Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches (original) (raw)

• Calvi, L.M. et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841–846 (2003).
  Article CAS PubMed Google Scholar
• Zhang, J. et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836–841 (2003).
  Article CAS PubMed Google Scholar
• Avecilla, S.T. et al. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat. Med. 10, 64–71 (2004).
  Article CAS PubMed Google Scholar
• Nagasawa, T. et al. Microenvironmental niches in the bone marrow required for B-cell development. Nat. Rev. Immunol. 6, 107–116 (2006).
  Article CAS PubMed Google Scholar
• Hardy, R.R., Carmack, C.E., Shinton, S.A., Kemp, J.D. & Hayakawa, K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173, 1213–1225 (1991).
  Article CAS PubMed Google Scholar
• Loder, F. et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 190, 75–89 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Cariappa, A. et al. Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity 23, 397–407 (2005).
  Article CAS PubMed Google Scholar
• Moser, K., Tokoyoda, K., Radbruch, A., MacLennan, I. & Manz, R.A. Stromal niches, plasma cell differentiation and survival. Curr. Opin. Immunol. 18, 265–267 (2006).
  Article CAS PubMed Google Scholar
• Tokoyoda, K., Egawa, T., Sugiyama, T., Choi, B.I. & Nagasawa, T. Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity 20, 707–718 (2004).
  Article CAS PubMed Google Scholar
• Di Rosa, F. & Pabst, R. The bone marrow: a nest for migratory memory T cells. Trends Immunol. 26, 360–366 (2005).
  Article CAS PubMed Google Scholar
• Masopust, D., Vezys, V., Marzo, A.L. & Lefrancois, L. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291, 2413–2417 (2001).
  Article CAS PubMed Google Scholar
• Mazo, I.B. et al. Bone marrow is a major reservoir and site of recruitment for central memory CD8· T cells. Immunity 22, 259–270 (2005).
  Article CAS PubMed Google Scholar
• Feuerer, M. et al. Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nat. Med. 9, 1151–1157 (2003).
  Article CAS PubMed Google Scholar
• Cavanagh, L.L. et al. Activation of bone marrow–resident memory T cells by circulating, antigen-bearing dendritic cells. Nat. Immunol. 6, 1029–1037 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Feuerer, M. et al. Bone marrow microenvironment facilitating dendritic cell: CD4 T cell interactions and maintenance of CD4 memory. Int. J. Oncol. 25, 867–876 (2004).
  PubMed Google Scholar
• Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245–252 (1998).
  Article CAS PubMed Google Scholar
• Shortman, K. & Naik, S.H. Steady-state and inflammatory dendritic-cell development. Nat. Rev. Immunol. 7, 19–30 (2007).
  Article CAS PubMed Google Scholar
• Shortman, K. & Liu, Y.J. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2, 151–161 (2002).
  Article CAS PubMed Google Scholar
• Steinman, R.M. & Witmer, M.D. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc. Natl. Acad. Sci. USA 75, 5132–5136 (1978).
  Article CAS PubMed PubMed Central Google Scholar
• Jung, S. et al. Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20, 4106–4114 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Niess, J.H. et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307, 254–258 (2005).
  Article CAS PubMed Google Scholar
• Soos, T.J. et al. CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int. 70, 591–596 (2006).
  Article CAS PubMed Google Scholar
• Landsman, L., Varol, C. & Jung, S. Distinct differentiation potential of blood monocyte subsets in the lung. J. Immunol. 178, 2000–2007 (2007).
  Article CAS PubMed Google Scholar
• Varol, C. et al. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J. Exp. Med. 204, 171–180 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Mazo, I.B. et al. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. J. Exp. Med. 188, 465–474 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Jung, S. et al. In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 17, 211–220 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Zaft, T., Sapoznikov, A., Krauthgamer, R., Littman, D.R. & Jung, S. CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells. J. Immunol. 175, 6428–6435 (2005).
  Article CAS PubMed Google Scholar
• Allman, D. et al. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J. Immunol. 167, 6834–6840 (2001).
