Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease (original) (raw)

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Acknowledgements

This study was funded by the National Basic Research Program of China (973 Plan) (2011CB503901 and 2006CB503805) from the Ministry of Science and Technology of China, by the National Science Foundation of China (30930047), by the High-Tech Research and Development Program of China (863 Plan) (2009AA022703, 2012AA02A516 and 2006AA02A406) and by a grant from the Ministry of Science and Technology of China (2006BAI01A01). This study was also supported by Biomedical Project from the Council of Science and Technology, Beijing (H020220030130).

Author information

Author notes

  1. Xiangfeng Lu, Laiyuan Wang and Runsheng Chen: These authors contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Xiangfeng Lu, Laiyuan Wang, Shufeng Chen, Xueli Yang, Jianfeng Huang, Jianxin Li, Jie Cao, Jichun Chen, Dongliang Ge, Ying Li, Liancheng Zhao, Lanying Chen, Donghua Liu, Jingping Chen, Xiufang Duan, Yongchen Hao, Qi Zhao, Dahai Yu, Qianqian Wang, Ying Yang, Fangchao Liu, Qunxia Mao, Xiaohua Liang, Jingfeng Ji, Xingbo Mo, Dianjiang Li, Guoping Chai, Xiangdong Li, Zhenhan Du, Xigui Wu & Dongfeng Gu
  2. National Human Genome Center at Beijing, Beijing, China
    Laiyuan Wang, Hongfan Li, Xuehui Liu & Chenlong Dou
  3. Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    Lin He & Yongyong Shi
  4. National Engineering Research Center for Beijing Biochip Technology (NERCBBT), Beijing, China
    Jing Cheng & Liang Zhang
  5. Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing, China
    Jing Cheng
  6. Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri, USA
    C Charles Gu
  7. Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China
    Tangchun Wu & Ligui Wang
  8. Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumchi, China
    Yitong Ma
  9. Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
    Zhongjie Fan
  10. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
    Xiaoyang Zhou
  11. Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, China
    Fanghong Lu & Zhendong Liu
  12. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China
    Cailiang Yao & Chong Shen
  13. Department of Cardiology, Fujian Provincial People's Hospital, Fuzhou, China
    Xiaodong Pu & Lin Yu
  14. Department of Epidemiology and Social Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
    Xianghua Fang
  15. Department of Cardiology, The Affiliated Hospital of Beihua University, Beihua University, Jilin, China
    Lihua Xu
  16. Department of Cardiology, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an,, China
    Jianjun Mu
  17. Center for Chronic and Noncommunicable Disease Control and Prevention, Sichuan Center of Disease Control and Prevention, Chengdu, China
    Xianping Wu
  18. Cardiovascular Disease Prevention Center, Shougang Hospital, Peking University, Beijing, China
    Runping Zheng
  19. Department of Cardiology, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Naqiong Wu, Yida Tang & Yuejin Yang
  20. School of Public Health, Hebei United University, Tangshan, China
    Yun Li
  21. Department of Cardiology, Anzhen Hospital, Capital Medical University, Beijing, China
    Xiaoli Liu
  22. Department of Emergency Medicine, Beijing Jishuitan Hospital, Beijing, China
    Mengqin Wang
  23. School of Public Health, Zhengzhou University, Zhengzhou, China
    Dongsheng Hu
  24. School of Medicine, Shenzhen University, Shenzhen, China
    Dongsheng Hu
  25. Department of Internal Medicine, Xinle Red Cross Hospital, Xinle, China
    Xu Ji
  26. Department of Internal Medicine, Yuxian Renmin Hospital, Yuxian, China
    Dongshuang Guo
  27. Institute of Geriatrics, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China
    Dongling Sun
  28. Renqiu Heath Bureau, Renqiu, China
    Panpan Chen
  29. Nantong Center of Disease Control and Prevention, Nantong, China
    Zili Yang
  30. Zhangqiu Heath Bureau, Zhangqiu, China
    Qingjie Meng
  31. Xin'an Heath Bureau, Xin'an, China
    Dong Wang
  32. Department of Internal Medicine, Shijiazhuang Greatwall Hospital, Shijiazhuang, China
    Renping Wang
  33. Department of Cardiology, Hanzhong Renmin Hospital, Hanzhong, China
    Jun Yang
  34. Medizinische Klinik II, Universität zu Lübeck, Lübeck, Germany
    Heribert Schunkert & Jeanette Erdmann
  35. Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Universität zu Lübeck, Lübeck, Germany
    Heribert Schunkert & Jeanette Erdmann
  36. Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
    Nilesh J Samani
  37. Leicester National Institute for Health Research, Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK
    Nilesh J Samani
  38. Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Sekar Kathiresan
  39. Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
    Sekar Kathiresan
  40. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Sekar Kathiresan
  41. The Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Muredach P Reilly
  42. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Xiaozhong Peng, Depei Liu & Boqin Qiang
  43. Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Runsheng Chen

