Şeref Ezirganlı - Academia.edu (original) (raw)

Papers by Şeref Ezirganlı

Journal of biotechnology and strategic health research, Jun 8, 2023

Objectives. The aim of this study was to evaluate histological effects of a new combination folkl... more Objectives. The aim of this study was to evaluate histological effects of a new combination folkloric medicinal plant extract on bone healing in premaxillary suture expansion in rats. Materials and methods. Thirty male Sprague–Dawley rats were used in this study. Rats were evenly divided into three groups (one control and two experimental groups) of ten each. The animals were subjected to premaxillary suture expansion by helix springs. The only expansion group is defined as the control group (Group A). The experimental groups are defined as OstokinPlus-10 (Group B) and OstokinPlus-20 (Group C). In the experimental groups, 10 and 20 ml/kg OstokinPlus herbals were applied systemically after the expansion by use of an orogastric tube during the time of study. The springs were placed and activated to deliver a 30 cN force. After 5 days, the springs were removed and replaced with short lengths of rectangular retaining wire. Tooth separation was maintained for 15 days. After a consolidation period of 15 days, the animals were euthanatized and the maxillary bone containing the midpalatal suture cartilage was surgically removed. The specimens were prepared for histomorphometric assessment of the regenerated bone. Results. The midpalatal suture was successfully distracted following application of the activated helix spring. The distracted premaxillary suture was filled with new bone formation and unorganized fibrous tissues. Newly formed bone percentage and the bone area were found to have significant differences (p< 0.05). For investigated parameters, Group B and Group C revealed more positive results than Group A. Conclusion: OstokinPlus herbal had positive effects on bone healing and formation during premaxillary suture expansion

Gazi Üniversitesi Diş Hekimliği Fakültesi Dergisi, 2012

Journal of Craniofacial Surgery, 2017

Maxillary expansion of the median palatal suture is a common procedure in orthodontics. Even afte... more Maxillary expansion of the median palatal suture is a common procedure in orthodontics. Even after retention, there is a strong tendency to relapse in the expanded suture. The authors' objectives are to accelerate the bone formation process in the expanded suture and to reduce the required retention time by using an energy drink (ED). Twenty rats were divided into 2 groups (n ¼ 20). The expansion-only group was defined as the control group (Group C). The other group was defined as the expansionplus-energy drink group (Group ED). In Group ED, ED was administered systemically through oro-gastric tubes after the expansion period. After 5 days of expansion, the springs were removed and replaced with short lengths of rectangular retaining wire. Tooth separation was maintained for 12 days. Histomorphometric analysis showed significant differences between the 2 groups in terms of newly formed bone (P ¼ 0.018) and the bone area (P ¼ 0.007). For the parameters that were investigated, Group ED had better results than Group C. These results show that systemic administration of an ED during the early stages of the orthopedic expansion of the intermaxillary suture areas can stimulate bone formation and decrease the time required for retention.

Acta Odontologica Scandinavica, Nov 6, 2014

Objective. The aim of this study is to analyze histologically the effect of CAPE on bone healing ... more Objective. The aim of this study is to analyze histologically the effect of CAPE on bone healing of Critical Size Defect (CSD) in rat calvaria. Study design. Thirty-two 3-month-old male rats were used. The animals were randomly divided into four groups. Group A received isotonic saline solution, Group B received CAPE (50 mmol/kg) locally, Group C received CAPE (100 mmol/kg) locally and Group D received CAPE (10 mmol/kg/day i.p. for 28 days) systematically. A 5-mm diameter calvarial defect was created in the right side of the parietal bone without damaging the underlying dura mater. Twenty-eight days after the surgery, all the animals were sacrificed. The original defect area was removed from the animal's calvarium bone en bloc. Beginning at the center of the surgical defect, serial sections of 6 mm thick were cut longitudinally. The sections were stained with hematoxylin and eosin for analysis under a light microscope. The sections were analyzed for the presence of inflammatory infiltrate, connective tissue formation and new bone formation. Computer-assisted histomorphometic measurements were carried out with an automated image analysis system. Results. The total new bone areas were significantly greater in group D than in all groups and group C was statistically insignificant from the other groups (p < 0.05). Group B had a greater, but not statistically significant (p > 0.05), amount of total regenerated bone area than the control group. Conclusion. The results indicate that 100 mmol/kg topical and 10 mmol/kg/day systemic application of CAPE increases bone healing, especially with systemic application.

