Regulatory T cells in the control of immune pathology (original) (raw)

• Gershon, R. K. A disquisition on suppressor T cells. Transplant. Rev. 26, 170–185 (1975).
  CAS PubMed Google Scholar
• Mason, D. & Powrie, F. Control of immune pathology by regulatory T cells. Curr. Opin. Immunol. 10, 649–655 (1998).
  CAS PubMed Google Scholar
• Shevach, E. M. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18, 423–449 (2000).
  CAS PubMed Google Scholar
• Sakaguchi, S. Animal models of autoimmunity and their relevance to human diseases. Curr. Opin. Immunol. 12, 684–690 (2000).
  CAS PubMed Google Scholar
• Roncarolo, M. G. & Levings, M. K. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr. Opin. Immunol. 12, 676–683 (2000).
  CAS PubMed Google Scholar
• Fowell, D. & Mason, D. Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential. J. Exp. Med. 177, 627–636 (1993).
  CAS PubMed Google Scholar
• Hafler, D. A. & Weiner, H. L. Immunologic mechanisms and therapy in multiple sclerosis. Immunol. Rev. 144, 75–107 (1995).
  CAS PubMed Google Scholar
• Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 1151–1164 (1995).
  CAS PubMed Google Scholar
• Hemmer, B., Vergelli, M., Pinilla, C., Houghten, R. & Martin, R. Probing degeneracy in T-cell recognition using peptide combinatorial libraries. Immunol. Today. 19, 163–168 (1998).
  CAS PubMed Google Scholar
• Mason, D. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 19, 395–404 (1998).
  CAS PubMed Google Scholar
• Hausmann, S. & Wucherpfennig, K. W. Activation of autoreactive T cells by peptides from human pathogens. Curr. Opin. Immunol. 9, 831–838 (1997).
  CAS PubMed PubMed Central Google Scholar
• Schwartz, R. H. Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 184, 1–8 (1996).
  CAS PubMed Google Scholar
• Miller, J. F. & Basten, A. Mechanisms of tolerance to self. Curr. Opin. Immunol. 8, 815–821 (1996).
  CAS PubMed Google Scholar
• Zinkernagel, R. M. et al. Antigen localisation regulates immune responses in a dose- and time- dependent fashion: a geographical view of immune reactivity. Immunol. Rev. 156, 199–209 (1997).
  CAS PubMed Google Scholar
• Coutinho, A., Salaun, J., Corbel, C., Bandeira, A. & Le Douarin, N. The role of thymic epithelium in the establishment of transplantation tolerance. Immunol. Rev. 133, 225–240 (1993).
  CAS PubMed Google Scholar
• Le Douarin, N. et al. Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells. Immunol. Rev. 149, 35–53 (1996).
  CAS PubMed Google Scholar
• Asano, M., Toda, M., Sakaguchi, N. & Sakaguchi, S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184, 387–396 (1996).
  CAS PubMed Google Scholar
• Seddon, B. & Mason, D. Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor β and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4+CD45RC− cells and CD4+CD8− thymocytes. J. Exp. Med. 189, 279–288 (1999).
  CAS PubMed PubMed Central Google Scholar
• Olivares-Villagomez, D., Wang, Y. & Lafaille, J. J. Regulatory CD4+ T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J. Exp. Med. 188, 1883–1894 (1998).
  CAS PubMed PubMed Central Google Scholar
• Van de Keere, F. & Tonegawa, S. CD4+ T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J. Exp. Med. 188, 1875–1882 (1998).
  CAS PubMed PubMed Central Google Scholar
• Mordes, J. P. et al. Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat. Diabetologia 30, 22–26 (1987).
  CAS PubMed Google Scholar
• Powrie, F., Leach, M. W., Mauze, S., Caddle, L. B. & Coffman, R. L. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 5, 1461–1471 (1993).
  CAS PubMed Google Scholar
• Read, S., Malmstrom, V. & Powrie, F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation. J. Exp. Med. 192, 295–302 (2000).
  CAS PubMed PubMed Central Google Scholar
• Stockinger, G., Barthlott, T. & Kassiotis, G. T cell regulation: a special job or everyone's responsibility? Nature Immunol. 2, 757–758 (2001).
  CAS Google Scholar
• Takahashi, T. et al. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10, 1969–1980 (1998).
  CAS PubMed Google Scholar
• Thornton, A. E. & Shevach, E. M. CD4+ CD25+ Immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188, 287–296 (1998).
  CAS PubMed PubMed Central Google Scholar
• Suri-Payer, E., Amar, Z. A., Thornton, A. M. & Shevach, E. M. CD4+ CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160, 1212–1218 (1998).
  CAS PubMed Google Scholar
• Salomon, B. et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431–440 (2000).
  CAS PubMed Google Scholar
• Takahashi, T. et al. Immunologic self-tolerance maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192, 303–310 (2000).
