Structure of the dengue virus envelope protein after membrane fusion (original) (raw)

References

  1. Skehel, J. J. & Wiley, D. C. Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu. Rev. Biochem. 69, 531–569 (2000)
    Article CAS PubMed Google Scholar
  2. Wilson, I. A., Skehel, J. J. & Wiley, D. C. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution. Nature 289, 366–373 (1981)
    Article ADS CAS PubMed Google Scholar
  3. Baker, K. A., Dutch, R. E., Lamb, R. A. & Jardetzky, T. S. Structural basis for paramyxovirus-mediated membrane fusion. Mol. Cell 3, 309–319 (1999)
    Article CAS PubMed Google Scholar
  4. Melikyan, G. B. et al. Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion. J. Cell Biol. 151, 413–423 (2000)
    Article CAS PubMed PubMed Central Google Scholar
  5. Russell, C. J., Jardetzky, T. S. & Lamb, R. A. Membrane fusion machines of paramyxoviruses: capture of intermediates of fusion. EMBO J. 20, 4024–4034 (2001)
    Article CAS PubMed PubMed Central Google Scholar
  6. Bullough, P. A., Hughson, F. M., Skehel, J. J. & Wiley, D. C. Structure of influenza haemagglutinin at the pH of membrane fusion. Nature 371, 37–43 (1994)
    Article ADS CAS PubMed Google Scholar
  7. Chen, J., Skehel, J. J. & Wiley, D. C. N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA(2) subunit to form an N cap that terminates the triple-stranded coiled coil. Proc. Natl Acad. Sci. USA 96, 8967–8972 (1999)
    Article ADS CAS PubMed PubMed Central Google Scholar
  8. Rey, F. A., Heinz, F. X., Mandl, C., Kunz, C. & Harrison, S. C. The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution. Nature 375, 291–298 (1995)
    Article ADS CAS PubMed Google Scholar
  9. Lescar, J. et al. The fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH. Cell 105, 137–148 (2001)
    Article CAS PubMed Google Scholar
  10. Modis, Y., Ogata, S., Clements, D. & Harrison, S. C. A ligand-binding pocket in the dengue virus envelope glycoprotein. Proc. Natl Acad. Sci. USA 100, 6986–6991 (2003)
    Article ADS CAS PubMed PubMed Central Google Scholar
  11. Allison, S. L. et al. Oligomeric rearrangement of tick-borne encephalitis virus envelope proteins induced by an acidic pH. J. Virol. 69, 695–700 (1995)
    CAS PubMed PubMed Central Google Scholar
  12. Ferlenghi, I. et al. Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus. Mol. Cell 7, 593–602 (2001)
    Article CAS PubMed Google Scholar
  13. Kuhn, R. J. et al. Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell 108, 717–725 (2002)
    Article CAS PubMed PubMed Central Google Scholar
  14. Allison, S. L., Schalich, J., Stiasny, K., Mandl, C. W. & Heinz, F. X. Mutational evidence for an internal fusion peptide in flavivirus envelope protein E. J. Virol. 75, 4268–4275 (2001)
    Article CAS PubMed PubMed Central Google Scholar
  15. Levy-Mintz, P. & Kielian, M. Mutagenesis of the putative fusion domain of the Semliki Forest virus spike protein. J. Virol. 65, 4292–4300 (1991)
    CAS PubMed PubMed Central Google Scholar
  16. Ahn, A., Gibbons, D. L. & Kielian, M. The fusion peptide of Semliki Forest virus associates with sterol-rich membrane domains. J. Virol. 76, 3267–3275 (2002)
    Article CAS PubMed PubMed Central Google Scholar
  17. Gibbons, D. L. et al. Conformational change and protein–protein interactions of the fusion protein of Semliki Forest virus. Nature 427, 320–325 (2004)
    Article ADS CAS PubMed Google Scholar
  18. Stiasny, K., Allison, S. L., Schalich, J. & Heinz, F. X. Membrane interactions of the tick-borne encephalitis virus fusion protein E at low pH. J. Virol. 76, 3784–3790 (2002)
    Article CAS PubMed PubMed Central Google Scholar
  19. Wimley, W. C. & White, S. H. Partitioning of tryptophan side-chain analogs between water and cyclohexane. Biochemistry 31, 12813–12818 (1992)
    Article CAS PubMed Google Scholar
  20. Allison, S. L., Stiasny, K., Stadler, K., Mandl, C. W. & Heinz, F. X. Mapping of functional elements in the stem-anchor region of tick-borne encephalitis virus envelope protein E. J. Virol. 73, 5605–5612 (1999)
    CAS PubMed PubMed Central Google Scholar
  21. Zhang, W. et al. Visualization of membrane protein domains by cryo-electron microscopy of dengue virus. Nature Struct. Biol. 10, 907–912 (2003)
    Article CAS PubMed Google Scholar
  22. Crill, W. D. & Roehrig, J. T. Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cells. J. Virol. 75, 7769–7773 (2001)
    Article CAS PubMed PubMed Central Google Scholar
  23. Jennings, A. D. et al. Analysis of a yellow fever virus isolated from a fatal case of vaccine-associated human encephalitis. J. Infect. Dis. 169, 512–518 (1994)
    Article CAS PubMed Google Scholar
  24. Lobigs, M. et al. Host cell selection of Murray Valley encephalitis virus variants altered at an RGD sequence in the envelope protein and in mouse virulence. Virology 176, 587–595 (1990)
    Article CAS PubMed Google Scholar
  25. Holzmann, H., Heinz, F. X., Mandl, C. W., Guirakhoo, F. & Kunz, C. A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model. J. Virol. 64, 5156–5159 (1990)
    CAS PubMed PubMed Central Google Scholar
