Studying the mononuclear phagocyte system in the molecular age (original) (raw)

• Fogg, D. K. et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311, 83–87 (2006). This study was the first to characterize a dedicated macrophage and DC progenitor.
  Article CAS PubMed Google Scholar
• Auffray, C. et al. CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J. Exp. Med. 206, 595–606 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Onai, N. et al. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nature Immunol. 8, 1207–1216 (2007).
  Article CAS Google Scholar
• Naik, S. H. et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nature Immunol. 8, 1217–1226 (2007). References 3 and 4 were the first characterizations of a DC-restricted progenitor (termed the CDP) that gives rise to classical DCs and plasmacytoid DCs.
  Article CAS Google Scholar
• Liu, K. et al. In vivo analysis of dendritic cell development and homeostasis. Science 324, 392–397 (2009). This was the first characterization of pre-DCs and how they are related to MDPs and CDPs.
  Article CAS PubMed PubMed Central Google Scholar
• Reizis, B., Bunin, A., Ghosh, H. S., Lewis, K. L. & Sisirak, V. Plasmacytoid dendritic cells: recent progress and open questions. Annu. Rev. Immunol. 29, 163–183 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Ingersoll, M. A., Platt, A. M., Potteaux, S. & Randolph, G. J. Monocyte trafficking in acute and chronic inflammation. Trends Immunol. 10 Jun 2011 (doi:10.1016/j.it.2011.05.001).
  Article CAS PubMed PubMed Central Google Scholar
• Chow, A. et al. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J. Exp. Med. 208, 261–271 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Iannacone, M. et al. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature 465, 1079–1083 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Hildner, K. et al. Batf3 deficiency reveals a critical role for CD8α+ dendritic cells in cytotoxic T cell immunity. Science 322, 1097–1100 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Ginhoux, F. et al. The origin and development of nonlymphoid tissue CD103+ DCs. J. Exp. Med. 206, 3115–3130 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Bogunovic, M. et al. Origin of the lamina propria dendritic cell network. Immunity 31, 513–525 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Edelson, B. T. et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells. J. Exp. Med. 207, 823–836 (2010). This was the first report that BATF3 is a crucial transcription factor for both CD8α+ and CD103+ DCs, a basis for the future classification of DC subsets.
  CAS PubMed PubMed Central Google Scholar
• Hashimoto, D., Miller, J. & Merad, M. Characterizing DC and macrophage heterogeneity in vivo. Immunity 35, 323–335 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Chitu, V. & Stanley, E. R. Colony-stimulating factor-1 in immunity and inflammation. Curr. Opin. Immunol. 18, 39–48 (2006).
  Article CAS PubMed Google Scholar
• Merad, M. & Manz, M. G. Dendritic cell homeostasis. Blood 113, 3418–3427 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• van Rooijen, N. & van Kesteren-Hendrikx, E. Clodronate liposomes: perspectives in research and therapeutics. J. Liposome Res. 12, 81–94 (2002).
  Article CAS PubMed Google Scholar
• Sudo, T. et al. Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M. Oncogene 11, 2469–2476 (1995).
  CAS PubMed Google Scholar
• MacDonald, K. P. et al. An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation. Blood 116, 3955–3963 (2010).
  Article CAS PubMed Google Scholar
• Hashimoto, D. et al. Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J. Exp. Med. 208, 1069–1082 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Irvine, K. M. et al. A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. FASEB J. 20, 1921–1923 (2006).
  Article CAS PubMed Google Scholar
• Ohno, H. et al. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol. Cancer Ther. 5, 2634–2643 (2006).
  Article CAS PubMed Google Scholar
• Conway, J. G. et al. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc. Natl Acad. Sci. USA 102, 16078–16083 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Burns, C. J. & Wilks, A. F. c-FMS inhibitors: a patent review. Expert Opin. Ther. Pat. 21, 147–165 (2011).
  Article CAS PubMed Google Scholar
• Zhang, Y. et al. APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease. J. Immunol. 169, 7111–7118 (2002).
  Article CAS PubMed Google Scholar
• Wang, H. et al. Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation. J. Clin. Invest. 116, 2105–2114 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Junt, T. et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 450, 110–114 (2007).
  Article CAS PubMed Google Scholar
• McGill, J., Van Rooijen, N. & Legge, K. L. Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs. J. Exp. Med. 205, 1635–1646 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Mircescu, M. M., Lipuma, L., van Rooijen, N., Pamer, E. G. & Hohl, T. M. Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection. J. Infect. Dis. 200, 647–656 (2009).
