Taking the brake off T cells in chronic viral infection (original) (raw)

Nature Medicine volume 12, pages 276–277 (2006)Cite this article

During chronic viral infections, CD8+ T cells lose much of their ability to proliferate, produce cytokines and kill. A new discovery shows how to restore their antiviral function.

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Figure 1: Therapy with PD-L1–specific antibody restores impaired CD8+ T-cell functions in LCMV infection.

Katie Ris

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Authors and Affiliations

  1. Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, and are supported by the NIDDK intramural research program., Bethesda, 20892, Maryland, USA
    Eui-Cheol Shin & Barbara Rehermann

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  1. Eui-Cheol Shin
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  2. Barbara Rehermann
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Shin, EC., Rehermann, B. Taking the brake off T cells in chronic viral infection.Nat Med 12, 276–277 (2006). https://doi.org/10.1038/nm0306-276

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