Metabolite profiles and the risk of developing diabetes (original) (raw)

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Acknowledgements

This work was supported by US National Institutes of Health contract NO1-HC-25195, R01-DK-HL081572, the Donald W. Reynolds Foundation, the Leducq Foundation and the American Heart Association. S.C. is also supported by an award from the Ellison Foundation. J.C.F. is also supported by the Massachusetts General Hospital and a Clinical Scientist Development Award from the Doris Duke Charitable Foundation.

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Authors and Affiliations

  1. Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Thomas J Wang, Eugene P Rhee, Gregory D Lewis & Robert E Gerszten
  2. Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Thomas J Wang, Susan Cheng, Elizabeth McCabe, Gregory D Lewis, Christopher J O'Donnell & Robert E Gerszten
  3. Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, Massachusetts, USA
    Thomas J Wang, Martin G Larson, Ramachandran S Vasan, Susan Cheng, Elizabeth McCabe, Caroline S Fox & Christopher J O'Donnell
  4. Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, USA
    Martin G Larson
  5. Cardiology Section, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA
    Ramachandran S Vasan
  6. Division of Cardiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Susan Cheng
  7. Renal Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Eugene P Rhee
  8. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Eugene P Rhee, Gregory D Lewis, Christopher J O'Donnell, Stephen A Carr, Vamsi K Mootha, Jose C Florez, Amanda Souza, Clary B Clish & Robert E Gerszten
  9. Division of Endocrinology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Caroline S Fox
  10. Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Caroline S Fox
  11. Jean Mayer US Department of Agriculture Human Nutrition Research Center, Tufts University, Boston, Massachusetts, USA
    Paul F Jacques
  12. Department of Experimental Medical Science, Lund University, Malmö, Sweden
    Céline Fernandez
  13. Diabetes Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Vamsi K Mootha & Jose C Florez
  14. Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Vamsi K Mootha
  15. Department of Clinical Sciences, Lund University, Malmö, Sweden
    Olle Melander

Authors

  1. Thomas J Wang
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  2. Martin G Larson
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  3. Ramachandran S Vasan
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  4. Susan Cheng
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  5. Eugene P Rhee
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  6. Elizabeth McCabe
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  7. Gregory D Lewis
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  8. Caroline S Fox
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  9. Paul F Jacques
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  10. Céline Fernandez
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  11. Christopher J O'Donnell
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  12. Stephen A Carr
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  13. Vamsi K Mootha
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  14. Jose C Florez
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  15. Amanda Souza
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  16. Olle Melander
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  17. Clary B Clish
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  18. Robert E Gerszten
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Contributions

T.J.W. conceived of the study, designed the experiments, analyzed and interpreted the data and wrote the manuscript. A.S. and E.P.R., under the direction of C.B.C., developed the metabolic profiling platform, performed mass spectrometry experiments and analyzed the data. S.A.C. and V.K.M. helped in the establishment of the metabolite profiling platform and manuscript revision. G.D.L. contributed to data analysis and manuscript generation. M.G.L., R.S.V., S.C. and E.M. helped in experimental design, performed statistical analyses and assisted in manuscript generation. C.J.O. and C.S.F. helped in experimental design and manuscript revision. P.F.J. directed the dietary analyses in the Framingham Heart Study and contributed to manuscript revision. J.C.F. assisted in the interpretation of the data and contributed to manuscript revision. O.M. and C.F. performed the replication analyses in the Malmö Diet and Cancer cohort and contributed to manuscript revision. R.E.G. conceived of the study, designed the experiments, analyzed and interpreted the data and wrote the manuscript.

Corresponding authors

Correspondence toThomas J Wang or Robert E Gerszten.

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Competing interests

T.J.W., R.S.V., M.G.L., V.K.M. and R.E.G. are named as co-inventors on a patent application to the US Patent Office pertaining to metabolite predictors of diabetes. J.C.F. has received consulting honoraria from Publicis Healthcare, Merck, bioStrategies, XOMA and Daiichi-Sankyo and has been a paid invited speaker at internal scientific seminars hosted by Pfizer and Alnylam Pharmaceuticals.

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Wang, T., Larson, M., Vasan, R. et al. Metabolite profiles and the risk of developing diabetes.Nat Med 17, 448–453 (2011). https://doi.org/10.1038/nm.2307

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