The significance of unstable chromosomes in colorectal cancer (original) (raw)

• Bach, S. P., Renehan, A. G. & Potten, C. S. Stem cells: the intestinal stem cell as a paradigm. Carcinogenesis 21, 469–476 (2000).
  Article CAS PubMed Google Scholar
• Loeb, L. A., Springgate, C. F. & Battula, N. Errors in DNA replication as a basis of malignant changes. Cancer Res. 34, 2311–2321 (1974).
  CAS PubMed Google Scholar
• Morin, P. J. et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275, 1787–1790 (1997).
  Article CAS PubMed Google Scholar
• Sparks, A. B., Morin, P. J., Vogelstein, B. & Kinzler, K. W. Mutational analysis of the APC /b-catenin/Tcf pathway in colorectal cancer. Cancer Res. 58, 1130–1134 (1998).
  CAS PubMed Google Scholar
• Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colon cancer. Cell 87, 159–170 (1996).
  Article CAS PubMed Google Scholar
• Polakis, P. Wnt signaling and cancer. Genes Dev. 14, 1837–1851 (2000).
  CAS PubMed Google Scholar
• Fearon, E. R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759–767 (1990).
  Article CAS PubMed Google Scholar
• Luebeck, E. G. & Moolgavkar, S. H. Multistage carcinogenesis and the incidence of colorectal cancer. Proc. Natl Acad. Sci. USA 99, 15095–15100 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Nowell, P. C. The clonal evolution of tumor cell populations. Science 194, 23–28 (1976).
  Article CAS PubMed Google Scholar
• Cahill, D. P., Kinzler, K. W., Vogelstein, B. & Lengauer, C. Genetic instability and Darwinian selection in tumours. Trends Cell Biol. 9, M57–M60 (1999).
  Article CAS PubMed Google Scholar
• Klein, C. A. et al. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet 360, 683–9 (2002).
  Article CAS PubMed Google Scholar
• Lengauer, C., Kinzler, K. W. & Vogelstein, B. Genetic instabilities in human cancers. Nature 396, 643–9 (1998).
  Article CAS PubMed Google Scholar
• Thiagalingam, S. et al. Mechanisms underlying losses of heterozygosity in human colorectal cancers. Proc. Natl Acad. Sci. USA 98, 2698–2702 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Kern, S. E. et al. Clinical and pathological associations with allelic loss in colorectal carcinoma. JAMA 261, 3099–3103 (1989).
  Article CAS PubMed Google Scholar
• Heim, S. & Mitelman, F. in Cancer Cytogenetics 369–388 (Wiley-Liss, New York, 1995).
  Google Scholar
• Lengauer, C., Kinzler, K. W. & Vogelstein, B. Genetic instability in colorectal cancers. Nature 386, 623–627 (1997).
  Article CAS PubMed Google Scholar
• Ohshima, K. et al. Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma. Cancer Lett. 158, 141–150. (2000).
  Article CAS PubMed Google Scholar
• Cahill, D. P. et al. Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300–303 (1998).
  Article CAS PubMed Google Scholar
• Jin, D. Y., Spencer, F. & Jeang, K. T. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 93, 81–91 (1998).
  Article CAS PubMed Google Scholar
• Michel, L. S. et al. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409, 355–359 (2001).
  Article CAS PubMed Google Scholar
• Jallepalli, P. V. & Lengauer, C. Chromosome segregation and cancer: cutting through the mystery. Nature Rev. Cancer 1, 109–117 (2001).
  Article CAS Google Scholar
• Kolodner, R. D., Putnam, C. D. & Myung, K. Maintenance of genome stability in Saccharomyces cerevisiae. Science 297, 552–557 (2002).
  Article CAS PubMed Google Scholar
• Duesberg, P. & Li, R. Multistep carcinogenesis: a chain reaction of aneuploidizations. Cell Cycle 2, 202–210 (2003).
  Article CAS PubMed Google Scholar
• Duesberg, P., Stindl, R. & Hehlmann, R. Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy. Proc. Natl Acad. Sci. USA 97, 14295–14300 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Nigg, E. A. Centrosome aberrations: cause or consequence of cancer progression? Nature Rev. Cancer 2, 815–825 (2002).
  Article CAS Google Scholar
• Doxsey, S. The centrosome — a tiny organelle with big potential. Nature Genet. 20, 104–106 (1998).
  Article CAS PubMed Google Scholar
• Spencer, F., Gerring, S. L., Connelly, C. & Hieter, P. Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124, 237–249 (1990).
  CAS PubMed PubMed Central Google Scholar
• Knudson, A. G. Two genetic hits (more or less) to cancer. Nature Rev. Cancer 1, 157–162 (2001).
  Article CAS Google Scholar
• Brat, D. J. et al. The structural basis of molecular genetic deletions. An integration of classical cytogenetic and molecular analyses in pancreatic adenocarcinoma. Am. J. Pathol. 150, 383–391 (1997).
  CAS PubMed PubMed Central Google Scholar
• Cavenee, W. K. et al. Genetic origin of mutations predisposing to retinoblastoma. Science 228, 501–503 (1985).
  Article CAS PubMed Google Scholar
• Shih, I. M. et al. Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res. 61, 818–822 (2001).
