A physical map of the mouse genome (original) (raw)
References
- Fleischmann, R. D. et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269, 496–512 (1995)
Article CAS PubMed Google Scholar - Churcher, C. et al. The nucleotide sequence of Saccharomyces cerevisiae chromosome IX. Nature 387, 84–87 (1997)
CAS PubMed Google Scholar - The yeast genome directory. Nature 387 (suppl.), 5 (1997)
- The C. elegans Sequencing Consortium Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282, 2012–2018 (1998)
Article Google Scholar - Adams, M. D. et al. The genome sequence of Drosophila melanogaster. Science 287, 2185–2195 (2000)
Article PubMed Google Scholar - Lander, E. S. et al. Initial sequencing and analysis of the human genome. Nature 409, 860–921 (2001)
Article CAS PubMed Google Scholar - Venter, J. C. et al. The sequence of the human genome. Science 291, 1304–1351 (2001)
Article CAS PubMed Google Scholar - Collins, J. & Hohn, B. Cosmids: a type of plasmid gene-cloning vector that is packageable in vitro in bacteriophage lambda heads. Proc. Natl Acad. Sci. USA 75, 4242–4246 (1978)
Article CAS PubMed PubMed Central Google Scholar - Shizuya, H. et al. Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proc. Natl Acad. Sci. USA 89, 8794–8797 (1992)
Article CAS PubMed PubMed Central Google Scholar - Coulson, A., Sulston, J., Brenner, S. & Karn, J. Towards a physical map of the genome of the nematode Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 83, 7821–7825 (1986)
Article CAS PubMed PubMed Central Google Scholar - Olson, M. V. et al. Random-clone strategy for genomic restriction mapping in yeast. Proc. Natl Acad. Sci. USA 83, 7826–7830 (1986)
Article CAS PubMed PubMed Central Google Scholar - Bentley, D. R. et al. The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X. Nature 409, 942–943 (2001)
Article CAS PubMed Google Scholar - McPherson, J. D. et al. A physical map of the human genome. Nature 409, 934–941 (2001)
Article CAS PubMed Google Scholar - Green, E. D. Strategies for the systematic sequencing of complex genomes. Nature Rev. Genet. 2, 573–583 (2001)
Article CAS PubMed Google Scholar - Dunham, I. et al. The DNA sequence of human chromosome 22. Nature 402, 489–495 (1999)
Article CAS PubMed Google Scholar - Waterston, R. & Sulston, J. E. The Human Genome Project: reaching the finish line. Science 282, 53–54 (1998)
Article CAS PubMed Google Scholar - Nadeau, J. H. & Taylor, B. A. Lengths of chromosomal segments conserved since divergence of man and mouse. Proc. Natl Acad. Sci. USA 81, 814–818 (1984)
Article CAS PubMed PubMed Central Google Scholar - DeBry, R. W. & Seldin, M. F. Human/mouse homology relationships. Genomics 33, 337–351 (1996)
Article CAS PubMed Google Scholar - Nadeau, J. H. & Sankoff, D. Counting on comparative maps. Trends Genet. 14, 495–501 (1998)
Article CAS PubMed Google Scholar - Thomas, J. W. et al. Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Genome Res. 10, 624–633 (2000)
Article CAS PubMed PubMed Central Google Scholar - Kim, J. et al. Homology-driven assembly of a sequence-ready mouse BAC contig map spanning regions related to the 46-Mb gene-rich euchromatic segments of human chromosome 19. Genomics 74, 129–141 (2001)
Article CAS PubMed Google Scholar - Osoegawa, K. et al. Bacterial artificial chromosome libraries for mouse sequencing and functional analysis. Genome Res. 10, 116–128 (2000)
CAS PubMed PubMed Central Google Scholar - Hardison, R. C., Oeltjen, J. & Miller, W. Long human–mouse sequence alignments reveal novel regulatory elements: a reason to sequence the mouse genome. Genome Res. 7, 959–966 (1997)
Article CAS PubMed Google Scholar - Koop, B. F. et al. The human T-cell receptor TCRAC/TCRDC (Cα/Cδ) region: organization, sequence, and evolution of 97.6 kb of DNA. Genomics 19, 478–493 (1994)
Article CAS PubMed Google Scholar - Ashworth, L. K. et al. An integrated metric physical map of human chromosome 19. Nature Genet. 11, 422–427 (1995)
Article CAS PubMed Google Scholar - Kent, W. J. The BLAST-like alignment tool. Genome Res. 12, 656–664 (2002)
Article CAS PubMed PubMed Central Google Scholar - Copeland, N. G. et al. A genetic linkage map of the mouse: current applications and future prospects. Science 262, 57–66 (1993)
