Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics (original) (raw)

• Aebersold DM, Burri P, Beer KT, Laissue J, Djonov V, Greiner RH et al. (2001). Expression of hypoxia-inducible factor-1α: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 61: 2911–2916.
  CAS PubMed Google Scholar
• Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J et al. (2001). Constitutive expression of hypoxia-inducible factor-1α renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res 61: 6548–6554.
  CAS PubMed Google Scholar
• Bachtiary B, Schindl M, Pötter R, Dreier B, Knocke TH, Hainfellner JA et al. (2003). Overexpression of hypoxia-inducible factor 1α indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer. Clin Cancer Res 9: 2234–2240.
  CAS PubMed Google Scholar
• Barnhart BC, Simon MC . (2007). Metastasis and stem cell pathways. Cancer Metastasis Rev 26: 261–271.
  CAS PubMed PubMed Central Google Scholar
• Bertout JA, Patel SA, Fryer BH, Durham AC, Covello KL, Olive KP et al. (2009). Heterozygosity for hypoxia inducible factor 1α decreases the incidence of thymic lymphomas in a p53 mutant mouse model. Cancer Res 69: 3213–3220.
  CAS PubMed PubMed Central Google Scholar
• Bindra RS, Crosby ME, Glazer PM . (2007). Regulation of DNA repair in hypoxic cancer cells. Cancer Metastasis Rev 26: 249–260.
  Article CAS PubMed Google Scholar
• Birner P, Gatterbauer B, Oberhuber G, Schindl M, Rössler K, Prodinger A et al. (2001a). Expression of hypoxia-inducible factor-1α in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Cancer 92: 165–171.
  CAS PubMed Google Scholar
• Birner P, Schindl M, Obermair A, Breitenecker G, Oberhuber G . (2001b). Expression of hypoxia-inducible factor 1α in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. Clin Cancer Res 7: 1661–1668.
  CAS PubMed Google Scholar
• Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G . (2000). Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 60: 4693–4696.
  CAS PubMed Google Scholar
• Bos R, van der Groep P, Greijer AE, Shvarts A, Meijer S, Pinedo HM et al. (2003). Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 97: 1573–1581.
  PubMed Google Scholar
• Brahimi-Horn MC, Chiche J, Pouysségur J . (2007). Hypoxia and cancer. J Mol Med 85: 1301–1307.
  PubMed Google Scholar
• Brugarolas JB, Vazquez F, Reddy A, Sellers WR, Kaelin Jr WG . (2003). TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell 4: 147–158.
  CAS PubMed Google Scholar
• Burri P, Djonov V, Aebersold DM, Lindel K, Studer U, Altermatt HJ et al. (2003). Significant correlation of hypoxia-inducible factor-1α with treatment outcome in cervical cancer treated with radical radiotherapy. Int J Radiat Oncol Biol Phys 56: 494–501.
  CAS PubMed Google Scholar
• Cai Q, Murakami M, Si H, Robertson ES . (2007). A potential α-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1α in normoxia. J Virol 81: 10413–10423.
  CAS PubMed PubMed Central Google Scholar
• Cai QL, Knight JS, Verma SC, Zald P, Robertson ES . (2006). EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors. PLoS Pathog 2: e116.
  PubMed PubMed Central Google Scholar
• Cavallaro U, Christofori G . (2004). Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 4: 118–132.
  CAS PubMed Google Scholar
• Chan DA, Giaccia AJ . (2007). Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev 26: 333–339.
  CAS PubMed Google Scholar
• Chang Q, Qin R, Huang T, Gao J, Feng Y . (2006). Effect of antisense hypoxia-inducible factor 1α on progression, metastasis, and chemosensitivity of pancreatic cancer. Pancreas 32: 297–305.
  CAS PubMed Google Scholar
• Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F et al. (2003). Dominant-negative hypoxia-inducible factor-1α reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 162: 1283–1291.
  CAS PubMed PubMed Central Google Scholar
• Chiche J, Ilc K, Laferrière J, Trottier E, Dayan F, Mazure NM et al. (2009). Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 69: 358–368.
  CAS PubMed Google Scholar
• Cleven AH, van Engeland M, Wouters BG, de Bruine AP . (2007). Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. Cell Oncol 29: 229–240.
