Juan Marquez | National Institute Of Fashion Technology (original) (raw)
Papers by Juan Marquez
Digestion, 2013
Previous research has shown that infliximab (IFX) is effective in the management of moderate to s... more Previous research has shown that infliximab (IFX) is effective in the management of moderate to severe active ulcerative colitis (UC). Latin American studies are lacking. To evaluate the efficacy of IFX treatment (including corticosteroid withdrawal, complete mucosal healing, colectomy and hospitalization rates) in patients with moderate to severe UC. A retrospective and descriptive study was conducted on patients with UC in Medellín (Colombia). We included patients steroid dependent or refractory to conventional treatment. Between October 2005 and July 2011, 28 patients with moderate to severe UC received IFX infusions; the median of the follow-up was 27.4 months (range: 1-69 months). Twenty-four patients (86%) had a short-term primary response, whilst 19 (68%) achieved initial clinical remission. After 1 year, 17 (71%) out of the 24 patients who had an initial response were also showing a sustained response, and 10 (42%) remained in clinical remission. At 6 months, complete mucosal healing was observed in 29% of patients and endoscopic improvement in 57%. This is the first study to evaluate the IFX use in patients with moderate to severe active UC in a Latin American population. We found that IFX therapy is effective for inducing clinical remission, and that most patients who had an initial response showed a long-term sustained response.
Frontiers in computational neuroscience, 2015
Mounting evidence suggests that both α and γ motoneurons are active during movement and posture, ... more Mounting evidence suggests that both α and γ motoneurons are active during movement and posture, but how does the central motor system coordinate the α-γ controls in these tasks remains sketchy due to lack of in vivo data. Here a computational model of α-γ control of muscles and spindles was used to investigate α-γ integration and coordination for movement and posture. The model comprised physiologically realistic spinal circuitry, muscles, proprioceptors, and skeletal biomechanics. In the model, we divided the cortical descending commands into static and dynamic sets, where static commands (α s and γ s ) were for posture maintenance and dynamic commands (α d and γ d ) were responsible for movement. We matched our model to human reaching movement data by straightforward adjustments of descending commands derived from either minimal-jerk trajectories or human EMGs. The matched movement showed smooth reach-to-hold trajectories qualitatively close to human behaviors, and the reproduced...
The existence of a magnetic birefringence of vacuum is one of the most important predictions of q... more The existence of a magnetic birefringence of vacuum is one of the most important predictions of quantum electrodynamics, which has not yet been verified. In this contribution, we present a new project, the BMV (Biréfringence Magnétique du Vide) project, a collaboration between different Grenoble, Lyon and Toulouse institutes. The proposed experimental set-up, compared to previous attempts, should improve the signal
Megagauss Magnetic Field Generation, its Application to Science and Ultra-High Pulsed-Power Technology - Proceedings of the VIIIth International Conference on Megagauss Magnetic Field Generation and Related Topics, 2004
The 14.4 MJ pulsed capacitor bank generator will be operational in December 1998. We present the ... more The 14.4 MJ pulsed capacitor bank generator will be operational in December 1998. We present the characteristics of the pulse generator in the first section and justify the choice of a high operation voltage, here 24 kV, necessary to operate the 14 MJ coils. The second section is a comment on the reliability of the pulsed bank.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2009
Work has been intensified around the integration of textile and measurement technology for physio... more Work has been intensified around the integration of textile and measurement technology for physiological measurements in the last years. As a result nowadays it is possible to find available commercial products for cardiovascular personal healthcare monitoring. Most of the efforts have been focused in the acquisition of EKG for cardiovascular monitoring where textile electrodes have shown satisfactory performance. Electrical Bioimpedance is another type of physiological measurement that can be used for personal healthcare monitoring where the integration and the performance of the textile electrodes has not been investigated that thoroughly. In this work, the influence of the textile electrodes on the measurements and on the estimation of the Cole (R(0), R(infinity), f(C) and alpha) and body composition (TBW, ICW, ECW and FFM) parameters has been especially addressed. Complex Spectroscopy 4-electrode wrist-to-ankle electrical bioimpedance measurements taken with conventional Ag/AgCl...
