ArticleCASPubMed Google Scholar
Hashimshony, T., Zhang, J., Keshet, I., Bustin, M. & Cedar, H. The role of DNA methylation in setting up chromatin structure during development. Nat. Genet.34, 187–192 (2003). ArticleCASPubMed Google Scholar
Fitzpatrick, D.R. et al. Distinct methylation of the interferon γ (IFN-γ) and interleukin 3 (IL-3) genes in newly activated primary CD8+ T lymphocytes: regional IFN-γ promoter demethylation and mRNA expression are heritable in CD44highCD8+ T cells. J. Exp. Med.188, 103–117 (1998). ArticleCASPubMedPubMed Central Google Scholar
Saccani, S., Pantano, S. & Natoli, G. Two waves of nuclear factor κB recruitment to target promoters. J. Exp. Med.193, 1351–1359 (2001). ArticleCASPubMedPubMed Central Google Scholar