Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe (original) (raw)

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Acknowledgements

We are grateful to all of the patients who contributed to this study. We also thank the probands from the community-based cohorts of PopGen, KORA, the Heinz Nixdorf Recall (HNR) study, the Rotterdam Elderly Study, as well as the Munich controls. This study was supported by the German Federal Ministry of Education and Research (BMBF), within the context of the National Genome Research Network plus (NGFNplus) and the MooDS-Net (grant 01GS08144 to SC and MMN, grant 01GS08147 to MR). MMN also received support from the Alfried Krupp von Bohlen und Halbach-Stiftung. Further funding came from the European Union Seventh Framework Programme (FP7/2007–2011) under grant agreement no. 242257 (ADAMS). The Heinz Nixdorf Recall cohort was established with the support of the Heinz Nixdorf Foundation (Dr G Schmidt, Chairman). This study was also supported by The Polish Ministry of Science and Higher Education (grant N N402 244035 to PMC), The Danish Council for Strategic Research (grant no. 2101–07-0059), H Lundbeck A/S, the Faculty of Health Sciences, Aarhus University and the Stanley Medical Research Institute. Genotyping of the Dutch samples from Utrecht was sponsored by NIMH funding, R01 MH078075.

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Author notes

1. M Rietschel and M Mattheisen: These authors contributed equally to this work.
2. R A Ophoff and S Cichon: These authors contributed equally to this work.

Authors and Affiliations

1. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
   M Rietschel, J Strohmaier, R Breuer, C Schmael, S Meier, J Nikitopoulos & T G Schulze
2. Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
   M Mattheisen, F Degenhardt, T W Mühleisen, S Herms, B Haenisch, L Priebe, F B Basmanav, A J Forstner, P Hoffmann, M Alexander, J Schumacher, M M Nöthen & S Cichon
3. Institute of Human Genetics, University of Bonn, Bonn, Germany
   M Mattheisen, F Degenhardt, T W Mühleisen, S Herms, B Haenisch, L Priebe, F B Basmanav, A J Forstner, P Hoffmann, M Alexander, J Schumacher, M M Nöthen, M M Nöthen & S Cichon
4. Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, Bonn, Germany
   M Mattheisen, M Steffens & T F Wienker
5. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
   P Kirsch, C Esslinger & A Meyer-Lindenberg
6. Department of Human Genetics, Aarhus University, Aarhus, Denmark
   D Demontis & A D Børglum
7. Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland
   P M Czerski, P Kapelski & J Hauser
8. Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany
   I Giegling & D Rujescu
9. Department of Medical Genetics and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
   E Strengman & R A Ophoff
10. Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark
    O Mors
11. National Centre for Register-based Research, Aarhus University, Aarhus, Denmark
    P B Mortensen
12. Department Clinical Chemistry and Immunology, Section of Neonatal Screening and Hormones, The State Serum Institute, Copenhagen, Denmark
    D M Hougaard
13. AROS Aplied Biotechnology A/S and Department of Molecular Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark
    T Ørntoft
14. Institute of Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, Essen, Germany
    S Moebus
15. Department of Psychiatry, University of Bonn, Bonn, Germany
    R Mössner & W Maier
16. Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    H-E Wichmann
17. Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany
    H-E Wichmann
18. Institute of Clinical Molecular Biology, Christian-Albrechts University Kiel, Kiel, Germany
    S Schreiber
19. Department of Internal Medicine, Genetics Laboratory, Eramsmus Medical Center Rotterdam, Rotterdam, The Netherlands
    F Rivandeneira & A G Uitterlinden
20. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    F Rivandeneira, A Hofman & A G Uitterlinden
21. UCLA Center for Neurobehavioral Genetics, Los Angeles, CA, USA
    R M Cantor & R A Ophoff
22. Department of Psychiatry, Division of Mind and Brain Research, Charite Medical University Berlin, Charité Campus Mitte, Berlin, Germany
    S Erk & H Walter
23. Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    S Erk & H Walter
24. Department of Psychiatry and Psychotherapy, Georg-August-University Göttingen, G, ö, ttingen, Germany
    T G Schulze
25. Department of Psychological Medicine and Neurology, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK
    N Craddock, M J Owen & M C O'Donovan
26. Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark
    A D Børglum
27. Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany
    S Cichon

Authors

1. M Rietschel
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2. M Mattheisen
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3. F Degenhardt
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4. T W Mühleisen
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5. P Kirsch
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6. C Esslinger
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7. S Herms
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8. D Demontis
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9. M Steffens
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10. J Strohmaier
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11. B Haenisch
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12. R Breuer
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13. P M Czerski
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14. I Giegling
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15. E Strengman
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16. C Schmael
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17. O Mors
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18. P B Mortensen
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19. D M Hougaard
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20. T Ørntoft
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21. P Kapelski
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22. L Priebe
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23. F B Basmanav
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24. A J Forstner
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25. P Hoffmann
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26. S Meier
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27. J Nikitopoulos
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28. S Moebus
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29. M Alexander
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30. R Mössner
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31. H-E Wichmann
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32. S Schreiber
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33. F Rivandeneira
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34. A Hofman
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35. A G Uitterlinden
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36. T F Wienker
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37. J Schumacher
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38. J Hauser
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39. W Maier
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40. R M Cantor
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41. S Erk
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42. T G Schulze
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43. N Craddock
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44. M J Owen
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45. M C O'Donovan
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46. A D Børglum
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47. D Rujescu
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48. H Walter
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49. A Meyer-Lindenberg
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50. M M Nöthen
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51. R A Ophoff
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52. S Cichon
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Consortia