  Article CAS PubMed Google Scholar
• Traeger, T. et al. Selective depletion of alveolar macrophages in polymicrobial sepsis increases lung injury, bacterial load and mortality but does not affect cytokine release. Respiration 77, 203–213 (2009).
  Article CAS PubMed Google Scholar
• Qualls, J. E., Kaplan, A. M., van Rooijen, N. & Cohen, D. A. Suppression of experimental colitis by intestinal mononuclear phagocytes. J. Leukoc. Biol. 80, 802–815 (2006).
  Article CAS PubMed Google Scholar
• Bennett, C. L. & Clausen, B. E. DC ablation in mice: promises, pitfalls, and challenges. Trends Immunol. 28, 525–531 (2007).
  Article CAS PubMed Google Scholar
• Duffield, J. S. et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J. Clin. Invest. 115, 56–65 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Stoneman, V. et al. Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques. Circ. Res. 100, 884–893 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Cailhier, J. F. et al. Resident pleural macrophages are key orchestrators of neutrophil recruitment in pleural inflammation. Am. J. Respir. Crit. Care Med. 173, 540–547 (2006).
  Article CAS PubMed Google Scholar
• Cailhier, J. F. et al. Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation. J. Immunol. 174, 2336–2342 (2005).
  Article CAS PubMed Google Scholar
• Saxena, V., Ondr, J. K., Magnusen, A. F., Munn, D. H. & Katz, J. D. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J. Immunol. 179, 5041–5053 (2007).
  Article CAS PubMed Google Scholar
• Devey, L. et al. Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism. Mol. Ther. 17, 65–72 (2009).
  Article CAS PubMed Google Scholar
• Fallowfield, J. A. et al. Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. J. Immunol. 178, 5288–5295 (2007).
  Article CAS PubMed Google Scholar
• Duffield, J. S. et al. Conditional ablation of macrophages halts progression of crescentic glomerulonephritis. Am. J. Pathol. 167, 1207–1219 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Henderson, N. C. et al. Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Am. J. Pathol. 172, 288–298 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Lin, S. L., Castano, A. P., Nowlin, B. T., Lupher, M. L. & Duffield, J. S. Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations. J. Immunol. 183, 6733–6743 (2009).
  Article CAS PubMed Google Scholar
• Machida, Y. et al. Renal fibrosis in murine obstructive nephropathy is attenuated by depletion of monocyte lineage, not dendritic cells. J. Pharmacol. Sci. 114, 464–473 (2010).
  Article CAS PubMed Google Scholar
• Qi, F. et al. Depletion of cells of monocyte lineage prevents loss of renal microvasculature in murine kidney transplantation. Transplantation 86, 1267–1274 (2008).
  Article CAS PubMed Google Scholar
• Chua, A. C. L., Hodson, L. J., Moldenhauer, L. M., Robertson, S. A. & Ingman, W. V. Dual roles for macrophages in ovarian cycle-associated development and remodelling of the mammary gland epithelium. Development 137, 4229–4238 (2010).
  Article CAS PubMed Google Scholar
• Jasper, M. J. et al. Macrophage-derived LIF and IL1B regulate α(1,2)fucosyltransferase 2 (Fut2) expression in mouse uterine epithelial cells during early pregnancy. Biol. Reprod. 84, 179–188 (2011).
  Article CAS PubMed Google Scholar
• Withers, S. B. et al. Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat. Arterioscler. Thromb. Vasc. Biol. 31, 908–913 (2011).
  Article CAS PubMed Google Scholar
• Burnett, S. H. et al. Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene. J. Leukoc. Biol. 75, 612–623 (2004).
  Article CAS PubMed Google Scholar
• Burnett, S. H. et al. Development of peritoneal adhesions in macrophage depleted mice. J. Surg. Res. 131, 296–301 (2006).
  Article CAS PubMed Google Scholar
• Miyake, Y. et al. Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J. Clin. Invest. 117, 2268–2278 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Asano, K. et al. CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens. Immunity 34, 85–95 (2011).
  Article CAS PubMed Google Scholar
• Jung, S. et al. In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 17, 211–220 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Bar-On, L. & Jung, S. Defining dendritic cells by conditional and constitutive cell ablation. Immunol. Rev. 234, 76–89 (2010).
