Capecchi, M.R. Generating mice with targeted mutations. Nat. Med.7, 1086–1090 (2001). ArticleCAS Google Scholar
Smithies, O. Forty years with homologous recombination. Nat. Med.7, 1083–1086 (2001). ArticleCAS Google Scholar
Cheah, S.S. & Behringer, R.R. Contemporary gene targeting strategies for the novice. Mol. Biotechnol.19, 297–304 (2001). ArticleCAS Google Scholar
Hrabe de Angelis, M.H. et al. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat. Genet.25, 444–447 (2000). ArticleCAS Google Scholar
Nolan, P.M. et al. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat. Genet.25, 440–443 (2000). ArticleCAS Google Scholar
Zambrowicz, B.P. et al. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature392, 608–611 (1998). ArticleCAS Google Scholar
Mitchell, K.J. et al. Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat. Genet.28, 241–249 (2001). ArticleCAS Google Scholar
Leighton, P.A. et al. Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature410, 174–179 (2001). ArticleCAS Google Scholar
Yang, X.W., Model, P. & Heintz, N. Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome. Nat. Biotechnol.15, 859–865 (1997). ArticleCAS Google Scholar
Yang, X.W., Wynder, C., Doughty, M.L. & Heintz, N. BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin. Nat. Genet.22, 327–335 (1999). ArticleCAS Google Scholar
Lee, E.C. et al. A highly efficient _Escherichia coli_-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics73, 56–65 (2001). ArticleCAS Google Scholar
Heintz, N. BAC to the future: the use of bac transgenic mice for neuroscience research. Nat. Rev. Neurosci.2, 861–870 (2001). ArticleCAS Google Scholar
Joyner, A.L. (ed.) Gene Targeting; a Practical Approach, edn. 2 (Oxford University Press, New York, 1999). Google Scholar
Hasty, P., Rivera-Perez, J. & Bradley, A. The length of homology required for gene targeting in embryonic stem cells. Mol. Cell Biol.11, 5586–5591 (1991). ArticleCAS Google Scholar
Deng, C. & Capecchi, M.R. Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol. Cell Biol.12, 3365–3371 (1992). ArticleCAS Google Scholar
Zhang, H., Hasty, P. & Bradley, A. Targeting frequency for deletion vectors in embryonic stem cells. Mol. Cell Biol.14, 2404–2410 (1994). ArticleCAS Google Scholar
Waldman, A.S. & Liskay, R.M. Dependence of intrachromosomal recombination in mammalian cells on uninterrupted homology. Mol. Cell Biol.8, 5350–5357 (1988). ArticleCAS Google Scholar
te Riele, H., Maandag, E.R. & Berns, A. Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. Proc. Natl. Acad. Sci. USA89, 5128–5132 (1992). ArticleCAS Google Scholar
Mansour, S.L., Thomas, K.R. & Capecchi, M.R. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature336, 348–352 (1988). ArticleCAS Google Scholar
Mansour, S.L., Thomas, K.R., Deng, C.X. & Capecchi, M.R. Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. Proc. Natl. Acad. Sci. USA87, 7688–7692 (1990). ArticleCAS Google Scholar
Puri, M.C., Rossant, J., Alitalo, K., Bernstein, A. & Partanen, J. The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. EMBO J.14, 5884–5891 (1995). ArticleCAS Google Scholar
Miquerol, L., Gertsenstein, M., Harpal, K., Rossant, J. & Nagy, A. Multiple developmental roles of VEGF suggested by a _lacZ_-tagged allele. Dev. Biol.212, 307–322 (1999). ArticleCAS Google Scholar
Zhang, Y., Buchholz, F., Muyrers, J.P. & Stewart, A.F. A new logic for DNA engineering using recombination in Escherichia coli. Nat. Genet.20, 123–128 (1998). ArticleCAS Google Scholar
Muyrers, J.P., Zhang, Y., Testa, G. & Stewart, A.F. Rapid modification of bacterial artificial chromosomes by ET-recombination. Nucleic Acids Res.27, 1555–1557 (1999). ArticleCAS Google Scholar
Narayanan, K., Williamson, R., Zhang, Y., Stewart, A.F. & Ioannou, P.A. Efficient and precise engineering of a 200 kb β-globin human/bacterial artificial chromosome in E. coli DH10B using an inducible homologous recombination system. Gene Ther.6, 442–447 (1999). ArticleCAS Google Scholar
Angrand, P.O., Daigle, N., van der Hoeven, F., Scholer, H.R. & Stewart, A.F. Simplified generation of targeting constructs using ET recombination. Nucleic Acids Res.27, e16 (1999). ArticleCAS Google Scholar
Yu, D. et al. An efficient recombination system for chromosome engineering in Escherichia coli. Proc. Natl. Acad. Sci. USA97, 5978–5983 (2000). ArticleCAS Google Scholar
Muyrers, J.P., Zhang, Y. & Stewart, A.F. Techniques: recombinogenic engineering–new options for cloning and manipulating DNA. Trends Biochem. Sci.26, 325–331 (2001). ArticleCAS Google Scholar
Gregory, S.G. et al. A physical map of the mouse genome. Nature418, 743–750 (2002). ArticleCAS Google Scholar
Bodine, S.C. et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science294, 1704–1708 (2001). ArticleCAS Google Scholar
Testa, G. et al. Large BAC-based targeting constructs present new options for genomic engineering. Nat. Biotechnol.21, 443–447 (2003). ArticleCAS Google Scholar
Matise, M., Auerbach, W. & Joyner, A.L. in Gene Targeting: A Practical Approach (ed. Joyner, A.L.) 101–132 (Oxford University Press, New York, 2000). Google Scholar
Swiatek, P.J. & Gridley, T. Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev.7, 2071–2084 (1993). ArticleCAS Google Scholar
Auerbach, W. et al. Establishment and chimera analysis of 129/SvEv- and C57BL/6-derived mouse embryonic stem cell lines. Biotechniques29, 1024–1028, 1030, 1032 (2000). ArticleCAS Google Scholar
Schuster-Gossler, K. et al. Use of coisogenic host blastocysts for efficient establishment of germline chimeras with C57BL/6J ES cell lines. Biotechniques31, 1022–1024, 1026 (2001). ArticleCAS Google Scholar
Lundsteen, C. & Lind, A.M. A test of a climate room for preparation of chromosome slides. Clin. Genet.28, 260–262 (1985). ArticleCAS Google Scholar
Pinkel, D., Straume, T. & Gray, J.W. Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proc. Natl. Acad. Sci. USA83, 2934–2938 (1986). ArticleCAS Google Scholar
Lichter, P., Cremer, T., Borden, J., Manuelidis, L. & Ward, D.C. Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries. Hum. Genet.80, 224–234 (1988). ArticleCAS Google Scholar
Pecker, I. et al. Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene. Genomics35, 39–45 (1996). ArticleCAS Google Scholar
Suri, C. et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell87, 1171–1180 (1996). ArticleCAS Google Scholar