  CAS PubMed PubMed Central Google Scholar
• Dales JP, Garcia S, Meunier-Carpentier S, Andrac-Meyer L, Haddad O, Lavaut MN et al. (2005). Overexpression of hypoxia-inducible factor HIF-1α predicts early relapse in breast cancer: retrospective study in a series of 745 patients. Int J Cancer 116: 734–739.
  CAS PubMed Google Scholar
• Daponte A, Ioannou M, Mylonis I, Simos G, Minas M, Messinis IE et al. (2008). Prognostic significance of hypoxia-inducible factor 1α (HIF-1α) expression in serous ovarian cancer: an immunohistochemical study. BMC Cancer 8: 335.
  PubMed PubMed Central Google Scholar
• Dewhirst MW, Cao Y, Moeller B . (2008). Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 8: 425–437.
  CAS PubMed PubMed Central Google Scholar
• Escuin D, Kline ER, Giannakakou P . (2005). Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1α accumulation and activity by disrupting microtubule function. Cancer Res 65: 9021–9028.
  CAS PubMed PubMed Central Google Scholar
• Fath DM, Kong X, Liang D, Lin Z, Chou A, Jiang Y et al. (2006). Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-α. J Biol Chem 281: 13612–13619.
  CAS PubMed Google Scholar
• Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, Raman V et al. (2007). HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell 12: 230–238.
  CAS PubMed PubMed Central Google Scholar
• Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A et al. (2003). Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300: 1155–1159.
  CAS PubMed Google Scholar
• Gatenby RA, Gillies RJ . (2008). A microenvironmental model of carcinogenesis. Nat Rev Cancer 8: 56–61.
  CAS PubMed Google Scholar
• Generali D, Berruti A, Brizzi MP, Campo L, Bonardi S, Wigfield S et al. (2006). Hypoxia-inducible factor-1α expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. Clin Cancer Res 12: 4562–4568.
  CAS PubMed Google Scholar
• Giatromanolaki A, Koukourakis MI, Simopoulos C, Polychronidis A, Gatter KC, Harris AL et al. (2004). c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1α dependent. Clin Cancer Res 10: 7972–7977.
  CAS PubMed Google Scholar
• Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Talks K, Pezzella F et al. (2001). Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumors and survival. Br J Cancer 85: 881–890.
  CAS PubMed PubMed Central Google Scholar
• Giatromanolaki A, Sivridis E, Kouskoukis C, Gatter KC, Harris AL, Koukourakis MI . (2003). Hypoxia-inducible factors 1α and 2α are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. Melanoma Res 13: 493–501.
  CAS PubMed Google Scholar
• Gillies RJ, Gatenby RA . (2007). Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev 26: 311–317.
  CAS PubMed Google Scholar
• Gray LH, Conger AO, Ebert M, Hornsey S, Scott OCA . (1953). The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 26: 638–648.
  CAS PubMed Google Scholar
• Griffiths EA, Pritchard SA, Valentine HR, Whitchelo N, Bishop PW, Ebert MP et al. (2007). Hypoxia-inducible factor-1α expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas. Br J Cancer 96: 95–103.
  CAS PubMed Google Scholar
• Hahnfeldt P, Folkman J, Hlatky L . (2003). Minimizing long-term tumor burden: the logic for metronomic chemotherapeutic dosing and its antiangiogenic basis. J Theor Biol 220: 545–554.
  PubMed Google Scholar
• Harris AL . (2002). Hypoxia—a key regulatory factor in tumor growth. Nat Rev Cancer 2: 38–47.
  CAS PubMed Google Scholar
• Hiraga T, Kizaka-Kondoh S, Hirota K, Hiraoka M, Yoneda T . (2007). Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer. Cancer Res 67: 4157–4163.
  CAS PubMed Google Scholar
• Imamura T, Kikuchi H, Herraiz MT, Park DY, Mizukami Y, Mino-Kenduson M et al. (2009). HIF-1α and HIF-2α have divergent roles in colon cancer. Int J Cancer 124: 763–771.
  CAS PubMed PubMed Central Google Scholar
• Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM . (2002). Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway. J Biol Chem 277: 29936–29944.
  CAS PubMed Google Scholar
• Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL et al. (2005). HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 8: 143–153.
