Mujeeb Memon | SINDH AGRICULTURE UNIVERSITY (original) (raw)

Papers by Mujeeb Memon

Research paper thumbnail of Lack of reversal from lead acetate‐induced hepatotoxicity, free radical generation and oxidative stress in Wistar rats (1139.17)

Research paper thumbnail of Failure of recovery from lead‐acetate‐induced oxidative stress and cardiotoxicity in Wistar rats (648.14)

Research paper thumbnail of Reversal of Diabetic Complications in Andrology Parameters of Alloxan-Induced Diabetic Male Wistar Rats Treated with Cleome rutidosperma Leaves

Folia Veterinaria, 2020

Male infertility is one of the complications associated with diabetes mellitus. This study report... more Male infertility is one of the complications associated with diabetes mellitus. This study reported the effect of managing experimentally-induced diabetes in male Wistar rats with Cleome rutidosperma leaf extract at doses of 100 mg.kg−1, 200 mg.kg−1 or 400 mg.kg−1 for 14 days. Further deterioration or amelioration of reproductive derangement was assessed by changes in sperm morphology, sperm characteristics, and testicular histo-pathology. Andrology profile of diabetic untreated rats showed significant (P < 0.05) derangements compared to normoglycaemic rats. The profile of diabetic rats treated with the extract of C. rutidosperma, especially at the 200 mg.kg−1 dose showed a significant decrease in abnormal sperm cells, increases in sperm motility, live/ dead ratio and count compared to the untreated diabetic rats. Histopathology showed spermatogenic arrest and degeneration of Sertoli cells in the diabetic untreated rats, but was restored in the C. rutidosperma treated rats. This ...

Research paper thumbnail of Comparison of the prevalence of trypanosomal infection in indigenous cattle in the Guinea and Derived Savannah Vegetational Zones of South-Western Nigeria

Nigerian Journal of Animal Production, 2021

wo hundred and two blood samples from White Fulani breed of cattle, comprising 130 from the Guine... more wo hundred and two blood samples from White Fulani breed of cattle, comprising 130 from the Guinea Savannah and 72 from the derived Savannah vegetational zones of South-Western Nigeria were examined for presence of trypanosomes. These animals were reared under the nomadic system of management such that they were constantly exposed to tsetse bite both during the day and night The results of this analysis showed that the prevalence of trypanosomal infection in the Derived Savannah and Guinea Savannah vegetational zones were 45.8% and 27.5 % respectively. Though the incidence of trypanosomal infection is less in the Guinea Savannah vegetational zone reluta to the Derived Savannah, livestock production during the dry season is severely limited due to inadequate pasture at this time of the year.

Research paper thumbnail of Telferia Occidentalis and Vitamin C Attenuate Phenylhydrazine-Induced Haemolytic Anaemia and Associated Cardio-renal Dysfunctions via Inhibition of Oxidative Stress and Proapoptotic -Protein (Bax) Expressions

Drug Research, 2017

Background The study investigated the modulatory roles of the aqueous leaf extract of Telferia oc... more Background The study investigated the modulatory roles of the aqueous leaf extract of Telferia occidentalis, a traditional haematinic, and vitamin C on cardiovascular dysfunction associated with subchronic Phenylhydrazine exposure. Methods Fifty adult male rats were randomly selected and divided into one of five groups of ten animals each: Control; 40 mgkg−1 Phenylhydrazine (PHZ); PHZ with 100 mgkg−1 T.occidentalis; PHZ with 200 mgkg−1 T.occidentalis; and PHZ with 100 mgkg−1 vitamin C. Results Oral exposure of rats to PHZ, without T. occidentalis or vitamin C treatment, resulted in a significant (p<0.05) decrease in the haematological parameters, but increased the blood pressure parameters of rats However, treatment with vitamin C and T. occidentalis leaf extract significantly (p<0.05) ameliorated the aforementioned PHZ-induced alterations of rats haemogram, and blood pressure. Biochemical analysis revealed significant (p<0.05) reduction in the activities of superoxide dism...

Research paper thumbnail of Biochemical and electrocardiographic studies on the beneficial effects of gallic acid in cyclophosphamide-induced cardiorenal dysfunction

Journal of Complementary and Integrative Medicine, 2017

BackgroundCardiac toxicity is one of the life-threatening complications of cancer therapy. Cyclop... more BackgroundCardiac toxicity is one of the life-threatening complications of cancer therapy. Cyclophosphamide (CYP) is an alkylating agent with potent antineoplastic and immunosuppressive properties and possibly the most widely used antineoplastic agent. Chronic cardiotoxicity associated with CYP is characterized by progressive heart failure developing from weeks to years after therapy.MethodsIn this study, rats were administered with (60 mg/kg and 120 mg/kg) alone or in combination with single intraperitoneal (200 mg/kg) administration of CYP for 7 days. CYP was only administered on day 1.ResultsThe administration of CYP led to a significant (p<0.05) increase in cardiac and renal malondialdehyde (MDA) contents and hydrogen peroxide (HConclusionsIn this study, treatment with gallic acid (60 mg/kg and 120 mg/kg) restored the enzymic and non-enzymic antioxidants and also attenuated cardiotoxic and nephrotoxic effect of CYP through free radical scavenging activity, anti-inflammatory a...

