Dendritic cells and the control of immunity (original) (raw)

• Steinman, R. M. in Fundamental Immunology(ed. Paul, W. E.) 4th edn (Lippincott-Raven, Philadelphia, in the press).
• Inaba, K.et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176, 1693–1702 (1992).
  Article CAS PubMed Google Scholar
• Caux, C., Dezutter-Dambuyant, C., Schmitt, D. & Banchereau, J. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 360, 258–261 (1992).
  Article ADS CAS PubMed Google Scholar
• Szabolcs, P., Moore, M. A. S. & Young, J. W. Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-α. J. Immunol. 154, 5851–5861 (1995).
  CAS PubMed Google Scholar
• Romani, N.et al. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180, 83–93 (1994).
  Article CAS PubMed Google Scholar
• Sallusto, F. & Lanzavecchia, A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179, 1109–1118 (1994).
  Article CAS PubMed Google Scholar
• Sallusto, F. & Lanzavecchia, A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate antigen to the MHC class II compartment. Downregulation by cytokines and bacterial products. J. Exp. Med. 182, 389–400 (1995).
  Article CAS PubMed Google Scholar
• Romani, N.et al. Generation of mature dendritic cells from human blood: An improved method with special regard to clinical applicability. J. Immunol. Meth. 196, 137–151 (1996).
  Article CAS Google Scholar
• Reddy, A., Sapp, M., Feldman, M., Subklewe, M. & Bhardwaj, N. Amonocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells. Blood 90, 3640–3646 (1997).
  CAS PubMed Google Scholar
• Maraskovsky, E.et al. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 and ligand-treated mice: Multiple dendritic cell subpopulations identified. J. Exp. Med. 184, 1953–1962 (1996).
  Article CAS PubMed Google Scholar
• Adema, G. J.et al. Adendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. Nature 387, 713–717 (1997).
  Article ADS CAS PubMed Google Scholar
• Mueller, C. G. F.et al. Polymerase chain reaction selects a novel disintegrin-proteinase from CD40-activated germinal center dendritic cells. J. Exp. Med. 186, 655–663 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Greaves, D. R.et al. CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3α and is highly expressed in human dendritic cells. J. Exp. Med. 186, 837–844 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Winzler, C.et al. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J. Exp. Med. 185, 317–328 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Bhardwaj, N., Young, J. W., Nisanian, A. J., Baggers, J. & Steinman, R. M. Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses. J. Exp. Med. 178, 633–642 (1993).
  Article CAS PubMed Google Scholar
• Inaba, K., Inaba, M., Naito, M. & Steinman, R. M. Dendritic cell progenitors phagocytose particulates, including Bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J.Exp. Med. 178, 479–488 (1993).
  Article CAS PubMed Google Scholar
• Moll, H., Fuchs, H., Blank, C. & Rollinghoff, M. Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells. Eur. J. Immunol. 23, 1595–1601 (1993).
  Article CAS PubMed Google Scholar
• Zitvogel, L.et al. Therapy of murine tumors with tumor peptide pulsed dendritic cells: Dependence on T-cells, B7 costimulation, and Th1-associated cytokines. J. Exp. Med. 183, 87–97 (1996).
  Article CAS PubMed Google Scholar
• Paglia, P., Chiodoni, C., Rodolfo, M. & Colombo, M. P. Murine dendritic cells loaded in vitro with soluble protein prime CTL against tumor antigen in vivo. J. Exp. Med. 183, 317–322 (1996).
  Article CAS PubMed Google Scholar
• Mayordomo, J. I.et al. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nature Med. 1, 1297–1302 (1995).
  Article CAS PubMed Google Scholar
• Hsu, F. J.et al. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nature Med. 2, 52–58 (1996).
  Article CAS PubMed Google Scholar
• Ingulli, E., Mondino, A., Khoruts, A. & Jenkins, M. K. In vivo detection of dendritic cell antigen presentation to CD4+ T cells. J. Exp. Med. 185, 2133–2141 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Luther, S. A., Gulbranson-Judge, A., Acha-Orbea, H. & Maclennan, I. C. M. Viral superantigen drives extrafollicular and follicular B differentiation leading to virus-specific antibody production. J. Exp. Med. 185, 551–562 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Kudo, S., Matsuno, K., Ezaki, T. & Ogawa, M. Anovel migration pathway for rat dendritic cells from the blood: Hepatic sinusoids-lymph translocation. J. Exp. Med. 185, 777–784 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Inaba, K.et al. High levels of a major histocompatibility complex II–self peptide complex on dendritic cells from lymph node. J. Exp. Med. 186, 665–672 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Cella, M.et al. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184, 747–752 (1996).
  Article CAS PubMed Google Scholar
• Koch, F.et al. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184, 741–747 (1996).