Angle Orthodontist, May 19, 2015

Objective: To compare the extent of canine distalization and the transversal changes, postdistali... more Objective: To compare the extent of canine distalization and the transversal changes, postdistalization gingival indices, and mobility scores between patients who were undergoing orthodontic treatment involving upper premolar extraction with (experimental group) or without piezocision. Materials and Methods: Twenty maxillary canines of 10 patients were evaluated with split mouth design. Pre-and postdistalization dental casts were prepared and scanned with an orthodontic scanner to compare the extent of distalization and transversal changes between the two groups. The pre-and postdistalization gingival indices and mobility scores were also calculated. Results: Three-dimensional analysis of the models revealed significant differences in tooth movement (lesser anchorage loss and greater canine distalization) between the experimental and control groups. Furthermore, the distalization time was shortened in the experimental group. There were no differences in the transversal changes, pre-and postdistalization gingival indices, or mobility scores between groups. Conclusion: Piezocision-assisted distalization accelerates tooth movement, decreases the anchorage loss for posterior teeth, and does not induce any maxillary transversal change. Moreover, piezocision does not have any adverse effects on periodontal health.

Turkiye Klinikleri Journal of Dental Sciences-Special Topics, 2012

Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie, 2015

Nearly 5% of the the world's population has temporomandibular disorder (TMD) severe enough to mak... more Nearly 5% of the the world's population has temporomandibular disorder (TMD) severe enough to make them seek treatment. A third of the total population has at least one TMD symptom. There are different types of splints to treat TMD. In our study, we compared the success of two different appliances [stabilization splint (ss), nociceptive trigeminal inhibition splint (NTI)] by using Fonseca's questionnaire, the OHQoL-UK and visual analog scale (VAS). A total of 40 patients suffering from TMD were included in this study and answered questionnaires twice, at the beginning of the treatment and 3 months later. Regarding TMD alone, 39 patients (97.5%) had some degree of the disorder, 7 of of these cases being mild (17.5%), 15 moderate (37.5%), and 17 severe (42.5%). We analyzed posttreatment changes compared to baseline. Pain complaints decreased in both groups, and the OHQoL-UK revealed better quality of life after treatment. Based on the posttreatment Fonseca's questionnaires, significant changes in the patients' complaints in the group SS (p<0.01) were observed. The group NTI also displayed changes but these were not statistically significant after treatment (p>0.05). Patients in both groups had fewer TMD complaints after TMJ treatment. According to the Fonseca's questionnaire, the patients' major TMD complaint was clenching-grinding, followed by pain in the craniomandibular joint, or earache.

International journal of oral and maxillofacial surgery, 2009

The aim of this study was to evaluate the prevalence of second molar distal caries in a Turkish p... more The aim of this study was to evaluate the prevalence of second molar distal caries in a Turkish population and to determine the factors that affect it. Clinical records and panoramic radiographs of partially erupted mandibular third molars were reviewed in this retrospective study. The analysis outcome measures were the patients' age, second molar distal caries, third molar angulation and second and third molar contact point localization. Prevalence of second molar distal caries in the population was 20%. This prevalence was 47% when the third molar had an angulation of 31-70 degrees (majority of mesioangular third molars) and 43% at 70-90 degrees (all horizontal third molars). The contact point on the second molar amelocemental junction and increasing age had significant effects on caries formation. The results revealed that second molar distal caries justifies prophylactic third molar removal and partially erupted third molars that have an angulation of 30-90 degrees with a co...

