Another detour on the Toll road to the interferon antiviral response (original) (raw)

Nature Structural & Molecular Biology volume 11, pages 1028–1030 (2004)Cite this article

Recent characterization of two distinct signals leading to IRF-3 activation in response to double-stranded RNA recognition by Toll-like receptor 3 provides new mechanistic information on the regulatory events that link the detection of viral invasion by the cell with the development of the antiviral response.

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Figure 1: Double-stranded RNA (dsRNA) and virus-mediated signals leading to interferon gene activation.

Kimberly Caesar

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Authors and Affiliations

  1. Departments of Microbiology & Immunology, Lady Davis Institute for Medical Research-Jewish General Hospital, Medicine and Oncology, McGill University, Montreal, H3T 1E2, Canada
    John Hiscott

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Hiscott, J. Another detour on the Toll road to the interferon antiviral response.Nat Struct Mol Biol 11, 1028–1030 (2004). https://doi.org/10.1038/nsmb1104-1028

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