- Assoian RK, Schwartz MA . (2001). Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr Opin Genet Dev 11: 48–53.
Article CAS Google Scholar
- Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M . (2004). Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature 428: 190–193.
Article CAS Google Scholar
- Bhatt KV, Spofford LS, Aram G, McMullen M, Pumiglia K, Aplin AE . (2005). Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling. Oncogene 12: 3459–3471.
Article Google Scholar
- Bond M, Sala-Newby GB, Newby AC . (2004). Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability: a novel mechanism regulating smooth muscle cell proliferation. J Biol Chem 279: 37304–37310.
Article CAS Google Scholar
- Brandeis M, Hunt T . (1996). The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase. EMBO J 15: 5280–5289.
Article CAS Google Scholar
- Calipel A, Lefevre G, Pouponnot C, Mouriaux F, Eychene A, Mascarelli F . (2003). Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK pathway. J Biol Chem 278: 42409–42418.
Article CAS Google Scholar
- Carrano AC, Eytan E, Hershko A, Pagano M . (1999). SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1: 193–199.
Article CAS Google Scholar
- Carrano AC, Pagano M . (2001). Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression. J Cell Biol 153: 1381–1390.
Article CAS Google Scholar
- Catzavelos C, Bhattacharya N, Ung YC, Wilson JA, Roncari L, Sandhu C et al. (1997). Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer. Nat Med 3: 227–230.
Article CAS Google Scholar
- Collisson EA, De A, Suzuki H, Gambhir SS, Kolodney MS . (2003). Treatment of metastatic melanoma with an orally available inhibitor of the Ras-Raf-MAPK cascade. Cancer Res 63: 5669–5673.
CAS PubMed Google Scholar
- Conner SR, Scott G, Aplin AE . (2003). Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells. J Biol Chem 278: 34548–34554.
Article CAS Google Scholar
- Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S et al. (2002). Mutations of the BRAF gene in human cancer. Nature 417: 949–954.
Article CAS Google Scholar
- Delmas C, Aragou N, Poussard S, Cottin P, Darbon JM, Manenti S . (2003). MAP kinase-dependent degradation of p27Kip1 by calpains in choroidal melanoma cells. Requirement of p27Kip1 nuclear export. J Biol Chem 278: 12443–12451.
Article CAS Google Scholar
- Fero ML, Randel E, Gurley KE, Roberts JM, Kemp CJ . (1998). The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature 396: 177–180.
Article CAS Google Scholar
- Florenes VA, Mælandsmo GM, Kerbel RS, Slingerland JM, Nesland JM, Holm R . (1998). Protein expression of the cell-cycle inhibitor p27Kip1 in malignant melanoma: inverse correlation with disease-free survival. Am J Pathol 153: 305–312.
Article CAS Google Scholar
- Galan JM, Peter M . (1999). Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism. Proc Natl Acad Sci USA 96: 9124–9129.
Article CAS Google Scholar
- Ganoth D, Bornstein G, Ko TK, Larsen B, Tyers M, Pagano M et al. (2001). The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol 3: 321–324.
Article CAS Google Scholar
- Garriga J, Bhattacharya S, Calbo J, Marshall RM, Truongcao M, Haines DS et al. (2003). CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2. Mol Cell Biol 23: 5165–5173.
Article CAS Google Scholar
- Gstaiger M, Jordan R, Lim M, Catzavelos C, Mestan J, Slingerland J et al. (2001). Skp2 is oncogenic and overexpressed in human cancers. Proc Natl Acad Sci USA 98: 5043–5048.
Article CAS Google Scholar
- Gysin S, Lee S-H, Dean NM, McMahon M . (2005). Pharmacologic inhibition of RAF->MEK->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1. Cancer Res 65: 4870–4880.
Article CAS Google Scholar
- Hanahan D, Weinberg RA . (2000). The hallmarks of cancer. Cell 100: 57–70.
Article CAS Google Scholar
- Hao B, Zheng N, Schulman BA, Wu G, Miller JJ, Pagano M et al. (2005). Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell 20: 9–19.
Article CAS Google Scholar
- Harbour JW, Dean DC . (2000). The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev 14: 2393–2409.
Article CAS Google Scholar
- Henriet P, Zhong ZD, Brooks PC, Weinberg KI, DeClerck YA . (2000). Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1. Proc Natl Acad Sci USA 97: 10026–10031.