Article CAS PubMed Google Scholar - Dietrich, W. F. et al. A comprehensive genetic map of the mouse genome. Nature 380, 149–152 (1996)
Article CAS PubMed Google Scholar - Cai, W. W. et al. An SSLP marker-anchored BAC framework map of the mouse genome. Nature Genet. 29, 133–134 (2001)
Article CAS PubMed Google Scholar - Hudson, T. J. et al. A radiation hybrid map of mouse genes. Nature Genet. 29, 201–205 (2001)
Article CAS PubMed Google Scholar - Schuler, G. D. Sequence mapping by electronic PCR. Genome Res. 7, 541–550 (1997)
Article CAS PubMed PubMed Central Google Scholar - Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. Basic local alignment search tool. J. Mol. Biol. 215, 403–410 (1990)
Article CAS PubMed Google Scholar - Ross, M. T., LaBrie, S., McPherson, J. P. & Stanton, V. P. in Current Protocols in Human Genetics (eds Dracopoli, N. C. et al.) 5.6.1–5.6.5 (Wiley, New York, 1999)
Google Scholar - Puttagunta, R. et al. Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Genome Res. 10, 1369–1380 (2000)
Article CAS PubMed PubMed Central Google Scholar - Carver, E. A. & Stubbs, L. Zooming in on the human–mouse comparative map: genome conservation re-examined on a high-resolution scale. Genome Res. 7, 1123–1137 (1997)
Article CAS PubMed Google Scholar - Watkins-Chow, D. E. et al. Genetic mapping of 21 genes on mouse chromosome 11 reveals disruptions in linkage conservation with human chromosome 5. Genomics 40, 114–122 (1997)
Article CAS PubMed Google Scholar - Stubbs, L. et al. Detailed comparative map of human chromosome 19q and related regions of the mouse genome. Genomics 35, 499–508 (1996)
Article CAS PubMed Google Scholar - Dehal, P. et al. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. Science 293, 104–111 (2001)
Article CAS PubMed Google Scholar - Pletcher, M. T., Wiltshire, T., Cabin, D. E., Villanueva, M. & Reeves, R. H. Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21. Genomics 74, 45–54 (2001)
Article CAS PubMed Google Scholar - Oeltjen, J. C. et al. Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. Genome Res. 7, 315–329 (1997)
Article CAS PubMed Google Scholar - Batzoglou, S., Pachter, L., Mesirov, J. P., Berger, B. & Lander, E. S. Human and mouse gene structure: comparative analysis and application to exon prediction. Genome Res. 10, 950–958 (2000)
Article CAS PubMed PubMed Central Google Scholar - Marra, M. A. et al. High throughput fingerprint analysis of large-insert clones. Genome Res. 7, 1072–1084 (1997)
Article CAS PubMed PubMed Central Google Scholar - Soderlund, C., Humphray, S., Dunham, A. & French, L. Contigs built with fingerprints, markers, and FPC V4. 7. Genome Res. 10, 1772–1787 (2000)
Article CAS PubMed PubMed Central Google Scholar - Zhao, S. et al. Mouse BAC ends quality assessment and sequence analyses. Genome Res. 11, 1736–1745 (2001)
Article PubMed PubMed Central Google Scholar - Altschul, S. F. & Gish, W. Local alignment statistics. Methods Enzymol. 266, 460–480 (1996)
Article CAS PubMed Google Scholar - Nusbaum, C. et al. A YAC-based physical map of the mouse genome. Nature Genet. 22, 388–393 (1999)
Article CAS PubMed Google Scholar - Evans, E. P. in Genetic Variants of the Laboratory Mouse (eds Lyon, M. F., Rastan, S. & Brown, S. D. M.) 1446 (Oxford Univ. Press, New York, 1996)
Google Scholar - Pletcher, M. T. et al. Chromosome evolution: the junction of mammalian chromosomes in the formation of mouse chromosome 10. Genome Res. 10, 1463–1467 (2000)
Article CAS PubMed PubMed Central Google Scholar - Martindale, D. W. et al. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Mamm. Genome 11, 890–898 (2000)
Article CAS PubMed Google Scholar - DeSilva, U. et al. Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. Genome Res. 12, 3–15 (2002)
Article CAS PubMed PubMed Central Google Scholar
Acknowledgements
The authors acknowledge the support of the Wellcome Trust, the National Institutes of Health and the US Department of Energy. We are grateful to the web team at the Sanger Institute for assistance with developing map displays, to P. Deloukas for RH map analysis, and E. Arnold-Berkowits, S. Lo, J. Gill and all present and past members of the Institute for Genomic Research BAC end sequencing team for the sequencing work.