Research paper thumbnail of Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical

International Journal of Preventive Medicine, 2016

Background: Gallic acid (GA) is an endogenous plant phenol known to have antioxidant, free radica... more Background: Gallic acid (GA) is an endogenous plant phenol known to have antioxidant, free radical scavenging ability, anti-inflammatory, anti-cancer, and anti-fungal properties. The aim of this study was to assess the protective effect of GA on cyclophosphamide (CPA)-induced hepatotoxicity in male Wistar rats. Methods: Sixty rats were grouped into six groups of 10 rats per group. Group 1 received distilled water. Group 2 received CPA at 200 mg/kg single dose intraperitoneally on day 1. Groups 3 and 4 received a single dose of CPA (200 mg/kg) intraperitoneally on day 1 and then were treated with GA at 60 and 120 mg/kg body weight for 14 days, respectively. Rats in Groups 5 and 6 only received GA at 60 and 120 mg/kg body weight for 14 days, respectively. GA was administered orally. Results: CPA induced hepatic damage as indicated by significant elevation (P < 0.05) in aspartate aminotransferase, organ weight, and evidence by the histological study. CPA also induced hepatic oxidative stress as indicated by significant elevation (P < 0.05) in malondialdehyde content, hydrogen peroxide (H 2 O 2) generation, nitrite level, and the level of glutathione (GSH) peroxidase crashed in the CPA-treated group. GA enhanced the antioxidant defense system as indicated by significant elevation (P < 0.05) in GSH level, catalase activity, and GSH-S-transferase activity. Conclusions: Taken together, the result of this present study shows that GA has a protective effect on CPA-induced hepatotoxicity.

Research paper thumbnail of Studies on the Evaluation of Moisture and Ash Content in Kamori, Pateri and Tapri Goat Meat

The aim of this work was to evaluate the moisture and ash content in meat of three different loca... more The aim of this work was to evaluate the moisture and ash content in meat of three different local breeds of goat (Kamori, Pateri and Tapri). A total of 30 samples were randomly collected from the local market of Tandojam- Pakistan. The results revealed that the average moisture content in meat of Kamori breed was 76.56 ± 0.72% which is comparatively higher than the mean moisture content in meat of Pateri and Tapri i.e. 72.63 ± 1.13% and 69.88 ± 0.93% respectively. The over all moisture content in goat meat varied in a range of 65.92 and 80.02% (mean 73.02 ± 0.732%). There were statistically highly significant differences (P< 0.001) observed in meat of different breeds of goat. Further results of LSD (0.05) comparison of means revealed that the moisture content in meat of different of goat are significant (P< 0.001) from each other. The ash content in meat of all three breeds of goat meat was in a range of 0.87 and 1.97% (mean 1.40 ± 0.049%). Statistically there were highly si...

Research paper thumbnail of The ethnobotanical, phytochemical and mineral analyses of phragmanthera incana (klotzsch), a species of mistletoe growing on three plant hosts in South-Western Nigeria

International journal of biomedical science : IJBS, 2013

Mistletoe is collected wildly on various plants and Phragmanthera incana is noted to grow on diff... more Mistletoe is collected wildly on various plants and Phragmanthera incana is noted to grow on different plant hosts. This study was designed to carry out the ethnobotanical survey, phytochemical and mineral analyses of Phragmanthera incana, a species of mistletoe growing on three plant hosts namely Cocoa (Theobroma cacao), Kolanut (Cola nitida) and Bush mango (Irvingia gabonensis). Mistletoe samples were identified at the Forestry Research Institute of Nigeria Herbarium. Phragmanthera incana was screened for its phytochemical constituents and mineral cations along its hosts following standard methods and to confirm if the mistletoe species is host specific. The powdered samples of the mistletoe species (Phragmanthera incana) was used for both the phytochemical screening and the cation mineral analysis. The uses and the harvesting methods of mistletoe were also reviewed extensively in this paper.

Research paper thumbnail of Hepatocellular carcinoma and the underlying mechanisms

African health sciences, 2010

The incidence of hepatocellular carcinoma is increasing worldwide as well as the associated risk ... more The incidence of hepatocellular carcinoma is increasing worldwide as well as the associated risk factors, some of which include exposure to aflatoxin B1, Hepatitis B (HBV) virus and hepatitis C (HCV) virus. Mutation of tumour suppressor gene p53 at codon 249(ser) at exon 7 has been found to contribute significantly to replication of damaged DNA and subsequent tumour progression. The x gene of HBV (HBx) is the most common open reading frame integrated into the host genome in hepatocellular carcinoma and the integrated HBx is frequently mutated in hepatocellular carcinoma. Mutant HBx proteins still retain their ability to bind to p53 thereby attenuating DNA repair and p53-mediated apoptosis.