GROUP Investigators

Genetic Risk and Outcome in Psychosis (GROUP Investigators)

• René S Kahn
• , Don H Linszen
• , Jim van Os
• , Durk Wiersma
• , Richard Bruggeman
• , Wiepke Cahn
• , Lieuwe de Haan
• , Lydia Krabbendam
• & Inez Myin-Germeys

SGENE-plus Consortium

(Only those persons responsible for the samples of Replication 2 are listed)

• Hreinn Stefansson
• , Stacy Steinberg
• , Omar Gustafsson
• , Engilbert Sigurdsson
• , Hannes Petursson
• , Augustine Kong
• , Kari Stefansson
• , Olli P H Pietiläinen
• , Annamari Tuulio-Henriksson
• , Tiina Paunio
• , Jouko Lonnqvist
• , Jaana Suvisaari
• , Leena Peltonen
• , Mirella Ruggeri
• , Sarah Tosato
• , Muriel Walshe
• , Robin Murray
• , David A Collier
• , David St Clair
• , Thomas Hansen
• , Andres Ingason
• , Klaus D Jakobsen
• , Linh Duong
• , Thomas Werge
• , Ingrid Melle
• , Ole A Andreassen
• , Srdjan Djurovic
• , István Bitter
• , János M Réthelyi
• , Lilia Abramova
• , Vasily Kaleda
• , Vera Golimbet
• , Erik G Jönsson
• , Lars Terenius
• , Ingrid Agartz
• , Ruud van Winkel
• , Gunter Kenis
• , Marc De Hert
• , Jan Veldink
• , Carsten Wiuf
• & Michael Didriksen

Corresponding authors

Correspondence toM Rietschel or S Cichon.

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Competing interests

The authors declare no conflict of interest.

Additional information

René S Kahn1, Don H Linszen2, Jim van Os3, Durk Wiersma4, Richard Bruggeman4, Wiepke Cahn1, Lieuwe de Haan2, Lydia Krabbendam3 and Inez Myin-Germeys3 1 Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands; 2 Academic Medical Centre University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands; 3 Maastricht University Medical Centre, South Limburg Mental Health Research and Teaching Network, Maastricht, The Netherlands and 4 University Medical Center Groningen, Department of Psychiatry, University of Groningen, Groningen, The Netherlands.

Hreinn Stefansson1, Stacy Steinberg1, Omar Gustafsson1, Engilbert Sigurdsson2, Hannes Petursson2, Augustine Kong1, Kari Stefansson1, Olli PH Pietiläinen3,4, Annamari Tuulio-Henriksson5, Tiina Paunio6, Jouko Lonnqvist5, Jaana Suvisaari5, Leena Peltonen3,4, Mirella Ruggeri7, Sarah Tosato7, Muriel Walshe8, Robin Murray8, David A Collier8, David St Clair9, Thomas Hansen10, Andres Ingason10, Klaus D Jakobsen10, Linh Duong10, Thomas Werge10, Ingrid Melle11, Ole A Andreassen12, Srdjan Djurovic12, István Bitter13, János M Réthelyi13, Lilia Abramova14, Vasily Kaleda14, Vera Golimbet14, Erik G Jönsson15, Lars Terenius15, Ingrid Agartz15, Ruud van Winkel16,17, Gunter Kenis16, Marc De Hert17, Jan Veldink18, Carsten Wiuf19 and Michael Didriksen20 1 deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland; 2 Department of Psychiatry, National University Hospital, Hringbraut, IS-101 Reykjavik, Iceland; 3 Institute for Molecular Medicine Finland FIMM and Department of Medical Genetics, University of Helsinki, FI-00014 Helsinki, Finland; 4 Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK; 5 Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FI-00300 Helsinki, Finland; 6 Health Genomics Unit, National Institute for Health and Welfare THL, FI-00270 Helsinki, Finland; 7 Section of Psychiatry and Clinical Psychology, University of Verona, 37134 Verona, Italy; 8 Institute of Psychiatry, King's College, London SE5 8AF, UK; 9 Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen AB25 2ZD, UK; 10 Institute of Biological Psychiatry, Mental Health Centre Sct. Hans Copenhagen University Hospital, DK-4000 Roskilde, Denmark; 11 Department of Medical Genetics, Ulleval University Hospital, Institute of Psychiatry, University of Oslo, Kirkeveien 166, N-0407 Oslo, Norway; 12 Department of Psychiatry, Ullevål University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166, N-0407 Oslo, Norway; 13 Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary; 14 Mental Health Research Center, Russian Academy of Medical Sciences, Zagorodnoe sh. 2/2, 117152 Moscow, Russia; 15 Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, R5:00, SE-171 76 Stockholm, Sweden; 16 Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands; 17 University Psychiatric Centre Catholic University Leuven, Leuvensesteenweg 517, B-3070 Kortenberg, Belgium; 18 Rudolf Magnus Institute of Neuroscience, Department of Neurology, UMC Utrecht, 3584 CG Utrecht, The Netherlands; 19 Bioinformatics Research Centre, Aarhus University, DK-8000 Aarhus C, Denmark and 20 Discovery Biology Research, H Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark.

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Rietschel, M., Mattheisen, M., Degenhardt, F. et al. Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe.Mol Psychiatry 17, 906–917 (2012). https://doi.org/10.1038/mp.2011.80

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• Received: 19 October 2010
• Revised: 13 May 2011
• Accepted: 23 May 2011
• Published: 12 July 2011
• Issue Date: September 2012
• DOI: https://doi.org/10.1038/mp.2011.80

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