Article CAS Google Scholar
- Hingorani SR, Jacobetz MA, Robertson GP, Herlyn M, Tuveson DA . (2003). Suppression of BRAF(V599E) in human melanoma abrogates transformation. Cancer Res 63: 5198–5202.
CAS PubMed Google Scholar
- Inui N, Kitagawa K, Miwa S, Hattori T, Chida K, Nakamura H et al. (2003). High expression of Cks1 in human non-small cell lung carcinomas. Biochem Biophys Res Comm 303: 978–984.
Article CAS Google Scholar
- Ishida N, Hara T, Kamura T, Yoshida M, Nakayama K, Nakayama KI . (2002). Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem 277: 14355–14358.
Article CAS Google Scholar
- Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M et al. (2004). An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell 16: 47–58.
Article CAS Google Scholar
- Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H et al. (2003). Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc Natl Acad Sci USA 100: 10231–10236.
Article CAS Google Scholar
- Kamura T, Hara T, Matsumoto M, Ishida N, Okumura F, Hatakeyama S et al. (2004). Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat Cell Biol 6: 1229–1235.
Article CAS Google Scholar
- Karasarides M, Chiloeches A, Hayward R, Niculescu-Duvaz D, Scanlon I, Friedlos F et al. (2004). B-RAF is a therapeutic target in melanoma. Oncogene 23: 6292–6298.
Article CAS Google Scholar
- Katagiri Y, Hozumi Y, Kondo S . (2006). Knockdown of Skp2 by siRNA inhibits melanoma cell growth in vitro and in vivo. J Dermatol Sci 42: 215–224.
Article CAS Google Scholar
- Kawana H, Tamaru J, Tanaka T, Hirai A, Saito Y, Kitagawa M et al. (1998). Role of p27Kip1 and cyclin-dependent kinase 2 in the proliferation of non-small cell lung cancer. Am J Pathol 153: 505–513.
Article CAS Google Scholar
- Kossatz U, Dietrich N, Zender L, Buer J, Manns MP, Malek NP . (2004). Skp2-dependent degradation of p27kip1 is essential for cell cycle progression. Genes Dev 18: 2602–2607.
Article CAS Google Scholar
- Latres E, Chiarle R, Schulman BA, Pavletich NP, Pellicer A, Inghirami G et al. (2001). Role of the F-box protein Skp2 in lymphomagenesis. Proc Natl Acad Sci USA 98: 2515–2520.
Article CAS Google Scholar
- Li Q, Murphy M, Ross J, Sheehan C, Carlson JA . (2004). Skp2 and p27kip1 expression in melanocytic nevi and melanoma: an inverse relationship. J Cutan Pathol 31: 633–642.
Article Google Scholar
- Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF et al. (1997). Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 3: 231–234.
Article CAS Google Scholar
- Maldonado JL, Fridlyand J, Patel H, Jain AN, Busam K, Kageshita T et al. (2003). Determinants of BRAF mutations in primary melanomas. J Natl Cancer Inst 95: 1878–1890.
Article CAS Google Scholar
- Malek NP, Sundberg H, McGrew S, Nakayama K, Kyriakides TR, Roberts JM . (2001). A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature 413: 323–327.
Article CAS Google Scholar
- Mirza AM, Gysin S, Malek N, Nakayama K-I, Roberts JM, McMahon M . (2004). Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT. Mol Cell Biol 24: 10868–10881.
Article CAS Google Scholar
- Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A et al. (1999). Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev 13: 1181–1189.
Article CAS Google Scholar
- Mori M, Mimori K, Shiraishi T, Tanaka S, Ueo H, Sugimachi K et al. (1997). p27 expression and gastric carcinoma. Nat Med 3: 593.
Article CAS Google Scholar
- Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, Kitagawa K et al. (2000). Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J 19: 2069–2081.
Article CAS Google Scholar
- Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N, Hatakeyama S et al. (2004). Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell 6: 661–672.
Article CAS Google Scholar
- Pfaffl MW . (2001). A new mathematical model for relative quantification in real-time RT–PCR. Nucleic Acids Res 29: e45.
Article CAS Google Scholar
- Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L et al. (1994). Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78: 761–771.