Research paper thumbnail of Curcumin: from food spice to cancer prevention

Asian Pacific journal of cancer prevention : APJCP, 2009

Curcumin [1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6 heptadiene-3, 5-dione] is an orange-yellow co... more Curcumin [1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6 heptadiene-3, 5-dione] is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder. It is known to have a variety of biologic and pharmacologic activities, including anti-inflammatory, anti-oxidant, and anticarcinogenic potential. It is a potent inhibitor of cytochrome P450 with capacity to simultaneously induce detoxifying enzymes such as glutathione S-transferase and as such may find application as a chemopreventive agent. Curcumin is a potent inhibitor of cyclooxygenase-2, lipooxygenase, ornithine decarboxylase (ODC), nuclear factor-kappaB, c-Jun N-terminal kinase and protein kinase C and has also been demonstrated to play a vital role against pathological conditions such as cancer, atherosclerosis, and neurodegenerative diseases.

Research paper thumbnail of A survey of commonly used herbal drugs in veterinary practice in southwest Nigeria

Research paper thumbnail of Population Diversity of Mosquito Fauna in and around Tandojam- Pakistan

International Journal for Agro Veterinary and Medical Sciences, 2012

Research work was undertaken to investigate the prevalence of mosquito genera in Tandojam and its... more Research work was undertaken to investigate the prevalence of mosquito genera in Tandojam and its surroundings from May to June 2010. A total of 2316 mosquito samples were collected which belongs to five genera viz; Culex, Anopheles, Aedes, Uranotaenia and Psorophora comprising 49%, 16%, 1.4%, 11.7% and 21.8% respectively. A total of 563 mosquitoes were collected from marshy/swampy areas, Psorophora were the most abundant 218 (38.7%) followed by 138 (24.5%), 123 (21.8%) and 84 (14.9%) Uranotaenia, Anopheles and Culex respectively. A total of 277 mosquitoes were collected from lavatories among which Culex were dominant 239 (86.3%) followed by 23 (8.3%) Anopheles and 15 (5.4%) Psorophora were identified. There were 186 mosquitoes collected from ditches and Culex were the most prevalent as 105 samples (56.5%) were collected followed by 81 samples (43.5%) Anopheles. A total of 552 mosquitoes were collected from grassy areas results revealed that Psorophora were the most abundant that is 273 (49.5%) followed by Uranotaenia, Culex, Aedes and Anopheles. with abundance of 133 (24%), 94 (17%), 32 (5.8%) and 20 (3.6%) respectively. A total of 629 adult mosquitoes were collected from animal pens. The most common genus Culex comprising 524 samples (83.3%) and least common was Anopheles 105 samples (16.7%). A total of 109 adult mosquito samples were taken from houses/containers belongs to 2 genera. Culex were by far the most abundant 89 (81.7%) followed by Anopheles 20 (18.3%).

Research paper thumbnail of Effects of dexamethasone on the infectivity of Trypanosoma vivax Y486 and the haematological changes in Nigerian domestic chickens (Gallus gallus …

VETERINARSKI ARHIV, 2004

ADEDAPO, A. A., A. B. SABA, O. A. DINA, G. M. A. OLADEJO: Effects of dexamethasone on the infecti... more ADEDAPO, A. A., A. B. SABA, O. A. DINA, G. M. A. OLADEJO: Effects of dexamethasone on the infectivity of Trypanosoma vivax Y486 and the haematological changes in Nigerian domestic chickens (Gallus gallus domesticus). Vet. arhiv 74, 371-381, 2004.

Research paper thumbnail of Prevalence and pathological lesions of bovine tuberculosis assessment through routine procedures of meat inspection in infected cattle in Karachi metropolitan corporation abattoirs

Pure and Applied Biology, 2019

Bovine tuberculosis (bTB) caused by Mycobacterium bovis is one of the most important zoonotic dis... more Bovine tuberculosis (bTB) caused by Mycobacterium bovis is one of the most important zoonotic disease that poses huge economic losses in livestock population worldwide. A cross sectional study was therefore designed to investigate its prevalence and efficacy of meat inspection procedures for its detection in slaughtered cattle at two abattoirs of Karachi. A total 2000 were examined during March 2015 to September 2016 in which 943 animals were found suspected for bTB and necropsied from which 1170 organ samples were collected. The data collected was analyzed using Chi-square test. Results of regular and complete examination revealed that 8.12% organ samples had positive lesions of tuberculosis. The highest frequency of lesions were observed in lungs and its associated lymphnodes (64%) i.e. mediastinal lymphnodes (27%), tracheobronchial lymphnodes (26%), lungs (11%) respectively. There was a significant difference (P < 0.05) in prevalence of bTB amongst sex of cattle. Females were found at high risk of bTB. It was concluded from the results that however bTB is highly prevalent in cattle and sensitivity of inspection protocols may influence reporting positive cases. Thus it is suggested that more advanced and sensitive methods should be used for screening of tuberculosis in cattle population.

