beena sangwan - Academia.edu (original) (raw)

Papers by beena sangwan

Drug research, Jun 19, 2020

Background Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat na... more Background Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy and radiotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. Objectives In this research mucoadhesive microspheres were developed in order to carry out the absorption of drug through nasal mucosa with the aim to improve therapeutic efficacy, avoid hepatic first pass metabolism and increase residence time. Material and Methods Mucoadhesive microspheres of Granisetron using chitosan as polymer were prepared by emulsification cross-linking method to increase the residence time on the mucosa. The surface of prepared microspheres was characterized by SEM (Scanning electron microscopy) and evaluated for particle size, encapsulation efficiency, production yield, swelling ability, in-vitro mucoadhesion, in-vitro drug release and stability study. Result Among all the formulations F6 with drug/polymer ratio of 1:3 displayed the best result. On drug release kinetic model study, all the formulations follow Zero order. Stability studies revealed that the microspheres kept at 25±2°C and 60±5% RH showed the maximum stability. Conclusion After all the evaluation parameters and result obtained it can be said that these results confirmed the suitability of Granisetron mucoadhesive chitosan microspheres for nasal delivery system.

Zenodo (CERN European Organization for Nuclear Research), Mar 15, 2019

Critical Reviews in Therapeutic Drug Carrier Systems, 2022

In the last few years, the polymeric micelles played a major role as a drug carrier in nano-sized... more In the last few years, the polymeric micelles played a major role as a drug carrier in nano-sized drug delivery system. The polymeric micelles are designed from synthetic block co-polymers and graft copolymers. In the mixed micelles, the bilayer lipid membrane and surfactants are used. Both micelles are in nano-sized and used to enhance the drug delivery to treat different diseases. In this review, we will discuss some examples from the literature included demonstrating the polymeric micelles used as drug-carriers in skin cancer treatment by using different drugs. We also summarized mixed micelles, polymeric micelles in skin drug delivery, various polymers, and techniques of polymeric micelles. These micelles may improve delivery of drug in the skin's targeted sites in specific and dermatological diseases like skin cancer, acne, and fungal infection. In the comparison of surfactant micelles, the polymeric micelles are more stable. Polymeric micelles act as a colloidal carrier for incorporating poorly water-soluble and amphiphilic drugs.

Journal of Pharmaceutical Research, Sep 1, 2017

The aim of the study was to develop a gastroretentive floating drug delivery system of atorvastat... more The aim of the study was to develop a gastroretentive floating drug delivery system of atorvastatin calcium by effervescence technique. Design/methodology/approach: The objective behind the study was to investigate the effect of concentration of HPMC K4M (X), concentration of guar gum (X), concentration of sodium bicarbonate (X) on the release of 1 2 3 atorvastatin calcium using central composite design.The floating tablets were formulated using atorvastatin calcium (20% w/w), HPMC K4M (5-15% w/w), guar gum (5-15% w/w), sodium bicarbonate (4-12% w/w), lactose (q.s.), talc (2% w/w) and magnesium stearate (1% w/w). Atorvastatin calcium floating tablets were evaluated for physical characterization viz. hardness, swelling index, floating capacity, weight variation, friability, in vitro drug release and kinetic studies. Findings: All tablets were floated for more than 12 hrs in 0.1 N HCl at 37±0.5°C and the in vitro drug release was found to be vary from 79% to 93%. The percentage cumulative drug released was maximum at low value of HPMC, low value of guar gum and high value of sodium bicarbonate. A mathematical model was developed to formulate floating tablets of atorvastatin calcium. The data fitting to Korsemeyer-Peppas equation revealed that the release mechanism from the dosage form followed the non-fickian transport. Value: The gastroretentive floating tablets of atorvastatin calcium will enhance the patient compliance and play a vital role in improving patient's quality of life.

Pharmacognosy Research, Dec 15, 2022

Acta pharmaceutica sciencia, 2021

The main objective of the present study was to developed and evaluated the Bifonazole (BFZ) loade... more The main objective of the present study was to developed and evaluated the Bifonazole (BFZ) loaded Nanostructured lipid carriers (NLCs) for topical delivery of BFZ. BFZ-NLCs were deve26ted for Particle size, EE, DL and drug release profiles. The invitro release studies show better drug release over 24h as compared to the marketed formulation. Ex-vivo skin permeation and Pharmacodynamic studies indicated that NLCs get effectively reduced the fungal infection. In-vitro antifungal activity study shows that the BFZ-NLCs were more effective in inhibiting the growth of Candida Albicans. Therefore, the study concludes that NLCs showed a continuous release profile and has the prospective for treatment of topical fungal infections.

Polimery w medycynie, Jun 25, 2020

Comprehensive review of the role of acrylic acid derivative polymers in floating drug delivery sy... more Comprehensive review of the role of acrylic acid derivative polymers in floating drug delivery system.