  CAS PubMed PubMed Central Google Scholar
• Papiernik, M., de Moraes, M. L., Pontoux, C., Vasseur, F. & Penit, C. Regulatory CD4 T cells: expression of IL-2R α chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 10, 371–378 (1998).
  CAS PubMed Google Scholar
• Stephens, L. A. & Mason, D. CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25− subpopulations. J. Immunol. 165, 3105–3110 (2000).
  CAS PubMed Google Scholar
• Hara, M. et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol. 166, 3789–3796 (2001).
  CAS PubMed Google Scholar
• Gao, Q., Rouse, T. M., Kazmerzak, K. & Field, E. H. CD4+CD25+ cells regulate CD8 cell anergy in neonatal tolerant mice. Transplantation 68, 1891–1897 (1999).
  CAS PubMed Google Scholar
• Taylor, P. A., Noelle, R. J. & Blazar, B. R. CD4+CD25+ Immune Regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J. Exp. Med. 193, 1311–1318 (2001).
  CAS PubMed PubMed Central Google Scholar
• Shimizu, J., Yamazaki, S. & Sakaguchi, S. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163, 5211–5218 (1999).
  CAS PubMed Google Scholar
• Annacker, O. et al. CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166, 3008–3018 (2001).
  CAS PubMed Google Scholar
• Itoh, M. et al. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162, 5317–5326 (1999).
  CAS PubMed Google Scholar
• Stephens, L. A., Mottet, C., Mason, D. & Powrie, F. Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur. J. Immunol. 31, 1247–1254 (2001).
  CAS PubMed Google Scholar
• Taams, L. S. et al. Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population. Eur. J. Immunol. 31, 1122–1131 (2001).
  CAS PubMed Google Scholar
• Dieckmann, D., Plottner, H., Berchtold, S., Berger, T. & Schuler, G. Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood. J. Exp. Med. 193, 1303–1310 (2001).
  CAS PubMed PubMed Central Google Scholar
• Levings, M. K., Sangregorio, R. & Roncarolo, M. G. Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193, 1295–1302 (2001).
  CAS PubMed PubMed Central Google Scholar
• Jonuleit, H. et al. Identification and functional characterization of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193, 1285–1294 (2001).
  CAS PubMed PubMed Central Google Scholar
• Olivares-Villagomez, D., Wensky, A. K., Wang, Y. & Lafaille, J. J. Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis. J. Immunol. 164, 5499–5507 (2000).
  CAS PubMed Google Scholar
• Jenkins, M. K. & Schwartz, R. H. Antigen presentation by chemically modified splenocytes induces antigen- specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165, 302–319 (1987).
  CAS PubMed Google Scholar
• Chai, J. G. et al. Anergic T cells act as suppressor cells in vitro and in vivo. Eur. J. Immunol. 29, 686–692 (1999).
  CAS PubMed Google Scholar
• Taams, L. S. et al. Anergic T cells actively suppress T cell responses via the antigen- presenting cell. Eur. J. Immunol. 28, 2902–2912 (1998).
  CAS PubMed Google Scholar
• Vendetti, S. et al. Anergic T cells inhibit the antigen-presenting function of dendritic cells. J. Immunol. 165, 1175–1181 (2000).
  CAS PubMed Google Scholar
• Buer, J. et al. Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo. J. Exp. Med. 187, 177–183 (1998).
  CAS PubMed PubMed Central Google Scholar
• Sundstedt, A. et al. Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo. J. Immunol. 158, 180–186 (1997).
  CAS PubMed Google Scholar
• Groux, H., Bigler, M., de Vries, J. E. & Roncarolo, M. G. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J. Exp. Med. 184, 19–29 (1996).
  CAS PubMed Google Scholar
• Groux, H. et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737–742 (1997).
  CAS PubMed Google Scholar
• Cottrez, F., Hurst, S. D., Coffman, R. L. & Groux, H. T regulatory cells 1 inhibit a Th2-specific response in vivo. J. Immunol. 165, 4848–4853 (2000).
  CAS PubMed Google Scholar
• Chen, Y., Kuchroo, V. K., Inobe, J., Hafler, D. A. & Weiner, H. L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265, 1237–1240 (1994).
  CAS PubMed Google Scholar
• Neurath, M. F. et al. Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance. J. Exp. Med. 183, 2605–2616 (1996).
  CAS PubMed Google Scholar
• Weiner, H. L. Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol. Today 18, 335–343 (1997).
  CAS PubMed Google Scholar
• Waldmann, H. & Cobbold, S. Regulating the immune response to transplants. A role for CD4+ regulatory cells? Immunity 14, 399–406 (2001).
  CAS PubMed Google Scholar
• Zhai, Y. & Kupiec-Weglinski, J. W. What is the role of regulatory T cells in transplantation tolerance? Curr. Opin. Immunol. 11, 497–503 (1999).