Research paper thumbnail of Comparative study on the potency of trivalent vaccine of foot and mouth disease in different cattle breeds and triggered immune response signaling pathway

Large Animal Review, 2020

Research paper thumbnail of Toxoplasma Gondii Infection in Caprine and Ovine in the Desert Areas of Tharparkar: Seroprevalence and Risk Factors

Mujeeb-ur-Rahman Memon1*, Jahan Ara Baloch2, Abdullah G. Arijo3, Allah Bux Kachiwal4 and Nida Pir... more Mujeeb-ur-Rahman Memon1*, Jahan Ara Baloch2, Abdullah G. Arijo3, Allah Bux Kachiwal4 and Nida Pirzada5 1Department of Veterinary Medicine 2Pathology Section, Central Veterinary Diagnostic Laboratory, Tandojam 3Department of Veterinary Parasitology, Sindh Agriculture University, Tandojam 4Department of Veterinary Physiology 5Baqai Veterinary College, Karachi *Corresponding author: drmujeebsau@gmail.com

Research paper thumbnail of Studies on the prevalence of ectoparasites in owned dogs and major risk infestation to human health in Karachi, Sindh Pakistan

The present study was conducted to investigate the prevalence, intensity and distribution of natu... more The present study was conducted to investigate the prevalence, intensity and distribution of natural infestation of ectoparasites and their species in owned dogs during the period of June to November 2017 in Karachi, Sindh, Pakistan. One hundred fifty domestic dogs (90 males, 60 females) with age ranging from 60 days to 9 years were examined for ectoparasites infestation including (tick, lice, flea and mite) in Karachi city. A prevalence of ectoparasites 43.33% was identified in dogs. A total number of 164 ectoparasites were collected. The most common ectoparasites were Rhipicephalus sanguineus tick, which infested 59 of the 150 dogs (39.33%) followed by Ctenocephalides canis and Demodex canis was identified on 7/150 dogs (4.67%), Dermacentor reticulates and Trichodectes canis 6/150 dogs (4.0%) respectively and Ctenocephalides felis 2/150 (1.33%), that the highest infestation rate was seen in June (30.86%). No itching and scratching was found in 93.6 percent. Ectoparasites were sign...

Research paper thumbnail of Factors influencing knowledge and practices for prevention of bovine tuberculosis amongst workers at Abattoir in Karachi

Pure and Applied Biology

Present study was designed to investigate the level of knowledge and practices for prevention of ... more Present study was designed to investigate the level of knowledge and practices for prevention of Bovine Tuberculosis amongst workers at two abattoirs in Karachi. The Data was collected from the herdsman and abattoirs worker at two abattoirs namely City Abattoir Cattle Colony in Landhi and New Karachi slaughterhouse (kamailas) which were working under Karachi Municipal Corporation.120 abattoir workers were interviewed and information was obtained, while frequency counts, percentages and independent sample ttest were used to analyze data. Data indicates the ratio of respondent including herd man and abattoirs workers having no knowledge to those having knowledge was 85:15 Statistical analysis revealed that level of education is potential factor influencing risk of BTB zoonoses amongst abattoir workers Educated respondent were having twice higher knowledge than un educated (OR 0.454, 95% CI 0.236-0.872 P < 0.024).Educated workers demonstrated three time higher practices for preventive measures than non-educated (OR 0.607, 95% CI 0.335-1.102, P< 0.133). Despite having awareness amongst abattoirs worker there was lower level of good practices It was therefore concluded that along with launching awareness program from government organizations it must be ensure practical application of WHO and FAO guidelines for TB free world under one health program ending 2030.

Research paper thumbnail of Factors influencing knowledge and practices for prevention of bovine tuberculosis amongst workers at Abattoir in Karachi

Pure and Applied Biology

Present study was designed to investigate the level of knowledge and practices for prevention of ... more Present study was designed to investigate the level of knowledge and practices for prevention of Bovine Tuberculosis amongst workers at two abattoirs in Karachi. The Data was collected from the herdsman and abattoirs worker at two abattoirs namely City Abattoir Cattle Colony in Landhi and New Karachi slaughterhouse (kamailas) which were working under Karachi Municipal Corporation.120 abattoir workers were interviewed and information was obtained, while frequency counts, percentages and independent sample ttest were used to analyze data. Data indicates the ratio of respondent including herd man and abattoirs workers having no knowledge to those having knowledge was 85:15 Statistical analysis revealed that level of education is potential factor influencing risk of BTB zoonoses amongst abattoir workers Educated respondent were having twice higher knowledge than un educated (OR 0.454, 95% CI 0.236-0.872 P < 0.024).Educated workers demonstrated three time higher practices for preventive measures than non-educated (OR 0.607, 95% CI 0.335-1.102, P< 0.133). Despite having awareness amongst abattoirs worker there was lower level of good practices It was therefore concluded that along with launching awareness program from government organizations it must be ensure practical application of WHO and FAO guidelines for TB free world under one health program ending 2030.