Current Cancer Therapy Reviews, Jun 9, 2020

Aim: The objective behind this present work is the development and characterization of silver nan... more Aim: The objective behind this present work is the development and characterization of silver nanoparticles from Dalbergia sissoo leaf extracts and the analysis of anticancer activity. Methods: Silver nanoparticles were prepared by using the aqueous solution of Dalbergia sisoo leaf extract and silver nitrate. The formation of nanoparticles was determined by the color change during the preparation of plant extract to metal ion in a fixed ratio. The prepared nanoparticles were then characterized by TEM, FTIR, DLS, XRD, and SEM. Silver nanoparticles were also evaluated for anticancer activity. Results: Synthesized silver nanoparticles were having good anticancer activity against MCF 7 cancer cell line as compared to the standard drug Doxorubicin. Conclusion: The particle size of nanoparticles was found to lie in the range of 10 to 50 nm.

Drug research, Aug 3, 2020

Background Vildagliptin is an antidiabetic agent, belongs to the dipeptidyl peptidase IV (DPP-4) ... more Background Vildagliptin is an antidiabetic agent, belongs to the dipeptidyl peptidase IV (DPP-4) inhibitors. Objective The aim of investigation was to develop a simple UV-visible Spectrophotometric method for the determination of vildagliptin in its pure form and pharmaceutical formulations, further to validate the developed method. Material and Methods Vildagliptin was estimated using UV-Visible double beam spectrophotometer at the wavelength of maximum absorption (210 nm) in acidic medium containing 0.1N HCl. The drug was characterized by melting point, Differential Scanning Calorimetry (DSC), and Fourier Transform Infra-Red (FTIR) techniques. The analysis of the drug was carried out by novel UV-Visible method which was validated analytical parameters like linearity, precision, and accuracy as per guidelines laid down by International Conference on Harmonization (ICH). Result Melting point of drug was found 154°C which is corresponds to its actual melting range. Similarly by the interpretation of spectra the drug was confirmed. The linear response for concentration range of 5–60 µg/ml of vildagliptin was recorded with regression coefficient 0.999. The accuracy was found between 98–101%. Precision for intraday and interday was found to be 1.263 and 1.162 respectively, which are within the limits. To establish the sensitivity of the method, limit of detection (LOD) and limit of quantification (LOQ) were determined which were found to be 0.951 µg/ml and 2.513 µg/ml respectively. Conclusion The UV method developed and validated for vildagliptin drug was found to be linear, accurate, precise and economical which can be used for the testing of its pharmaceutical formulations.

Rasayan journal of Chemistry, 2019

Indian Journal of Pharmaceutical Education and Research

Both melanoma and non-melanoma are the most common types of skin cancers affecting various popula... more Both melanoma and non-melanoma are the most common types of skin cancers affecting various populations across the globe. Skin malignancy is more prevalent among Caucasian populations. Non-melanoma types of skin cancers are further classified as basal cell and squamous cell carcinomas, respectively. The incidence of non-melanoma type of cancers is relatively higher than melanoma type of skin cancers. Recently published data shows that melanoma of the skin stands as the seventeenth most common type of cancer across the world. Niosome is a drug carrier in a novel drug delivery system wherein the drug is enclosed within the vesicle, which is made up of non-ionic surfactants that are stabilized by the addition of cholesterol. Niosomes help to overcome certain difficulties of skin drug deliveries such as insolubility, instability, low bioavailability, and fast debasement of medications. This review article mainly focuses on the use of niosomes in dermatology particularly aiming at the delivery of drugs via skin. In addition, this review discusses the specific use of niosomal drug delivery systems that may be useful in clinics. The niosomes are gaining popularity in the field of topical drug delivery due to their excellent characteristics like proficiency to carry both hydrophilic and lipophilic drugs, increasing the penetration of drugs, and enhancing drug stability and drug release at sustained levels.

Critical Reviews™ in Therapeutic Drug Carrier Systems

Drug Delivery Letters

Background: Microspheres are controlled drug delivery systems (CDDS) because they have the potent... more Background: Microspheres are controlled drug delivery systems (CDDS) because they have the potential to encapsulate various drugs, nucleic acids, and proteins. Their benefits include biocompatiblity, greater bioavailability, and controlled release. Presently, existing antiulcer agents suffer from severe side effects which restricted their utility and encouraged the requirement of a harmless and proficient new antiulcer agent. The rationale of the present research work was to absorb the drug in the stomach for better antiulcer potential and fewer side effects. Objective: The rationale of the current investigational effort is to prepare and examine floating microspheres using berberine hydrochloride to increase gastric retention without interaction with the mucosa inside the stomach. Methods: The capillary extrusion technique was used with the aid of chitosan, a polymer in addition to sodium lauryl sulphate, a crosslinking agent. Scanning electron microscopy characterized the surface ...

