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Papers by fadime kılınç

Research paper thumbnail of Epidemiological characteristics of different types of adult acne in Turkey: a prospective, controlled, multicenter study

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Late-onset acne is the type of acne that begins in adulthood. Finally, recurrent acne is the form... more Late-onset acne is the type of acne that begins in adulthood. Finally, recurrent acne is the form that begins in adolescence and is characterized by a relapse in adulthood after an acne-free period without the use of any medication (1-3). Although evidence about some of these types is controversial, many triggering factors of adult acne have been documented so far. In this regard, internal factors such as high body mass index, hormonal imbalance, and genetic factors have been proposed to cause the occurrence or aggravation of acne. On the other hand, stress, smoking, using cosmetic products, and oral contraceptives

Research paper thumbnail of Complementary and alternative treatment methods practiced by parents in pediatric cases diagnosed with atopic dermatitis

Journal of Dermatological Treatment

Research paper thumbnail of Investigation of The Relationship Between Seborrheic Dermatitis and Metabolic Syndrome Parameters

Journal of Cosmetic Dermatology

Research paper thumbnail of Investigation of plasma thiol/disulfide balance in male patients with androgenetic alopecia

Journal of Cosmetic Dermatology, 2021

BackgroundAndrogenetic alopecia (AGA) is the most common cause of hair loss in men. In addition t... more BackgroundAndrogenetic alopecia (AGA) is the most common cause of hair loss in men. In addition to genetic and hormonal factors, oxidative stress (OS) is suggested as a factor in the etiology.AimIn this study, we aimed to investigate the presence of OS due to thiol disulfide balance deterioration in male patients with AGA.Materials and MethodsA total of 45 male AGA patients and 42 healthy male controls were included in the study. Native thiol, disulfide, and total thiol levels were assessed through automated spectrophotometry. The relationship between total protein, albumin, native thiol, disulfide, and total thiol levels in addition to demographic and clinical characteristics of the patients were examined.ResultsThe mean age of the patients was 32.6 ± 10 years, and the median AGA duration in the patients was 3 years. There was no statistically significant difference in terms of native thiol, disulfide, total thiol levels, disulfide/total thiol, disulfide/native thiol, and native th...

Research paper thumbnail of Can thiol‐disulfide balance be an indicator of oxidative stress for hyperhidrosis?

Journal of Cosmetic Dermatology, 2021

BackgroundHyperhidrosis is responsible for various causes. The increased reactive oxygen radical ... more BackgroundHyperhidrosis is responsible for various causes. The increased reactive oxygen radical production with insufficient antioxidant mechanism capacity may play a role in the etiopathogenesis of hyperhidrosis. It is probable to gather data about oxidative stress by detecting plasma thiol/disulfide ratio.The aim of this study was to determine whether thiol‐disulfide balance changes in patients with hyperhidrosis.MethodsThe files of patients who were diagnosed with hyperhidrosis in the dermatology outpatient clinic between 2015 and 2018 and whose native thiol, total thiol, and disulfide values were examined for any reason were examined.ResultsSeventy‐three patients were included in the study. 33 of the patients with hyperhidrosis were primary.Mean age; for primary hyperhidrosis patients (PHH) = 26.36 ± 7.61, primary hyperhidrosis (PHH) control group = 27.16 ± 7.94; secondary hyperhidrosis (SHH) patients = 47.88 ± 12.29, SHH control (45.40 ± 12.02). The native thiol values of PHH ...

Research paper thumbnail of Research on the balance of thiol-disulfide in blood serum in women with telogen effluvium

International Journal of Trichology, 2019

Backgrounds: Telogen effluvium (TE) is the most common reason for hair loss in humans. Although t... more Backgrounds: Telogen effluvium (TE) is the most common reason for hair loss in humans. Although the exact etiopathogenesis of TE has not been revealed clearly and completely, multifactorial etiologies are to be blamed. In recent years, since oxidative stress (OS) has been shown to play an important role in the etiopathogenesis of so many diseases, the effects of OS on several skin diseases are researched and analyzed. Thiols are antioxidant components that include sulfur group, and the balance of thiol-disulfide has an important role in the formation and prevention of OS. This balance is destroyed in many diseases and its effect on TE is not clearly understood yet. Objectives: In this study, we aimed to search the thiol–disulfide balance that could reveal OS in patients with TE. Materials and Methods: Fifty-two patients with TE and control group of 46 persons were included in the study. Native thiol, disulfide, and total thiol levels were evaluated by a new, automatic spectrophotometric method. Disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol rates were calculated. Results: There was no statistical difference between TE patients and control group in terms of native thiol, disulfide, and total thiol levels. Thiol–disulfide balance was fixed and not affected in TE patients.

Research paper thumbnail of Cutaneous findings in patients with chronic venous insufficiency

Journal of Cosmetic Dermatology, 2021

BackgroundVenous hypertension causes many different cutaneous findings such as varicosities, tela... more BackgroundVenous hypertension causes many different cutaneous findings such as varicosities, telangiectasia, edema, and pigmentation, dermatitis, and venous ulcers on the skin.ObjectiveThis study aims to investigate the cutaneous signs and symptoms of chronic venous insufficiency (CVI) and to examine their contribution to early diagnosis.MethodsA total of 150 patients were included in the study who applied to the dermatology outpatient clinic and were diagnosed with skin disease related to CVI or had skin findings. Patient's age, gender, complaints, occupation, additional diseases, drug usage, history of prolonged standing and travel, smoking habit, number of pregnancies, history of varicose veins in the family, dermatological diagnosis/findings, and venous Doppler ultrasonography reports were examined retrospectively.Results56% of patients were women. Mean age was 56.69 ± 13.6 years. Overall, 82.7% of total patients had at least one skin finding. The most frequent skin findings...