  Article CAS PubMed Google Scholar
• Reis e Sousa, C.et al. In vivo microbial stimulation induces rapid CD40L-independent production of IL-12 by dendritic cells and their re-distribution to T cell areas. J. Exp. Med. 186, 1819–1829 (1997).
  Article CAS PubMed Google Scholar
• Caux, C.et al. B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J. Exp. Med. 180, 1841–1847 (1994).
  Article CAS PubMed Google Scholar
• Inaba, K.et al. The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J. Exp. Med. 180, 1849–1860 (1994).
  Article CAS PubMed Google Scholar
• Bhardwaj, N.et al. Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic resonses from human CD8+ T cells. J. Clin. Invest. 94, 797–807 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Bender, A., Bui, L. K., Feldman, M. A. V., Larsson, M. & Bhardwaj, N. Inactivated influenza virus, when presented on dendritic cells, elicits human CD8+ cytolytic T cell responses. J. Exp. Med. 182, 1663–1671 (1995).
  Article CAS PubMed Google Scholar
• Caux, C.et al. Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180, 1263–1272 (1994).
  Article CAS PubMed Google Scholar
• Wong, B. R.et al. TRANCE, a new TNF family member predominantly expressed in T cells, is a dendritic cell specific survival factor. J. Exp. Med. 186, 2075–2080 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Anderson, D. M.et al. Ahomologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390, 175–179 (1997).
  Article ADS CAS PubMed Google Scholar
• Lukas, M.et al. Human cutaneous dendritic cells migrate through dermal lymphatic vessels in a skin organ culture model. J. Invest. Dermatol. 106, 1293–1299 (1996).
  Article CAS PubMed Google Scholar
• Reis e Sousa, C., Stahl, P. D. & Austyn, J. M. Phagocytosis of antigens by Langerhans cells in vitro. J.Exp. Med. 178, 509–519 (1993).
  Article CAS PubMed Google Scholar
• Svensson, M., Stockinger, B. & Wick, M. J. Bone marrow-derived dendritic cells can process bacteria for MHC-1 and MHC-II presentation to T cells. J. Immunol. 158, 4229–4236 (1997).
  CAS PubMed Google Scholar
• Jiang, W.et al. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375, 151–155 (1995).
  Article ADS CAS PubMed Google Scholar
• Nijman, H. W.et al. Antigen capture and MHC class II compartments of freshly isolated and cultured human blood dendritic cells. J. Exp. Med. 182, 163–174 (1995).
  Article CAS PubMed Google Scholar
• Pierre, P.et al. Developmental regulation of MHC class II transport in mouse dendritic cells. Nature 388, 787–792 (1997).
  Article ADS CAS PubMed Google Scholar
• Cella, M., Engering, A., Pinet, V., Pieters, J. & Lanzavecchia, A. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 388, 782–787 (1997).
  Article ADS CAS PubMed Google Scholar
• Albert, M. L., Sauter, B. & Bhardwaj, N. Dendritic cells acquire antigen from apoptotic cells and induce class-I restricted CTLs. Nature 392, 86–89 (1998).
  Article ADS CAS PubMed Google Scholar
• Buelens, C.et al. Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by IL-10. Eur. J. Immunol. 27, 1848–1852 (1997).
  Article CAS PubMed Google Scholar
• Sallusto, F., Nicolo, C., De Maria, R., Corinti, S. & Testi, R. Ceramide inhibits antigen uptake and presentation by dendritic cells. J. Exp. Med. 184, 2411–2416 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Granelli-Piperno, A., Pope, M., Inaba, K. & Steinman, R. M. Coexpression of REL and SP1 transcription factors in HIV-1 induced, dendritic cell-T cell syncytia. Proc. Natl Acad. Sci. USA 92, 1094–10948 (1995).
  Article Google Scholar
• Kitajima, T., Arizumi, K., Bergstresser, P. R. & Takashima, A. Anovel mechanism of glucocorticoid-induced immune suppression: The inhibition of T cell-mediated terminal maturation of a murine dendritic cell line. J. Clin. Invest. 98, 142–147 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Brocker, T. Survival of mature CD4 T lymphocytes is dependent on MHC class II expressing dendritic cells. J. Exp. Med. 186, 1223–1232 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• O'Doherty, U.et al. Human blood contains two subsets of dendritic cells, one immunologically mature, and the other immature. Immunology 82, 487–493 (1994).
  CAS PubMed PubMed Central Google Scholar
• Brown, K. A.et al. Human blood dendritic cells: binding to vascular endothelium and expression of adhesion molecules. Clin. Exp. Immunol. 107, 601–607 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Matsuno, K., Ezaki, T., Kudo, S. & Uehara, Y. Alife stage of particle-laden rat dendritic cells in vivo: their terminal division, active phagocytosis and translocation from the liver to hepatic lymph. J. Exp. Med. 183, 1865–1878 (1996).