Research paper thumbnail of Lack of reversal from lead acetate‐induced hepatotoxicity, free radical generation and oxidative stress in Wistar rats (1139.17)

Research paper thumbnail of Failure of recovery from lead‐acetate‐induced oxidative stress and cardiotoxicity in Wistar rats (648.14)

Research paper thumbnail of Reversal of Diabetic Complications in Andrology Parameters of Alloxan-Induced Diabetic Male Wistar Rats Treated with Cleome rutidosperma Leaves

Folia Veterinaria, 2020

Male infertility is one of the complications associated with diabetes mellitus. This study report... more Male infertility is one of the complications associated with diabetes mellitus. This study reported the effect of managing experimentally-induced diabetes in male Wistar rats with Cleome rutidosperma leaf extract at doses of 100 mg.kg−1, 200 mg.kg−1 or 400 mg.kg−1 for 14 days. Further deterioration or amelioration of reproductive derangement was assessed by changes in sperm morphology, sperm characteristics, and testicular histo-pathology. Andrology profile of diabetic untreated rats showed significant (P < 0.05) derangements compared to normoglycaemic rats. The profile of diabetic rats treated with the extract of C. rutidosperma, especially at the 200 mg.kg−1 dose showed a significant decrease in abnormal sperm cells, increases in sperm motility, live/ dead ratio and count compared to the untreated diabetic rats. Histopathology showed spermatogenic arrest and degeneration of Sertoli cells in the diabetic untreated rats, but was restored in the C. rutidosperma treated rats. This ...

Research paper thumbnail of Comparison of the prevalence of trypanosomal infection in indigenous cattle in the Guinea and Derived Savannah Vegetational Zones of South-Western Nigeria

Nigerian Journal of Animal Production, 2021

wo hundred and two blood samples from White Fulani breed of cattle, comprising 130 from the Guine... more wo hundred and two blood samples from White Fulani breed of cattle, comprising 130 from the Guinea Savannah and 72 from the derived Savannah vegetational zones of South-Western Nigeria were examined for presence of trypanosomes. These animals were reared under the nomadic system of management such that they were constantly exposed to tsetse bite both during the day and night The results of this analysis showed that the prevalence of trypanosomal infection in the Derived Savannah and Guinea Savannah vegetational zones were 45.8% and 27.5 % respectively. Though the incidence of trypanosomal infection is less in the Guinea Savannah vegetational zone reluta to the Derived Savannah, livestock production during the dry season is severely limited due to inadequate pasture at this time of the year.

Research paper thumbnail of Telferia Occidentalis and Vitamin C Attenuate Phenylhydrazine-Induced Haemolytic Anaemia and Associated Cardio-renal Dysfunctions via Inhibition of Oxidative Stress and Proapoptotic -Protein (Bax) Expressions

Drug Research, 2017

Background The study investigated the modulatory roles of the aqueous leaf extract of Telferia oc... more Background The study investigated the modulatory roles of the aqueous leaf extract of Telferia occidentalis, a traditional haematinic, and vitamin C on cardiovascular dysfunction associated with subchronic Phenylhydrazine exposure. Methods Fifty adult male rats were randomly selected and divided into one of five groups of ten animals each: Control; 40 mgkg−1 Phenylhydrazine (PHZ); PHZ with 100 mgkg−1 T.occidentalis; PHZ with 200 mgkg−1 T.occidentalis; and PHZ with 100 mgkg−1 vitamin C. Results Oral exposure of rats to PHZ, without T. occidentalis or vitamin C treatment, resulted in a significant (p<0.05) decrease in the haematological parameters, but increased the blood pressure parameters of rats However, treatment with vitamin C and T. occidentalis leaf extract significantly (p<0.05) ameliorated the aforementioned PHZ-induced alterations of rats haemogram, and blood pressure. Biochemical analysis revealed significant (p<0.05) reduction in the activities of superoxide dism...

Research paper thumbnail of Biochemical and electrocardiographic studies on the beneficial effects of gallic acid in cyclophosphamide-induced cardiorenal dysfunction

Journal of Complementary and Integrative Medicine, 2017

BackgroundCardiac toxicity is one of the life-threatening complications of cancer therapy. Cyclop... more BackgroundCardiac toxicity is one of the life-threatening complications of cancer therapy. Cyclophosphamide (CYP) is an alkylating agent with potent antineoplastic and immunosuppressive properties and possibly the most widely used antineoplastic agent. Chronic cardiotoxicity associated with CYP is characterized by progressive heart failure developing from weeks to years after therapy.MethodsIn this study, rats were administered with (60 mg/kg and 120 mg/kg) alone or in combination with single intraperitoneal (200 mg/kg) administration of CYP for 7 days. CYP was only administered on day 1.ResultsThe administration of CYP led to a significant (p<0.05) increase in cardiac and renal malondialdehyde (MDA) contents and hydrogen peroxide (HConclusionsIn this study, treatment with gallic acid (60 mg/kg and 120 mg/kg) restored the enzymic and non-enzymic antioxidants and also attenuated cardiotoxic and nephrotoxic effect of CYP through free radical scavenging activity, anti-inflammatory a...