  CAS PubMed Google Scholar
• Jiang BH, Agani F, Passaniti A, Semenza GL . (1997). V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res 57: 5328–5335.
  CAS PubMed Google Scholar
• Kaelin Jr WG, Ratcliffe PJ . (2008). Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30: 393–402.
  CAS PubMed Google Scholar
• Kaluz S, Kaluzov M, Stanbridge EJ . (2006). Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1α C-terminal activation domain. Mol Cell Biol 26: 5895–5907.
  CAS PubMed PubMed Central Google Scholar
• Kaluz S, Kaluzov M, Stanbridge EJ . (2008). Comment on the role of FIH in the inhibitory effect of bortezomib on hypoxia-inducible factor-1. Blood 111: 5258–5259.
  CAS PubMed Google Scholar
• Kerbel RS, Kamen BA . (2004). The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 4: 423–436.
  CAS PubMed Google Scholar
• Kondo K, Kim WY, Lechpammer M, Kaelin Jr WG . (2003). Inhibition of HIF-2α is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 1: e83.
  PubMed PubMed Central Google Scholar
• Kondo S, Seo SY, Yoshizaki T, Wakisaka N, Furukawa M, Joab I et al. (2006). EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1α through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells. Cancer Res 66: 9870–9877.
  CAS PubMed Google Scholar
• Kong D, Park EJ, Stephen AG, Calvani M, Cardellina JH, Monks A et al. (2005). Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res 65: 9047–9055.
  CAS PubMed Google Scholar
• Kong X, Lin Z, Liang D, Fath D, Sang N, Caro J . (2006). Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1α. Mol Cell Biol 26: 2019–2028.
  CAS PubMed PubMed Central Google Scholar
• Korkolopoulou P, Patsouris E, Konstantinidou AE, Pavlopoulos PM, Kavantzas N, Boviatsis E et al. (2004). Hypoxia-inducible factor 1α/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis. Neuropathol Appl Neurobiol 30: 267–278.
  CAS PubMed Google Scholar
• Koshiji M, To KK, Hammer S, Kumamoto K, Harris AL, Modrich P et al. (2005). HIF-1α induces genetic instability by transcriptionally downregulating MutSα expression. Mol Cell 17: 793–803.
  CAS PubMed Google Scholar
• Koukourakis MI, Giatromanolaki A, Sivridis E, Simopoulos C, Turley H, Talks K et al. (2002). Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer. Int J Radiat Oncol Biol Phys 53: 1192–1202.
  CAS PubMed Google Scholar
• Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH et al. (2006). Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel–Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res 66: 2725–2731.
  CAS PubMed Google Scholar
• Kronblad A, Jirstrom K, Ryden L, Nordenskjold B, Landberg G . (2006). Hypoxia inducible factor-1α is a prognostic marker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response. Int J Cancer 118: 2609–2616.
  CAS PubMed Google Scholar
• Kung AL, Wang S, Klco JM, Kaelin WG, Livingston DM . (2000). Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med 6: 1335–1340.
  CAS PubMed Google Scholar
• Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK . (2002). FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16: 1466–1471.
  CAS PubMed PubMed Central Google Scholar
• Lau KW, Tian YM, Raval RR, Ratcliffe PJ, Pugh CW . (2007). Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms. Br J Cancer 96: 1284–1292.
  CAS PubMed PubMed Central Google Scholar
• Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL . (2001). HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21: 3995–4004.
  CAS PubMed PubMed Central Google Scholar
• Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL . (2009). Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci USA 106: 2353–2358.
  CAS PubMed PubMed Central Google Scholar
• Li F, Sonveaux P, Rabbani ZN, Liu S, Yan B, Huang Q et al. (2007). Regulation of HIF-1α stability through _S_-nitrosylation. Mol Cell 26: 63–74.
  PubMed PubMed Central Google Scholar
• Li L, Lin X, Staver M, Shoemaker A, Semizarov D, Fesik SW et al. (2005). Evaluating hypoxia-inducible factor-1α as a cancer therapeutic target via inducible RNA interference in vivo. Cancer Res 65: 7249–7258.
  CAS PubMed Google Scholar
• Liao D, Corle C, Seagroves TN, Johnson RS . (2007). Hypoxia-inducible factor-1α is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 67: 563–572.