  Article CAS PubMed Google Scholar
• McWilliam, A. S.et al. Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli. J. Exp. Med. 184, 2429–2432 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Roake, J. A.et al. Dendritic cell loss from non-lymphoid tissues following systemic administration of lipopolysaccharide, tumour necrosis factor, and interleukin-1. J. Exp. Med. 181, 2237–2248 (1995).
  Article CAS PubMed Google Scholar
• MacPherson, G. G., Jenkins, C. D., Stein, M. J. & Edwards, C. Endotoxin-mediated dendritic cell release from the intestine: Characterization of released dendritic cells and TNF dependence. J.Immunol. 154, 1317–1322 (1995).
  CAS PubMed Google Scholar
• De Smedt, T.et al. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J. Exp. Med. 184, 1413–1424 (1996).
  Article CAS PubMed Google Scholar
• Hosoi, J.et al. Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature 363, 159–162 (1993).
  Article ADS CAS PubMed Google Scholar
• Sozzani, S.et al. Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines. J. Immunol. 155, 3292–3295 (1995).
  CAS PubMed Google Scholar
• Young, J. W., Szabolcs, P. & Moore, M. A. S. Identification of dendritic cell colony-forming units among normal CD4+ bone marrow progenitors that are expanded by c-_kit_-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor α. J. Exp. Med. 182, 1111–1120 (1995).
  Article CAS PubMed Google Scholar
• Saunders, D.et al. Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 184, 2185–2196 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Flores-Romo, L.et al. CD40 ligation on human CD34+ hematopoietic progenitors induces their proliferation and differentiation into functional dendritic cells. J. Exp. Med. 185, 341–349 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Caux, C.et al. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+ TNFα. J. Exp. Med. 184, 695–706 (1996).
  Article CAS PubMed Google Scholar
• Strunk, D., Egger, C., Leitner, G., Hanau, D. & Stingl, G. Askin homing molecule defines the Langerhans cells progenitor in human peripheral blood. J. Exp. Med. 185, 1131–1136 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Caux, C.et al. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNFα: II Functional analysis. Blood 90, 1458–1470 (1997).
  CAS PubMed Google Scholar
• Szabolcs, P.et al. Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-CFU intermediate. Blood 87, 4520–4530 (1996).
  CAS PubMed Google Scholar
• Borkowski, T. A., Letterio, J. J., Farr, A. G. & Udey, M. C. Arole for endogenous transforming growth factor β1 in Langerhans cell biology: The skin of transforming growth factor β1 null mice is devoid of epidermal Langerhans cells. J. Exp. Med. 184, 2417–2422 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Suss, G. & Shortman, K. Asubclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand induced apoptosis. J. Exp. Med. 183, 1789–1796 (1996).
  Article CAS PubMed Google Scholar
• Ardavin, C., Wu, L., Li, C. & Shortman, K. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 362, 761–763 (1993).
  Article ADS CAS PubMed Google Scholar
• Grouard, G.et al. The enigmatic plasmacytoid T cells develop into dendritic cells with IL-3 and CD40-ligand. J. Exp. Med. 185, 1101–1111 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Lieberman, P. H.et al. Langerhans cell [eosinophilic] granulomatosis. A clinicopathologic study encompassing 50 years. Am. J. Surg. Pathol. 20, 519–552 (1996).
  Article CAS PubMed Google Scholar
• Dubois, B.et al. Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes. J. Exp. Med. 185, 941–951 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Fayette, J.et al. Human dendritic cells skew isotype switching of CD40-activated naive B cells towards IgA1 and IgA2. J. Exp. Med. 185, 1909–1918 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Frankel, S. S.et al. Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid. Science 272, 115–117 (1996).
  Article ADS CAS PubMed Google Scholar
• Frankel, S. S.et al. Active replication of HIV-1 at the lymphoepithelial surface of the tonsil. Am. J. Pathol. 151, 89–96 (1997).
  CAS PubMed PubMed Central Google Scholar
• Kelsall, B. L. & Strober, W. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's Patch. J. Exp. Med. 183, 237–247 (1996).
  Article CAS PubMed Google Scholar
• Matsumoto, M.et al. Distinct roles of lymphotoxin-α and type 1 TNF receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells. J. Exp. Med. 186, 1997–2004 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Liu, Y.-J., Grouard, G., de Bouteiller, O. & Banchereau, J. Follicular dendritic cells and germinal centers. Int. Rev. Cytology 166, 139–179 (1996).
  Article CAS Google Scholar
• Liu, Y.-J.et al. Follicular dendritic cells specifically express the long CR2/CD21 isoform. J. Exp. Med. 185, 165–170 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Grouard, G., Durand, I., Filgueira, L., Banchereau, J. & Liu, Y.-J. Dendritic cells capable of stimulating T cells in germinal centres. Nature 384, 364–367 (1996).
