- Sinha, S.R. & Kossoff, E.H. The ketogenic diet. Neurologist 11, 161–170 (2005).
Article PubMed Google Scholar
- Gowers, W.R. Epilepsy and Other Chronic Convulsive Diseases (Churchill, London, 1881).
Google Scholar
- Sutula, T.P. Mechanisms of epilepsy progression: current theories and perspectives from neuroplasticity in adulthood and development. Epilepsy Res. 60, 161–171 (2004).
Article PubMed Google Scholar
- He, X.P. et al. Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. Neuron 43, 31–42 (2004).
Article CAS PubMed Google Scholar
- Maue, R.A., Kraner, S.D., Goodman, R.H. & Mandel, G. Neuron-specific expression of the rat brain type II sodium channel gene is directed by upstream regulatory elements. Neuron 4, 223–231 (1990).
Article CAS PubMed Google Scholar
- Mori, N., Stein, R., Sigmund, O. & Anderson, D.J. A cell type-preferred silencer element that controls the neural-specific expression of the SCG10 gene. Neuron 4, 583–594 (1990).
Article CAS PubMed Google Scholar
- Bruce, A.W. et al. Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc. Natl. Acad. Sci. USA 101, 10458–10463 (2004).
Article CAS PubMed PubMed Central Google Scholar
- Roopra, A., Huang, Y. & Dingledine, R. Neurological disease: listening to gene silencers. Mol. Interv. 1, 219–228 (2001).
CAS PubMed Google Scholar
- Roopra, A. et al. Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex. Mol. Cell. Biol. 20, 2147–2157 (2000).
Article CAS PubMed PubMed Central Google Scholar
- Huang, Y., Myers, S.J. & Dingledine, R. Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. Nat. Neurosci. 2, 867–872 (1999).
Article CAS PubMed Google Scholar
- Grimes, J.A. et al. The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. J. Biol. Chem. 275, 9461–9467 (2000).
Article CAS PubMed Google Scholar
- Andres, M.E. et al. CoREST: a functional corepressor required for regulation of neural-specific gene expression. Proc. Natl. Acad. Sci. USA 96, 9873–9878 (1999).
Article CAS PubMed PubMed Central Google Scholar
- Battaglioli, E. et al. REST repression of neuronal genes requires components of the hSWI.SNF complex. J. Biol. Chem. 277, 41038–41045 (2002).
Article CAS PubMed Google Scholar
- Roopra, A., Qazi, R., Schoenike, B., Daley, T.J. & Morrison, J.F. Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes. Mol. Cell 14, 727–738 (2004).
Article CAS PubMed Google Scholar
- Luger, K., Mader, A.W., Richmond, R.K., Sargent, D.F. & Richmond, T.J. Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature 389, 251–260 (1997).
Article CAS PubMed Google Scholar
- Strahl, B.D. & Allis, C.D. The language of covalent histone modifications. Nature 403, 41–45 (2000).
Article CAS PubMed Google Scholar
- Peterson, C.L. ATP-dependent chromatin remodeling: going mobile. FEBS Lett. 476, 68–72 (2000).
Article CAS PubMed Google Scholar
- Guarente, L. & Picard, F. Calorie restriction—the SIR2 connection. Cell 120, 473–482 (2005).
Article CAS PubMed Google Scholar
- Zhang, Q., Piston, D.W. & Goodman, R.H. Regulation of corepressor function by nuclear NADH. Science 295, 1895–1897 (2002).
CAS PubMed Google Scholar
- Timmusk, T. & Metsis, M. Regulation of BDNF promoters in the rat hippocampus. Neurochem. Int. 25, 11–15 (1994).
Article CAS PubMed Google Scholar
- Ballas, N., Grunseich, C., Lu, D.D., Speh, J.C. & Mandel, G. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 121, 645–657 (2005).
Article CAS PubMed Google Scholar
- Belyaev, N.D. et al. Distinct RE1 silencing transcription factor (REST)-containing complexes interact with different target genes. J. Biol. Chem. 279, 556–561 (2004).
Article CAS PubMed Google Scholar
- Wood, I.C. et al. Interaction of the repressor element 1–silencing transcription factor (REST) with target genes. J. Mol. Biol. 334, 863–874 (2003).
Article CAS PubMed Google Scholar
- Stryer, L. Biochemistry (W.H. Freeman and Co., New York, 2002).
Google Scholar
- Mirnezami, A.H. et al. Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription. Curr. Biol. 13, 1234–1239 (2003).
Article CAS PubMed Google Scholar
- Kim, J.H., Cho, E.J., Kim, S.T. & Youn, H.D. CtBP represses p300-mediated transcriptional activation by direct association with its bromodomain. Nat. Struct. Mol. Biol. 12, 423–428 (2005).
