Brigitte Brisson - Academia.edu (original) (raw)

Papers by Brigitte Brisson

StEG-Tandem ist eine Teilstudie der vom Bundesministerium für Bildung und Forschung (BMBF) geförd... more StEG-Tandem ist eine Teilstudie der vom Bundesministerium für Bildung und Forschung (BMBF) geförderten Studie zur Entwicklung von Ganztagsschulen (StEG). Die Teilstudie wird gemeinsam von Mitarbeiterinnen und Mitarbeitern des Deutschen Institut für Internationale Pädagogische Forschung (DIPF) und der Universität Kassel durchgeführt. StEG-Tandem zielt darauf ab, die Hausaufgabenbetreuung bzw. die Lernzeiten an fünf integrierten Gesamtschulen durch die Einführung von kooperativen Lernformen weiterzuentwickeln. Um die individuellen Kompetenzen der Schülerinnen und Schüler zu stärken sollen sie in der Hausaufgabenbetreuung oder in den Lernzeiten gezielt dazu angeregt werden mit gleichaltrigen Schülerinnen und Schülern in Tandems oder Kleingruppen zusammenzuarbeiten. Zudem sollen ältere Schülerinnen und Schüler zu Mentorinnen und Mentoren ausgebildet werden, die jüngere Schülerinnen und Schüler regelmäßig bei der Bearbeitung ihrer Aufgaben unterstützen (Peer Mentoring). Im Rahmen von StE...

International Journal of Molecular Sciences, 2022

Osteosarcoma (OS) is a highly malignant bone tumour that has seen little improvement in treatment... more Osteosarcoma (OS) is a highly malignant bone tumour that has seen little improvement in treatment modalities in the past 30 years. Understanding what molecules contribute to OS biology could aid in the discovery of novel therapies. Extracellular vesicles (EVs) serve as a mode of cell-to-cell communication and have the potential to uncover novel protein signatures. In our research, we developed a novel pipeline to isolate, characterize, and profile EVs from normal bone and osteosarcoma tissue explants from canine OS patients. Proteomic analysis of vesicle preparations revealed a protein signature related to protein metabolism. One molecule of interest, PSMD14/Rpn11, was explored further given its prognostic potential in human and canine OS, and its targetability with the drug capzimin. In vitro experiments demonstrated that capzimin induces apoptosis and reduces clonogenic survival, proliferation, and migration in two metastatic canine OS cell lines. Capzimin also reduces the viabili...

The Canadian veterinary journal = La revue veterinaire canadienne, 2019

A boxer dog was evaluated because of lethargy, vomiting, and abdominal pain. Ultrasonography reve... more A boxer dog was evaluated because of lethargy, vomiting, and abdominal pain. Ultrasonography revealed multiple cystic structures in the abdomen. Exploratory laparotomy revealed 3 well-encapsulated hepatic masses and abdominal effusion with suppurative inflammation. Collectively, these findings suggested the hepatic masses were most likely abscesses. However, histologic examination of the hepatic masses revealed multi-cystic structures, consistent with alveolar echinococcosis. The diagnosis was confirmed by DNA sequencing. The dog was treated with daily albendazole, but within a few weeks exhibited adverse side effects. After 6 months, the dog's condition deteriorated, and it was euthanized.

Journal of the American Veterinary Medical Association, 2021

OBJECTIVE To describe surgical management and associated outcomes for dogs with primary spontaneo... more OBJECTIVE To describe surgical management and associated outcomes for dogs with primary spontaneous pneumothorax. ANIMALS 110 client-owned dogs with primary spontaneous pneumothorax that underwent surgical management. PROCEDURES Medical records at 7 veterinary teaching hospitals were reviewed. Data collected included signalment, history, clinical signs, radiographic and CT findings, surgical methods, intraoperative and postoperative complications, outcomes, and histopathologic findings. Follow-up information was obtained by contacting the referring veterinarian or owner. RESULTS 110 dogs were included, with a median follow-up time of 508 days (range, 3 to 2,377 days). Ninety-nine (90%) dogs underwent median sternotomy, 9 (8%) underwent intercostal thoracotomy, and 2 (2%) underwent thoracoscopy as the sole intervention. Bullous lesions were most commonly found in the left cranial lung lobe (51/156 [33%] lesions) and right cranial lung lobe (37/156 [24%] lesions). Of the 100 dogs followed up for > 30 days, 13 (13%) had a recurrence of pneumothorax, with median time between surgery and recurrence of 9 days. Recurrence was significantly more likely to occur ≤ 30 days after surgery, compared with > 30 days after surgery. Recurrence > 30 days after surgery was rare (3 [3%]). No risk factors for recurrence were identified. CONCLUSIONS AND CLINICAL RELEVANCE Lung lobectomy via median sternotomy resulted in resolution of pneumothorax in most dogs with primary spontaneous pneumothorax. Recurrence of pneumothorax was most common in the immediate postoperative period, which may have reflected failure to identify lesions during the initial thoracic exploration, rather than development of additional bullae.