  26. Jiang, W. R., Lowe, A., Higgs, S., Reid, H. & Gould, E. A. Single amino acid codon changes detected in louping ill virus antibody-resistant mutants with reduced neurovirulence. J. Gen. Virol. 74, 931–935 (1993)
    Article CAS PubMed Google Scholar
  27. Gao, G. F., Hussain, M. H., Reid, H. W. & Gould, E. A. Identification of naturally occurring monoclonal antibody escape variants of louping ill virus. J. Gen. Virol. 75, 609–614 (1994)
    Article CAS PubMed Google Scholar
  28. Cecilia, D. & Gould, E. A. Nucleotide changes responsible for loss of neuroinvasiveness in Japanese encephalitis virus neutralization-resistant mutants. Virology 181, 70–77 (1991)
    Article CAS PubMed Google Scholar
  29. Chen, Y. et al. Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate. Nature Med. 3, 866–871 (1997)
    Article CAS PubMed Google Scholar
  30. Navarro-Sanchez, E. et al. Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses. EMBO Rep. 4, 1–6 (2003)
    Article Google Scholar
  31. Tassaneetrithep, B. et al. DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. J. Exp. Med. 197, 823–829 (2003)
    Article CAS PubMed PubMed Central Google Scholar
  32. Stiasny, K., Allison, S. L., Marchler-Bauer, A., Kunz, C. & Heinz, F. X. Structural requirements for low-pH-induced rearrangements in the envelope glycoprotein of tick-borne encephalitis virus. J. Virol. 70, 8142–8147 (1996)
    CAS PubMed PubMed Central Google Scholar
  33. Chan, D. C. & Kim, P. S. HIV entry and its inhibition. Cell 93, 681–684 (1998)
    Article CAS PubMed Google Scholar
  34. Kuzmin, P. I., Zimmerberg, J., Chizmadzhev, Y. A. & Cohen, F. S. A quantitative model for membrane fusion based on low-energy intermediates. Proc. Natl Acad. Sci. USA 98, 7235–7240 (2001)
    Article ADS CAS PubMed PubMed Central Google Scholar
  35. Razinkov, V. I., Melikyan, G. B. & Cohen, F. S. Hemifusion between cells expressing hemagglutinin of influenza virus and planar membranes can precede the formation of fusion pores that subsequently fully enlarge. Biophys. J. 77, 3144–3151 (1999)
    Article CAS PubMed PubMed Central Google Scholar
  36. Kozlov, M. M. & Chernomordik, L. V. A mechanism of protein-mediated fusion: coupling between refolding of the influenza hemagglutinin and lipid rearrangements. Biophys. J. 75, 1384–1396 (1998)
    Article CAS PubMed PubMed Central Google Scholar
  37. Wahlberg, J. M., Bron, R., Wilschut, J. & Garoff, H. Membrane fusion of Semliki Forest virus involves homotrimers of the fusion protein. J. Virol. 66, 7309–7318 (1992)
    CAS PubMed PubMed Central Google Scholar
  38. Han, X., Bushweller, J. H., Cafiso, D. S. & Tamm, L. K. Membrane structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutinin. Nature Struct. Biol. 8, 715–720 (2001)
    Article CAS PubMed Google Scholar
  39. Ito, H., Watanabe, S., Sanchez, A., Whitt, M. A. & Kawaoka, Y. Mutational analysis of the putative fusion domain of Ebola virus glycoprotein. J. Virol. 73, 8907–8912 (1999)
    CAS PubMed PubMed Central Google Scholar
  40. Kemble, G. W., Danieli, T. & White, J. M. Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion. Cell 76, 383–391 (1994)
    Article CAS PubMed Google Scholar
  41. Armstrong, R. T., Kushnir, A. S. & White, J. M. The transmembrane domain of influenza hemagglutinin exhibits a stringent length requirement to support the hemifusion to fusion transition. J. Cell Biol. 151, 425–437 (2000)
    Article CAS PubMed PubMed Central Google Scholar
  42. Dutch, R. E. & Lamb, R. A. Deletion of the cytoplasmic tail of the fusion protein of the paramyxovirus simian virus 5 affects fusion pore enlargement. J. Virol. 75, 5363–5369 (2001)
    Article CAS PubMed PubMed Central Google Scholar
  43. Baldwin, C. E., Sanders, R. W. & Berkhout, B. Inhibiting HIV-1 entry with fusion inhibitors. Curr. Med. Chem. 10, 1633–1642 (2003)
    Article CAS PubMed Google Scholar
  44. Kilby, J. M. et al. Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry. Nature Med. 4, 1302–1307 (1998)
    Article CAS PubMed Google Scholar
  45. Hahn, Y. S. et al. Nucleotide sequence of dengue 2 RNA and comparison of the encoded proteins with those of other flaviviruses. Virology 162, 167–180 (1988)
    Article CAS PubMed Google Scholar
  46. Ivy, J., Nakano, E. & Clements, D. Subunit immunogenic composition against dengue infection. US Patent 6,165,477 (1997)
  47. Cuzzubbo, A. J. et al. Use of recombinant envelope proteins for serological diagnosis of dengue virus infection in an immunochromatographic assay. Clin. Diagn. Lab. Immunol. 8, 1150–1155 (2001)
    CAS PubMed PubMed Central Google Scholar
  48. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307–326 (1997)
    Article CAS PubMed Google Scholar
  49. Navaza, J. Implementation of molecular replacement in AMoRe. Acta Crystallogr. D 57, 1367–1372 (2001)
    Article CAS PubMed Google Scholar
  50. Brünger, A. T. et al. Crystallography NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905–921 (1998)
    Article PubMed Google Scholar
  51. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110–119 (1991)
    Article PubMed Google Scholar

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