Inhibition of respiratory viruses by nasally administered siRNA (original) (raw)

References

  1. Openshaw, P.J.M. Potential therapeutic implications of new insights into respiratory syncytial virus disease. Respir. Res. 3 (Suppl 1), S15–S20 (2002).
    PubMed PubMed Central Google Scholar
  2. Easton, A.J., Domachowske, J.B. & Rosenberg, H.F. Animal pneumoviruses: molecular genetics and pathogenesis. Clin. Microbiol. Rev. 17, 390–412 (2004).
    Article CAS Google Scholar
  3. Maggon, K. & Barik, S. New drugs and treatment for respiratory syncytial virus. Rev. Med. Virol. 14, 149–168 (2004).
    Article CAS Google Scholar
  4. Sullender, W.M. Respiratory syncytial virus genetic and antigenic diversity. Clin. Microbiol. Rev. 13, 1–15 (2000).
    Article CAS Google Scholar
  5. Razinkov, V., Huntley, C.C., Ellestad, G. & Krishnamurthy, G. RSV entry inhibitors block F-protein mediated fusion with model membranes. Antivir. Res. 55, 189–200 (2002).
    Article CAS Google Scholar
  6. Morton, C.J. et al. Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay. Virology 311, 275–288 (2003).
    Article CAS Google Scholar
  7. Burke, E., Dupuy, L., Wall, C. & Barik, S. Role of cellular actin in the gene expression and morphogenesis of human respiratory syncytial virus. Virology 252, 137–148 (1998).
    Article CAS Google Scholar
  8. Burke, E., Mahoney, N.M., Almo, S.C. & Barik, S. Profilin is required for optimal actin-dependent transcription of respiratory syncytial virus genome RNA. J. Virol. 74, 669–675 (2000).
    Article CAS Google Scholar
  9. Gupta, S., De, B.P., Drazba, J.A. & Banerjee, A.K. Involvement of actin microfilaments in the replication of human parainfluenza virus type 3. J. Virol. 72, 2655–2662 (1998).
    CAS PubMed PubMed Central Google Scholar
  10. Peebles, R.S., Jr., Hashimoto, K. & Graham, B.S. The complex relationship between respiratory syncytial virus and allergy in lung disease. Viral. Immunol. 16, 25–34 (2003).
    Article CAS Google Scholar
  11. Haynes, L.M., Jones, L.P., Barskey, A., Anderson, L.J. & Tripp, R.A. Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P. J. Virol. 77, 9831–9844 (2003).
    Article CAS Google Scholar
  12. Polack, F.P. et al. A role for immune complexes in enhanced respiratory syncytial virus disease. J. Exp. Med. 196, 859–865 (2002).
    Article CAS Google Scholar
  13. Novina, C.D. & Sharp, P.A. The RNAi revolution. Nature 430, 161–164 (2004).
    Article CAS Google Scholar
  14. Bitko, V. & Barik, S. Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses. BMC Microbiol. 1, 34 (2001).
    Article CAS Google Scholar
  15. Barik, S. Control of nonsegmented negative-strand RNA virus replication by siRNA. Virus Res. 102, 27–35 (2004).
    Article CAS Google Scholar
  16. Elbashir, S.M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494–498 (2001).
    Article CAS Google Scholar
  17. Reynolds, A. et al. Rational siRNA design for RNA interference. Nat. Biotechnol. 22, 326–330 (2004).
    Article CAS Google Scholar
  18. Schwarz, D.S. et al. Asymmetry in the assembly of the RNAi enzyme complex. Cell 115, 199–208 (2003).
    Article CAS Google Scholar
  19. Khvorova, A., Reynolds, A. & Jayasena, S.D. Functional siRNAs and miRNAs exhibit strand bias. Cell 115, 209–216 (2003). Erratum in: Cell 115, 505 (2003).
    Article CAS Google Scholar
  20. Graham, B.S., Perkins, M.D., Wright, P.F. & Karzon, D.T. Primary respiratory syncytial virus infection in mice. J. Med. Virol. 26, 153–162 (1988).
    Article CAS Google Scholar
  21. van Schaik, S.M., Enhorning, G., Vargas, I. & Welliver, R.C. Respiratory syncytial virus affects pulmonary function in BALB/c mice. J. Infect. Dis. 177, 269–276 (1998).
    Article CAS Google Scholar
  22. Haeberle, H.A. et al. Inducible expression of inflammatory chemokines in respiratory syncytial virus-infected mice: role of MIP-1alpha in lung pathology. J. Virol. 75, 878–890 (2001).
    Article CAS Google Scholar
  23. Durbin, A.P., Elkins, W.R. & Murphy, B.R. African green monkeys provide a useful nonhuman primate model for the study of human parainfluenza virus types-1, -2, and -3 infection. Vaccine 18, 2462–2469 (2000).
    Article CAS Google Scholar
  24. Ge, Q., Filip, L., Bai, A., Nguyen, T., Eisen, H.N. & Chen, J. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc. Natl. Acad. Sci. USA 101, 8676–8681 (2004).