Meandros Medical and Dental Journal, Apr 1, 2020

Original Article / Özgün Araştırma Meandros Med Dent J 2019 Öz Amaç: Median suturun maksiller gen... more Original Article / Özgün Araştırma Meandros Med Dent J 2019 Öz Amaç: Median suturun maksiller genişletilmesi ortodonti sıklıkla yapılan bir uygulamadır. Retansiyon sonrasında bile genişlemiş suturda geriye gidiş görülebilmektedir. Amacımız bu suturdaki genişlemedeki kemikleşmeyi hızlandırmak ve kemikleşmeye etkisi olan üzüm çekirdeği ekstresi kullanarak retansiyon süresini kısaltmaktır. Gereç ve Yöntemler: Yirmi adet rat iki gruba ayrıldı. Kontrol Grubuna sadece ekspansiyon yapıldı. Deney grubuna ise ekspansiyona ilaveten üzüm çekirdeği ekstresi verildi. Deney grubuna ekspansiyon sonrası orogastrik yöntemle sistemik olarak ekstreler verildi. Maksillaya springler uygulanıp aktiflendi. 5 gün sonra springler çıkartıldı ve köşeli tellerle retansiyon yapıldı.12 gün pekiştirme yapıldı. Objective: Expansion of the median palatal suture is a common procedure in orthodontics. Even after retention, there is a strong tendency to relapse in the expanded suture. Our objectives were to accelerate the bone formation processes in the expanded suture and to reduce the required retention time by using grape seed extract (GS), which can potentially stimulate bone formation. Materials and Methods: Twenty rats were divided into two groups (n=20). The expansion only group was defined as the control group (Group C). The other group was defined as the expansion plus grape seed extract group (Group GS). In Group GS, GS was administered systemically via orogastric tubes after the expansion period. The springs were placed and activated to deliver a force. After 5 days, the springs were removed and replaced with short lengths of rectangular retaining wire. Tooth separation was maintained for 12 days. Results: We observed significant differences in the percentage of newly formed bone (p<0.05) and bone area (p<0.05) between the two groups. For the parameters investigated, Group GS had better bone formation than Group C. Conclusion: Systemic administration of GS during the early stages of the orthopedic expansion of the inter-premaxillary suture areas can stimulate bone formation and decrease the time needed for retention.

DergiPark (Istanbul University), Feb 1, 2010

Liken planus; deri, müköz membranlar, kıl folikülleri ve tırnakları etkileyen subakut veya kronik... more Liken planus; deri, müköz membranlar, kıl folikülleri ve tırnakları etkileyen subakut veya kronik inflamatuar mukokutanöz bir hastalıktır. Hastaların yaklaşık %50'sinde hem ağız hem de deri lezyonları beraber bulunur. 1-3 Hastalık ilk defa klinik olarak 1869'da Wilson tarafından açıklanmış ve histolopatolojik görüntüsü 1906 yılında Dubreuilh tarafından tarif edilmiştir. 3 Oral liken planus (OLP), oral mukozanın kronik inflamatuar bir hastalığıdır. Daha çok kadınlarda görülmektedir. Çocuklarda nadir görülmekle birlikte genellikle 30-60 yaş aralığında fazla ABSTRACT Aim: In this study, it is aimed to investigate oral lichen planus according to demographic data in 41 histopathologically diagnosed patients who referred to our clinic between the years 1999 and 2009. Material and Method: Our study has been performed based on histopathologic datum of cases in protocol record. Patients have been analyzed according to age, sex, and localization. Results: It has been found that average age in lesion cases was 45 (with a range from 22-71) and male/female ratio was 1.41/1. The lesions have been most frequently encountered on buccal mucosa (60.5%). This location was followed by labial mucosa (21%), tongue (11.5%), and gingival zone (7%). Conclusion: It was showed in this study differs from the other studies that cases of oral lichen planus were seen in male more than in female in our location.

Ado klinik bilimler dergisi, Apr 1, 2011

Bu rapor, Antalya'da düzenlenen "5th AÇBİD International Oral & Maxillofacial Surgery Society Con... more Bu rapor, Antalya'da düzenlenen "5th AÇBİD International Oral & Maxillofacial Surgery Society Congress" kongresinde 25-29 Mayıs, 2011 tarihleri arasında poster bildirisi olarak sunulmuştur.