Research paper thumbnail of Bacterial Skin Infections in Children

Turkish Journal of Pediatric Disease, 2018

Amaç: Çocukluk çağında görülen bakteriyel deri enfeksiyonlarının sıklığı, klinik, demografik ve e... more Amaç: Çocukluk çağında görülen bakteriyel deri enfeksiyonlarının sıklığı, klinik, demografik ve epidemiyolojik özelliklerinin araştırılmasıdır. Gereç ve Yöntemler: Çalışmaya 0-16 yaş arasında bakteriyel deri hastalığı tanısı alan hastalar dâhil edildi. Hastaların; yaşları, cinsiyeti, enfeksiyonun tipi, lezyonların yerleşim yeri, enfeksiyonların mevsimlere göre dağılımı, aile öyküsü, yaşadığı yer, sosyoekonomik durum ve eşlik eden hastalıklar kaydedildi. Bulgular: Bakteriyel deri enfeksiyonu tanısı konan 135 çocuk hastanın 71'i kız (%52.6), 64'ü erkek (%47.4)'ti. Yaş gruplarına göre yapılan değerlendirmede; hastaların %34'ü 0-2 yaşta, %18.5'i 3-5 yaşta, %31'i 6-11 yaşta, %16.2'si 11-16 yaştaydı. Hastalarda altı çeşit bakteriyel deri enfeksiyonu mevcuttu. İmpetigo %37, sekonder piyoderma %21.5, paronişi %16.2, follikülit %14.1, fronkül %8.9, sellülit %2.2 oranında saptandı. Yaz ve sonbahar aylarında daha sık görüldüğü izlendi (%34, %36). Eşlik eden hastalık %9.6 olguda mevcuttu. Sonuç: Çocuklarda bakteriyel deri enfeksiyonları sık görülür ve çoğu önlenebilir hastalıklardır. Komplikasyonları açısından erken tanı ve tedavisi önemlidir. Bu nedenle, halkın bu konuda eğitimi ve koruyucu hekimlik yönünden de bulaşmayı azaltacak önlemlerin alınması gereklidir.

Research paper thumbnail of Clinical and Demographic Analysis of Patients with Hand, Foot and Mouth Disease Diagnosis

Ankara Medical Journal, 2018

Objectives: Hand, foot and mouth disease is a viral infection which is characterized by fever, ve... more Objectives: Hand, foot and mouth disease is a viral infection which is characterized by fever, vesicular lesions in palm, sole, and mouth, and is frequent observed in children. We aimed to investigate the clinical characteristics of 33 patients admitted to the Clinic of Dermatology in Ankara Atatürk Training and Research Hospital between 2015 and 2017. Materials and Methods: Thirty-three patients were evaluated for the presence of symptoms such as fever, pain, burning, pruritus, age, sex, localization of lesions, family and atopy history. Results: The median age of the 33 patients studied was 12.21±9.45 years (min-max: 1-36), there were 23 children and 10 adults. The mean duration of illness was calculated as 3,9±1,9 days (min-max: 1-7). 36.36% of the patients (n = 12) were male. 26 (78.78%) patients had fever history. There were atopy histories in 5 patients (15.15%), and medical history in the family and close encountered persons of 9 patients (27.27%). Eight patients (24.24%) complained of sore throat, 7 patients (21.21%) of itching. Vesicular lesions were monitored in the palms and soles of 31 patients (93.93%) and in the mouths of 24 patients (72.72%). The most frequent involvement site was hand palm (96.96%). Only 2 patients (6.06%) developed onychomadesis after the disease. Conclusion: We have observed a female gender dominance unlike other studies. It should not be forgotten that; although more common in children, the disease can be observed also in young adults, it can involve body parts other than hand-foot-mouth, and long follow-ups are important in the severe form of the disease.

Research paper thumbnail of Analysis of The Patients with Lichenoid Drug Reactions: A Retrospective Study

Medical Science and Discovery, 2018

For that reason, we aimed to research the clinical and demographical characteristics of the patie... more For that reason, we aimed to research the clinical and demographical characteristics of the patients who are suffering with LDR, uncommon disease disturbing patients for a long period of time.

Research paper thumbnail of Examination of Clinical and Demographic Characteristics of 14 Cases with Frontal Fibrosing Alopecia

Medical Science and Discovery, 2018

Objective: Frontal fibrosing alopecia (FFA) is a rare type of cicatricial alopecia seen in postme... more Objective: Frontal fibrosing alopecia (FFA) is a rare type of cicatricial alopecia seen in postmenopausal women characterized with band-type frontal/frontotemporal hair traction and/or significant or complete loss of the eyebrows. We aimed to present the demographic, clinical and laboratory characteristics of female patients diagnosed and followed-up with FFA in our clinic by comparing these with the literature data. Method: A total of 14 patients who admitted to our outpatient clinic with alopecia on the frontotemporal/frontal hairline and were clinically and/or histopathologically diagnosed with FFA between 2011 and 2016 were evaluated in a retrospective manner. The patients were reviewed in terms of the age of lesion onset, localization, accompanying symptom or disease, and treatment options. Results: The ages of the patients who were followed-up in our outpatient clinic with FFA were between 52 and 73 (mean 2 years). Eight patients (57%) had total eyebrow loss,. Laboratory tests were in normal limits or negative. Comorbidities included thyroid disease, hypertension and coronary artery disease diabetes mellitus. For treatment, all patients were given systemic, intralesional and topical steroid, and topical minoxidil at various times. Four patients received hydroxychloroquine, 2 patients acitretin, 2 patients Vitamin E, 1 patient itraconazole, and 1 patient topical tacrolimus. Conclusion: FFA should be considered in middle aged and elderly postmenopausal women presenting with hair loss complaints and were detected to have frontal hairline traction and cicatricial alopecia, and the diagnosis should be supported by biopsy. Thereby, the disease progression may be prevented or delayed with early diagnosis and proper treatment..