Article CAS PubMed Google Scholar
- Wick, A.N., Drury, D.R. & Morita, T.N. 2-Deoxyglucose: a metabolic block for glucose. Proc. Soc. Exp. Biol. Med. 89, 579–582 (1955).
Article CAS PubMed Google Scholar
- Chandramouli, V. & Carter, J.R., Jr. Metabolic effects of 2-deoxy-D-glucose in isolated fat cells. Biochim. Biophys. Acta 496, 278–291 (1977).
Article CAS PubMed Google Scholar
- Kokaia, M. et al. Suppressed epileptogenesis in BDNF mutant mice. Exp. Neurol. 133, 215–224 (1995).
Article CAS PubMed Google Scholar
- Golarai, G. & Sutula, T.P. Functional alterations in the dentate gyrus after induction of long-term potentiation, kindling, and mossy fiber sprouting. J. Neurophysiol. 75, 343–353 (1996).
Article CAS PubMed Google Scholar
- Scharfman, H.E. Hyperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor. J. Neurophysiol. 78, 1082–1095 (1997).
Article CAS PubMed Google Scholar
- Conner, J.M., Lauterborn, J.C., Yan, Q., Gall, C.M. & Varon, S. Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. J. Neurosci. 17, 2295–2313 (1997).
Article CAS PubMed PubMed Central Google Scholar
- Yan, Q. et al. Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system. Neuroscience 78, 431–448 (1997).
Article CAS PubMed Google Scholar
- Binder, D.K., Routbort, M.J. & McNamara, J.O. Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fiber pathway of adult rat hippocampus. J. Neurosci. 19, 4616–4626 (1999).
Article CAS PubMed PubMed Central Google Scholar
- Koyama, R. et al. Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the dentate gyrus. J. Neurosci. 24, 7215–7224 (2004).
Article CAS PubMed PubMed Central Google Scholar
- Scharfman, H.E., Goodman, J.H. & Sollas, A.L. Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus. J. Neurosci. 19, 5619–5631 (1999).
Article CAS PubMed PubMed Central Google Scholar
- Binder, D.K., Croll, S.D., Gall, C.M. & Scharfman, H.E. BDNF and epilepsy: too much of a good thing? Trends Neurosci 24, 47–53 (2001).
Article CAS PubMed Google Scholar
- Lahteinen, S. et al. Decreased BDNF signalling in transgenic mice reduces epileptogenesis. Eur. J. Neurosci. 15, 721–734 (2002).
Article PubMed Google Scholar
- Stafstrom, C.E. Dietary approaches to epilepsy treatment: old and new options on the menu. Epilepsy Curr. 4, 215–222 (2004).
Article PubMed PubMed Central Google Scholar
- Murray, K.D. et al. Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy. J. Comp. Neurol. 418, 411–422 (2000).
Article CAS PubMed Google Scholar
- Mohanti, B.K. et al. Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas. Int. J. Radiat. Oncol. Biol. Phys. 35, 103–111 (1996).
Article CAS PubMed Google Scholar
- Imai, S., Armstrong, C.M., Kaeberlein, M. & Guarente, L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795–800 (2000).
Article CAS PubMed Google Scholar
- Brunet, A. et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011–2015 (2004).
Article CAS PubMed Google Scholar
- Douma, S. et al. Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 430, 1034–1039 (2004).
Article CAS PubMed Google Scholar
- Pearse, R.N., Swendeman, S.L., Li, Y., Rafii, D. & Hempstead, B.L. A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. Blood 105, 4429–4436 (2005).
Article CAS PubMed Google Scholar
- Warburg, O. The Metabolism of Tumors (Arnold Constable, London, 1930).
Google Scholar
- Mazumdar, A. et al. Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. Nat. Cell Biol. 3, 30–37 (2001).
Article CAS PubMed Google Scholar
- Westbrook, T.F. et al. A genetic screen for candidate tumor suppressors identifies REST. Cell 121, 837–848 (2005).
Article CAS PubMed Google Scholar
- Sutula, T. & Steward, O. Quantitative analysis of synaptic potentiation during kindling of the perforant path. J. Neurophysiol. 56, 732–746 (1986).
Article CAS PubMed Google Scholar
- Sayin, U., Osting, S., Hagen, J., Rutecki, P. & Sutula, T. Spontaneous seizures and loss of axo-axonic and axo-somatic inhibition induced by repeated brief seizures in kindled rats. J. Neurosci. 23, 2759–2768 (2003).
Article CAS PubMed PubMed Central Google Scholar