Proceedings of 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 1994
Abstract-A methodology based on heart rate variability (HRV) analysis, is proposed to study ambul... more Abstract-A methodology based on heart rate variability (HRV) analysis, is proposed to study ambulatory sudden death in Chagas patients who died while wearing a Holter monitor. The HRV evolution over time before death is carefully reviewed and a Compressed Spectral Array ( ...
Gastroenterology, 2014
No therapy has been proven to prevent the recurrence of diverticulitis. Mesalamine has shown effi... more No therapy has been proven to prevent the recurrence of diverticulitis. Mesalamine has shown efficacy in preventing relapse in inflammatory bowel disease, and there is preliminary evidence that it might be effective for diverticular disease. We investigated the efficacy of mesalamine in preventing recurrence of diverticulitis in 2 identical but separate phase 3, randomized, double-blind, placebo-controlled, multicenter trials (identical confirmatory trials were conducted for regulatory reasons). We evaluated the efficacy and safety of multimatrix mesalamine vs placebo in the prevention of recurrent diverticulitis in 590 (PREVENT1) and 592 (PREVENT2) adult patients with ≥1 episodes of acute diverticulitis in the previous 24 months that resolved without surgery. Patients received mesalamine (1.2 g, 2.4 g, or 4.8 g) or placebo once daily for 104 weeks. The primary end point was the proportion of recurrence-free patients at week 104. Diverticulitis recurrence was defined as surgical intervention at any time for diverticular disease or presence of computed tomography scan results demonstrating bowel wall thickening (>5 mm) and/or fat stranding consistent with diverticulitis. For a portion of the study, recurrence also required the presence of abdominal pain and an increase in white blood cells. Mesalamine did not reduce the rate of diverticulitis recurrence at week 104. Among patients in PREVENT1, 53%-63% did not have disease recurrence, compared with 65% of those given placebo. Among patients in PREVENT2, 59%-69% of patients did not have disease recurrence, compared with 68% of those given placebo. Mesalamine did not reduce time to recurrence, and the proportions of patients requiring surgery were comparable among treatment groups. No new adverse events were identified with mesalamine administration. Mesalamine was not superior to placebo in preventing recurrent diverticulitis. Mesalamine is not recommended for this indication. ClinicalTrials.gov ID: NCT00545740 and NCT00545103.
The use of polymer replication methods such as Micro Injection Molding (MIM), can reduce drastica... more The use of polymer replication methods such as Micro Injection Molding (MIM), can reduce drastically production costs of Micro Electro Mechanical Systems (MEMS) at medium or large scale. The MIM replication of micro-features with high aspect ratios is a problem which requires a complex molding cycle, and further flow modelling techniques, that have to be more deeply investigated. A special approach to this problem is developed in the present work, in which a new modular mold is designed to be employed in MIM experiments. The new design considers important factors such as mold temperature and cavities venting that are determinant in the filling of micro-features. But the main goal of the proposed system is the ability to replace the investigated cavity in a short period of time, without discarding the most of the mold structure components, becoming very suitable equipment for MIM research activity.
The assumed active Volcanoes has been extensive monitored by means of several techniques, as GPS ... more The assumed active Volcanoes has been extensive monitored by means of several techniques, as GPS equipment in order to search important slope changes, surface temperature, volcanic tremors, camera films, changes in gravity or magnetic fields, among others. In particular the Popocatepetl Volcano, situated near to the cities of Mexico and Puebla, has been monitored from around 20 years ago. The
Proceedings of Computers in Cardiology Conference, 1993
Mal de Chaaas, a tropical infection, is a major public health problem in Latin America. The infec... more Mal de Chaaas, a tropical infection, is a major public health problem in Latin America. The infection can lead to heart disease - chagasic myocarditis - ultimately resulting in arrhythmic death. The high resolution electrocardiogram may offer a means of monitoring the evolution of ...
Apunts. Medicina de l'Esport, 2008
Journal of Human Sport and Exercise, 2010
Abstract: The main aim of this study was to determine if short-term post exercise recovery, cycli... more Abstract: The main aim of this study was to determine if short-term post exercise recovery, cycling performance and blood analysis were altered when consuming three different beverages with the same amounts of calories, a carbohydrate-only beverage (CHO, 9% ...