Research paper thumbnail of Etyopathogenesis and Oxidative Stress Relationship in Mild Severe Alopecia Areata

Turkish Journal of Dermatology / Türk Dermatoloji Dergisi, 2017

Alopesi areata (AA); skarsız kıl kaybı ile karakterize, rekürren, otoimmün, inflamatuvar bir hast... more Alopesi areata (AA); skarsız kıl kaybı ile karakterize, rekürren, otoimmün, inflamatuvar bir hastalıktır. Etyopatogenezi tam bilinmemekte, genetik, emosyonel, çevresel faktörler ve otoimmünite suçlanmaktadır. Çalışmadaki amacımız; AA etyopatogenezinde oksidatif stresin rolünü araştırmaktır. Yöntemler: Çalışmaya 37 AA'lı hasta ve kontrol grubu olarak 35 sağlıklı gönüllü dahil edildi. Hasta ve kontrol grubu serum örneklerinde total antioksidan kapasite (TAK) ve total oksidan kapasite (TOK) ölçülerek oksidatif stres indeksi (OSİ) hesaplandı. Bulgular: Hasta grubunun TAK değerlerinin kontrol grubuna göre daha yüksek olduğu belirlendi (p=0,036). İki grup arasında TOK açısından istatistiksel olarak sınırda, anlamsız bir farklılık saptandı (p=0,058). OSİ açısından iki grup arasında anlamlı bir fark yoktu (p=0,270). Sonuç: AA etyopatogenezinde oksidatif stresin rolü olabilir. TAK değerlerindeki artış yama tarzı hafif şiddetli AA'da antioksidan sistemin yeterli çalıştığını düşündürmektedir.

Research paper thumbnail of Acquired aquagenic acrokeratoderma: A case series

TURKDERM, 2016

Akuajenik siringeal akrokeratoderma (ASA); 2-4 dakika su teması sonrası oluşan ödematöz beyaz ren... more Akuajenik siringeal akrokeratoderma (ASA); 2-4 dakika su teması sonrası oluşan ödematöz beyaz renkli papül ve plaklarla karakterize, etiyolojisi bilinmeyen, nadir, edinsel bir palmoplantar keratoderma türüdür 1,2. ASA ilk olarak 1996 yılında English ve McCollough tarafından "geçici reaktif papülo translucent akrokeratoderma" ismiyle tanımlanmıştır 3. Lezyonlar sıklıkla palmar alanda görülmesine rağmen, el dorseli ve ayaklar da etkilenebilir 1,2,4. Genellikle adölesanları ve genç erişkin kadınları etkiler, bildirilen erkek olgu sayısı sınırlıdır 1,3,5. Biz burada; kliniğimizde ASA tanısı konulan ve tedavi edilen erkek hastaların klinik ve laboratuvar bulgularını literatür ile karşılaştırarak sunmayı amaçladık. 2011-2014 tarihleri arasında, polikliniğimizde klinik ve/veya histopatolojik olarak ASA tanısı konulan hastalar retrospektif olarak incelendi. Poliklinik başvurusu esnasında hastalardan, dosyalarından bilgi alınacağına dair bilgilendirilmiş onam formu alındı. Hastalar, cinsiyet, lezyon başlangıç yaşı, lokalizasyonu, kalıcılığı, eşlik eden semptom ya da hastalık, aile öyküsü ve tedaviye yanıt açısından detaylı olarak gözden geçirildi. Olgu Sunumu Çalışmaya suyla temastan kısa süre sonra elleri ve ayaklarında beyazlaşma şikayeti olan, klinik ve/veya histopatolojik olarak Akuajenik siringeal akrokeratoderma (ASA); etiyolojisi bilinmeyen, sıklıkla adölesan ve genç erişkin kadınları etkileyen, nadir, edinsel bir keratoderma türüdür. Klinik olarak suyla temastan birkaç dakika sonra ortaya çıkan, geçici ödematöz beyaz papül ve plaklarla karakterizedir. Sıklıkla palmar yüzeylerde lokalizedir, el dorsalleri ve ayak tabanını da etkileyebilir. Bu çalışmada; literatürde kadın predominansı üzerinde durulmasına rağmen, kliniğimizde ASA tanısı alan altı erkek hastanın klinik özelliklerinin incelenmesi amaçlanmıştır. Anahtar Kelimeler: Akuajenik siringeal akrokeratoderma, erkek, el dorseli Aquagenic syringeal acrokeratoderma (ASA) is a rare kind of an acquired keratoderma that predominantly affects adolescents and young females. The etiology is unknown. Clinically, ASA is characterized by transient edematous white papules and plaques occurring a few minutes after exposure to water. It is most commonly localized on the palms, but may also affect the plantar area and dorsum of the hand. Despite the female predominance mentioned in the literature, the aim of this study was to investigate the clinical characteristics of six male patients diagnosed with ASA in our clinic.

Research paper thumbnail of Primary cutaneous follicle center lymphoma: A case report

Our Dermatology Online, 2016

Primary cutaneous B-cell lymphomas are defined as malignantB-cell proliferations presenting with ... more Primary cutaneous B-cell lymphomas are defined as malignantB-cell proliferations presenting with cutaneous involvement alone and no evidence of extracutaneous manifestationswhen complete staging has been performed. Primary cutaneous folicul centre cell lymphoma (PCFCCL) is a relatively rare entity. Here, we report a 66-year-old female patient presented with six mounts history of erythematous papules and nodules over the skin of neck and body PCFCCL was diagnosed by skin biopsies. No evidence of systemic involvement was present at the time of diagnosis. She was not taken terapy but ones six mounts was done control and she hasn't got new lesions. Twelve months later she remains asymptomatic.

Research paper thumbnail of Linear atrophoderma of Moulin located on the face

Our Dermatology Online, 2016

Linear atrophoderma of Moulin (LAM) is a rare dermatosis characterized by hyperpigmented and depr... more Linear atrophoderma of Moulin (LAM) is a rare dermatosis characterized by hyperpigmented and depressed bandlike lesions localized along the Blaschko lines. LAM most commonly prefers the trunk and the limbs, while it is more rarely localized in the head and neck region. So far, any case of isolated facial lesion has not been reported. We present a-36-year old male patient with isolated facial lesion. We were observed slightly improvement in the lesion with topical calcipotriole therapy for 2 months.

