The emerging roles of YAP and TAZ in cancer (original) (raw)
Pan, D. The Hippo signaling pathway in development and cancer. Dev. Cell19, 491–505 (2010). ArticleCAS Google Scholar
Harvey, K. F., Zhang, X. & Thomas, D. M. The Hippo pathway and human cancer. Nature Rev. Cancer13, 246–257 (2013). ArticleCAS Google Scholar
Mo, J. S., Park, H. W. & Guan, K. L. The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep.15, 642–656 (2014). ArticleCAS Google Scholar
Johnson, R. & Halder, G. The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nature Rev. Drug Discov.13, 63–79 (2014). ArticleCAS Google Scholar
Nishioka, N. et al. The Hippo signaling pathway components LATS and YAP pattern TEAD4 activity to distinguish mouse trophectoderm from inner cell mass. Dev. Cell16, 398–410 (2009). ArticleCAS Google Scholar
Xin, M. et al. Hippo pathway effector YAP promotes cardiac regeneration. Proc. Natl Acad. Sci. USA110, 13839–13844 (2013). ArticleCAS Google Scholar
Varelas, X. The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Development141, 1614–1626 (2014). ArticleCAS Google Scholar
Calvo, F. et al. Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nature Cell Biol.15, 637–646 (2013). ArticleCAS Google Scholar
Zhang, J. et al. YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nature Cell Biol.11, 1444–1450 (2009). ArticleCAS Google Scholar
Fujii, M. et al. TGFβ synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. J. Exp. Med.209, 479–494 (2012). ArticleCAS Google Scholar
Aragona, M. et al. A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell154, 1047–1059 (2013). ArticleCAS Google Scholar
Dupont, S. et al. Role of YAP/TAZ in mechanotransduction. Nature474, 179–183 (2011). ArticleCAS Google Scholar
Friedl, P. & Alexander, S. Cancer invasion and the microenvironment: plasticity and reciprocity. Cell147, 992–1009 (2011). ArticleCAS Google Scholar
Tang, Y. et al. MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis. Dev. Cell25, 402–416 (2013). ArticleCAS Google Scholar
Zhao, B. et al. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev.26, 54–68 (2012). Article Google Scholar
Codelia, V. A., Sun, G. & Irvine, K. D. Regulation of YAP by mechanical strain through JNK and Hippo signaling. Curr. Biol.24, 2012–2017 (2014). ArticleCAS Google Scholar
Yu, F. X. et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell150, 780–791 (2012). ArticleCAS Google Scholar
Zhao, B. et al. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev.25, 51–63 (2011). Article Google Scholar
Adler, J. J. et al. Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases. Proc. Natl Acad. Sci. USA110, 17368–17373 (2013). ArticleCAS Google Scholar
O'Hayre, M. et al. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nature Rev. Cancer13, 412–424 (2013). ArticleCAS Google Scholar
Chen, D. et al. LIFR is a breast cancer metastasis suppressor upstream of the Hippo–YAP pathway and a prognostic marker. Nature Med.18, 1511–1517 (2012). ArticleCAS Google Scholar
Fan, R., Kim, N. G. & Gumbiner, B. M. Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1. Proc. Natl Acad. Sci. USA110, 2569–2574 (2013). ArticleCAS Google Scholar
Azzolin, L. et al. YAP/TAZ incorporation in the β-Catenin destruction complex orchestrates the WNT response. Cell158, 157–170 (2014). ArticleCAS Google Scholar
Barry, E. R. et al. Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature493, 106–110 (2013). Article Google Scholar
Heallen, T. et al. Hippo pathway inhibits WNT signaling to restrain cardiomyocyte proliferation and heart size. Science332, 458–461 (2011). ArticleCAS Google Scholar
Rosenbluh, J. et al. β-catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell151, 1457–1473 (2012). ArticleCAS Google Scholar
Varelas, X. et al. The Hippo pathway regulates WNT/β-catenin signaling. Dev. Cell18, 579–591 (2010). ArticleCAS Google Scholar
Varelas, X. et al. TAZ controls SMAD nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nature Cell Biol.10, 837–848 (2008). ArticleCAS Google Scholar
Alarcon, C. et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGFβ pathways. Cell139, 757–769 (2009). ArticleCAS Google Scholar
Attisano, L. & Wrana, J. L. Signal integration in TGFβ, WNT, and Hippo pathways. F1000Prime Rep.5, 17 (2013). Article Google Scholar
Kumar, M. S., Lu, J., Mercer, K. L., Golub, T. R. & Jacks, T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nature Genet.39, 673–677 (2007). ArticleCAS Google Scholar
Mori, M. et al. Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell156, 893–906 (2014). ArticleCAS Google Scholar
Zhao, B. et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev.21, 2747–2761 (2007). ArticleCAS Google Scholar