  CAS PubMed Google Scholar
• Cobbold, S. & Waldmann, H. Infectious tolerance. Curr. Opin. Immunol. 10, 518–524 (1998).
  CAS PubMed Google Scholar
• Davies, J. D. et al. CD4+ CD45RB low-density cells from untreated mice prevent acute allograft rejection. J. Immunol. 163, 5353–5357 (1999).
  CAS PubMed Google Scholar
• Seddon, B. & Mason, D. The third function of the thymus. Immunol. Today 21, 95–99 (2000).
  CAS PubMed Google Scholar
• Saoudi, A., Seddon, B., Fowell, D. & Mason, D. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J. Exp. Med. 184, 2393–2398 (1996).
  CAS PubMed PubMed Central Google Scholar
• Herbelin, A., Gombert, J. M., Lepault, F., Bach, J. F. & Chatenoud, L. Mature mainstream TCRαβ+CD4+ thymocytes expressing L-selectin mediate “active tolerance” in the nonobese diabetic mouse. J. Immunol. 161, 2620–2628 (1998).
  CAS PubMed Google Scholar
• Singh, B. et al. Control of intestinal inflammation by regulatory T cells. Immunol. Rev. 182, (in the press, 2001).
• Modigliani, Y., Bandeira, A. & Coutinho, A. A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens. Immunol. Rev. 149, 155–120 (1996).
  CAS PubMed Google Scholar
• Jordan, M. S., Riley, M. P., von Boehmer, H. & Caton, A. J. Anergy and suppression regulate CD4+ T cell responses to a self peptide. Eur. J. Immunol. 30, 136–144 (2000).
  CAS PubMed Google Scholar
• Jordan, M. S. et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nature Immunol. 2, 301–306 (2001).
  CAS Google Scholar
• Suri-Payer, E. et al. Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells. Eur. J. Immunol. 29, 669–677 (1999).
  CAS PubMed Google Scholar
• Kumanogoh, A. et al. Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development. J. Immunol. 166, 353–360 (2001).
  CAS PubMed Google Scholar
• Kuniyasu, Y. et al. Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int. Immunol. 12, 1145–1155 (2000).
  CAS PubMed Google Scholar
• Seddon, B. & Mason, D. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J. Exp. Med. 189, 877–882 (1999).
  CAS PubMed PubMed Central Google Scholar
• Duchmann, R. et al. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin. Exp. Immunol. 102, 448–455 (1995).
  CAS PubMed PubMed Central Google Scholar
• Khoo, U. Y., Proctor, I. E. & Macpherson, A. J. CD4+ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens. J. Immunol. 158, 3626–3634 (1997).
  CAS PubMed Google Scholar
• Taguchi, O. et al. Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens. Immunology 82, 365–369 (1994).
  CAS PubMed PubMed Central Google Scholar
• Modigliani, Y. et al. Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium. Eur. J. Immunol. 26, 1807–1815 (1996).
  CAS PubMed Google Scholar
• Thorstenson, K. M. & Khoruts, A. Generation of anergic CD25+CD4+ T cells with immunoregulatory potential in vivo following induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 167, 188–195 (2001).
  CAS PubMed Google Scholar
• O'Garra, A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8, 275–283 (1998).
  CAS PubMed Google Scholar
• Lanzavecchia, A. & Sallusto, F. Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells. Science 290, 92–97 (2000).
  CAS PubMed Google Scholar
• Steinbrink, K., Wolfl, M., Jonuleit, H., Knop, J. & Enk, A. H. Induction of tolerance by IL-10-treated dendritic cells. J. Immunol. 159, 4772–4780 (1997).
  CAS PubMed Google Scholar
• Jonuleit, H., Schmitt, E., Schuler, G., Knop, J. & Enk, A. H. Induction of interleukin 10-producing, nonproliferating CD4+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192, 1213–1222 (2000).
  CAS PubMed PubMed Central Google Scholar
• Dhodapkar, M. V., Steinman, R. M., Krasovsky, J., Munz, C. & Bhardwaj, N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 193, 233–238 (2001).
  CAS PubMed PubMed Central Google Scholar
• Yamagiwa, S., Gray, J. D., Hashimoto, S. & Horwitz, D. A. A role for TGF-β in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J. Immunol. 166, 7282–7289 (2001).
  CAS PubMed Google Scholar
• Hoyne, G. F. et al. Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells. Int. Immunol. 12, 177–185 (2000).
  CAS PubMed Google Scholar
• Powrie, F., Carlino, J., Leach, M. W., Mauze, S. & Coffman, R. L. A critical role for transforming growth factor-β but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RBlo CD4+ T cells. J. Exp. Med. 183, 2669–2674 (1996).