Research paper thumbnail of Nail Disorders in Children, a clinical study

Our Dermatology Online, 2016

During the period between May to December 2011 at the Children's Hospital Pediatric Hematology an... more During the period between May to December 2011 at the Children's Hospital Pediatric Hematology and Oncology in Ankara, clinical records of 133 patients admitted for nail disorders at the age group of 0-16 years to dermatology outpatient deoartment were evaluated retrospectively. Our study was approved by the local ABSTRACT Introduction: Aims of the study to investigate the frequency and the nature ofnail disorders in children significant clinical data is available. Nail disorders although common in children in some parts of our country. This study was carried out to document the clinical and demographic pattern of nail disorders in a dermatology outpatient clinic of a pediatric hospital in Ankara, Turkey. Material and Methods: All consecutive patients a total of 3000 children from age 0-16 were admitted to dermatology outpatient clinic of Ankara Pediatric Hematology and Oncology Education and Research Hospital during January 2011 to December 2011 were studied and retrospectively evaluated for age, gender, drug use, diseases, systemic or genetic disorders and demographic features. Diagnostic evaluation results were noted and patients were categorized for demographic features and diagnosis. Results: These 133 patients (M: F 58:75, %44 vs 56, respectively) were under 16 years of age and have 17 different dermatological disorders related with nail symptoms. Fifty three of (39,8%) these patient were under 2 years of age, 31 (23.3%) were between 3-5 years, 30 (22.5%) were between 6-11 years old, 19 of 133 (14%), 2 were between 11-16 years of age. Through all of ages and independent of gender the most etiologies of nail disorders were, onychomadesis, paronychia, onycholysis, onychomycosis and systemic nail presentation of systemic dermatosis. Conclusion: Nail disorders are different in children than in adults. In our study, the first 5 years of age was found in 53% of nail disorders. Nail disorders are uncommon but may be seen as a part of a systemic disease and may be associated wit h cosmetic and psychologic problem.

Research paper thumbnail of A case of dermatosis neglecta

TURKDERM, 2015

Deniz Demirseren ve ark. Deri grefti üzerinde gelişen dermatozis neglekta olgusu Resim 2. Papillo... more Deniz Demirseren ve ark. Deri grefti üzerinde gelişen dermatozis neglekta olgusu Resim 2. Papillomatozis gösteren epidermiste sarmal biçimli hiperkeratoz alanlarının yanısıra, dermiste de skar dokusu gelişimi Resim 3. Bir ay sonraki kontrolde lezyonun görünümü

Research paper thumbnail of Subungual Ekzositozlu Bir Çocuk Olgu

Turkish Journal of Pediatric Disease, 2015

Subungual ekzositoz, terminal falanksların distalinde ortaya çıkan, akkiz, benign, soliter, nadir... more Subungual ekzositoz, terminal falanksların distalinde ortaya çıkan, akkiz, benign, soliter, nadir görülen bir kemik tümörüdür (1-3). Normal kemik dokusunun dışarı doğru büyümesi sonucunda ortaya çıkar (3).Uzun zaman osteokondromanın bir varyantı olarak kabul edilmiş olmakla birlikte, son yıllarda bu iki hastalığın klinik, histopatolojik ve radyolojik olarak farklı iki antite olduğu düşünülmektedir (4,5). Adölesan ve genç erişkinlerde daha sıktır. %80 ayak birinci parmakta ortaya çıkar (2). Parmaktaki ağrı ve şişlikten dolayı genellikle tırnak batması ya da kallus olarak yanlış tanı almaktadır. Burada; sağ ayak birinci parmakta şişlik, ağrı, şekil bozukluğu olan, radyolojik olarak subungual ekzositoz tanısı konan 16 yaşında bir erkek hasta sunulmaktadır.

Research paper thumbnail of Eruptive vellus hair cysts on the face: a case report and literature review

TURKDERM, 2013

Eruptif vellus kıl kisti genelde göğüs ve ekstremitelerde ortaya çıkan, çok sayıda, asemptomatik,... more Eruptif vellus kıl kisti genelde göğüs ve ekstremitelerde ortaya çıkan, çok sayıda, asemptomatik, komedon benzeri papüllerle karakterize, ender rastlanan bir deri hastalığıdır. Çocuk ve genç erişkinlerde daha sık görülmektedir. Etyolojisi tam bilinmeyen rahatsızlık sporadik şekilde gelişebileceği gibi otozomal dominant yolla kalıtsal geçiş de gösterebilmektedir. Burada; yüzün alın ve yanak bölgelerinde yoğun yerleşim gösteren, çok sayıda, grimsi sarı-renginde papülleri bulunan, eruptif vellus kıl kisti tanısı koyduğumuz 28 yaşında bir kadın, lezyonların yüz yerleşimi ve farklı görünümü nedeniyle sunularak ayırıcı tanısı, tedavi alternatifleri literatür verileri eşliğinde tartışıldı. (Türkderm 2013; 47: 59-62) Anah tar Ke li me ler: Eruptif vellus kıl kisti, yüz Sum mary Eruptive vellus hair cyst (EVHC) is a rare skin disease and is characterized by asymptomatic comedone-like papules on the anterior chest and limbs. EVHC is more common among children and young adults. Its etiology is not fully known, and it may occur sporadically or be inherited as an autosomal dominant gene. In this paper, we present a 28-year-old female patient with EVHC who presented with a large number of dense, grayish-yellow colored papules on frontal and cheek regions of the face. Due to the location of the lesions on the face and their dissimilar appearances, differential diagnosis and treatment alternatives are evaluated in the light of the literature.

Research paper thumbnail of Angina Bullosa Hemorrhagica: A Case Report

Turkish Journal of Dermatology / Türk Dermatoloji Dergisi, 2015

Anjina bülloza hemorajika; oral mukozada ağrısız hemorajik büllerle karakterize, nadir rastlanan,... more Anjina bülloza hemorajika; oral mukozada ağrısız hemorajik büllerle karakterize, nadir rastlanan, benign bir hastalıktır. Eşlik eden hematolojik ya da vezikulobüllöz bir hastalık yoktur. Patogenezi tam bilinmeyen hastalıkta major tetikleyici faktör minör travmadır. Burada; oral mukozasında lokal travmaya sekonder, tekrarlayıcı hemorajik bülleri olan, aile öyküsü de tarif eden 35 yaşında bir erkek hasta, nadir rastlanması nedeniyle sunulmaktadır. Anahtar kelimeler: Bül, hemorajik, yumuşak damak, travma, anjina, oral mukoza Çıkar Çatışması: Yazarlar bu makale ile ilgili olarak herhangi bir çıkar çatışması bildirmemiştir.