  Article CAS PubMed Google Scholar
• Sapoznikov, A. et al. Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J. Exp. Med. 204, 1923–1933 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Plaks, V. et al. Uterine DCs are crucial for decidua formation during embryo implantation in mice. J. Clin. Invest. 118, 3954–3965 (2008).
  CAS PubMed PubMed Central Google Scholar
• Lucas, M., Schachterle, W., Oberle, K., Aichele, P. & Diefenbach, A. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26, 503–517 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Hochweller, K., Striegler, J., Hammerling, G. J. & Garbi, N. A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. Eur. J. Immunol. 38, 2776–2783 (2008).
  Article CAS PubMed Google Scholar
• Kissenpfennig, A. et al. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22, 643–654 (2005).
  Article CAS PubMed Google Scholar
• Bennett, C. L. et al. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J. Cell Biol. 169, 569–576 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Nagao, K. et al. Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc. Natl Acad. Sci. USA 106, 3312–3317 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Ginhoux, F. et al. Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state. J. Exp. Med. 204, 3133–3146 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Bursch, L. S. et al. Identification of a novel population of Langerin+ dendritic cells. J. Exp. Med. 204, 3147–3156 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Farrand, K. J. et al. Langerin+ CD8α+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens. J. Immunol. 183, 7732–7742 (2009).
  CAS PubMed Google Scholar
• GeurtsvanKessel, C. H. et al. Clearance of influenza virus from the lung depends on migratory langerin+CD11b− but not plasmacytoid dendritic cells. J. Exp. Med. 205, 1621–1634 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Birnberg, T. et al. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 29, 986–997 (2008).
  Article CAS PubMed Google Scholar
• Ohnmacht, C. et al. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J. Exp. Med. 206, 549–559 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Teichmann, L. L. et al. Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage. Immunity 33, 967–978 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Christopher, M. J., Rao, M., Liu, F., Woloszynek, J. R. & Link, D. C. Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. J. Exp. Med. 208, 251–260 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Kuipers, H., Schnorfeil, F. M., Fehling, H. J., Bartels, H. & Brocker, T. Dicer-dependent microRNAs control maturation, function, and maintenance of Langerhans cells in vivo. J. Immunol. 185, 400–409 (2010).
  Article CAS PubMed Google Scholar
• Buch, T. et al. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nature Methods 2, 419–426 (2005).
  Article CAS PubMed Google Scholar
• Brockschnieder, D., Pechmann, Y., Sonnenberg-Riethmacher, E. & Riethmacher, D. An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus. Genesis 44, 322–327 (2006).
  Article CAS PubMed Google Scholar
• Voehringer, D., Liang, H. E. & Locksley, R. M. Homeostasis and effector function of lymphopenia-induced “memory-like” T cells in constitutively T cell-depleted mice. J. Immunol. 180, 4742–4753 (2008).
  Article CAS PubMed Google Scholar
• Faust, N., Varas, F., Kelly, L. M., Heck, S. & Graf, T. Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages. Blood 96, 719–726 (2000).
  CAS PubMed Google Scholar
• Sasmono, R. T. et al. A macrophage colony-stimulating factor receptor–green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 101, 1155–1163 (2003).
  Article CAS PubMed Google Scholar
• Jung, S. et al. Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20, 4106–4114 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Saederup, N. et al. Selective chemokine receptor usage by central nervous system myeloid cells in CCR2–red fluorescent protein knock-in mice. PLoS ONE 5, e13693 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Boes, M. et al. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature 418, 983–988 (2002).
  Article CAS PubMed Google Scholar
• Lindquist, R. L. et al. Visualizing dendritic cell networks in vivo. Nature Immunol. 5, 1243–1250 (2004).
  Article CAS Google Scholar
• Hume, D. A. Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity. J. Leukoc. Biol. 89, 525–538 (2011).
  Article CAS PubMed Google Scholar
• MacDonald, K. P. et al. The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. J. Immunol. 175, 1399–1405 (2005).
  Article CAS PubMed Google Scholar
• Sasmono, R. T. et al. Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. J. Leukoc. Biol. 82, 111–123 (2007).
  Article CAS PubMed Google Scholar
• Ginhoux, F. et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841–845 (2010). This report showed that adult microglia are derived from primitive macrophages that arise prior to embryonic day 8.
  Article CAS PubMed PubMed Central Google Scholar
• Helft, J., Ginhoux, F., Bogunovic, M. & Merad, M. Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice. Immunol. Rev. 234, 55–75 (2010).