Veterinary Surgery, 2020

OBJECTIVE To compare long-term clinical outcomes of dogs with single congenital extrahepatic port... more OBJECTIVE To compare long-term clinical outcomes of dogs with single congenital extrahepatic portosystemic shunts (CEHPSS) treated with thin film banding (TFB) consisting of polyolefin fiber or ameroid ring constrictor (ARC) placement in dogs. DESIGN Retrospective, two-center clinical study. ANIMALS Client-owned dogs (n = 123) with single CEHPSS undergoing gradual attenuation via TFB (n = 85) or ARC (n = 38). METHODS Medical records of dogs with CEHPSS were reviewed. Follow-up data were collected from the referring veterinarian and/or owner via standardized questionnaire. Data were analyzed to compare short-term mortality rate and long-term outcome (>6 months). RESULTS Dogs in the TFB group were older than dogs in the ARC group (median age, 19 vs 12 months, respectively; P = .01). There was no difference in survival to discharge between dogs in the TFB (81/85 [95.3%]) and ARC (37/38 [97.4%]; P > .99) groups. Preoperative levetiracetam was more frequently administered to dogs treated with TFB (64/85 [75.3%]) than to dogs treated with ARC (15/38 [39.5%;] P = .0002). Postoperative seizures were reported in 10 (8.1%) dogs; their prevalence did not differ between dogs treated with TFB (9/85 [10.6%]) and dogs treated with ARC (1/38 [2.6%]; P = .17). Median follow-up time for dogs treated with TFB (58.0 months, range 8-130) and ARC (63.3 months, range 7-138; P = .24) did not differ. CONCLUSION Gradual attenuation of a single CEHPSS with either TFB or ARC resulted in similar long-term clinical outcomes and low postoperative morbidity and mortality rates. CLINICAL SIGNIFICANCE Thin film banding (polyolefin fiber) offers an alternative leading to clinical outcomes similar to ARC in dogs with single CEHPSS.

The Canadian veterinary journal. La revue vétérinaire canadienne, 2015

A 2-year-old Labrador retriever dog was referred for evaluation of parasternal chronic draining s... more A 2-year-old Labrador retriever dog was referred for evaluation of parasternal chronic draining sinus tracts associated with sternal osteomyelitis secondary to the presence of a residual wooden foreign body. The use of gentamicin-impregnated collagen sponges as adjunctive therapy to osteomyelitis treatment is reported herein.

Journal of Veterinary Internal Medicine, 2015

Background: Serum N-terminal pro-C-natriuretic peptide (NT-proCNP) has shown promise as a diagnos... more Background: Serum N-terminal pro-C-natriuretic peptide (NT-proCNP) has shown promise as a diagnostic biomarker for sepsis. Its sensitivity to detect dogs with septic peritonitis (SP) is reportedly low, perhaps attributable to the compartmentalization of NT-proCNP in the abdominal cavity. Objectives: To evaluate the use of an ELISA for the measurement of NT-proCNP in canine abdominal fluid and to describe the peri-operative pattern of abdominal fluid and serum NT-proCNP concentrations in dogs with SP. Animals: Five client-owned dogs with nonseptic abdominal effusion of varying etiologies and 12 client-owned dogs with SP undergoing abdominal surgery and placement of a closed-suction abdominal drain (CSAD). Six dogs were included upon hospital admission; 6 were included the day after surgery. Methods: Prospective pilot study. A commercially available ELISA kit was analytically validated for use on canine abdominal fluid. The NT-proCNP concentrations were measured in the abdominal fluid of control dogs, and in serum and abdominal fluid of dogs with SP from admission for CSAD removal. Results: In dogs with SP, admission abdominal fluid NT-proCNP concentrations were lower than the concurrent serum concentrations (P = 0.031), and lower than control canine abdominal fluid concentrations (P = 0.015). Postoperatively, abdominal fluid NT-proCNP concentrations remained lower than serum concentrations (P < 0.050), except on day 4. Conclusions and Clinical Importance: The ELISA kit was able to measure NT-proCNP in canine abdominal fluid. In dogs with SP, low serum NT-proCNP concentrations cannot be explained by abdominal compartmentalization.

Fingeroth/Advances in Intervertebral Disc Disease in Dogs and Cats, 2014

Journal of the American Veterinary Medical Association, Jan 15, 2014

To compare the efficacy of canine vaginal impedometry in identifying the preovulatory luteinizing... more To compare the efficacy of canine vaginal impedometry in identifying the preovulatory luteinizing hormone (LH) peak to that of currently used methods (serum progesterone concentration measurement, vaginal cytologic evaluation, and vaginoscopy). Prospective study. 12 sexually intact female dogs. 12 mature postpubertal Beagle (n = 3), Beagle-cross (2), and hound-cross (7) bitches ranging from 7.5 to 27.5 kg (16.5 to 60.6 lb) were enrolled in the study. After the onset of spontaneous proestrus, determined on the basis of appearance of serosanguineous vaginal discharge, serum progesterone assays, vaginoscopy, vaginal cytologic evaluation, and vaginal impedometry were performed daily until approximately 4 days after peak LH concentration (day 0) as measured by radioimmunoassay. Vaginal impedometry was compared against serum progesterone concentration measurement, vaginal cytologic evaluation, and vaginoscopy as a method for accurately identifying the LH peak and therefore the optimal bre...