Research paper thumbnail of Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical

International Journal of Preventive Medicine, 2016

Background: Gallic acid (GA) is an endogenous plant phenol known to have antioxidant, free radica... more Background: Gallic acid (GA) is an endogenous plant phenol known to have antioxidant, free radical scavenging ability, anti-inflammatory, anti-cancer, and anti-fungal properties. The aim of this study was to assess the protective effect of GA on cyclophosphamide (CPA)-induced hepatotoxicity in male Wistar rats. Methods: Sixty rats were grouped into six groups of 10 rats per group. Group 1 received distilled water. Group 2 received CPA at 200 mg/kg single dose intraperitoneally on day 1. Groups 3 and 4 received a single dose of CPA (200 mg/kg) intraperitoneally on day 1 and then were treated with GA at 60 and 120 mg/kg body weight for 14 days, respectively. Rats in Groups 5 and 6 only received GA at 60 and 120 mg/kg body weight for 14 days, respectively. GA was administered orally. Results: CPA induced hepatic damage as indicated by significant elevation (P < 0.05) in aspartate aminotransferase, organ weight, and evidence by the histological study. CPA also induced hepatic oxidative stress as indicated by significant elevation (P < 0.05) in malondialdehyde content, hydrogen peroxide (H 2 O 2) generation, nitrite level, and the level of glutathione (GSH) peroxidase crashed in the CPA-treated group. GA enhanced the antioxidant defense system as indicated by significant elevation (P < 0.05) in GSH level, catalase activity, and GSH-S-transferase activity. Conclusions: Taken together, the result of this present study shows that GA has a protective effect on CPA-induced hepatotoxicity.

Research paper thumbnail of Studies on the Evaluation of Moisture and Ash Content in Kamori, Pateri and Tapri Goat Meat

The aim of this work was to evaluate the moisture and ash content in meat of three different loca... more The aim of this work was to evaluate the moisture and ash content in meat of three different local breeds of goat (Kamori, Pateri and Tapri). A total of 30 samples were randomly collected from the local market of Tandojam- Pakistan. The results revealed that the average moisture content in meat of Kamori breed was 76.56 ± 0.72% which is comparatively higher than the mean moisture content in meat of Pateri and Tapri i.e. 72.63 ± 1.13% and 69.88 ± 0.93% respectively. The over all moisture content in goat meat varied in a range of 65.92 and 80.02% (mean 73.02 ± 0.732%). There were statistically highly significant differences (P< 0.001) observed in meat of different breeds of goat. Further results of LSD (0.05) comparison of means revealed that the moisture content in meat of different of goat are significant (P< 0.001) from each other. The ash content in meat of all three breeds of goat meat was in a range of 0.87 and 1.97% (mean 1.40 ± 0.049%). Statistically there were highly si...

Research paper thumbnail of The ethnobotanical, phytochemical and mineral analyses of phragmanthera incana (klotzsch), a species of mistletoe growing on three plant hosts in South-Western Nigeria

International journal of biomedical science : IJBS, 2013

Mistletoe is collected wildly on various plants and Phragmanthera incana is noted to grow on diff... more Mistletoe is collected wildly on various plants and Phragmanthera incana is noted to grow on different plant hosts. This study was designed to carry out the ethnobotanical survey, phytochemical and mineral analyses of Phragmanthera incana, a species of mistletoe growing on three plant hosts namely Cocoa (Theobroma cacao), Kolanut (Cola nitida) and Bush mango (Irvingia gabonensis). Mistletoe samples were identified at the Forestry Research Institute of Nigeria Herbarium. Phragmanthera incana was screened for its phytochemical constituents and mineral cations along its hosts following standard methods and to confirm if the mistletoe species is host specific. The powdered samples of the mistletoe species (Phragmanthera incana) was used for both the phytochemical screening and the cation mineral analysis. The uses and the harvesting methods of mistletoe were also reviewed extensively in this paper.

Research paper thumbnail of Hepatocellular carcinoma and the underlying mechanisms

African health sciences, 2010

The incidence of hepatocellular carcinoma is increasing worldwide as well as the associated risk ... more The incidence of hepatocellular carcinoma is increasing worldwide as well as the associated risk factors, some of which include exposure to aflatoxin B1, Hepatitis B (HBV) virus and hepatitis C (HCV) virus. Mutation of tumour suppressor gene p53 at codon 249(ser) at exon 7 has been found to contribute significantly to replication of damaged DNA and subsequent tumour progression. The x gene of HBV (HBx) is the most common open reading frame integrated into the host genome in hepatocellular carcinoma and the integrated HBx is frequently mutated in hepatocellular carcinoma. Mutant HBx proteins still retain their ability to bind to p53 thereby attenuating DNA repair and p53-mediated apoptosis.