  CAS PubMed Google Scholar
• Liao D, Johnson RS . (2007). Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev 26: 281–290.
  CAS PubMed Google Scholar
• Liu Y, Tao J, Li Y, Yang J, Yu Y, Wang M et al. (2009). Targeting hypoxia-inducible factor-1α with Tf–PEI–shRNA complex via transferrin receptor-mediated endocytosis inhibits melanoma growth. Mol Ther 17: 269–277.
  CAS PubMed Google Scholar
• Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL . (2007). RACK1 competes with HSP90 for binding to HIF-1α and is required for O2-independent and HSP90 inhibitor-induced degradation of HIF-1α. Mol Cell 25: 207–217.
  PubMed PubMed Central Google Scholar
• Lukashev D, Ohta A, Sitkovsky M . (2007). Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues. Cancer Metastasis Rev 26: 273–279.
  CAS PubMed Google Scholar
• Luwor RB, Lu Y, Li X, Mendelsohn J, Fan Z . (2005). The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1α, leading to transcriptional inhibition of vascular endothelial growth factor expression. Oncogene 24: 4433–4441.
  CAS PubMed Google Scholar
• Majumder PK, Yeh JJ, George DJ, Febbo PG, Kum J, Xue Q et al. (2004). mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 10: 594–601.
  CAS PubMed Google Scholar
• Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H et al. (2007). Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells. J Biol Chem 282: 14073–14082.
  CAS PubMed Google Scholar
• Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ et al. (2005). Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105: 659–669.
  CAS PubMed Google Scholar
• Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ et al. (1997). Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 94: 8104–8109.
  CAS PubMed PubMed Central Google Scholar
• Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME et al. (1999). The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271–275.
  CAS PubMed Google Scholar
• Mayerhofer M, Valent P, Sperr WR, Griffin JD, Sillaber C . (2002). BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1α, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood 100: 3767–3775.
  CAS PubMed Google Scholar
• Melillo G . (2007). Targeting hypoxia cell signaling for cancer therapy. Cancer Metastasis Rev 26: 341–352.
  CAS PubMed Google Scholar
• Moeller BJ, Cao Y, Li CY, Dewhirst MW . (2004). Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5: 429–441.
  CAS PubMed Google Scholar
• Moeller BJ, Richardson RA, Dewhirst MW . (2007). Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment. Cancer Metastasis Rev 26: 241–248.
  CAS PubMed Google Scholar
• Mole DR, Blancher C, Copley RR, Pollard PJ, Gleadle JM, Ragoussis J et al. (2009). Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem 284: 16767–16775.
  CAS PubMed PubMed Central Google Scholar
• Nakamura M, Bodily JM, Beglin M, Kyo S, Inoue M, Laimins LA . (2009). Hypoxia-specific stabilization of HIF-1α by human papillomaviruses. Virology 387: 442–448.
  CAS PubMed Google Scholar
• Nanni S, Benvenuti V, Grasselli A, Priolo C, Aiello A, Mattiussi S et al. (2009). Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer. J Clin Invest 119: 1093–1108.
  CAS PubMed PubMed Central Google Scholar
• Pagès G, Pouyssègur J . (2005). Transcriptional regulation of the vascular endothelial growth factor gene—a concert of activating factors. Cardiovasc Res 65: 564–573.
  PubMed Google Scholar
• Pore N, Jiang Z, Gupta A, Cerniglia G, Kao GD, Maity A . (2006). EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms. Cancer Res 66: 3197–3204.
  CAS PubMed Google Scholar
• Qian DZ, Kachhap SK, Collis SJ, Verheul HM, Carducci MA, Atadja P et al. (2006). Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1α. Cancer Res 66: 8814–8821.
  CAS PubMed Google Scholar
• Quintero M, Brennan PA, Thomas GJ, Moncada S . (2006). Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1α in cancer: role of free radical formation. Cancer Res 66: 770–774.
  CAS PubMed Google Scholar
• Rajaganeshan R, Prasad R, Guillou PJ, Poston G, Scott N, Jayne DG . (2008). The role of hypoxia in recurrence following resection of Dukes’ B colorectal cancer. Int J Colorectal Dis 23: 1049–1055.