Viral Immunology, 2012
Human papillomavirus (HPV) is associated with premalignant lesions such as high-grade cervical in... more Human papillomavirus (HPV) is associated with premalignant lesions such as high-grade cervical intraepithelial neoplasia (CIN-III) with potential progression to cervical carcinoma. There are now preventive vaccines against HPV. However, no effective therapeutic vaccine or immunological treatment exists for individuals already infected or for the 470,000 women that develop high-grade dysplasia, carcinoma in situ, and cervical cancer each year. More than half of these women die from cervical cancer. Relative nonimmunogenicity of HPV infection is one of the main reasons for the difficulty in designing a comprehensive therapeutic vaccine against HPV-induced premalignant lesions and cervical carcinoma. HPV E6 and E7 proteins, the major HPV oncogenes, are highly immunogenic but fail to induce cross-reactive and protective immune responses against heterologous strains. We designed and synthesized a therapeutic peptide vaccine comprised of multivalent peptide mixtures called hypervariable epitope constructs (HECs) that represent the major epitope variants of the oncogenic E7 structural protein, and assessed their immunogenicity and in vivo efficacy in mice. Our results show that this peptide vaccine can induce strong, HPV-specific, T-helper cell and CTL responses. More significantly, we have demonstrated that the vaccine is efficacious as a therapeutic agent in a mouse HPV tumor model. Therefore, the HPV HEC vaccine approach described herein can potentially prevent progression of HPV-associated premalignant lesions, and may also be therapeutic against tumors associated with HPV.
Tissue Engineering Part C: Methods, 2009
Engineered tissues represent a natural environment for studying cell physiology, mechanics, and f... more Engineered tissues represent a natural environment for studying cell physiology, mechanics, and function. Cellular interactions with the extracellular matrix proteins are important determinants of cell physiology and tissue mechanics. Dysregulation of these parameters can result in diseases such as cardiac fibrosis and atherosclerosis. In this report we present a novel system to produce hydrogel tissue constructs (HTCs) and to characterize their mechanical properties. HTCs are grown in custom chambers and a robotic system is used to indent them and measure the resulting forces. Force measurements are then used to estimate HTC pretension (cellular contractility). Pretension was reduced in a dose-dependent manner by cytochalasin D (CD) treatment; the highest concentration (2 mM) resulted in *10-fold decrease. On the other hand, treatment with fetal bovine serum (20%) resulted in approximately threefold increase in pretension. Excellent repeatability and precision were observed in measurements from replicate HTCs. The coefficient of statistical variance of quantified pretension ranged from 7% to 15% (n ¼ 4). Due to the small size (4Â4Â0.8 mm) of the HTCs, this system of profiling HTC mechanics can readily be used in high-throughput applications. In particular, it can be used for screening chemical libraries in search of drugs that can alter tissue mechanics.
Journal of Human Sport and Exercise, 2009
... Millard-Stafford et al., (2005) compared the effects of a carbohydrateprotein beverage with ... more ... Millard-Stafford et al., (2005) compared the effects of a carbohydrateprotein beverage with an isocaloric CHO beverage and reported time to fatigue results similar to those found in the present study, thus supporting the position that much of the performance difference observed ...
International Journal of Architectural Computing, 2005
This paper proposes a general method to make animated presentations of architectural designs, bas... more This paper proposes a general method to make animated presentations of architectural designs, based on cinematographic techniques. Particularly, it reviews theoretical documentation about filmmaking as well as several productions that exhibit remarkable locations. The proposed method first comprises of a planning stage, with the narrative and graphic formulation of the presentation. Next is an elaboration or adjustment stage for the digital modelling of the design, and finally, there is an animation production and editing stage. Likewise, the research sets up a computer implementation of some activities and characteristics, and experiments in the programming of camera movements for architectural animations. In general, this work suggests focusing on the communication of the qualitative features of the design, instead of the elaboration of the digital model, and on emphasizing the visual diversity, graphic style and narrative construction of the presentation.