  Article CAS PubMed Google Scholar
• Mempel, T. R., Scimone, M. L., Mora, J. R. & von Andrian, U. H. In vivo imaging of leukocyte trafficking in blood vessels and tissues. Curr. Opin. Immunol. 16, 406–417 (2004).
  Article CAS PubMed Google Scholar
• Samokhvalov, I. M., Samokhvalova, N. I. & Nishikawa, S. Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature 446, 1056–1061 (2007). This was the first published technique for the fate mapping of yolk sac-derived haematopoietic cells in adult mice.
  Article CAS PubMed Google Scholar
• Brown, B. D., Venneri, M. A., Zingale, A., Sergi Sergi, L. & Naldini, L. Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer. Nature Med. 12, 585–591 (2006). This was the first demonstration that microRNAs can be used for de-targeting transgenes and vectors.
  Article CAS PubMed Google Scholar
• Brown, B. D. & Naldini, L. Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nature Rev. Genet. 10, 578–585 (2009).
  Article CAS PubMed Google Scholar
• Brown, B. D. et al. Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state. Nature Biotech. 25, 1457–1467 (2007).
  Article CAS Google Scholar
• Gentner, B. et al. Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy. Sci. Transl. Med. 2, 58ra84 (2010).
  Article CAS PubMed Google Scholar
• Luber, C. A. et al. Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. Immunity 32, 279–289 (2010).
  Article CAS PubMed Google Scholar
• Paul, P. et al. A genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. Cell 145, 268–283 (2011).
  Article CAS PubMed Google Scholar
• Amit, I. et al. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science 326, 257–263 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Bivona, T. G. et al. FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR. Nature 471, 523–526 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Root, D. E., Hacohen, N., Hahn, W. C., Lander, E. S. & Sabatini, D. M. Genome-scale loss-of-function screening with a lentiviral RNAi library. Nature Methods 3, 715–719 (2006).
  Article CAS PubMed Google Scholar
• Premsrirut, P. K. et al. A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell 145, 145–158 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Mestas, J. & Hughes, C. C. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172, 2731–2738 (2004).
  Article CAS PubMed Google Scholar
• Willinger, T., Rongvaux, A., Strowig, T., Manz, M. G. & Flavell, R. A. Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement. Trends Immunol. 32, 321–327 (2011).
  Article CAS PubMed Google Scholar
• Rathinam, C. et al. Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood 118, 3119–3128 (2011). This paper demonstrated remarkable improvement in engraftment of human myeloid cells when human CSF1 was knocked into Rag2 −/− Il2rg −/− recipient mice.
  Article CAS PubMed Google Scholar
• Strowig, T. et al. Transgenic expression of human signal regulatory protein α in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice. Proc. Natl Acad. Sci. USA 108, 13218–13223 (2011). This paper demonstrated remarkable improvement in engraftment of human haematopoietic cells when human SIRPA was genetically engineered into Rag2 −/− Il2rg −/− recipient mice.
  Article CAS PubMed PubMed Central Google Scholar
• Lugo-Villarino, G. et al. Identification of dendritic antigen-presenting cells in the zebrafish. Proc. Natl Acad. Sci. USA 107, 15850–15855 (2010). This was the first report to characterize a DC population in zebrafish.
  Article CAS PubMed PubMed Central Google Scholar
• White, R. M. et al. Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell 2, 183–189 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Wittamer, V., Bertrand, J. Y., Gutschow, P. W. & Traver, D. Characterization of the mononuclear phagocyte system in zebrafish. Blood 117, 7126–7135 (2011).
  Article CAS PubMed Google Scholar
• Jenkins, S. J. et al. Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 332, 1284–1288 (2011). This was the first publication to show that, in the context of nematode challenge, macrophages at the site of infection are derived from local populations, rather than from recruited blood precursors.
  Article CAS PubMed PubMed Central Google Scholar
• Merad, M. et al. Langerhans cells renew in the skin throughout life under steady-state conditions. Nature Immunol. 3, 1135–1141 (2002).
  Article CAS Google Scholar
• Li, J., Chen, K., Zhu, L. & Pollard, J. W. Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. Genesis 44, 328–335 (2006).
  Article CAS PubMed Google Scholar
• Varol, C. et al. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J. Exp. Med. 204, 171–180 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Pollard, J. W. Trophic macrophages in development and disease. Nature Rev. Immunol. 9, 259–270 (2009).