  CAS PubMed Google Scholar
• Rapisarda A, Uranchimeg B, Scudiero DA, Selby M, Sausville EA, Shoemaker RH et al. (2002). Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 62: 4316–4324.
  CAS PubMed Google Scholar
• Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ et al. (2009). Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis. Br J Cancer 100: 1666–1673.
  CAS PubMed PubMed Central Google Scholar
• Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, LI J-L et al. (2005). Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel–Lindau-associated renal cell carcinoma. Mol Cell Biol 25: 5675–5686.
  CAS PubMed PubMed Central Google Scholar
• Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q et al. (2000). Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α. Genes Dev 14: 34–44.
  CAS PubMed PubMed Central Google Scholar
• Schindl M, Schoppmann SF, Samonigg H, Hausmaninger H, Kwasny W, Gnant M et al. (2002). Overexpression of hypoxia-inducible factor 1α is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin Cancer Res 8: 1831–1837.
  CAS PubMed Google Scholar
• Schmitz KJ, Müller CI, Reis H, Alakus H, Winde G, Baba HA et al. (2009). Combined analysis of hypoxia-inducible factor 1α and metallothionein indicates an aggressive subtype of colorectal carcinoma. Int J Colorectal Dis 24: 1287–1296.
  PubMed Google Scholar
• Schrijvers ML, van der Laan BF, de Bock GH, Pattje WJ, Mastik MF, Menkema L et al. (2008). Overexpression of intrinsic hypoxia markers HIF-1α and CA-IX predict for local recurrence in stage T1-T2 glottic laryngeal carcinoma treated with radiotherapy. Int J Radiat Oncol Biol Phys 72: 161–169.
  CAS PubMed Google Scholar
• Schwartz DL, Powis G, Thitai-Kumar A, He Y, Bankson J, Williams R et al. (2009). The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects. Mol Cancer Ther 8: 947–958.
  CAS PubMed PubMed Central Google Scholar
• Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD et al. (2005). Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell 7: 77–85.
  CAS PubMed Google Scholar
• Semenza GL . (2000). Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol 35: 71–103.
  CAS PubMed Google Scholar
• Semenza GL . (2009a). Oxygen homeostasis. Systems Biol Med (doi:10.1002/wsbm.69).
  CAS PubMed Google Scholar
• Semenza GL . (2009b). Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol 19: 12–16.
  CAS PubMed Google Scholar
• Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL et al. (2009). mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz–Jeghers syndrome. Proc Natl Acad Sci USA 106: 11137–11142.
  CAS PubMed PubMed Central Google Scholar
• Shin DH, Chun YS, Lee DS, Huang LE, Park JW . (2008). Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1. Blood 111: 3131–3136.
  CAS PubMed Google Scholar
• Shin YC, Joo CH, Gack MU, Lee HR, Jung JU . (2008). Kaposi's sarcoma-associated herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible factor-1α to induce vascular endothelial growth factor expression. Cancer Res 68: 1751–1759.
  CAS PubMed Google Scholar
• Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI . (2002). Association of hypoxia-inducible factors 1α and 2α with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 95: 1055–1063.
  CAS PubMed Google Scholar
• Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA et al. (2000). The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α. Cancer Res 60: 4873–4880.
  CAS PubMed Google Scholar
• Stoeltzing O, McCarty MF, Wey JS, Fan F, Liu W, Belcheva A et al. (2004). Role of hypoxia-inducible factor 1α in gastric cancer cell growth, angiogenesis, and vessel maturation. J Natl Cancer Inst 96: 946–956.
  CAS PubMed Google Scholar
• Sullivan R, Graham CH . (2007). Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev 26: 319–331.
  CAS PubMed Google Scholar
• Sun HC, Qiu ZJ, Liu J, Sun J, Jiang T, Huang KJ et al. (2007). Expression of hypoxia-inducible factor-1α and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis. Int J Oncol 30: 1359–1367.
  CAS PubMed Google Scholar
• Swietach P, Vaughan-Jones RD, Harris AL . (2007). Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev 26: 299–310.
  CAS PubMed Google Scholar
• Swinson DE, Jones JL, Cox G, Richardson D, Harris AL, O'Byrne KJ . (2004). Hypoxia-inducible factor-1α in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways. Int J Cancer 111: 43–50.
  CAS PubMed Google Scholar
• Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ et al. (2000). The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157: 411–421.