Research paper thumbnail of Epidemiological characteristics of different types of adult acne in Turkey: a prospective, controlled, multicenter study

Acta Dermatovenerologica Alpina Pannonica et Adriatica

Late-onset acne is the type of acne that begins in adulthood. Finally, recurrent acne is the form... more Late-onset acne is the type of acne that begins in adulthood. Finally, recurrent acne is the form that begins in adolescence and is characterized by a relapse in adulthood after an acne-free period without the use of any medication (1-3). Although evidence about some of these types is controversial, many triggering factors of adult acne have been documented so far. In this regard, internal factors such as high body mass index, hormonal imbalance, and genetic factors have been proposed to cause the occurrence or aggravation of acne. On the other hand, stress, smoking, using cosmetic products, and oral contraceptives

Research paper thumbnail of Complementary and alternative treatment methods practiced by parents in pediatric cases diagnosed with atopic dermatitis

Journal of Dermatological Treatment

Research paper thumbnail of Investigation of The Relationship Between Seborrheic Dermatitis and Metabolic Syndrome Parameters

Journal of Cosmetic Dermatology

Research paper thumbnail of Investigation of plasma thiol/disulfide balance in male patients with androgenetic alopecia

Journal of Cosmetic Dermatology, 2021

BackgroundAndrogenetic alopecia (AGA) is the most common cause of hair loss in men. In addition t... more BackgroundAndrogenetic alopecia (AGA) is the most common cause of hair loss in men. In addition to genetic and hormonal factors, oxidative stress (OS) is suggested as a factor in the etiology.AimIn this study, we aimed to investigate the presence of OS due to thiol disulfide balance deterioration in male patients with AGA.Materials and MethodsA total of 45 male AGA patients and 42 healthy male controls were included in the study. Native thiol, disulfide, and total thiol levels were assessed through automated spectrophotometry. The relationship between total protein, albumin, native thiol, disulfide, and total thiol levels in addition to demographic and clinical characteristics of the patients were examined.ResultsThe mean age of the patients was 32.6 ± 10 years, and the median AGA duration in the patients was 3 years. There was no statistically significant difference in terms of native thiol, disulfide, total thiol levels, disulfide/total thiol, disulfide/native thiol, and native th...

Research paper thumbnail of Can thiol‐disulfide balance be an indicator of oxidative stress for hyperhidrosis?

Journal of Cosmetic Dermatology, 2021

BackgroundHyperhidrosis is responsible for various causes. The increased reactive oxygen radical ... more BackgroundHyperhidrosis is responsible for various causes. The increased reactive oxygen radical production with insufficient antioxidant mechanism capacity may play a role in the etiopathogenesis of hyperhidrosis. It is probable to gather data about oxidative stress by detecting plasma thiol/disulfide ratio.The aim of this study was to determine whether thiol‐disulfide balance changes in patients with hyperhidrosis.MethodsThe files of patients who were diagnosed with hyperhidrosis in the dermatology outpatient clinic between 2015 and 2018 and whose native thiol, total thiol, and disulfide values were examined for any reason were examined.ResultsSeventy‐three patients were included in the study. 33 of the patients with hyperhidrosis were primary.Mean age; for primary hyperhidrosis patients (PHH) = 26.36 ± 7.61, primary hyperhidrosis (PHH) control group = 27.16 ± 7.94; secondary hyperhidrosis (SHH) patients = 47.88 ± 12.29, SHH control (45.40 ± 12.02). The native thiol values of PHH ...

Research paper thumbnail of Research on the balance of thiol-disulfide in blood serum in women with telogen effluvium

International Journal of Trichology, 2019

Backgrounds: Telogen effluvium (TE) is the most common reason for hair loss in humans. Although t... more Backgrounds: Telogen effluvium (TE) is the most common reason for hair loss in humans. Although the exact etiopathogenesis of TE has not been revealed clearly and completely, multifactorial etiologies are to be blamed. In recent years, since oxidative stress (OS) has been shown to play an important role in the etiopathogenesis of so many diseases, the effects of OS on several skin diseases are researched and analyzed. Thiols are antioxidant components that include sulfur group, and the balance of thiol-disulfide has an important role in the formation and prevention of OS. This balance is destroyed in many diseases and its effect on TE is not clearly understood yet. Objectives: In this study, we aimed to search the thiol–disulfide balance that could reveal OS in patients with TE. Materials and Methods: Fifty-two patients with TE and control group of 46 persons were included in the study. Native thiol, disulfide, and total thiol levels were evaluated by a new, automatic spectrophotometric method. Disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol rates were calculated. Results: There was no statistical difference between TE patients and control group in terms of native thiol, disulfide, and total thiol levels. Thiol–disulfide balance was fixed and not affected in TE patients.

Research paper thumbnail of Cutaneous findings in patients with chronic venous insufficiency

Journal of Cosmetic Dermatology, 2021

BackgroundVenous hypertension causes many different cutaneous findings such as varicosities, tela... more BackgroundVenous hypertension causes many different cutaneous findings such as varicosities, telangiectasia, edema, and pigmentation, dermatitis, and venous ulcers on the skin.ObjectiveThis study aims to investigate the cutaneous signs and symptoms of chronic venous insufficiency (CVI) and to examine their contribution to early diagnosis.MethodsA total of 150 patients were included in the study who applied to the dermatology outpatient clinic and were diagnosed with skin disease related to CVI or had skin findings. Patient's age, gender, complaints, occupation, additional diseases, drug usage, history of prolonged standing and travel, smoking habit, number of pregnancies, history of varicose veins in the family, dermatological diagnosis/findings, and venous Doppler ultrasonography reports were examined retrospectively.Results56% of patients were women. Mean age was 56.69 ± 13.6 years. Overall, 82.7% of total patients had at least one skin finding. The most frequent skin findings...

