Douglas Kerr MD - Academia.edu (original) (raw)

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Papers by Douglas Kerr MD

Research paper thumbnail of Venous hypertensive myelopathy as a potential mimic of transverse myelitis

Research paper thumbnail of Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies

Research paper thumbnail of Transverse myelitis after lumbar steroid injection in a patient with Behcet's disease

Spinal Cord, Jun 28, 2005

Research paper thumbnail of Diagnosis pathway for patients with amyotrophic lateral sclerosis: retrospective analysis of the US Medicare longitudinal claims database

BMC Neurology, Nov 4, 2013

Research paper thumbnail of Fibrocartilaginous embolism: a cause of acute ischemic myelopathy

Spinal Cord, Nov 11, 2008

Research paper thumbnail of Histogram based quantification of spinal cord injury level using somatosensory evoked potentials

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2010

This paper uses an entropy based metric to study the somatosensory evoked potential (SEP) in rode... more This paper uses an entropy based metric to study the somatosensory evoked potential (SEP) in rodents afflicted with focal demyelination spinal cord injury (SCI). It has been shown that amplitude characteristics of the SEP signal are a strong indicator of the integrity of the spinal cord sensory pathways. Compared to conventional correlation based metrics, the metric used in this paper exploits the amplitude histogram of SEP signals to provide a robust assessment of the different degrees of demyelination in the spinal cord. Results are presented using actual SEP signals collected on rodents with various levels of SCI.

Research paper thumbnail of Spinal cord injury evaluation using morphological difference of somatosensory evoked potentials

2011 5th International Conference on Bioinformatics and Biomedical Engineering, 2011

Research paper thumbnail of Using Variations of Somatosensory Evoked Potentials to Quantify Spinal Cord Injury Level

Research paper thumbnail of Fibrocartilaginous embolism: a cause of acute ischemic myelopathy

Research paper thumbnail of Transverse myelitis after lumbar steroid injection in a patient with Behcet's disease

Research paper thumbnail of Finding NMO: Neuromyelitis optica in children

Research paper thumbnail of Associations between retinal nerve fiber layer abnormalities and optic nerve examination

Research paper thumbnail of Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies

Research paper thumbnail of Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial

The Lancet Neurology, 2013

Research paper thumbnail of Slope analysis of somatosensory evoked potentials in spinal cord injury for detecting contusion injury and focal demyelination

Journal of Clinical Neuroscience, 2010

Research paper thumbnail of Idiopathic Transverse Myelitis

Archives of Neurology, 2005

Research paper thumbnail of Reduction of Disease Activity and Disability With High-Dose Cyclophosphamide in Patients With Aggressive Multiple Sclerosis

Archives of Neurology, 2008

Research paper thumbnail of Priapism in Infantile Transverse Myelitis

Archives of Neurology, 2009

Research paper thumbnail of Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis

Annals of Neurology, 2006

ObjectiveThe diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a spe... more ObjectiveThe diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a specific diagnostic test. Recent advances in proteomics, however, offer new opportunities for biomarker discovery and the study of disease pathogenesis.MethodsWe analyzed cerebrospinal fluid (CSF) samples from 29 patients with MS or clinically isolated syndromes (CIS), 27 patients with transverse myelitis (TM), 50 patients with human immunodeficiency virus (HIV) infection, and 27 patients with other neurological diseases (ONDs) by surface‐enhanced laser desorption/ionization time‐of‐flight mass spectroscopy.ResultsWe found a unique protein of 12.5kDa that was 100% specific for MS/CIS compared with TM or OND. Low levels of this protein were found in some patients with HIV infection. Tandem mass spectroscopy of a tryptic digest of this 12.5kDa protein identified it as a cleavage product of full‐length cystatin C (13.4kDa), an important inhibitor of cysteine proteases including the cathepsins....