The Canadian veterinary journal. La revue vétérinaire canadienne, 2012

This pilot study describes the effect of intraoperative peritoneal lavage (IOPL) on bacterial cou... more This pilot study describes the effect of intraoperative peritoneal lavage (IOPL) on bacterial counts and outcome in clinical cases of septic peritonitis. Intraoperative samples were cultured before and after IOPL. Thirty-three dogs with presumed septic peritonitis on the basis of cytology were managed surgically during the study period. Positive pre-lavage bacterial cultures were found in 14 cases, 13 of which were a result of intestinal leakage. The post-lavage cultures showed fewer isolates in 9 cases and in 1 case became negative. The number of dogs with a decrease in the concentration of bacteria cultured from pre-lavage to post-lavage samples was not statistically significant. There was no significant effect of the change in pre- to post-lavage culture, single versus multiple types of bacteria, selection of an appropriate empiric antimicrobial on survival or the need for subsequent surgery.

The Canadian veterinary journal. La revue vétérinaire canadienne, 2005

This report describes a case of septic peritonitis and gall bladder rupture in German shepherd do... more This report describes a case of septic peritonitis and gall bladder rupture in German shepherd dog that developed 7 d after surgical treatment for gastric dilation-volvulus. Histological examination confirmed gall bladder necrosis, secondary to an acute ischemic event. Postoperative acute necrotizing cholecystitis has not been a previously reported complication in dogs.

The Canadian veterinary journal. La revue vétérinaire canadienne, 2006

This study compared patient discomfort for 10 d following feline onychectomies performed using a ... more This study compared patient discomfort for 10 d following feline onychectomies performed using a CO2 surgical laser versus a scalpel blade. Both techniques appeared to result in discomfort of a similar duration, although the laser caused significantly less lameness than blade excision during the first 7 d.

The Canadian veterinary journal. La revue vétérinaire canadienne, 2004

A 4-year old, female spayed terrier was referred for hind end paresis that rapidly progressed to ... more A 4-year old, female spayed terrier was referred for hind end paresis that rapidly progressed to paralysis. Spinal radiographs revealed vertebral collapse and bony lysis. Myelography confirmed spinal cord compression and surgical exploration found an extradural soft tissue mass. Metastatic anal sac adenocarcinoma was diagnosed at postmortem examination.

The Canadian veterinary journal. La revue vétérinaire canadienne, 2005

The Canadian veterinary journal. La revue vétérinaire canadienne, 2004

The Canadian veterinary journal. La revue vétérinaire canadienne, 2010

This study reviewed confirmed cases of concurrent chylothorax and cranial vena caval (CrVC) throm... more This study reviewed confirmed cases of concurrent chylothorax and cranial vena caval (CrVC) thrombosis in dogs and cats, and determined predisposing factors for the development of chylothorax associated with CrVC thrombosis. The extent and location of the thrombus, the treatment regime, and the outcome are described. In all 4 cases, implantation of a jugular device was a predisposing factor to thrombosis of the CrVC, and there was extensive thrombosis of the CrVC extending from at least 1 jugular vein to just cranial to the heart. Chylothorax resolved in 3 of the 4 cases after medical and/or surgical intervention. The development of chylothorax concurrently with thrombosis of the CrVC in dogs and cats is likely dependent on the extent and location of the thrombus. Veterinary patients with indwelling jugular devices that develop acute respiratory signs should be assessed for chylothorax associated with thrombosis of the CrVC.

The Canadian veterinary journal. La revue vétérinaire canadienne, 2010

Compendium (Yardley, PA), 2012

Idiopathic chylothorax is a debilitating disease that can lead to respiratory and metabolic compr... more Idiopathic chylothorax is a debilitating disease that can lead to respiratory and metabolic compromise and fibrosing pleuritis. Previous investigation has provided theories for the etiology of this poorly understood disease. This article provides an overview of the pathophysiology and diagnosis of chylothorax. Thoracic duct imaging, including minimally invasive techniques, is also discussed, as it is frequently performed in the perioperative period. A companion article reviews nonsurgical and surgical techniques for treating and managing idiopathic chylothorax in dogs and cats.

Compendium (Yardley, PA), 2012

Idiopathic chylothorax is a debilitating disease that can lead to respiratory and metabolic compr... more Idiopathic chylothorax is a debilitating disease that can lead to respiratory and metabolic compromise and fibrosing pleuritis. Several treatment options are available once a diagnosis has been made. Although large-scale studies on the outcome of treatment for idiopathic chylothorax are lacking, long-term resolution of clinical signs is possible. Pathophysiology, diagnosis, and thoracic duct imaging are discussed in a companion article. This article provides an overview of nonsurgical and surgical management techniques for idiopathic chylothorax in dogs and cats.