    Article CAS Google Scholar
  25. Schlender, J., Bossert, B., Buchholz, U. & Conzelmann, K.-K. Bovine respiratory syncytial virus nonstructural proteins NS1 and NS2 cooperatively antagonize alpha/beta interferon-induced antiviral response. J. Virol. 74, 8234–8242 (2000)
    Article CAS Google Scholar
  26. Ramaswamy, M., Shi, L., Monick, M.M., Hunninghake, G.W. & Look, D.C. Specific inhibition of type I interferon signal transduction by respiratory syncytial virus. Am. J. Respir. Cell Mol. Biol. 30, 893–900 (2004).
    Article CAS Google Scholar
  27. Coiras, M.T., Aguilar, J.C., Garcia, M.L., Casas, I. & Perez-Brena, P. Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays. J. Med. Virol. 72, 484–495 (2004).
    Article CAS Google Scholar
  28. Haller, A.A., Mitiku, M. & MacPhail, M. Bovine parainfluenza virus type 3 (PIV3) expressing the respiratory syncytial virus (RSV) attachment and fusion proteins protects hamsters from challenge with human PIV3 and RSV. J. Gen. Virol. 84, 2153–2162 (2003).
    Article CAS Google Scholar
  29. Schmidt, A.C., McAuliffe, J.M., Murphy, B.R. & Collins, P.L. Recombinant bovine/human parainfluenza virus type 3 (B/HPIV3) expressing the respiratory syncytial virus (RSV) G and F proteins can be used to achieve simultaneous mucosal immunization against RSV and HPIV3. J. Virol. 75, 4594–4603 (2001).
    Article CAS Google Scholar
  30. Bernhard, W. et al. Phosphatidylcholine molecular species in lung surfactant: composition in relation to respiratory rate and lung development. Am. J. Respir. Cell Mol. Biol. 25, 725–731 (2001).
    Article CAS Google Scholar
  31. Volovitz, B., Welliver, R.C., De Castro, G., Krystofik, D.A. & Ogra, P.L. The release of leukotrienes in the respiratory tract during infection with respiratory syncytial virus: role in obstructive airway disease. Pediatr. Res. 24, 504–507 (1988).
    Article CAS Google Scholar
  32. Welliver, R.C., 2nd, Hintz, K.H., Glori, M. & Welliver, R.C., Sr. Zileuton reduces respiratory illness and lung inflammation, during respiratory syncytial virus infection, in mice. J. Infect. Dis. 187, 1773–1779 (2003).
    Article CAS Google Scholar
  33. McCaffrey, A.P. et al. Inhibition of hepatitis B virus in mice by RNA interference. Nat Biotechnol. 21, 639–644 (2003).
    Article CAS Google Scholar
  34. Song, E. et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat. Med. 9, 347–351 (2003).
    Article CAS Google Scholar
  35. Tompkins, S.M., Lo, C.Y., Tumpey, T.M. & Epstein, S.L. Protection against lethal influenza virus challenge by RNA interference in vivo. Proc. Natl. Acad. Sci. USA 101, 8682–8686 (2004).
    Article CAS Google Scholar
  36. Jackson, A.L. et al. Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. 21, 635–637 (2003).
    Article CAS Google Scholar
  37. Sledz, C.A., Holko, M., de Veer, M.J., Silverman, R.H. & Williams, B.R. Activation of theinterferon system by short-interfering RNAs. Nat. Cell Biol. 5, 834–839 (2003).
    Article CAS Google Scholar
  38. Persengiev, S.P., Zhu, X. & Green, M.R. Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA 10, 12–18 (2004).
    Article CAS Google Scholar
  39. Bridge, A., Pebernard, S., Ducraux, A., Nicoulaz, A.L. & Iggo, R. Induction of an interferonresponse by RNAi vectors in mammalian cells. Nat. Genet. 34, 263–264 (2003).
    Article CAS Google Scholar
  40. Kim, D.H. et al. Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat. Biotechnol. 22, 321–325 (2004).
    Article CAS Google Scholar
  41. Hutvagner, G., Simard, M.J., Mello, C.C. & Zamore, P.D. Sequence-specific inhibition of small RNA function. PLoS Biol. 2, E98 (2004).
  42. Das, A.T. et al. Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition. J. Virol. 78, 2601–2605 (2004).
    Article CAS Google Scholar
  43. Ueba, O. Respiratory syncytial virus. I. Concentration and purification of the infectious virus. Acta. Med. Okayama 32, 265–272 (1978).
    CAS PubMed Google Scholar
  44. Durbin, J.E. et al. The role of IFN in respiratory syncytial virus pathogenesis. J. Immunol. 168, 2944–2952 (2002).
    Article CAS Google Scholar
  45. Reinhart, B.J., Weinstein, E.G., Rhoades, M.W., Bartel, B. & Bartel, D.P. MicroRNAs in plants. Genes Dev. 16, 1616–1626 (2002).
    Article CAS Google Scholar

Download references