Research paper thumbnail of Derivation of Glial Restricted Precursors from E13 mice

Journal of Visualized Experiments, Jun 20, 2012

Research paper thumbnail of Venous hypertensive myelopathy as a potential mimic of transverse myelitis

Research paper thumbnail of Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies

Research paper thumbnail of Transverse myelitis after lumbar steroid injection in a patient with Behcet's disease

Spinal Cord, Jun 28, 2005

Research paper thumbnail of Diagnosis pathway for patients with amyotrophic lateral sclerosis: retrospective analysis of the US Medicare longitudinal claims database

BMC Neurology, Nov 4, 2013

Research paper thumbnail of Fibrocartilaginous embolism: a cause of acute ischemic myelopathy

Spinal Cord, Nov 11, 2008

Research paper thumbnail of Histogram based quantification of spinal cord injury level using somatosensory evoked potentials

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2010

This paper uses an entropy based metric to study the somatosensory evoked potential (SEP) in rode... more This paper uses an entropy based metric to study the somatosensory evoked potential (SEP) in rodents afflicted with focal demyelination spinal cord injury (SCI). It has been shown that amplitude characteristics of the SEP signal are a strong indicator of the integrity of the spinal cord sensory pathways. Compared to conventional correlation based metrics, the metric used in this paper exploits the amplitude histogram of SEP signals to provide a robust assessment of the different degrees of demyelination in the spinal cord. Results are presented using actual SEP signals collected on rodents with various levels of SCI.

Research paper thumbnail of Spinal cord injury evaluation using morphological difference of somatosensory evoked potentials

2011 5th International Conference on Bioinformatics and Biomedical Engineering, 2011

Research paper thumbnail of Using Variations of Somatosensory Evoked Potentials to Quantify Spinal Cord Injury Level

Research paper thumbnail of Fibrocartilaginous embolism: a cause of acute ischemic myelopathy

Research paper thumbnail of Transverse myelitis after lumbar steroid injection in a patient with Behcet's disease

Research paper thumbnail of Finding NMO: Neuromyelitis optica in children

Research paper thumbnail of Associations between retinal nerve fiber layer abnormalities and optic nerve examination

Research paper thumbnail of Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies

Research paper thumbnail of Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial

The Lancet Neurology, 2013

Research paper thumbnail of Slope analysis of somatosensory evoked potentials in spinal cord injury for detecting contusion injury and focal demyelination

Journal of Clinical Neuroscience, 2010

Research paper thumbnail of Idiopathic Transverse Myelitis

Archives of Neurology, 2005

Research paper thumbnail of Reduction of Disease Activity and Disability With High-Dose Cyclophosphamide in Patients With Aggressive Multiple Sclerosis

Archives of Neurology, 2008

Research paper thumbnail of Priapism in Infantile Transverse Myelitis

Archives of Neurology, 2009

Research paper thumbnail of Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis

Annals of Neurology, 2006

ObjectiveThe diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a spe... more ObjectiveThe diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a specific diagnostic test. Recent advances in proteomics, however, offer new opportunities for biomarker discovery and the study of disease pathogenesis.MethodsWe analyzed cerebrospinal fluid (CSF) samples from 29 patients with MS or clinically isolated syndromes (CIS), 27 patients with transverse myelitis (TM), 50 patients with human immunodeficiency virus (HIV) infection, and 27 patients with other neurological diseases (ONDs) by surface‐enhanced laser desorption/ionization time‐of‐flight mass spectroscopy.ResultsWe found a unique protein of 12.5kDa that was 100% specific for MS/CIS compared with TM or OND. Low levels of this protein were found in some patients with HIV infection. Tandem mass spectroscopy of a tryptic digest of this 12.5kDa protein identified it as a cleavage product of full‐length cystatin C (13.4kDa), an important inhibitor of cysteine proteases including the cathepsins....

Research paper thumbnail of Derivation of Glial Restricted Precursors from E13 mice

Journal of Visualized Experiments, Jun 20, 2012

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