Authors

  1. Xiangfeng Lu
  2. Laiyuan Wang
  3. Shufeng Chen
  4. Lin He
  5. Xueli Yang
  6. Yongyong Shi
  7. Jing Cheng
  8. Liang Zhang
  9. C Charles Gu
  10. Jianfeng Huang
  11. Tangchun Wu
  12. Yitong Ma
  13. Jianxin Li
  14. Jie Cao
  15. Jichun Chen
  16. Dongliang Ge
  17. Zhongjie Fan
  18. Ying Li
  19. Liancheng Zhao
  20. Hongfan Li
  21. Xiaoyang Zhou
  22. Lanying Chen
  23. Donghua Liu
  24. Jingping Chen
  25. Xiufang Duan
  26. Yongchen Hao
  27. Ligui Wang
  28. Fanghong Lu
  29. Zhendong Liu
  30. Cailiang Yao
  31. Chong Shen
  32. Xiaodong Pu
  33. Lin Yu
  34. Xianghua Fang
  35. Lihua Xu
  36. Jianjun Mu
  37. Xianping Wu
  38. Runping Zheng
  39. Naqiong Wu
  40. Qi Zhao
  41. Yun Li
  42. Xiaoli Liu
  43. Mengqin Wang
  44. Dahai Yu
  45. Dongsheng Hu
  46. Xu Ji
  47. Dongshuang Guo
  48. Dongling Sun
  49. Qianqian Wang
  50. Ying Yang
  51. Fangchao Liu
  52. Qunxia Mao
  53. Xiaohua Liang
  54. Jingfeng Ji
  55. Panpan Chen
  56. Xingbo Mo
  57. Dianjiang Li
  58. Guoping Chai
  59. Yida Tang
  60. Xiangdong Li
  61. Zhenhan Du
  62. Xuehui Liu
  63. Chenlong Dou
  64. Zili Yang
  65. Qingjie Meng
  66. Dong Wang
  67. Renping Wang
  68. Jun Yang
  69. Heribert Schunkert
  70. Nilesh J Samani
  71. Sekar Kathiresan
  72. Muredach P Reilly
  73. Jeanette Erdmann
  74. Xiaozhong Peng
  75. Xigui Wu
  76. Depei Liu
  77. Yuejin Yang
  78. Runsheng Chen
  79. Boqin Qiang
  80. Dongfeng Gu

Consortia

The Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium

Contributions

D. Gu conceived of and designed the study and supervised all the sample selection, genotyping, data analysis and interpretation. B.Q., Depei Liu and X. Peng participated in the study design and interpretation. Genotyping experiments were performed by S.C., Y.S., L. Zhang and H.L. under the supervision of D. Gu, L.H., J. Cheng and L.C. DNA sample preparation was carried out by Laiyuan Wang, H.L., T.W., Y.M., Q.Z., Yun Li, D.Y., Q.W., Ying Yang, F. Liu, Q. Mao, X. Liang, J.J., X.M., D. Li, Xuehui Liu and C.D. Phenotype collection and data management were conducted by J.H., S.C., J.L., J. Cao, Jichun Chen, Donghua Liu, Jingping Chen, X.D., T.W., Ligui Wang, Y.M., Z.F., Ying Li, L. Zhao, X.Z., F. Lu, Z.L., C.Y., C.S., X. Pu, L.Y., X.F., L.X., J.M., Xianping Wu, R.Z., N.W., Xiaoli Liu, M.W., D.H., X.J., D. Guo, D.S., P.C., G.C., Xigui Wu, L.C., Yuejin Yang, Y.T., X. Li, Z.D., Z.Y., Q. Meng, D.W., R.W. and J.Y. H.S., N.J.S., S.K., M.P.R. and J.E. provided the data from the CARDIoGRAM Consortium. Statistical analysis was performed by X. Lu, X.Y., Y.H., D. Ge, C.C.G. and R.C. The manuscript was written by D. Gu, X. Lu and Laiyuan Wang. All authors reviewed the manuscript.

Corresponding author

Correspondence toDongfeng Gu.

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The authors declare no competing financial interests.

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A full list of members and affiliations is provided in the Supplementary Note.

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Lu, X., Wang, L., Chen, S. et al. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.Nat Genet 44, 890–894 (2012). https://doi.org/10.1038/ng.2337

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