  CAS PubMed Google Scholar
• Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L. & Powrie, F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190, 995–1004 (1999).
  CAS PubMed PubMed Central Google Scholar
• Ding, L. & Shevach, E. M. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J. Immunol. 148, 3133–3139 (1992).
  CAS PubMed Google Scholar
• Fiorentino, D. F. et al. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 146, 3444–3451 (1991).
  CAS PubMed Google Scholar
• Takeuchi, M., Alard, P. & Streilein, J. W. TGF-β promotes immune deviation by altering accessory signals of antigen-presenting cells. J. Immunol. 160, 1589–1597 (1998).
  CAS PubMed Google Scholar
• Kitani, A. et al. Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-β1 plasmid: TGF-β1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor β2 chain downregulation. J. Exp. Med. 192, 41–52 (2000).
  CAS PubMed PubMed Central Google Scholar
• Letterio, J. J. & Roberts, A. B. Regulation of immune responses by TGF-β. Annu. Rev. Immunol. 16, 137–161 (1998).
  CAS PubMed Google Scholar
• Gorelik, L. & Flavell, R. A. Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12, 171–181 (2000).
  CAS PubMed Google Scholar
• Moore, K. W., de Waal Malefyt, R., Coffman, R. L. & O'Garra, A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19, 683–765 (2001).
  CAS PubMed Google Scholar
• Takeda, K. et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10, 39–49 (1999).
  CAS PubMed Google Scholar
• Thornton, A. M. & Shevach, E. M. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J. Immunol. 164, 183–190 (2000).
  CAS PubMed Google Scholar
• Cederbom, L., Hall, H. & Ivars, F. CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur. J. Immunol. 30, 1538–1543 (2000).
  CAS PubMed Google Scholar
• Shevach, E. M. Certified Professionals. CD4+CD25+ suppressor T cells. J. Exp. Med. 193, 41–46 (2001).
  Google Scholar
• Suri-Payer, E. & Cantor, H. Differential cytokine requirements for regulation of autoimmune gastritis and colitis by cd4(+)cd25(+)t cells. J. Autoimmunity 16, 115–123 (2001).
  CAS Google Scholar
• Lepault, F. & Gagnerault, M. C. Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice. J. Immunol. 164, 240–247 (2000).
  CAS PubMed Google Scholar
• Chambers, C. A., Kuhns, M. S., Egen, J. G. & Allison, J. P. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu. Rev. Immunol. 19, 565–594 (2001).
  CAS PubMed Google Scholar
• Chen, W., Jin, W. & Wahl, S. M. Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor β (TGF-β) production by murine CD4+ T cells. J. Exp. Med. 188, 1849–1857 (1998).
  CAS PubMed PubMed Central Google Scholar
• Malmstrom, V. et al. CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored scid mice. J. Immunol. 166, 6972–6981 (2001).
  CAS PubMed Google Scholar
• Scheerens, H., Hessel, E., de Waal-Malefyt, R., Leach, M. W. & Rennick, D. Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10−/− mice and Rag-2−/− mice reconstituted with CD4+CD45RBhi T cells. Eur. J. Immunol. 31, 1465–1474 (2001).
  CAS PubMed Google Scholar
• Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991–1045 (1994).
  CAS PubMed Google Scholar
• Medzhitov, R. & Janeway, C. A. Jr Innate immunity: the virtues of a nonclonal system of recognition. Cell 91, 295–298 (1997).
  CAS PubMed Google Scholar
• Mackay, C. R. Homing of naive, memory and effector lymphocytes. Curr. Opin. Immunol. 5, 423–427 (1993).
  CAS PubMed Google Scholar
• Randolph, G. J., Beaulieu, S., Lebecque, S., Steinman, R. M. & Muller, W. A. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 282, 480–483 (1998).
  CAS PubMed Google Scholar
• Albert, M. L. et al. Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. 188, 1359–1368 (1998).
  CAS PubMed PubMed Central Google Scholar
• Sauter, B. et al. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. 191, 423–434 (2000).
  CAS PubMed PubMed Central Google Scholar
• Kurts, C. et al. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184, 923–930 (1996).
  CAS PubMed Google Scholar
• Forster, I. & Lieberam, I. Peripheral tolerance of CD4 T cells following local activation in adolescent mice. Eur. J. Immunol. 26, 3194–3202 (1996).
  CAS PubMed Google Scholar
• Adler, A. J. et al. CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells. J. Exp. Med. 187, 1555–1564 (1998).
  CAS PubMed PubMed Central Google Scholar
• Banchereau, J. et al. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18, 767–811 (2000).
  CAS PubMed Google Scholar
• Taguchi, O. & Takahashi, T. Administration of anti-interleukin-2 receptorα antibody in vivo induces localized autoimmune disease. Eur. J. Immunol. 26, 1608–1612 (1996).
  CAS PubMed Google Scholar