Gut microbiota composition correlates with diet and health in the elderly (original) (raw)

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Acknowledgements

This work was supported by the Government of Ireland National Development Plan by way of a Department of Agriculture Food and Marine, and Health Research Board FHRI award to the ELDERMET project, as well as by a Science Foundation Ireland award to the Alimentary Pharmabiotic Centre. M.J.C. is funded by a fellowship from the Health Research Board of Ireland. We thank K. O’Donovan and P. Egan for clinical assistance, staff in Cork City and County hospitals for facilitating subject recruitment, S. Wong and B. Clayton for supercomputer access.

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Author notes

1. Marcus J. Claesson and Ian B. Jeffery: These authors contributed equally to this work.

Authors and Affiliations

1. Department of Microbiology, University College Cork, Ireland
   Marcus J. Claesson, Ian B. Jeffery, Susan E. Power, Eibhlís M. O’Connor, Siobhán Cusack, Hugh M. B. Harris, Gerald F. Fitzgerald, Jennifer Deane, Douwe van Sinderen, Colin Hill & Paul W. O’Toole
2. Alimentary Pharmabiotic Centre, University College Cork, Ireland
   Marcus J. Claesson, Ian B. Jeffery, Eibhlís M. O’Connor, Gerald F. Fitzgerald, Douwe van Sinderen, Catherine Stanton, Fergus Shanahan, Colin Hill, R. Paul Ross & Paul W. O’Toole
3. Department of Statistics, University College Cork, Ireland
   Susana Conde & Anthony P. Fitzgerald
4. Teagasc, Moorepark Food Research Centre, Moorepark, Fermoy, Co, Cork, Ireland ,
   Mairead Coakley, Bhuvaneswari Lakshminarayanan, Orla O’Sullivan, Catherine Stanton & R. Paul Ross
5. Cork University Hospital, Wilton, Cork, Ireland ,
   Michael O’Connor, Norma Harnedy & Denis O’Mahony
6. St. Finbarr’s Hospital, Douglas Road, Cork, Ireland ,
   Michael O’Connor, Norma Harnedy, Kieran O’Connor & Denis O’Mahony
7. Mercy University Hospital, Grenville Place, Cork, Ireland ,
   Kieran O’Connor
8. South Infirmary, Victoria University Hospital, Cork, Ireland
   Kieran O’Connor & Denis O’Mahony
9. Institute of Food and Health, University College Dublin, Ireland
   Martina Wallace & Lorraine Brennan
10. School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AT, UK ,
    Julian R. Marchesi
11. Department of Epidemiology and Public Health, University College Cork, Ireland
    Anthony P. Fitzgerald
12. Department of Medicine, University College Cork, Ireland
    Fergus Shanahan

Authors

1. Marcus J. Claesson
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2. Ian B. Jeffery
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3. Susana Conde
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4. Susan E. Power
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5. Eibhlís M. O’Connor
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6. Siobhán Cusack
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7. Hugh M. B. Harris
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8. Mairead Coakley
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9. Bhuvaneswari Lakshminarayanan
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10. Orla O’Sullivan
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11. Gerald F. Fitzgerald
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12. Jennifer Deane
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13. Michael O’Connor
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14. Norma Harnedy
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15. Kieran O’Connor
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16. Denis O’Mahony
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17. Douwe van Sinderen
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18. Martina Wallace
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19. Lorraine Brennan
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20. Catherine Stanton
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21. Julian R. Marchesi
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22. Anthony P. Fitzgerald
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23. Fergus Shanahan
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24. Colin Hill
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25. R. Paul Ross
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26. Paul W. O’Toole
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Contributions

All authors are members of the ELDERMET consortium (http://eldermet.ucc.ie). P.W.O.T., E.M.O.C., S.Cu.1 and R.P.R. managed the project; D.v.S., G.F.F., C.S., J.R.M., F.S., C.H., R.P.R. and PWOT designed the analyses; M.J.C., I.B.J., S.Co.3, E.M.O.C., H.M.B.H., M.C., B.L., O.O.S., A.P.F., S.E.P., M.W. and L.B. performed the analyses; J.D. performed DNA extraction and PCR; M.W. and L.B. performed NMR metabolomics; M.O.C., N.H., K.O.C. and D.O.M. performed clinical analyses; M.J.C., I.B.J., S.Co.3, E.M.O.C., L.B., J.R.M., A.P.F., R.P.R., C.H., F.S. and P.W.O.T. wrote the manuscript.

Corresponding author

Correspondence toPaul W. O’Toole.

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Competing interests

The authors declare no competing financial interests.

Additional information

Amplicon sequence data, shotgun sequence data, contigs, genes and annotations have been deposited inMG-RAST under the Project ID 154 (http://metagenomics.anl.gov/linkin.cgi?project154).

Supplementary information

Supplementary Information

This file contains Supplementary Figures 1–17, Supplementary Tables 1–6 and 8–9 (see separate fie for Supplementary Table 7), Supplementary Notes and Supplementary References. (PDF 2839 kb)

Supplementary Table 7

This table contains the clinical and dietary metadata. (XLSX 30 kb)

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Claesson, M., Jeffery, I., Conde, S. et al. Gut microbiota composition correlates with diet and health in the elderly.Nature 488, 178–184 (2012). https://doi.org/10.1038/nature11319

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• Received: 10 January 2012
• Accepted: 14 June 2012
• Published: 13 July 2012
• Issue Date: 09 August 2012
• DOI: https://doi.org/10.1038/nature11319