Research paper thumbnail of Curcumin: from food spice to cancer prevention

Asian Pacific journal of cancer prevention : APJCP, 2009

Curcumin [1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6 heptadiene-3, 5-dione] is an orange-yellow co... more Curcumin [1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6 heptadiene-3, 5-dione] is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder. It is known to have a variety of biologic and pharmacologic activities, including anti-inflammatory, anti-oxidant, and anticarcinogenic potential. It is a potent inhibitor of cytochrome P450 with capacity to simultaneously induce detoxifying enzymes such as glutathione S-transferase and as such may find application as a chemopreventive agent. Curcumin is a potent inhibitor of cyclooxygenase-2, lipooxygenase, ornithine decarboxylase (ODC), nuclear factor-kappaB, c-Jun N-terminal kinase and protein kinase C and has also been demonstrated to play a vital role against pathological conditions such as cancer, atherosclerosis, and neurodegenerative diseases.

Research paper thumbnail of A survey of commonly used herbal drugs in veterinary practice in southwest Nigeria

Research paper thumbnail of Population Diversity of Mosquito Fauna in and around Tandojam- Pakistan

International Journal for Agro Veterinary and Medical Sciences, 2012

Research work was undertaken to investigate the prevalence of mosquito genera in Tandojam and its... more Research work was undertaken to investigate the prevalence of mosquito genera in Tandojam and its surroundings from May to June 2010. A total of 2316 mosquito samples were collected which belongs to five genera viz; Culex, Anopheles, Aedes, Uranotaenia and Psorophora comprising 49%, 16%, 1.4%, 11.7% and 21.8% respectively. A total of 563 mosquitoes were collected from marshy/swampy areas, Psorophora were the most abundant 218 (38.7%) followed by 138 (24.5%), 123 (21.8%) and 84 (14.9%) Uranotaenia, Anopheles and Culex respectively. A total of 277 mosquitoes were collected from lavatories among which Culex were dominant 239 (86.3%) followed by 23 (8.3%) Anopheles and 15 (5.4%) Psorophora were identified. There were 186 mosquitoes collected from ditches and Culex were the most prevalent as 105 samples (56.5%) were collected followed by 81 samples (43.5%) Anopheles. A total of 552 mosquitoes were collected from grassy areas results revealed that Psorophora were the most abundant that is 273 (49.5%) followed by Uranotaenia, Culex, Aedes and Anopheles. with abundance of 133 (24%), 94 (17%), 32 (5.8%) and 20 (3.6%) respectively. A total of 629 adult mosquitoes were collected from animal pens. The most common genus Culex comprising 524 samples (83.3%) and least common was Anopheles 105 samples (16.7%). A total of 109 adult mosquito samples were taken from houses/containers belongs to 2 genera. Culex were by far the most abundant 89 (81.7%) followed by Anopheles 20 (18.3%).

Research paper thumbnail of Effects of dexamethasone on the infectivity of Trypanosoma vivax Y486 and the haematological changes in Nigerian domestic chickens (Gallus gallus …

VETERINARSKI ARHIV, 2004

ADEDAPO, A. A., A. B. SABA, O. A. DINA, G. M. A. OLADEJO: Effects of dexamethasone on the infecti... more ADEDAPO, A. A., A. B. SABA, O. A. DINA, G. M. A. OLADEJO: Effects of dexamethasone on the infectivity of Trypanosoma vivax Y486 and the haematological changes in Nigerian domestic chickens (Gallus gallus domesticus). Vet. arhiv 74, 371-381, 2004.

Research paper thumbnail of Prevalence and pathological lesions of bovine tuberculosis assessment through routine procedures of meat inspection in infected cattle in Karachi metropolitan corporation abattoirs

Pure and Applied Biology, 2019

Bovine tuberculosis (bTB) caused by Mycobacterium bovis is one of the most important zoonotic dis... more Bovine tuberculosis (bTB) caused by Mycobacterium bovis is one of the most important zoonotic disease that poses huge economic losses in livestock population worldwide. A cross sectional study was therefore designed to investigate its prevalence and efficacy of meat inspection procedures for its detection in slaughtered cattle at two abattoirs of Karachi. A total 2000 were examined during March 2015 to September 2016 in which 943 animals were found suspected for bTB and necropsied from which 1170 organ samples were collected. The data collected was analyzed using Chi-square test. Results of regular and complete examination revealed that 8.12% organ samples had positive lesions of tuberculosis. The highest frequency of lesions were observed in lungs and its associated lymphnodes (64%) i.e. mediastinal lymphnodes (27%), tracheobronchial lymphnodes (26%), lungs (11%) respectively. There was a significant difference (P < 0.05) in prevalence of bTB amongst sex of cattle. Females were found at high risk of bTB. It was concluded from the results that however bTB is highly prevalent in cattle and sensitivity of inspection protocols may influence reporting positive cases. Thus it is suggested that more advanced and sensitive methods should be used for screening of tuberculosis in cattle population.