Research paper thumbnail of Bacterial Skin Infections in Children

Turkish Journal of Pediatric Disease, 2018

Amaç: Çocukluk çağında görülen bakteriyel deri enfeksiyonlarının sıklığı, klinik, demografik ve e... more Amaç: Çocukluk çağında görülen bakteriyel deri enfeksiyonlarının sıklığı, klinik, demografik ve epidemiyolojik özelliklerinin araştırılmasıdır. Gereç ve Yöntemler: Çalışmaya 0-16 yaş arasında bakteriyel deri hastalığı tanısı alan hastalar dâhil edildi. Hastaların; yaşları, cinsiyeti, enfeksiyonun tipi, lezyonların yerleşim yeri, enfeksiyonların mevsimlere göre dağılımı, aile öyküsü, yaşadığı yer, sosyoekonomik durum ve eşlik eden hastalıklar kaydedildi. Bulgular: Bakteriyel deri enfeksiyonu tanısı konan 135 çocuk hastanın 71'i kız (%52.6), 64'ü erkek (%47.4)'ti. Yaş gruplarına göre yapılan değerlendirmede; hastaların %34'ü 0-2 yaşta, %18.5'i 3-5 yaşta, %31'i 6-11 yaşta, %16.2'si 11-16 yaştaydı. Hastalarda altı çeşit bakteriyel deri enfeksiyonu mevcuttu. İmpetigo %37, sekonder piyoderma %21.5, paronişi %16.2, follikülit %14.1, fronkül %8.9, sellülit %2.2 oranında saptandı. Yaz ve sonbahar aylarında daha sık görüldüğü izlendi (%34, %36). Eşlik eden hastalık %9.6 olguda mevcuttu. Sonuç: Çocuklarda bakteriyel deri enfeksiyonları sık görülür ve çoğu önlenebilir hastalıklardır. Komplikasyonları açısından erken tanı ve tedavisi önemlidir. Bu nedenle, halkın bu konuda eğitimi ve koruyucu hekimlik yönünden de bulaşmayı azaltacak önlemlerin alınması gereklidir.

Research paper thumbnail of Clinical and Demographic Analysis of Patients with Hand, Foot and Mouth Disease Diagnosis

Ankara Medical Journal, 2018

Objectives: Hand, foot and mouth disease is a viral infection which is characterized by fever, ve... more Objectives: Hand, foot and mouth disease is a viral infection which is characterized by fever, vesicular lesions in palm, sole, and mouth, and is frequent observed in children. We aimed to investigate the clinical characteristics of 33 patients admitted to the Clinic of Dermatology in Ankara Atatürk Training and Research Hospital between 2015 and 2017. Materials and Methods: Thirty-three patients were evaluated for the presence of symptoms such as fever, pain, burning, pruritus, age, sex, localization of lesions, family and atopy history. Results: The median age of the 33 patients studied was 12.21±9.45 years (min-max: 1-36), there were 23 children and 10 adults. The mean duration of illness was calculated as 3,9±1,9 days (min-max: 1-7). 36.36% of the patients (n = 12) were male. 26 (78.78%) patients had fever history. There were atopy histories in 5 patients (15.15%), and medical history in the family and close encountered persons of 9 patients (27.27%). Eight patients (24.24%) complained of sore throat, 7 patients (21.21%) of itching. Vesicular lesions were monitored in the palms and soles of 31 patients (93.93%) and in the mouths of 24 patients (72.72%). The most frequent involvement site was hand palm (96.96%). Only 2 patients (6.06%) developed onychomadesis after the disease. Conclusion: We have observed a female gender dominance unlike other studies. It should not be forgotten that; although more common in children, the disease can be observed also in young adults, it can involve body parts other than hand-foot-mouth, and long follow-ups are important in the severe form of the disease.

Research paper thumbnail of Analysis of The Patients with Lichenoid Drug Reactions: A Retrospective Study

Medical Science and Discovery, 2018

For that reason, we aimed to research the clinical and demographical characteristics of the patie... more For that reason, we aimed to research the clinical and demographical characteristics of the patients who are suffering with LDR, uncommon disease disturbing patients for a long period of time.

Research paper thumbnail of Examination of Clinical and Demographic Characteristics of 14 Cases with Frontal Fibrosing Alopecia

Medical Science and Discovery, 2018

Objective: Frontal fibrosing alopecia (FFA) is a rare type of cicatricial alopecia seen in postme... more Objective: Frontal fibrosing alopecia (FFA) is a rare type of cicatricial alopecia seen in postmenopausal women characterized with band-type frontal/frontotemporal hair traction and/or significant or complete loss of the eyebrows. We aimed to present the demographic, clinical and laboratory characteristics of female patients diagnosed and followed-up with FFA in our clinic by comparing these with the literature data. Method: A total of 14 patients who admitted to our outpatient clinic with alopecia on the frontotemporal/frontal hairline and were clinically and/or histopathologically diagnosed with FFA between 2011 and 2016 were evaluated in a retrospective manner. The patients were reviewed in terms of the age of lesion onset, localization, accompanying symptom or disease, and treatment options. Results: The ages of the patients who were followed-up in our outpatient clinic with FFA were between 52 and 73 (mean 2 years). Eight patients (57%) had total eyebrow loss,. Laboratory tests were in normal limits or negative. Comorbidities included thyroid disease, hypertension and coronary artery disease diabetes mellitus. For treatment, all patients were given systemic, intralesional and topical steroid, and topical minoxidil at various times. Four patients received hydroxychloroquine, 2 patients acitretin, 2 patients Vitamin E, 1 patient itraconazole, and 1 patient topical tacrolimus. Conclusion: FFA should be considered in middle aged and elderly postmenopausal women presenting with hair loss complaints and were detected to have frontal hairline traction and cicatricial alopecia, and the diagnosis should be supported by biopsy. Thereby, the disease progression may be prevented or delayed with early diagnosis and proper treatment..