Digestion, 2013
Previous research has shown that infliximab (IFX) is effective in the management of moderate to s... more Previous research has shown that infliximab (IFX) is effective in the management of moderate to severe active ulcerative colitis (UC). Latin American studies are lacking. To evaluate the efficacy of IFX treatment (including corticosteroid withdrawal, complete mucosal healing, colectomy and hospitalization rates) in patients with moderate to severe UC. A retrospective and descriptive study was conducted on patients with UC in Medellín (Colombia). We included patients steroid dependent or refractory to conventional treatment. Between October 2005 and July 2011, 28 patients with moderate to severe UC received IFX infusions; the median of the follow-up was 27.4 months (range: 1-69 months). Twenty-four patients (86%) had a short-term primary response, whilst 19 (68%) achieved initial clinical remission. After 1 year, 17 (71%) out of the 24 patients who had an initial response were also showing a sustained response, and 10 (42%) remained in clinical remission. At 6 months, complete mucosal healing was observed in 29% of patients and endoscopic improvement in 57%. This is the first study to evaluate the IFX use in patients with moderate to severe active UC in a Latin American population. We found that IFX therapy is effective for inducing clinical remission, and that most patients who had an initial response showed a long-term sustained response.
Frontiers in computational neuroscience, 2015
Mounting evidence suggests that both α and γ motoneurons are active during movement and posture, ... more Mounting evidence suggests that both α and γ motoneurons are active during movement and posture, but how does the central motor system coordinate the α-γ controls in these tasks remains sketchy due to lack of in vivo data. Here a computational model of α-γ control of muscles and spindles was used to investigate α-γ integration and coordination for movement and posture. The model comprised physiologically realistic spinal circuitry, muscles, proprioceptors, and skeletal biomechanics. In the model, we divided the cortical descending commands into static and dynamic sets, where static commands (α s and γ s ) were for posture maintenance and dynamic commands (α d and γ d ) were responsible for movement. We matched our model to human reaching movement data by straightforward adjustments of descending commands derived from either minimal-jerk trajectories or human EMGs. The matched movement showed smooth reach-to-hold trajectories qualitatively close to human behaviors, and the reproduced...
The existence of a magnetic birefringence of vacuum is one of the most important predictions of q... more The existence of a magnetic birefringence of vacuum is one of the most important predictions of quantum electrodynamics, which has not yet been verified. In this contribution, we present a new project, the BMV (Biréfringence Magnétique du Vide) project, a collaboration between different Grenoble, Lyon and Toulouse institutes. The proposed experimental set-up, compared to previous attempts, should improve the signal
Megagauss Magnetic Field Generation, its Application to Science and Ultra-High Pulsed-Power Technology - Proceedings of the VIIIth International Conference on Megagauss Magnetic Field Generation and Related Topics, 2004
The 14.4 MJ pulsed capacitor bank generator will be operational in December 1998. We present the ... more The 14.4 MJ pulsed capacitor bank generator will be operational in December 1998. We present the characteristics of the pulse generator in the first section and justify the choice of a high operation voltage, here 24 kV, necessary to operate the 14 MJ coils. The second section is a comment on the reliability of the pulsed bank.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2009
Work has been intensified around the integration of textile and measurement technology for physio... more Work has been intensified around the integration of textile and measurement technology for physiological measurements in the last years. As a result nowadays it is possible to find available commercial products for cardiovascular personal healthcare monitoring. Most of the efforts have been focused in the acquisition of EKG for cardiovascular monitoring where textile electrodes have shown satisfactory performance. Electrical Bioimpedance is another type of physiological measurement that can be used for personal healthcare monitoring where the integration and the performance of the textile electrodes has not been investigated that thoroughly. In this work, the influence of the textile electrodes on the measurements and on the estimation of the Cole (R(0), R(infinity), f(C) and alpha) and body composition (TBW, ICW, ECW and FFM) parameters has been especially addressed. Complex Spectroscopy 4-electrode wrist-to-ankle electrical bioimpedance measurements taken with conventional Ag/AgCl...