Research paper thumbnail of Comparative study on the potency of trivalent vaccine of foot and mouth disease in different cattle breeds and triggered immune response signaling pathway

Large Animal Review, 2020

Research paper thumbnail of Toxoplasma Gondii Infection in Caprine and Ovine in the Desert Areas of Tharparkar: Seroprevalence and Risk Factors

Mujeeb-ur-Rahman Memon1*, Jahan Ara Baloch2, Abdullah G. Arijo3, Allah Bux Kachiwal4 and Nida Pir... more Mujeeb-ur-Rahman Memon1*, Jahan Ara Baloch2, Abdullah G. Arijo3, Allah Bux Kachiwal4 and Nida Pirzada5 1Department of Veterinary Medicine 2Pathology Section, Central Veterinary Diagnostic Laboratory, Tandojam 3Department of Veterinary Parasitology, Sindh Agriculture University, Tandojam 4Department of Veterinary Physiology 5Baqai Veterinary College, Karachi *Corresponding author: drmujeebsau@gmail.com

Research paper thumbnail of Studies on the prevalence of ectoparasites in owned dogs and major risk infestation to human health in Karachi, Sindh Pakistan

The present study was conducted to investigate the prevalence, intensity and distribution of natu... more The present study was conducted to investigate the prevalence, intensity and distribution of natural infestation of ectoparasites and their species in owned dogs during the period of June to November 2017 in Karachi, Sindh, Pakistan. One hundred fifty domestic dogs (90 males, 60 females) with age ranging from 60 days to 9 years were examined for ectoparasites infestation including (tick, lice, flea and mite) in Karachi city. A prevalence of ectoparasites 43.33% was identified in dogs. A total number of 164 ectoparasites were collected. The most common ectoparasites were Rhipicephalus sanguineus tick, which infested 59 of the 150 dogs (39.33%) followed by Ctenocephalides canis and Demodex canis was identified on 7/150 dogs (4.67%), Dermacentor reticulates and Trichodectes canis 6/150 dogs (4.0%) respectively and Ctenocephalides felis 2/150 (1.33%), that the highest infestation rate was seen in June (30.86%). No itching and scratching was found in 93.6 percent. Ectoparasites were sign...

Research paper thumbnail of Factors influencing knowledge and practices for prevention of bovine tuberculosis amongst workers at Abattoir in Karachi

Pure and Applied Biology

Present study was designed to investigate the level of knowledge and practices for prevention of ... more Present study was designed to investigate the level of knowledge and practices for prevention of Bovine Tuberculosis amongst workers at two abattoirs in Karachi. The Data was collected from the herdsman and abattoirs worker at two abattoirs namely City Abattoir Cattle Colony in Landhi and New Karachi slaughterhouse (kamailas) which were working under Karachi Municipal Corporation.120 abattoir workers were interviewed and information was obtained, while frequency counts, percentages and independent sample ttest were used to analyze data. Data indicates the ratio of respondent including herd man and abattoirs workers having no knowledge to those having knowledge was 85:15 Statistical analysis revealed that level of education is potential factor influencing risk of BTB zoonoses amongst abattoir workers Educated respondent were having twice higher knowledge than un educated (OR 0.454, 95% CI 0.236-0.872 P < 0.024).Educated workers demonstrated three time higher practices for preventive measures than non-educated (OR 0.607, 95% CI 0.335-1.102, P< 0.133). Despite having awareness amongst abattoirs worker there was lower level of good practices It was therefore concluded that along with launching awareness program from government organizations it must be ensure practical application of WHO and FAO guidelines for TB free world under one health program ending 2030.

Research paper thumbnail of Factors influencing knowledge and practices for prevention of bovine tuberculosis amongst workers at Abattoir in Karachi

Pure and Applied Biology

Present study was designed to investigate the level of knowledge and practices for prevention of ... more Present study was designed to investigate the level of knowledge and practices for prevention of Bovine Tuberculosis amongst workers at two abattoirs in Karachi. The Data was collected from the herdsman and abattoirs worker at two abattoirs namely City Abattoir Cattle Colony in Landhi and New Karachi slaughterhouse (kamailas) which were working under Karachi Municipal Corporation.120 abattoir workers were interviewed and information was obtained, while frequency counts, percentages and independent sample ttest were used to analyze data. Data indicates the ratio of respondent including herd man and abattoirs workers having no knowledge to those having knowledge was 85:15 Statistical analysis revealed that level of education is potential factor influencing risk of BTB zoonoses amongst abattoir workers Educated respondent were having twice higher knowledge than un educated (OR 0.454, 95% CI 0.236-0.872 P < 0.024).Educated workers demonstrated three time higher practices for preventive measures than non-educated (OR 0.607, 95% CI 0.335-1.102, P< 0.133). Despite having awareness amongst abattoirs worker there was lower level of good practices It was therefore concluded that along with launching awareness program from government organizations it must be ensure practical application of WHO and FAO guidelines for TB free world under one health program ending 2030.