  Article CAS PubMed Google Scholar
• Hebel, K. et al. Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11chigh dendritic cells. Eur. J. Immunol. 36, 2912–2919 (2006).
  Article CAS PubMed Google Scholar
• Strasser, A. et al. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci. USA 88, 8661–8665 (1991).
  Article CAS PubMed PubMed Central Google Scholar
• Lesley, R., Kelly, L.M., Xu, Y. & Cyster, J.G. Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc. Natl. Acad. Sci. USA 103, 10717–10722 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Mackay, F. & Browning, J.L. BAFF: a fundamental survival factor for B cells. Nat. Rev. Immunol. 2, 465–475 (2002).
  Article CAS PubMed Google Scholar
• Gorelik, L. et al. Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells. J. Exp. Med. 198, 937–945 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Nardelli, B. et al. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 97, 198–204 (2001).
  Article CAS PubMed Google Scholar
• Litinskiy, M.B. et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat. Immunol. 3, 822–829 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Schiemann, B. et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293, 2111–2114 (2001).
  Article CAS PubMed Google Scholar
• Leng, L. et al. MIF signal transduction initiated by binding to CD74. J. Exp. Med. 197, 1467–1476 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Lue, H. et al. Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity. Oncogene 26, 5046–5059 (2007).
  Article CAS PubMed Google Scholar
• Starlets, D. et al. Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival. Blood 107, 4807–4816 (2006).
  Article CAS PubMed Google Scholar
• Lantner, F. et al. CD74 induces TAp63 expression leading to B cell survival. Blood 110, 4303–4311 (2007).
  Article CAS PubMed Google Scholar
• Calandra, T., Bernhagen, J., Mitchell, R.A. & Bucala, R. The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. J. Exp. Med. 179, 1895–1902 (1994).
  Article CAS PubMed Google Scholar
• Fingerle-Rowson, G. et al. The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc. Natl. Acad. Sci. USA 100, 9354–9359 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Qi, H., Egen, J.G., Huang, A.Y. & Germain, R.N. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312, 1672–1676 (2006).
  Article CAS PubMed Google Scholar
• Sipkins, D.A. et al. In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature 435, 969–973 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Bajenoff, M. et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25, 989–1001 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Morand, E.F., Leech, M. & Bernhagen, J. MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis. Nat. Rev. Drug Discov. 5, 399–410 (2006).
  Article CAS PubMed Google Scholar
• Balazs, M., Martin, F., Zhou, T. & Kearney, J. Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity 17, 341–352 (2002).
  Article CAS PubMed Google Scholar
• Cariappa, A., Chase, C., Liu, H., Russell, P. & Pillai, S. Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Blood 109, 2339–2345 (2007).
  Article CAS PubMed Google Scholar
• Nishizumi, H. et al. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity 3, 549–560 (1995).
  Article CAS PubMed Google Scholar
• Otipoby, K.L. et al. CD22 regulates thymus-independent responses and the lifespan of B cells. Nature 384, 634–637 (1996).
  Article CAS PubMed Google Scholar
• O'Keefe, T.L., Williams, G.T., Davies, S.L. & Neuberger, M.S. Hyperresponsive B cells in CD22-deficient mice. Science 274, 798–801 (1996).
  Article CAS PubMed Google Scholar
• Pan, C., Baumgarth, N. & Parnes, J.R. CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation. Immunity 11, 495–506 (1999).
  Article CAS PubMed Google Scholar
• Cariappa, A. et al. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity 14, 603–615 (2001).
  Article CAS PubMed Google Scholar
• Floyd, H., Nitschke, L. & Crocker, P.R. A novel subset of murine B cells that expresses unmasked forms of CD22 is enriched in the bone marrow: implications for B-cell homing to the bone marrow. Immunology 101, 342–347 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Shinkai, Y. et al. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science 259, 822–825 (1993).
  Article CAS PubMed Google Scholar
• Mazo, I.B. & von Andrian, U.H. Adhesion and homing of blood-borne cells in bone marrow microvessels. J. Leukoc. Biol. 66, 25–32 (1999).
  Article CAS PubMed Google Scholar