T cell fitness determined by signal strength (original) (raw)

References

  1. Kurts, C., Kosaka, H., Carbone, F.R., Miller, J.F. & Heath, W.R. Class I–restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8+ T cells. J. Exp. Med. 186, 239–245 (1997).
    Article CAS Google Scholar
  2. Heath, W.R. & Carbone, F.R. Cross-presentation in viral immunity and self-tolerance. Nat. Rev. Immunol. 1, 126–134 (2001).
    Article CAS Google Scholar
  3. Hernandez, J., Aung, S., Redmond, W.L. & Sherman, L.A. Phenotypic and functional analysis of CD8+ T cells undergoing peripheral deletion in response to cross-presentation of self-antigen. J. Exp. Med. 194, 707–717 (2001).
    Article CAS Google Scholar
  4. Hawiger, D. et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194, 769–779 (2001).
    Article CAS Google Scholar
  5. Lauvau, G. et al. Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science 294, 1735–1739 (2001).
    Article CAS Google Scholar
  6. Iezzi, G., Karjalainen, K. & Lanzavecchia, A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8, 89–95 (1998).
    Article CAS Google Scholar
  7. Iezzi, G., Scotet, E., Scheidegger, D. & Lanzavecchia, A. The interplay between the duration of TCR and cytokine signalling determines T cell polarization. Eur. J. Immunol. 29, 4092–4101 (1999).
    Article CAS Google Scholar
  8. Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708–712 (1999).
    Article CAS Google Scholar
  9. Reinhardt, R.L., Khoruts, A., Merica, R., Zell, T. & Jenkins, M.K. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410, 101–105 (2001).
    Article CAS Google Scholar
  10. Langenkamp, A. et al. T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification. Eur. J. Immunol. 32, 2046–2054 (2002).
    Article CAS Google Scholar
  11. Lanzavecchia, A. & Sallusto, F. Dynamics of T lymphocyte responses: intermediates, effectors and memory cells. Science 290, 92–97 (2000).
    Article CAS Google Scholar
  12. Valitutti, S., Muller, S., Cella, M., Padovan, E. & Lanzavecchia, A. Serial triggering of many T-cell receptors by a few peptide–MHC complexes. Nature 375, 148–151 (1995).
    Article CAS Google Scholar
  13. Viola, A. & Lanzavecchia, A. T cell activation determined by T cell receptor number and tunable thresholds. Science 273, 104–106 (1996).
    Article CAS Google Scholar
  14. Wulfing, C. et al. Kinetics and extent of T cell activation as measured with the calcium signal. J. Exp. Med. 185, 1815–1825 (1997).
    Article CAS Google Scholar
  15. Viola, A., Schroeder, S., Sakakibara, Y. & Lanzavecchia, A. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283, 680–682 (1999).
    Article CAS Google Scholar
  16. Tuosto, L. & Acuto, O. CD28 affects the earliest signaling events generated by TCR engagement. Eur. J. Immunol. 28, 2131–2142 (1998).
    Article CAS Google Scholar
  17. Fraser, J.D., Irving, B.A., Crabtree, G.R. & Weiss, A. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251, 313–316 (1991).
    Article CAS Google Scholar
  18. van Stipdonk, M.J., Lemmens, E.E. & Schoenberger, S.P. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2, 423–429 (2001).
    Article CAS Google Scholar
  19. Kaech, S.M. & Ahmed, R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2, 415–422 (2001).
    Article CAS Google Scholar
  20. Plas, D.R., Rathmell, J.C. & Thompson, C.B. Homeostatic control of lymphocyte survival: potential origins and implications. Nat. Immunol. 3, 515–521 (2002).
    Article CAS Google Scholar
  21. Goldrath, A.W. et al. Cytokine requirements for acute and basal homeostatic proliferation of naive and memory CD8+ T cells. J. Exp. Med. 195, 1515–1522 (2002).
    Article CAS Google Scholar
  22. Becker, T.C. et al. Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J. Exp. Med. 195, 1541–1548 (2002).
    Article CAS Google Scholar
  23. Schluns, K.S., Kieper, W.C., Jameson, S.C. & Lefrancois, L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1, 426–432 (2000).
    Article CAS Google Scholar
  24. Zhang, X., Sun, S., Hwang, I., Tough, D.F. & Sprent, J. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity 8, 591–599 (1998).
    Article CAS Google Scholar
  25. Ku, C.C., Murakami, M., Sakamoto, A., Kappler, J. & Marrack, P. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 288, 675–678 (2000).
    Article CAS Google Scholar