  CAS PubMed Google Scholar
• Huang, J. et al. APC mutations in colorectal tumors with mismatch repair deficiency. Proc. Natl Acad. Sci. USA 93, 9049–9054 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Fodde, R. et al. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nature Cell Biol. 3, 433–438. (2001).
  Article CAS PubMed Google Scholar
• Kaplan, K. B. et al. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nature Cell Biol. 3, 429–432 (2001).
  Article CAS PubMed Google Scholar
• Haigis, K. M., Caya, J. G., Reichelderfer, M. & Dove, W. F. Intestinal adenomas can develop with a stable karyotype and stable microsatellites. Proc. Natl Acad. Sci. USA 99, 8927–8931 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Sieber, O. M. et al. Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC. Proc. Natl Acad. Sci. USA 99, 16910–16915 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Shibata, D., Schaeffer, J., Li, Z. H., Capella, G. & Perucho, M. Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas. J. Natl Cancer Inst. 85, 1058–1063 (1993).
  Article CAS PubMed Google Scholar
• Aaltonen, L. A. et al. Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res. 54, 1645–1648 (1994).
  CAS PubMed Google Scholar
• Brueckl, W. M. et al. Microsatellite instability in colorectal adenomas: relevance and clinical importance. Int. J. Colorectal Dis. 15, 189–196 (2000).
  Article CAS PubMed Google Scholar
• Bomme, L. et al. Cytogenetic analysis of colorectal adenomas: karyotypic comparisons of synchronous tumors. Cancer Genet. Cytogenet. 106, 66–71 (1998).
  Article CAS PubMed Google Scholar
• Tsao, J. L. et al. Bladder cancer genotype stability during clinical progression. Genes Chromosom. Cancer 29, 26–32 (2000).
  Article CAS PubMed Google Scholar
• van Tilborg, A. A. et al. Molecular evolution of multiple recurrent cancers of the bladder. Hum. Mol. Genet. 9, 2973–2980 (2000).
  Article CAS PubMed Google Scholar
• Umayahara, K. et al. Comparative genomic hybridization detects genetic alterations during early stages of cervical cancer progression. Genes Chromosom. Cancer 33, 98–102 (2002).
  Article CAS PubMed Google Scholar
• Hermsen, M. et al. Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability. Gastroenterology 123, 1109–1119 (2002).
  Article CAS PubMed Google Scholar
• Bockmuhl, U. & Petersen, I. DNA ploidy and chromosomal alterations in head and neck squamous cell carcinoma. Virchows Arch. 441, 541–550 (2002).
  Article PubMed Google Scholar
• Pihan, G. A., Wallace, J., Zhou, Y. & Doxsey, S. J. Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas. Cancer Res. 63, 1398–1404 (2003).
  CAS PubMed Google Scholar
• Moskovitz, A. H. et al. Chromosomal instability in pancreatic ductal cells from patients with chronic pancreatitis and pancreatic adenocarcinoma. Genes Chromosom. Cancer 37, 201–206 (2003).
  Article PubMed Google Scholar
• Nowak, M. A. et al. The role of chromosomal instability in tumor initiation. Proc. Natl Acad. Sci. USA 99, 16226–16231 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Moolgavkar, S. H. & Knudson, A. G. Jr. Mutation and cancer: a model for human carcinogenesis. J. Natl Cancer Inst. 66, 1037–1052 (1981).
  Article CAS PubMed Google Scholar
• Michor, F., Iwasa, Y., Komarova, N. L. & Nowak, M. A. Local regulation of homeostasis favors chromosomal instability. Curr. Biol. 13, 581–584 (2003).
  Article CAS PubMed Google Scholar
• Komarova, N. L., Sengupta, A. & Nowak, M. A. Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability. J. Theor. Biol. 223, 433–450 (2003).
  Article CAS PubMed Google Scholar
• Weber, B. L. & Couch, F. J. Breast Cancer. In The Genetic Basis of Human Cancer (eds Vogelstein, B. & Kinzler, K. W.) 537–563 (MacGraw-Hill, New York, 1998).
  Google Scholar
• Marra, G. & Boland, C. R. Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. J. Natl Cancer Inst. 87, 1114–1125 (1995).
  Article CAS PubMed Google Scholar
• Peltomaki, P. Deficient DNA mismatch repair: a common etiologic factor for colon cancer. Hum. Mol. Genet. 10, 735–740 (2001).
  Article CAS PubMed Google Scholar
• Yamamoto, H., Imai, K. & Perucho, M. Gastrointestinal cancer of the microsatellite mutator phenotype pathway. J. Gastroenterol. 37, 153–163 (2002).
  Article CAS PubMed Google Scholar
• Boyer, J. C. et al. Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res. 55, 6063–6070.
• Speicher, M. R., Gwyn Ballard, S. & Ward, D. C. Karyotyping human chromosomes by combinatorial multi-fluor FISH. Nature Genet. 12, 368–375 (1996).
  Article CAS PubMed Google Scholar
• Ried, T. et al. Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Genes Chromosomes Cancer 15, 234–245 (1996).
  Article CAS PubMed Google Scholar
• Wang, T. L. et al. Digital karyotyping. Proc. Natl Acad. Sci. USA 99, 16156–16161 (2002).
  Article CAS PubMed PubMed Central Google Scholar