Chaulk, S. G., Lattanzi, V. J., Hiemer, S. E., Fahlman, R. P. & Varelas, X. The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7. J. Biol. Chem.289, 1886–1891 (2014). ArticleCAS Google Scholar
Hong, J. H. et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science309, 1074–1078 (2005). ArticleCAS Google Scholar
Cordenonsi, M. et al. The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell147, 759–772 (2011). ArticleCAS Google Scholar
Skibinski, A. et al. The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell Rep.6, 1059–1072 (2014). ArticleCAS Google Scholar
Yimlamai, D. et al. Hippo pathway activity influences liver cell fate. Cell157, 1324–1338 (2014). ArticleCAS Google Scholar
Chan, S. W. et al. A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res.68, 2592–2598 (2008). ArticleCAS Google Scholar
Reginensi, A. et al. YAP- and CDC42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet.9, e1003380 (2013). ArticleCAS Google Scholar
Zhang, N. et al. The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev. Cell19, 27–38 (2010). ArticleCAS Google Scholar
Liu-Chittenden, Y. et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev.26, 1300–1305 (2012). ArticleCAS Google Scholar
Zhang, W. et al. Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma. Sci. Signal.7, ra42 (2014). Article Google Scholar
Kapoor, A. et al. YAP1 activation enables bypass of oncogenic kras addiction in pancreatic cancer. Cell158, 185–197 (2014). ArticleCAS Google Scholar
Shao, D. D. et al. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell158, 171–184 (2014). ArticleCAS Google Scholar
Shackelford, D. B. & Shaw, R. J. The LKB1–AMPK pathway: metabolism and growth control in tumour suppression. Nature Rev. Cancer9, 563–575 (2009). ArticleCAS Google Scholar
Mohseni, M. et al. A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway. Nature Cell Biol.16, 108–117 (2014). ArticleCAS Google Scholar
Tumaneng, K. et al. YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29. Nature Cell Biol.14, 1322–1329 (2012). ArticleCAS Google Scholar
Feng, X. et al. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell25, 831–845 (2014). ArticleCAS Google Scholar
Yu, F. X. et al. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell25, 822–830 (2014). ArticleCAS Google Scholar
Wang, L. et al. Overexpression of YAP and TAZ is an independent predictor of prognosis in colorectal cancer and related to the proliferation and metastasis of colon cancer cells. PLoS ONE8, e65539 (2013). ArticleCAS Google Scholar
Liu, G. et al. Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Oncogenehttp://dx.doi.org/10.1038/onc.2014.281 (2014).
Nguyen, H. T. et al. Viral small T oncoproteins transform cells by alleviating Hippo-pathway-mediated inhibition of the YAP proto-oncogene. Cell Rep.8, 707–713 (2014). ArticleCAS Google Scholar
Imajo, M., Miyatake, K., Iimura, A., Miyamoto, A. & Nishida, E. A molecular mechanism that links Hippo signalling to the inhibition of WNT/β-catenin signalling. EMBO J.31, 1109–1122 (2012). ArticleCAS Google Scholar
Levy, D., Adamovich, Y., Reuven, N. & Shaul, Y. YAP1 phosphorylation by c-ABL is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol. Cell29, 350–361 (2008). ArticleCAS Google Scholar
Cottini, F. et al. Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers. Nature Med.20, 599–606 (2014). ArticleCAS Google Scholar
Yoo, H. Y. et al. A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma. Nature Genet.46, 371–375 (2014). ArticleCAS Google Scholar
Koontz, L. M. et al. The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression. Dev. Cell25, 388–401 (2013). ArticleCAS Google Scholar
Jiao, S. et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell25, 166–180 (2014). ArticleCAS Google Scholar
Sorrentino, G. et al. Metabolic control of YAP and TAZ by the mevalonate pathway. Nature Cell Biol.16, 357–366 (2014). ArticleCAS Google Scholar
Wang, Z. et al. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc. Natl Acad. Sci. USA111, E89–E98 (2014). ArticleCAS Google Scholar
Gronich, N. & Rennert, G. Beyond aspirin-cancer prevention with statins, metformin and bisphosphonates. Nature Rev. Clin. Oncol.10, 625–642 (2013). ArticleCAS Google Scholar
Kandoth, C. et al. Mutational landscape and significance across 12 major cancer types. Nature502, 333–339 (2013). ArticleCAS Google Scholar
Nguyen, H. B., Babcock, J. T., Wells, C. D. & Quilliam, L. A. LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of YAP. Oncogene32, 4100–4109 (2013). ArticleCAS Google Scholar
Moya, I. M. & Halder, G. Discovering the Hippo pathway protein–protein interactome. Cell Res.24, 137–138 (2014). ArticleCAS Google Scholar