  CAS PubMed PubMed Central Google Scholar
• Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP et al. (2004). Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6: 485–495.
  CAS PubMed Google Scholar
• Takahashi R, Tanaka S, Hiyama T, Ito M, Kitadai Y, Sumii M et al. (2003). Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncol Rep 10: 797–802.
  CAS PubMed Google Scholar
• Theodoropoulos VE, Lazaris AC, Kastriotis I, Spiliadi C, Theodoropoulos GE, Tsoukala V et al. (2005). Evaluation of hypoxia-inducible factor 1α overexpression as a predictor of tumor recurrence and progression in superficial urothelial bladder carcinoma. BJU Int 95: 425–431.
  CAS PubMed Google Scholar
• Theodoropoulos VE, Lazaris AC, Sofras F, Gerzelis I, Tsoukala V, Ghikonti I et al. (2004). Hypoxia-inducible factor 1α expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur Urol 46: 200–208.
  CAS PubMed Google Scholar
• Thomas GV, Tran C, Mellinghoff IK, Welsbie DS, Chan E, Fueger B et al. (2006). Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 12: 122–127.
  CAS PubMed Google Scholar
• Tomita M, Semenza GL, Michiels C, Matsuda T, Uchihara JN, Okudaira T et al. (2007). Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells. Biochem J 406: 317–323.
  CAS PubMed PubMed Central Google Scholar
• Trastour C, Benizri E, Ettore F, Ramaioli A, Chamorey E, Pouyssegur J et al. (2007). HIF-1α and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. Int J Cancer 120: 1443–1450.
  Google Scholar
• Tzao C, Lee SC, Tung HJ, Hsu HS, Hsu WH, Sun GH et al. (2008). Expression of hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF)-D as outcome predictors in resected esophageal squamous cell carcinoma. Dis Markers 25: 141–148.
  CAS PubMed PubMed Central Google Scholar
• Vaupel P, Mayer A, Hockel M . (2004). Tumor hypoxia and malignant progression. Methods Enzymol 381: 335–354.
  CAS PubMed Google Scholar
• Vleugel MM, Greijer AE, Shvarts A, van der Groep P, van Berkel M, Aarbodem Y et al. (2005). Differential prognostic impact of hypoxia induced and diffuse HIF-1α expression in invasive breast cancer. J Clin Pathol 58: 172–177.
  CAS PubMed PubMed Central Google Scholar
• Vogelstein B, Kinzler KW . (2004). Cancer genes and the pathways they control. Nat Med 10: 789–799.
  CAS PubMed Google Scholar
• Wang GL, Jiang BH, Rue EA, Semenza GL . (1995). Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92: 5510–5514.
  CAS PubMed PubMed Central Google Scholar
• Wang GL, Semenza GL . (1995). Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270: 1230–1237.
  CAS PubMed Google Scholar
• Wang XL, Xu R, Wu X, Gillespie D, Jensen R, Lu ZR . (2009). Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice. Mol Pharm 6: 738–746.
  CAS PubMed Google Scholar
• Yamamoto Y, Ibusuki M, Okumura Y, Kawasoe T, Kai K, Iyama K et al. (2008). Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer. Breast Cancer Res Treat 110: 465–475.
  CAS PubMed Google Scholar
• Yoo YG, Cho S, Park S, Lee MO . (2004). The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1α. FEBS Lett 577: 121–126.
  CAS PubMed Google Scholar
• Yu J, Zhang L, Hwang PM, Rago C, Kinzler KW, Vogelstein B . (1999). Identification and classification of p53-regulated genes. Proc Natl Acad Sci USA 96: 14517–14522.
  CAS PubMed PubMed Central Google Scholar
• Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR et al. (2008). Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth. Proc Natl Acad Sci USA 105: 19579–19586.
  CAS PubMed PubMed Central Google Scholar
• Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P et al. (2009). Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α. Science 324: 261–265.
  CAS PubMed PubMed Central Google Scholar
• Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM et al. (2000). Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60: 1541–1545.
  CAS PubMed Google Scholar
• Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D et al. (1999). Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res 59: 5830–5835.
  CAS PubMed Google Scholar
• Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E et al. (2000). Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 14: 391–396.
  CAS PubMed PubMed Central Google Scholar