  Article ADS CAS PubMed Google Scholar
• Brocker, T. & Karjalainen, K. Targeted expression of MHC class II molecules demonstrates that dendritic cells can induce negative but no positive selection of thymocytes in vivo. J. Exp. Med. 185, 541–550 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Laufer, T. M., DeKoning, J., Markowitz, J. S., Lo, D. & Glimcher, L. H. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383, 81–85 (1996).
  Article ADS CAS PubMed Google Scholar
• Zal, T., Volkmann, A. & Stockinger, B. Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen. J. Exp. Med. 180, 2089–2099 (1994).
  Article CAS PubMed Google Scholar
• Kurts, C.et al. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184, 923–930 (1996).
  Article CAS PubMed Google Scholar
• Kurts, C., Kosaka, H., Carbone, F. R., Miller, J. F. A. P. & Heath, W. R. Class I-restricted cross-presentation of exogenous self antigens leads to deletion of autoreactive CD8+ T cells. J. Exp. Med. 186, 239–245 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Forster, I. & Lieberam, I. Peripheral tolerance of CD4 T cells following local activation in adolescent mice. Eur. J. Immunol. 26, 3194–3202 (1996).
  Article CAS PubMed Google Scholar
• Soderberg-Naucler, C., Fish, K. N. & Nelson, J. A. Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell 91, 119–126 (1997).
  Article CAS PubMed Google Scholar
• Rettig, M. B.et al. Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science 276, 1851–1854 (1997).
  Article CAS PubMed Google Scholar
• Cameron, P. U.et al. Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science 257, 383–387 (1992).
  Article ADS CAS PubMed Google Scholar
• Weissman, D., Barker, T. D. & Fauci, A. S. The efficiency of acute infection of CD4+ T cells is markedly enhanced in the setting of antigen-specific immune activation. J. Exp. Med. 183, 687–692 (1996).
  Article CAS PubMed Google Scholar
• Pinchuk, L. M., Polacino, P. S., Agy, M. B., Klaus, S. J. & Clark, E. A. The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection. Immunity 1, 317–325 (1994).
  Article CAS PubMed Google Scholar
• Pope, M.et al. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 78, 389–398 (1994).
  Article CAS PubMed Google Scholar
• Grosjean, I.et al. Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4+ T cells. J. Exp. Med. 186, 801–812 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Schnorr, J.-J.et al. Induction of maturation of human blood dendritic cell precursors by measles virus is associated with immunosuppression. Proc. Natl Acad. Sci. USA 94, 5326–531 (1997).
  Article ADS CAS PubMed PubMed Central Google Scholar
• Fugier-Vivier, I.et al. Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of dendritic and T cells. J. Exp. Med. 186, 813–823 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Pope, M., Elmore, D., Ho, D. & Marx, P. Dendritic cell–T cell mixtures, isolated from the skin and mucosae of macaques, support the replication of SIV. AIDS Res. Hum. Retro. 13, 819–827 (1997).
  Article CAS Google Scholar
• Chaux, P., Moutet, M., Faivre, J., Martin, F. & Martin, M. Inflammatory cells infiltrating human colorectal carcinomas express HLA class II but not B7-1 and B7-2 constimulatory molecules of the T-cell activation. Lab. Invest. 74, 975–983 (1996).
  CAS PubMed Google Scholar
• Specht, J. M.et al. Dendritic cells retrovirally transduced with a model tumor antigen gene are therapeutically effective against established pulmonary metastates. J. Exp. Med. 186, 1213–1221 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Song, W.et al. Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model tumor antigen induce protective and therapeutic antitumor immunity. J. Exp. Med. 186, 1247–1256 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Schuler, G. & Steinman, R. M. Dendritic cells as adjuvants for immune-mediated resistance to tumors. J. Exp. Med. 186, 1183–1187 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Josien, R., Heslan, M., Soulillou, J.-P. & Cuturi, M.-C. Rat spleen dendritic cells express natural killer cell receptor protein 1 (NKR-P1) and have cytotoxic activity to select targets via a Ca2+-dependent mechanism. J. Exp. Med. 186, 467–472 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Condon, C., Watkins, S. C., Celluzzi, C. M., Thompson, K. & Falo, L. D. J DNA-based immunization by in vivo transfection of dendritic cells. Nature Med. 2, 1122–1128 (1996).
  Article CAS PubMed Google Scholar
• Casares, S., Inaba, K., Brumeanu, T., Steinman, R. M. & Bona, C. A. Antigen presentation by dendritic cells following immunization with DNA encoding a class II-restricted viral epitope. J. Exp. Med. 186, 1481–1486 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Colonna, M.et al. Acommon inhibitory receptor for MHC class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186, 1809–1818 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Vicari, A. P.et al. TECK: A novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity 7, 291–302 (1997).
  Article CAS PubMed Google Scholar