Proceedings of 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 1994
Abstract-A methodology based on heart rate variability (HRV) analysis, is proposed to study ambul... more Abstract-A methodology based on heart rate variability (HRV) analysis, is proposed to study ambulatory sudden death in Chagas patients who died while wearing a Holter monitor. The HRV evolution over time before death is carefully reviewed and a Compressed Spectral Array ( ...
Gastroenterology, 2014
No therapy has been proven to prevent the recurrence of diverticulitis. Mesalamine has shown effi... more No therapy has been proven to prevent the recurrence of diverticulitis. Mesalamine has shown efficacy in preventing relapse in inflammatory bowel disease, and there is preliminary evidence that it might be effective for diverticular disease. We investigated the efficacy of mesalamine in preventing recurrence of diverticulitis in 2 identical but separate phase 3, randomized, double-blind, placebo-controlled, multicenter trials (identical confirmatory trials were conducted for regulatory reasons). We evaluated the efficacy and safety of multimatrix mesalamine vs placebo in the prevention of recurrent diverticulitis in 590 (PREVENT1) and 592 (PREVENT2) adult patients with ≥1 episodes of acute diverticulitis in the previous 24 months that resolved without surgery. Patients received mesalamine (1.2 g, 2.4 g, or 4.8 g) or placebo once daily for 104 weeks. The primary end point was the proportion of recurrence-free patients at week 104. Diverticulitis recurrence was defined as surgical intervention at any time for diverticular disease or presence of computed tomography scan results demonstrating bowel wall thickening (>5 mm) and/or fat stranding consistent with diverticulitis. For a portion of the study, recurrence also required the presence of abdominal pain and an increase in white blood cells. Mesalamine did not reduce the rate of diverticulitis recurrence at week 104. Among patients in PREVENT1, 53%-63% did not have disease recurrence, compared with 65% of those given placebo. Among patients in PREVENT2, 59%-69% of patients did not have disease recurrence, compared with 68% of those given placebo. Mesalamine did not reduce time to recurrence, and the proportions of patients requiring surgery were comparable among treatment groups. No new adverse events were identified with mesalamine administration. Mesalamine was not superior to placebo in preventing recurrent diverticulitis. Mesalamine is not recommended for this indication. ClinicalTrials.gov ID: NCT00545740 and NCT00545103.
The use of polymer replication methods such as Micro Injection Molding (MIM), can reduce drastica... more The use of polymer replication methods such as Micro Injection Molding (MIM), can reduce drastically production costs of Micro Electro Mechanical Systems (MEMS) at medium or large scale. The MIM replication of micro-features with high aspect ratios is a problem which requires a complex molding cycle, and further flow modelling techniques, that have to be more deeply investigated. A special approach to this problem is developed in the present work, in which a new modular mold is designed to be employed in MIM experiments. The new design considers important factors such as mold temperature and cavities venting that are determinant in the filling of micro-features. But the main goal of the proposed system is the ability to replace the investigated cavity in a short period of time, without discarding the most of the mold structure components, becoming very suitable equipment for MIM research activity.
The assumed active Volcanoes has been extensive monitored by means of several techniques, as GPS ... more The assumed active Volcanoes has been extensive monitored by means of several techniques, as GPS equipment in order to search important slope changes, surface temperature, volcanic tremors, camera films, changes in gravity or magnetic fields, among others. In particular the Popocatepetl Volcano, situated near to the cities of Mexico and Puebla, has been monitored from around 20 years ago. The
Proceedings of Computers in Cardiology Conference, 1993
Mal de Chaaas, a tropical infection, is a major public health problem in Latin America. The infec... more Mal de Chaaas, a tropical infection, is a major public health problem in Latin America. The infection can lead to heart disease - chagasic myocarditis - ultimately resulting in arrhythmic death. The high resolution electrocardiogram may offer a means of monitoring the evolution of ...
Apunts. Medicina de l'Esport, 2008
Journal of Human Sport and Exercise, 2010
Abstract: The main aim of this study was to determine if short-term post exercise recovery, cycli... more Abstract: The main aim of this study was to determine if short-term post exercise recovery, cycling performance and blood analysis were altered when consuming three different beverages with the same amounts of calories, a carbohydrate-only beverage (CHO, 9% ...