Article CAS Google Scholar
- Rodier G, Makris C, Coulombe P, Scime A, Nakayama K, Nakayama KI et al. (2005). p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2. J Cell Biol 168: 55–66.
Article CAS Google Scholar
- Satyamoorthy K, Li G, Gerrero MR, Brose MS, Volpe P, Weber BL et al. (2003). Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res 63: 756–759.
CAS PubMed Google Scholar
- Sauter ER, Yeo U-C, von Stemm A, Zhu W, Litwin S, Tichansky DS et al. (2002). Cyclin D1 is a candidate oncogene in cutaneous melanoma. Cancer Res 62: 3200–3206.
CAS PubMed Google Scholar
- Shapira M, Ben-Izhak O, Bishara B, Futerman B, Minkov I, Krausz MM et al. (2004). Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma. Cancer 100: 1615–1621.
Article CAS Google Scholar
- Sharma A, Trivedi NR, Zimmerman MA, Tuveson DA, Smith CD, Robertson GP . (2005). Mutant V599E B-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res 65: 2412–2421.
Article CAS Google Scholar
- Sherr CJ, Roberts JM . (1999). CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13: 1501–1512.
Article CAS Google Scholar
- Sledz CA, Holko M, de Veer MJ, Silverman RH, Williams BR . (2003). Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 5: 834–839.
Article CAS Google Scholar
- Slingerland J, Pagano M . (2000). Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 183: 10–17.
Article CAS Google Scholar
- Spruck C, Strohmaier H, Watson M, Smith APL, Ryan A, Krek W et al. (2001). A CDK-independent function of mammalian Cks1: targeting of SCFSkp2 to the CDK inhibitor p27Kip1. Mol Cell 7: 639–650.
Article CAS Google Scholar
- Stahl JM, Sharma A, Cheung M, Zimmerman M, Cheng JQ, Bosenberg MW et al. (2004). Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res 64: 7002–7010.
Article CAS Google Scholar
- Sumimoto H, Hirata K, Yamagata S, Miyoshi H, Miyagishi M, Taira K et al. (2006). Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi. Int J Cancer 118: 472–476.
Article CAS Google Scholar
- Sumimoto H, Miyagishi M, Miyoshi H, Yamagata S, Shimizu A, Taira K et al. (2004). Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene 23: 6031–6039.
Article CAS Google Scholar
- Sutterluty H, Chatelain E, Marti A, Wirbelauer C, Senften M, Muller U et al. (1999). p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nat Cell Biol 1: 207–214.
Article CAS Google Scholar
- Tsvetkov LM, Yeh KH, Lee SJ, Sun H, Zhang H . (1999). p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol 9: 661–664.
Article CAS Google Scholar
- Vlach J, Hennecke S, Amati B . (1997). Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J 16: 5334–5344.
Article CAS Google Scholar
- Wang W, Ungermannova D, Jin J, Harper JW, Liu X . (2004). Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling. Oncogene 23: 1064–1075.
Article CAS Google Scholar
- Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin Jr WG . (2004). Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428: 194–198.
Article CAS Google Scholar
- Wellbrock C, Karasarides M, Marais R . (2004a). The Raf proteins take centre stage. Nat Rev Mol Cell Biol 5: 875–885.
Article CAS Google Scholar
- Wellbrock C, Ogilvie L, Hedley D, Karasarides M, Martin J, Niculescu-Duvaz D et al. (2004b). V599EB-RAF is an oncogene in melanocytes. Cancer Res 64: 2338–2342.
Article CAS Google Scholar
- Wirbelauer C, Sutterluty H, Blondel M, Gstaiger M, Peter M, Reymond F et al. (2000). The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts. EMBO J 19: 5362–5375.
Article CAS Google Scholar
- Woenckhaus C, Maile S, Uffmann S, Bansemir M, Dittberner T, Poetsch M et al. (2005). Expression of Skp2 and p27KIP1 in naevi and malignant melanoma of the skin and its relation to clinical outcome. Histol Histopathol 20: 501–508.
CAS PubMed Google Scholar
- Zhu XH, Nguyen H, Halicka HD, Traganos F, Koff A . (2004). Noncatalytic requirement for cyclin A-cdk2 in p27 turnover. Mol Cell Biol 24: 6058–6066.
Article CAS Google Scholar