Research paper thumbnail of Etyopathogenesis and Oxidative Stress Relationship in Mild Severe Alopecia Areata

Turkish Journal of Dermatology / Türk Dermatoloji Dergisi, 2017

Alopesi areata (AA); skarsız kıl kaybı ile karakterize, rekürren, otoimmün, inflamatuvar bir hast... more Alopesi areata (AA); skarsız kıl kaybı ile karakterize, rekürren, otoimmün, inflamatuvar bir hastalıktır. Etyopatogenezi tam bilinmemekte, genetik, emosyonel, çevresel faktörler ve otoimmünite suçlanmaktadır. Çalışmadaki amacımız; AA etyopatogenezinde oksidatif stresin rolünü araştırmaktır. Yöntemler: Çalışmaya 37 AA'lı hasta ve kontrol grubu olarak 35 sağlıklı gönüllü dahil edildi. Hasta ve kontrol grubu serum örneklerinde total antioksidan kapasite (TAK) ve total oksidan kapasite (TOK) ölçülerek oksidatif stres indeksi (OSİ) hesaplandı. Bulgular: Hasta grubunun TAK değerlerinin kontrol grubuna göre daha yüksek olduğu belirlendi (p=0,036). İki grup arasında TOK açısından istatistiksel olarak sınırda, anlamsız bir farklılık saptandı (p=0,058). OSİ açısından iki grup arasında anlamlı bir fark yoktu (p=0,270). Sonuç: AA etyopatogenezinde oksidatif stresin rolü olabilir. TAK değerlerindeki artış yama tarzı hafif şiddetli AA'da antioksidan sistemin yeterli çalıştığını düşündürmektedir.

Research paper thumbnail of Acquired aquagenic acrokeratoderma: A case series

TURKDERM, 2016

Akuajenik siringeal akrokeratoderma (ASA); 2-4 dakika su teması sonrası oluşan ödematöz beyaz ren... more Akuajenik siringeal akrokeratoderma (ASA); 2-4 dakika su teması sonrası oluşan ödematöz beyaz renkli papül ve plaklarla karakterize, etiyolojisi bilinmeyen, nadir, edinsel bir palmoplantar keratoderma türüdür 1,2. ASA ilk olarak 1996 yılında English ve McCollough tarafından "geçici reaktif papülo translucent akrokeratoderma" ismiyle tanımlanmıştır 3. Lezyonlar sıklıkla palmar alanda görülmesine rağmen, el dorseli ve ayaklar da etkilenebilir 1,2,4. Genellikle adölesanları ve genç erişkin kadınları etkiler, bildirilen erkek olgu sayısı sınırlıdır 1,3,5. Biz burada; kliniğimizde ASA tanısı konulan ve tedavi edilen erkek hastaların klinik ve laboratuvar bulgularını literatür ile karşılaştırarak sunmayı amaçladık. 2011-2014 tarihleri arasında, polikliniğimizde klinik ve/veya histopatolojik olarak ASA tanısı konulan hastalar retrospektif olarak incelendi. Poliklinik başvurusu esnasında hastalardan, dosyalarından bilgi alınacağına dair bilgilendirilmiş onam formu alındı. Hastalar, cinsiyet, lezyon başlangıç yaşı, lokalizasyonu, kalıcılığı, eşlik eden semptom ya da hastalık, aile öyküsü ve tedaviye yanıt açısından detaylı olarak gözden geçirildi. Olgu Sunumu Çalışmaya suyla temastan kısa süre sonra elleri ve ayaklarında beyazlaşma şikayeti olan, klinik ve/veya histopatolojik olarak Akuajenik siringeal akrokeratoderma (ASA); etiyolojisi bilinmeyen, sıklıkla adölesan ve genç erişkin kadınları etkileyen, nadir, edinsel bir keratoderma türüdür. Klinik olarak suyla temastan birkaç dakika sonra ortaya çıkan, geçici ödematöz beyaz papül ve plaklarla karakterizedir. Sıklıkla palmar yüzeylerde lokalizedir, el dorsalleri ve ayak tabanını da etkileyebilir. Bu çalışmada; literatürde kadın predominansı üzerinde durulmasına rağmen, kliniğimizde ASA tanısı alan altı erkek hastanın klinik özelliklerinin incelenmesi amaçlanmıştır. Anahtar Kelimeler: Akuajenik siringeal akrokeratoderma, erkek, el dorseli Aquagenic syringeal acrokeratoderma (ASA) is a rare kind of an acquired keratoderma that predominantly affects adolescents and young females. The etiology is unknown. Clinically, ASA is characterized by transient edematous white papules and plaques occurring a few minutes after exposure to water. It is most commonly localized on the palms, but may also affect the plantar area and dorsum of the hand. Despite the female predominance mentioned in the literature, the aim of this study was to investigate the clinical characteristics of six male patients diagnosed with ASA in our clinic.

Research paper thumbnail of Primary cutaneous follicle center lymphoma: A case report

Our Dermatology Online, 2016

Primary cutaneous B-cell lymphomas are defined as malignantB-cell proliferations presenting with ... more Primary cutaneous B-cell lymphomas are defined as malignantB-cell proliferations presenting with cutaneous involvement alone and no evidence of extracutaneous manifestationswhen complete staging has been performed. Primary cutaneous folicul centre cell lymphoma (PCFCCL) is a relatively rare entity. Here, we report a 66-year-old female patient presented with six mounts history of erythematous papules and nodules over the skin of neck and body PCFCCL was diagnosed by skin biopsies. No evidence of systemic involvement was present at the time of diagnosis. She was not taken terapy but ones six mounts was done control and she hasn't got new lesions. Twelve months later she remains asymptomatic.

Research paper thumbnail of Linear atrophoderma of Moulin located on the face

Our Dermatology Online, 2016

Linear atrophoderma of Moulin (LAM) is a rare dermatosis characterized by hyperpigmented and depr... more Linear atrophoderma of Moulin (LAM) is a rare dermatosis characterized by hyperpigmented and depressed bandlike lesions localized along the Blaschko lines. LAM most commonly prefers the trunk and the limbs, while it is more rarely localized in the head and neck region. So far, any case of isolated facial lesion has not been reported. We present a-36-year old male patient with isolated facial lesion. We were observed slightly improvement in the lesion with topical calcipotriole therapy for 2 months.