Viral Immunology, 2012
Human papillomavirus (HPV) is associated with premalignant lesions such as high-grade cervical in... more Human papillomavirus (HPV) is associated with premalignant lesions such as high-grade cervical intraepithelial neoplasia (CIN-III) with potential progression to cervical carcinoma. There are now preventive vaccines against HPV. However, no effective therapeutic vaccine or immunological treatment exists for individuals already infected or for the 470,000 women that develop high-grade dysplasia, carcinoma in situ, and cervical cancer each year. More than half of these women die from cervical cancer. Relative nonimmunogenicity of HPV infection is one of the main reasons for the difficulty in designing a comprehensive therapeutic vaccine against HPV-induced premalignant lesions and cervical carcinoma. HPV E6 and E7 proteins, the major HPV oncogenes, are highly immunogenic but fail to induce cross-reactive and protective immune responses against heterologous strains. We designed and synthesized a therapeutic peptide vaccine comprised of multivalent peptide mixtures called hypervariable epitope constructs (HECs) that represent the major epitope variants of the oncogenic E7 structural protein, and assessed their immunogenicity and in vivo efficacy in mice. Our results show that this peptide vaccine can induce strong, HPV-specific, T-helper cell and CTL responses. More significantly, we have demonstrated that the vaccine is efficacious as a therapeutic agent in a mouse HPV tumor model. Therefore, the HPV HEC vaccine approach described herein can potentially prevent progression of HPV-associated premalignant lesions, and may also be therapeutic against tumors associated with HPV.
Tissue Engineering Part C: Methods, 2009
Engineered tissues represent a natural environment for studying cell physiology, mechanics, and f... more Engineered tissues represent a natural environment for studying cell physiology, mechanics, and function. Cellular interactions with the extracellular matrix proteins are important determinants of cell physiology and tissue mechanics. Dysregulation of these parameters can result in diseases such as cardiac fibrosis and atherosclerosis. In this report we present a novel system to produce hydrogel tissue constructs (HTCs) and to characterize their mechanical properties. HTCs are grown in custom chambers and a robotic system is used to indent them and measure the resulting forces. Force measurements are then used to estimate HTC pretension (cellular contractility). Pretension was reduced in a dose-dependent manner by cytochalasin D (CD) treatment; the highest concentration (2 mM) resulted in *10-fold decrease. On the other hand, treatment with fetal bovine serum (20%) resulted in approximately threefold increase in pretension. Excellent repeatability and precision were observed in measurements from replicate HTCs. The coefficient of statistical variance of quantified pretension ranged from 7% to 15% (n ¼ 4). Due to the small size (4Â4Â0.8 mm) of the HTCs, this system of profiling HTC mechanics can readily be used in high-throughput applications. In particular, it can be used for screening chemical libraries in search of drugs that can alter tissue mechanics.
Journal of Human Sport and Exercise, 2009
... Millard-Stafford et al., (2005) compared the effects of a carbohydrateprotein beverage with ... more ... Millard-Stafford et al., (2005) compared the effects of a carbohydrateprotein beverage with an isocaloric CHO beverage and reported time to fatigue results similar to those found in the present study, thus supporting the position that much of the performance difference observed ...
International Journal of Architectural Computing, 2005
This paper proposes a general method to make animated presentations of architectural designs, bas... more This paper proposes a general method to make animated presentations of architectural designs, based on cinematographic techniques. Particularly, it reviews theoretical documentation about filmmaking as well as several productions that exhibit remarkable locations. The proposed method first comprises of a planning stage, with the narrative and graphic formulation of the presentation. Next is an elaboration or adjustment stage for the digital modelling of the design, and finally, there is an animation production and editing stage. Likewise, the research sets up a computer implementation of some activities and characteristics, and experiments in the programming of camera movements for architectural animations. In general, this work suggests focusing on the communication of the qualitative features of the design, instead of the elaboration of the digital model, and on emphasizing the visual diversity, graphic style and narrative construction of the presentation.