Ado klinik bilimler dergisi, Apr 1, 2012

Objective: Until recently, most reports about transmigration have documented that the canine is t... more Objective: Until recently, most reports about transmigration have documented that the canine is the only tooth which can migrate to the opposite side of the arch. The goal of the study was to define the transmigration of dif-ferent types of teeth in people in various regions of Turkey. Study Design: A total of 112,873 panoramic radiographic files from seven different Turkish cities were inspected. The following data were evaluated according to age, gender, number of transmigrant teeth, localization, eruption status, side, unilaterally or bilaterally and associated pathology or dental abnormalities. Results: Of the 112,873 radiographs included in the study, 90 were seen to present as transmigrant in 87 patients, representing 0.079 % of the sample. There were only two (0.0017 %) transmigrant lateral (TML) teeth and only three (0.0026%) transmigrant premolar (TMP) teeth encountered. The mean age at the time that the transmigrant

Cumhuriyet Dental Journal, 2009

Primary tooth impaction has been reported to be very rare and studies report prevalence rates of ... more Primary tooth impaction has been reported to be very rare and studies report prevalence rates of impaction to be form 1:10.000. Primary tooth impactions can occur because of various reasons, including ankylosis, congenitally missing permanent teeth, defects in periodontal membrane, trauma, injury of the periodontal ligament, precocious eruption of the first permanent molar, defective eruptive force, or a combination of these factors. In this article we present a case of impacted mandibular second deciduous molar tooth with pericoronitis and discuss the etiology and its management by surgical intervention in an 8 year old girl. OZET Gomulu sut dislerine ait cok az sayida rapor vardir ve bu calismalarda sut dislerinin gomulu kalma insidansi 10.000’de 1 olarak belirtilmistir. Cesitli nedenler sut dislerinin gomulu kalmasina neden olabilmektedir. Bunlar; ankiloz, konjenital olarak daimi dis eksikligi, periodontal membranda defekt, travma, periodontal ligamentte yaralanma, erken suren da...

Amac: Bu calismada, arti dislerin ozelliklerini ve prevalansini arastirip, olasi patolojiler ile ... more Amac: Bu calismada, arti dislerin ozelliklerini ve prevalansini arastirip, olasi patolojiler ile iliskilerini degerlendirmek ve uygulanacak tedavi protokollerine rehberlik yapmak amaclandi. Gerec ve Yontem: Bu retrospektif calismada, 2000–2010 yillari arasinda klinigimize basvuran hastalara ait 8955 adet panoramik rontgen ve hastalarin kayitlari kullanildi. Arti dislerin sayisi, lokalizasyonu, pozisyonu, tipi ve bicimi belirlendi. Patolojiler ya da komplikasyonlarla iliskileri ve herhangi bir tedavi uygulanip uygulanmadigi degerlendirildi. Bulgular: Yas ortalamalari 22,04±8,86 ve 5–67 yas araliginda olan 78 hastada 117 adet arti dis varligi tespit edildi. Arti dislerin en fazla erkeklerde goruldugu ve arti disi olan erkeklerin, arti disi olan kadinlara orani 1,29:1 olarak bulundu. En fazla 29 olgu ile distomolar (%35,80), 24 olgu ile meziyodens (%29,63), 20 olgu ile premolar (%24,69), 4 olgu ile paramolar (%4,94), 3 olgu ile lateral (%3,70) ve 1 olgu ile kanin (%1,24) arti disleri b...

Stafne'nin kemik kavitesi (SKK), ilk kez 1942'de Stafne tarafından rapor edilmiş olup, çoğunlukla... more Stafne'nin kemik kavitesi (SKK), ilk kez 1942'de Stafne tarafından rapor edilmiş olup, çoğunlukla hayatın 5-7. dekatları arasında erkeklerde görülmektedir. SKK genelde semptomsuz olup radyolüsent bir görünüme sahiptir ve rutin radyografik incelemeler sırasında tesadüfen bulunur. Bu kavite, alt çenede birinci büyük azı dişi ile angulus mandibula arasında, mandibular kanalın altında lokalizedir. İyi sınırlı yuvarlak ya da oval radyolüsensdir. SKK'nın görünümü genelde patognomoniktir ve SKK tedavi gerektirmez. Bu makalenin amacı, bilgisayarlı tomografi ile teşhis edilen SKK'ya sahip iki olguyu takdim etmektir.