Research paper thumbnail of Nail Disorders in Children, a clinical study

Our Dermatology Online, 2016

During the period between May to December 2011 at the Children's Hospital Pediatric Hematology an... more During the period between May to December 2011 at the Children's Hospital Pediatric Hematology and Oncology in Ankara, clinical records of 133 patients admitted for nail disorders at the age group of 0-16 years to dermatology outpatient deoartment were evaluated retrospectively. Our study was approved by the local ABSTRACT Introduction: Aims of the study to investigate the frequency and the nature ofnail disorders in children significant clinical data is available. Nail disorders although common in children in some parts of our country. This study was carried out to document the clinical and demographic pattern of nail disorders in a dermatology outpatient clinic of a pediatric hospital in Ankara, Turkey. Material and Methods: All consecutive patients a total of 3000 children from age 0-16 were admitted to dermatology outpatient clinic of Ankara Pediatric Hematology and Oncology Education and Research Hospital during January 2011 to December 2011 were studied and retrospectively evaluated for age, gender, drug use, diseases, systemic or genetic disorders and demographic features. Diagnostic evaluation results were noted and patients were categorized for demographic features and diagnosis. Results: These 133 patients (M: F 58:75, %44 vs 56, respectively) were under 16 years of age and have 17 different dermatological disorders related with nail symptoms. Fifty three of (39,8%) these patient were under 2 years of age, 31 (23.3%) were between 3-5 years, 30 (22.5%) were between 6-11 years old, 19 of 133 (14%), 2 were between 11-16 years of age. Through all of ages and independent of gender the most etiologies of nail disorders were, onychomadesis, paronychia, onycholysis, onychomycosis and systemic nail presentation of systemic dermatosis. Conclusion: Nail disorders are different in children than in adults. In our study, the first 5 years of age was found in 53% of nail disorders. Nail disorders are uncommon but may be seen as a part of a systemic disease and may be associated wit h cosmetic and psychologic problem.

Research paper thumbnail of A case of dermatosis neglecta

TURKDERM, 2015

Deniz Demirseren ve ark. Deri grefti üzerinde gelişen dermatozis neglekta olgusu Resim 2. Papillo... more Deniz Demirseren ve ark. Deri grefti üzerinde gelişen dermatozis neglekta olgusu Resim 2. Papillomatozis gösteren epidermiste sarmal biçimli hiperkeratoz alanlarının yanısıra, dermiste de skar dokusu gelişimi Resim 3. Bir ay sonraki kontrolde lezyonun görünümü

Research paper thumbnail of Subungual Ekzositozlu Bir Çocuk Olgu

Turkish Journal of Pediatric Disease, 2015

Subungual ekzositoz, terminal falanksların distalinde ortaya çıkan, akkiz, benign, soliter, nadir... more Subungual ekzositoz, terminal falanksların distalinde ortaya çıkan, akkiz, benign, soliter, nadir görülen bir kemik tümörüdür (1-3). Normal kemik dokusunun dışarı doğru büyümesi sonucunda ortaya çıkar (3).Uzun zaman osteokondromanın bir varyantı olarak kabul edilmiş olmakla birlikte, son yıllarda bu iki hastalığın klinik, histopatolojik ve radyolojik olarak farklı iki antite olduğu düşünülmektedir (4,5). Adölesan ve genç erişkinlerde daha sıktır. %80 ayak birinci parmakta ortaya çıkar (2). Parmaktaki ağrı ve şişlikten dolayı genellikle tırnak batması ya da kallus olarak yanlış tanı almaktadır. Burada; sağ ayak birinci parmakta şişlik, ağrı, şekil bozukluğu olan, radyolojik olarak subungual ekzositoz tanısı konan 16 yaşında bir erkek hasta sunulmaktadır.

Research paper thumbnail of Eruptive vellus hair cysts on the face: a case report and literature review

TURKDERM, 2013

Eruptif vellus kıl kisti genelde göğüs ve ekstremitelerde ortaya çıkan, çok sayıda, asemptomatik,... more Eruptif vellus kıl kisti genelde göğüs ve ekstremitelerde ortaya çıkan, çok sayıda, asemptomatik, komedon benzeri papüllerle karakterize, ender rastlanan bir deri hastalığıdır. Çocuk ve genç erişkinlerde daha sık görülmektedir. Etyolojisi tam bilinmeyen rahatsızlık sporadik şekilde gelişebileceği gibi otozomal dominant yolla kalıtsal geçiş de gösterebilmektedir. Burada; yüzün alın ve yanak bölgelerinde yoğun yerleşim gösteren, çok sayıda, grimsi sarı-renginde papülleri bulunan, eruptif vellus kıl kisti tanısı koyduğumuz 28 yaşında bir kadın, lezyonların yüz yerleşimi ve farklı görünümü nedeniyle sunularak ayırıcı tanısı, tedavi alternatifleri literatür verileri eşliğinde tartışıldı. (Türkderm 2013; 47: 59-62) Anah tar Ke li me ler: Eruptif vellus kıl kisti, yüz Sum mary Eruptive vellus hair cyst (EVHC) is a rare skin disease and is characterized by asymptomatic comedone-like papules on the anterior chest and limbs. EVHC is more common among children and young adults. Its etiology is not fully known, and it may occur sporadically or be inherited as an autosomal dominant gene. In this paper, we present a 28-year-old female patient with EVHC who presented with a large number of dense, grayish-yellow colored papules on frontal and cheek regions of the face. Due to the location of the lesions on the face and their dissimilar appearances, differential diagnosis and treatment alternatives are evaluated in the light of the literature.

Research paper thumbnail of Angina Bullosa Hemorrhagica: A Case Report

Turkish Journal of Dermatology / Türk Dermatoloji Dergisi, 2015

Anjina bülloza hemorajika; oral mukozada ağrısız hemorajik büllerle karakterize, nadir rastlanan,... more Anjina bülloza hemorajika; oral mukozada ağrısız hemorajik büllerle karakterize, nadir rastlanan, benign bir hastalıktır. Eşlik eden hematolojik ya da vezikulobüllöz bir hastalık yoktur. Patogenezi tam bilinmeyen hastalıkta major tetikleyici faktör minör travmadır. Burada; oral mukozasında lokal travmaya sekonder, tekrarlayıcı hemorajik bülleri olan, aile öyküsü de tarif eden 35 yaşında bir erkek hasta, nadir rastlanması nedeniyle sunulmaktadır. Anahtar kelimeler: Bül, hemorajik, yumuşak damak, travma, anjina, oral mukoza Çıkar Çatışması: Yazarlar bu makale ile ilgili olarak herhangi bir çıkar çatışması bildirmemiştir.