  26. Vander Heiden, M.G. & Thompson, C.B. Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat. Cell Biol. 1, E209–E216 (1999).
    Article CAS Google Scholar
  27. Newton, K. & Strasser, A. Cell death control in lymphocytes. Adv. Immunol. 76, 179–226 (2000).
    Article CAS Google Scholar
  28. Broome, H.E., Dargan, C.M., Krajewski, S. & Reed, J.C. Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal. J. Immunol. 155, 2311–2317 (1995).
    CAS PubMed Google Scholar
  29. Gett, A.V. & Hodgkin, P.D. Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation. Proc. Natl. Acad. Sci. USA 95, 9488–9493 (1998).
    Article CAS Google Scholar
  30. Bird, J.J. et al. Helper T cell differentiation is controlled by the cell cycle. Immunity 9, 229–237 (1998).
    Article CAS Google Scholar
  31. Tanchot, C. et al. Modifications of CD8+ T cell function during in vivo memory or tolerance induction. Immunity 8, 581–590 (1998).
    Article CAS Google Scholar
  32. Schwartz, R.H. T cell clonal anergy. Curr. Opin. Immunol. 9, 351–357 (1997).
    Article CAS Google Scholar
  33. Wells, A.D., Walsh, M.C., Sankaran, D. & Turka, L.A. T cell effector function and anergy avoidance are quantitatively linked to cell division. J. Immunol. 165, 2432–2443 (2000).
    Article CAS Google Scholar
  34. Valitutti, S., Dessing, M., Aktories, K., Gallati, H. & Lanzavecchia, A. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 181, 577–584 (1995).
    Article CAS Google Scholar
  35. Sugamura, K. et al. The interleukin-2 receptor γ chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu. Rev. Immunol. 14, 179–205 (1996).
    Article CAS Google Scholar
  36. Vander Heiden, M.G., Chandel, N.S., Williamson, E.K., Schumacker, P.T. & Thompson, C.B. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 91, 627–637 (1997).
    Article CAS Google Scholar
  37. Boise, L.H. et al. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL . Immunity 3, 87–98 (1995).
    Article CAS Google Scholar
  38. Hogquist, K.A. et al. T cell receptor antagonist peptides induce positive selection. Cell 76, 17–27 (1994).
    Article CAS Google Scholar
  39. Weber, S., Traunecker, A., Oliveri, F., Gerhard, W. & Karjalainen, K. Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor. Nature 356, 793–796 (1992).
    Article CAS Google Scholar
  40. Weninger, W., Crowley, M.A., Manjunath, N. & von Andrian, U.H. Migratory properties of naive, effector, and memory CD8+ T cells. J. Exp. Med. 194, 953–966 (2001).
    Article CAS Google Scholar
  41. Iezzi, G., Scheidegger, D. & Lanzavecchia, A. Migration and function of antigen primed nonpolarized T lymphocytes in vivo. J. Exp. Med. 193, 987–993 (2001).
    Article CAS Google Scholar
  42. Potsch, C., Vohringer, D. & Pircher, H. Distinct migration patterns of naive and effector CD8 T cells in the spleen: correlation with CCR7 receptor expression and chemokine reactivity. Eur. J. Immunol. 29, 3562–3570 (1999).
    Article CAS Google Scholar
  43. Masopust, D., Vezys, V., Marzo, A.L. & Lefrancois, L. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291, 2413–2417 (2001).
    Article CAS Google Scholar
  44. Cantrell, D.A. & Smith, K.A. Transient expression of interleukin 2 receptors. Consequences for T cell growth. J. Exp. Med. 158, 1895–1911 (1983).
    Article CAS Google Scholar
  45. Geginat, J., Sallusto, F. & Lanzavecchia, A. Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4+ T cells. J. Exp. Med. 194, 1711–1719 (2001).
    Article CAS Google Scholar
  46. Hernandez, J., Aung, S., Marquardt, K. & Sherman, L.A. Uncoupling of proliferative potential and gain of effector function by CD8+ T cells responding to self-antigens. J. Exp. Med. 196, 323–333 (2002).
    Article CAS Google Scholar
  47. Gorelik, L. & Flavell, R.A. Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12, 171–181 (2000).
    Article CAS Google Scholar
  48. Lenardo, M. et al. Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment. Annu. Rev. Immunol. 17, 221–253 (1999).
    Article CAS Google Scholar
  49. Ferreira, C., Barthlott, T., Garcia, S., Zamoyska, R. & Stockinger, B. Differential survival of naive CD4 and CD8 T cells. J. Immunol. 165, 3689–3694 (2000).
    Article CAS Google Scholar
  50. Stoll, S., Delon, J., Brotz, T.M. & Germain, R.N. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296, 1873–1876 (2002).
    Article Google Scholar

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