  Article CAS Google Scholar
• Ghosn, E. E. et al. Two physically, functionally, and developmentally distinct peritoneal macrophage subsets. Proc. Natl Acad. Sci. USA 107, 2568–2573 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Dorner, B. G. et al. Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells. Immunity 31, 823–833 (2009).
  Article CAS PubMed Google Scholar
• Sunderkotter, C. et al. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J. Immunol. 172, 4410–4417 (2004).
  Article PubMed Google Scholar
• Engel, D. R. et al. CCR2 mediates homeostatic and inflammatory release of Gr1high monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection. J. Immunol. 181, 5579–5586 (2008).
  Article CAS PubMed Google Scholar
• Kolaczkowska, E. et al. Resident peritoneal leukocytes are important sources of MMP-9 during zymosan peritonitis: superior contribution of macrophages over mast cells. Immunol. Lett. 113, 99–106 (2007).
  Article CAS PubMed Google Scholar
• Leendertse, M. et al. Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice. Innate Immun. 15, 3–12 (2009).
  Article CAS PubMed Google Scholar
• van Rooijen, N., Kors, N. & Kraal, G. Macrophage subset repopulation in the spleen: differential kinetics after liposome-mediated elimination. J. Leukoc. Biol. 45, 97–104 (1989).
  Article CAS PubMed Google Scholar
• Nikolic, T., Geutskens, S. B., van Rooijen, N., Drexhage, H. A. & Leenen, P. J. Dendritic cells and macrophages are essential for the retention of lymphocytes in (peri)-insulitis of the nonobese diabetic mouse: a phagocyte depletion study. Lab. Invest. 85, 487–501 (2005).
  Article PubMed Google Scholar
• Probst, H. C. et al. Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin. Exp. Immunol. 141, 398–404 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Hickman-Davis, J. M., Michalek, S. M., Gibbs-Erwin, J. & Lindsey, J. R. Depletion of alveolar macrophages exacerbates respiratory mycoplasmosis in mycoplasma-resistant C57BL mice but not mycoplasma-susceptible C3H mice. Infect. Immun. 65, 2278–2282 (1997).
  CAS PubMed PubMed Central Google Scholar
• Leemans, J. C. et al. Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice. J. Immunol. 166, 4604–4611 (2001).
  Article CAS PubMed Google Scholar
• Zhang-Hoover, J., Sutton, A., van Rooijen, N. & Stein-Streilein, J. A critical role for alveolar macrophages in elicitation of pulmonary immune fibrosis. Immunology 101, 501–511 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Bem, R. A. et al. Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 295, L314–L325 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Landsman, L., Varol, C. & Jung, S. Distinct differentiation potential of blood monocyte subsets in the lung. J. Immunol. 178, 2000–2007 (2007).
  Article CAS PubMed Google Scholar
• Sitia, G. et al. Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. PLoS Pathog. 7, e1002061 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Zhao, A. et al. Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology 135, 217–225 (2008).
  Article CAS PubMed Google Scholar
• Carmichael, M. D. et al. Role of brain macrophages on IL-1β and fatigue following eccentric exercise-induced muscle damage. Brain Behav. Immun. 24, 564–568 (2010).
  Article CAS PubMed Google Scholar
• Steel, C. D. et al. Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS. J. Neuroimmunol. 226, 81–92 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Tang, H. et al. The T helper type 2 response to cysteine proteases requires dendritic cell–basophil cooperation via ROS-mediated signaling. Nature Immunol. 11, 608–617 (2010).
  Article CAS Google Scholar
• King, I. L., Kroenke, M. A. & Segal, B. M. GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization. J. Exp. Med. 207, 953–961 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• van Rijt, L. S. et al. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J. Exp. Med. 201, 981–991 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Plitas, G. et al. Dendritic cells are required for effective cross-presentation in the murine liver. Hepatology 47, 1343–1351 (2008).
  Article PubMed Google Scholar
• Vallon-Eberhard, A., Landsman, L., Yogev, N., Verrier, B. & Jung, S. Transepithelial pathogen uptake into the small intestinal lamina propria. J. Immunol. 176, 2465–2469 (2006).
  Article CAS PubMed Google Scholar
• Kurimoto, I., van Rooijen, N., Dijkstra, C. D. & Streilein, J. W. Role of phagocytic macrophages in induction of contact hypersensitivity and tolerance by hapten applied to normal and ultraviolet B-irradiated skin. Immunology 83, 281–287 (1994).
  CAS PubMed PubMed Central Google Scholar