Experimental and Therapeutic Medicine, 2017

Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma ... more Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma or infection represent a significant and common clinical problem. The present study aimed to evaluate the effects of a commercially-available medicinal plant extract product, Ankaferd BloodStopper (ABS), on bone healing. The present study was performed on 24 female ovariectomized (OVX) rats. A defect on each rat calvarium was created using a trephine burr prior to the rats being divided into two groups. Defects were grafted with a gelatin sponge soaked with normal saline (control group) or plant extract (experimental group). Half of the animals were sacrificed after 2 weeks and the others after 4 weeks. In the control group, the defects were not filled with regenerated bone. By contrast, in the experimental group, all defect areas had an increased amount of regenerated bone and connective tissue. Osteoblastic activity appeared to be greater in the experimental group however, osteoclastic activity was observed to be higher in the control group. At 2 and 4 weeks, there was a significant difference in the amount of newly regenerated bone observed in the experimental group compared with the control group (P<0.05). Therefore, the results of the present study indicated that local ABS application had a positive effect on bone healing in the OVX rat model.

The Journal of craniofacial surgery, Jan 10, 2016

The purpose of this study was to histologically evaluate the effects on bone healing of nigella s... more The purpose of this study was to histologically evaluate the effects on bone healing of nigella sativa seed extract applied on calvarial defects in an ovariectomized rat model. The study included 32 female rats weighing 280 to 310 g with an average age of 3 months. A defect was created with a trephine burr on each rat calvarium. The rats were divided into 2 groups (control and study) of 8 animals each. All the defects were grafted with a gelatin sponge mixed with normal saline. In the study group, nigella sativa seed extract was applied systemically using an oro-gastric tube. Half of the animals in each group were sacrificed after 2 weeks, and the others after 4 weeks. In the control groups, the defects were not completely filled with regenerated bone. Osteoblast cells were observed more in the study groups. A higher rate of osteoclasts was determined in the control groups. In addition, the nigella sativa group had a statistically greater amount of bone formation than the others gro...

Cumhuriyet Dental Journal, 2010

Bu çalışmanın amacı, konjenital olarak kayıp olan ikinci küçük azıların cinsiyet ve lokalizasyona... more Bu çalışmanın amacı, konjenital olarak kayıp olan ikinci küçük azıların cinsiyet ve lokalizasyona göre dağılımı ve prevalansını değerlendirmektir.

Drug Design, Development and Therapy, 2015

Background: Narrow maxilla is a common problem in orthodontics and dentofacial orthopedics. To so... more Background: Narrow maxilla is a common problem in orthodontics and dentofacial orthopedics. To solve this problem, a procedure called rapid maxillary expansion (RME) has been used. However, relapse tendency is a major problem of RME. Although relapse tendency is not clearly understood, various treatment procedures and new applications have been investigated. The present study aimed to investigate the possible effectiveness of caffeic acid phenethyl ester (CAPE) on new bone formation in rat midpalatal suture after RME. Materials and methods: Twenty male Sprague Dawley rats were used in this study. The animals were randomly divided into two groups as control and CAPE group. In the CAPE group, CAPE was administered systemically via intraperitoneal injection. RME procedure was performed on all animals. For this purpose, the springs were placed on the maxillary incisors of rats and activated for 5 days. After then, the springs were removed and replaced with short lengths of rectangular retaining wire for consolidation period of 15 days. At the end of the study, histomorphometric analysis was carried out to assess new bone formation. Results: New bone formation was significantly greater in the CAPE group than the control group (P,0.05). CAPE enhances new bone formation in midpalatal suture after RME. Conclusion: These results show that CAPE may decrease the time needed for retention.