Results of a field experiment conducted during 2015-16 to study degradation of novaluron in chick... more Results of a field experiment conducted during 2015-16 to study degradation of novaluron in chickpea are reported. Novaluron (10 EC) at 37.5 (T1), 75 (T2) and 150 (T3) g a.i ha-1 at pod formation stage. Samples were drawn periodically at 0 (2h after spraying), 1, 3, 5, 7, 10, 15, harvest time and analyzed by GC-ECD. Novaluron dissipated following first order kinetics with half life 1.40-2.73 in green pods and 2.31-3.13 in soil. The average initial deposits of novaluron in green pods and soil were found to be 0.642, 1.705, 2.251 and 0.144, 0.186, 0.223 mg kg-1 at T1, T2 and T3, respectively. In case of green pods and soil 91 and 77% dissipation was observed at University recommended dose within 5 days after application. Harvest time grain and soil were found to be BDL.

Journal of Composites and Compounds, 2020

Drug delivery is known as the administration of drugs using suitable vehicle for achieving effect... more Drug delivery is known as the administration of drugs using suitable vehicle for achieving effective treatment with no unwanted effects. In recent years, various composite materials have been developed and evaluated for being used in different biomedical fields such as wound dressings, cardiac prosthesis, tissue engineering, and drug delivery. Zinc is the second most available element after Fe in our body. Nanoparticles based on metal oxides, such as zinc oxides and Zn-containing composites, can be considered as viable platforms for some biomedical uses, especially for drug delivery applications. Mg composite biomaterials are also suggested for diverse biomedical applications due to their good mechanical properties, biocompatibility, and bioactivity. This paper highlights applications of zinc and magnesium-based composites in development of drug delivery systems.

International Journal of Research in Pharmaceutical Sciences, 2020

The novel virus such as corona virus 2019 is the main cause of the disease that is declared by th... more The novel virus such as corona virus 2019 is the main cause of the disease that is declared by the WHO (World Health Origination). Some other virus similar to this virus were also discovered in initial year of 21th century such as SARS-CoV in 2003, HCoV NL63 in 2004, HKU1 in 2005, MERS-CoV in 2012, and SARS-CoV-2 in 2019. The first few cases of covid-19 were detected from direct contact to the infected animal to human which is also called as animal to human transmission. Due to direct exposure of this virus to infected animals the human to human transmission of the virus is as well possible, which is also likely to be consider and measured as core form of transmission. According to the reports of WHO by 26 February 2020, patients suffering from COVID-19 reduced gradually in China but rapidly increased in countries like Italy, Iran and South Korea. The infection caused by the COVID 19 is detected by looking at the symptoms and it ultimately confirmed by the reverse transcription poly...

Advance Pharmaceutical Journal, 2020

Nano suspension formulations are attractive, encouraging and consist purely poor water soluble dr... more Nano suspension formulations are attractive, encouraging and consist purely poor water soluble drugs without any matrix material. Nano suspension technology solved the problem of poorly aqueous soluble and less bioavailability is also overcome by using this technology. Nanosuspension formulation is applicable to all aqueous insoluble drugs. The objective behind this study is to review the work done on nanosuspensions and recent drugs used to formulate this dosage form with their uses. The formulation of nanosuspensions include drugs, stabilizers, organic solvents and other additives such as buffers, salts, polyols, osmogents and cryoprotectant. Nanosuspension formulations are synthesized by using wet mill, high-pressure homogenizer, emulsion-solvent evaporation, melt emulsification method and supercritical fluid techniques. Nanosuspensions can be administered by oral, parenteral, pulmonary and ocular routes. It can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels. This review article describes the nanosuspensions, their preparation methods, characterization, and recent applications of the nanosuspension.

Current Drug Therapy, 2020

Nanoparticles (Np) are the 21st century material in supreme formulations due to their unique prop... more Nanoparticles (Np) are the 21st century material in supreme formulations due to their unique properties and design. In review, systematic discussion of the synthesis, characterization, bio-applications, and risks of AgNps (Silver Nanoparticles) especially highlighting anticancer activity envisaging mechanisms as well as therapeutic approaches for cancer. Ag-Nps mainly possess toxicological concern. Benefits and Risk: AgNps have beneficial approaches for cancer treatment and angiogenesisrelated diseases like rheumatoid arthritis, atherosclerosis, diabetic psoriasis, retinopathy, endometriosis, and adiposity. Ag-Nps induced cytotoxicity through oxidative stress by the ROS (Reactive Oxygen Species) generation could be measured as dependent on different properties, such as nanoparticle shape, size, agglomeration, concentration, and aggregation. Result: The advancing nanotechnology-based therapy needs to be devised better, and it should offload the hitches of prevailing treatment approac...

Asian Journal of Pharmacy and Pharmacology, 2018