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Authors and Affiliations
- The Wellcome Trust Sanger Institute, CB10 1SA, Hinxton, Cambridge, UK
Simon G. Gregory, Carol E. Scott, Richard S. Evans, Paul W. Burridge, Tony V. Cox, Christopher A. Fox, Richard D. Hutton, Ian R. Mullenger, Kimbly J. Phillips, James Smith, Jim Stalker, Glen J. Threadgold, Tim Hubbard, Jane Rogers & David R. Bentley - Genome Sequencing Center, Washington University School of Medicine, St Louis, Missouri, 63108, USA
Mandeep Sekhon, Kristine Wylie, Asif Chinwalla, John Wallis, LaDeana Hillier, Jason Carter, Tony Gaige, Sara Jaeger, Colin Kremitzki, Dan Layman, Jason Maas, Rebecca McGrane, Kelly Mead, Rebecca Walker, Robert H. Waterston & John D. McPherson - Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, V5Z 4E6, Canada
Jacqueline Schein, Steven Jones, Michael Smith, Jennifer Asano, Ian Bosdet, Susanna Chan, Suganthi Chittaranjan, Readman Chiu, Chris Fjell, Noreen Girn, Catharine Gray, Ran Guin, Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Soo Sen Lee, Carrie Mathewson, Candice McLeavy, Steve Messervier, Steven Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Duane Smailus, Lorraine Spence, Jeff Stott, Sheryl Taylor, Wesley Terpstra, Miranda Tsai, Jill Vardy, Natasja Wye, George Yang & Marco Marra - The Institute for Genomic Research, Rockville, Maryland, 20850, USA
Shaying Zhao, Sofiya Shatsman, Bola Ayodeji, Keita Geer, Getahun Tsegaye, Alla Shvartsbeyn, Elizabeth Gebregeorgis, Margaret Krol, Daniel Russell, Larry Overton, Joel A. Malek, Mike Holmes, Michael Heaney, Jyoti Shetty, Tamara Feldblyum, William C. Nierman & Claire M. Fraser - Children's Hospital Oakland Research Institute, Oakland, California, 94609, USA
Kazutoyo Osoegawa, Joseph J. Catanese & Pieter J. de Jong - EMBL—European Bioinformatics Institute, CB10 1SD, Hinxton, Cambridge, UK
Ewan Birney - Department of Electrical Engineering, Washington University, St Louis, Missouri, 63130, USA
Dan Fuhrmann
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Correspondence toDavid R. Bentley.
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Supplementary information
41586_2002_BFnature00957_MOESM1_ESM.zip
This file contains a static version of the mouse fingerprint contig (FPC) map; it is an archive representation of the data at the time of publication. (Start with the file bac.1.0.html). A live, updated version of this data can be seen in CytoView at Ensembl (choose 'MapViewer'), and also at the NCBI (use the 'Jump to chr' box to select chromosome; if searching specific features, select 'cytoview' option to view the map). The FPC map was previous displayed in Ensembl before the availability of sequence covering most of the genome. Since then, Ensembl displays have switched to being sequence based, with the FPC data mapped onto it and visible through the CytoView interface. Both the sequence and the FPC map are being refined as the mouse genome is finished. (ZIP 3564 kb)
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Gregory, S., Sekhon, M., Schein, J. et al. A physical map of the mouse genome.Nature 418, 743–750 (2002). https://doi.org/10.1038/nature00957
- Received: 15 April 2002
- Accepted: 04 July 2002
- Published: 04 August 2002
- Issue Date: 15 August 2002
- DOI: https://doi.org/10.1038/nature00957