The Human β Globin Locus Introduced by YAC Transfer Exhibits a Specific and Reproducible Pattern of Developmental Regulation in Transgenic Mice (original) (raw)

Developmental regulation of human gamma- and beta-globin genes in the absence of the locus control region

Ajay Bhargava

Blood, 1994

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An embryonic-specific repressor element located 3′ to the Aγ-globin gene influences transcription of the human β-globin locus in transgenic mice

Eleni Katsantoni

Experimental Hematology, 2004

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Expression of Human Globin Genes in Transgenic Mice Carrying the β‐Globin Gene Cluster with a Mutation Causing Gγβ+ Hereditary Persistence of Fetal Hemoglobina

Ajay Bhargava

Annals of the New York Academy of Sciences, 1990

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Developmental regulation of a complete 70kb human β-globin locus in transgenic mice

Niall Dillon

Genes & Development, 1992

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Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice

Frank Grosveld

Genes & Development, 1992

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Expression of Human Globin Genes in Transgenic Mice Carrying the ?-Globin Gene Cluster with a Mutation Causing G ?? + Hereditary Persistence of Fetal Hemoglobin

Ajay Bhargava

Annals of the New York Academy of Sciences, 1990

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Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes

Michael Antoniou

Genes & Development, 1993

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Promoters of the murine embryonic -like globin genes Ey and h1 do not compete for interaction with the -globin locus control region

Steven Fiering

Proceedings of the National Academy of Sciences, 2003

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Human gamma- to beta-globin gene switching using a mini construct in transgenic mice

Joan Krakowsky

Molecular and Cellular Biology, 1992

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2 The regulation of human globin gene expression

Niall Dillon

1993

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The role of the −50 region of the human γ-globin gene in switching

Dubravka Drabek

The EMBO Journal, 2001

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Globin Gene Switching

Thalia Papayannopoulou

Journal of Biological Chemistry, 1996

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Human gamma- to beta-globin gene switching in transgenic mice

Tim Townes

Genes & Development, 1990

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Position-independent, high-level expression of the human β-globin gene in transgenic mice

David Greaves

Cell, 1987

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Erythroid-specific expression of human beta-globin genes in transgenic mice

Tim Townes

The EMBO Journal, 1985

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Locus control region-A gamma transgenic mice: a new model for studying the induction of fetal hemoglobin in the adult

PANTELIS CONSTANTOULAKIS

Blood, 1991

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Adult and fetal human globin genes are expressed following chromosomal transfer into MEL cells

V. Najfeld

Proceedings of the National Academy of Sciences, 1985

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Extent and high frequency of a short conversion between the human A? and G? fetal globin genes

Francois Morle

Human Genetics, 1990

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Analysis of a 70 kb segment of DNA containing the human ζ and α-globin genes linked to their regulatory element (HS-40) in transgenic mice

Dominic Wells

Nucleic Acids Research, 1994

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Intergenic Transcription and Developmental Remodeling of Chromatin Subdomains in the Human β-globin Locus

Karin Diderich

Molecular Cell, 2000

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Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice

Tim Townes

Proceedings of the National Academy of Sciences, 1987

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Persistent ����-globin expression in adult transgenic mice by HPFH -2, HPFH -3 and HPFH -6 breakpoint sequences

Eleni Katsantoni

2003

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Analysis of the human alpha-globin gene cluster in transgenic mice

Dominic Wells

Proceedings of the National Academy of Sciences, 1993

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Full Activity From Human β-Globin Locus Control Region Transgenes Requires 5′HS1, Distal β-Globin Promoter, and 3′ β-Globin Sequences

Dylan Pannell

Blood, 1998

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Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity

Tim Townes

Nucleic Acids Research, 2000

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Locus control region mediated regulation of adult β-globin gene expression

John Strouboulis, Jörg Bungert

Journal of Cellular Biochemistry, 2008

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Molecular analysis of the human fetal-to-adult globin switching

Suthat Fucharoen

PubMed, 1995

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Developmental and species-divergent globin switching are driven by BCL11A

Philip Tucker, Gregory C Ippolito

Nature, 2009

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Persistent fetal γ-globin expression in adult transgenic mice following deletion of two silencer elements located 3' to the human Aγ-globin gene

Eleni Katsantoni

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A chromosome 11-linked determinant controls fetal globin expression and the fetal-to-adult globin switch

V. Najfeld

Proceedings of the National Academy of Sciences, 1987

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Regulation of the Globin Genes

Paolo Moi

Pediatric Research, 2002

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Developmental regulation of globin gene expression

Mark Minie

Journal of Cell Science, 1992

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Developmental and inducible patterns of human θ1-globin gene expression in embryonic/fetal and adult erythroid cells

Nicholas Moschonas

American Journal of Hematology, 1990

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Intergenic transcription and transinduction of the human beta -globin locus

Peter Fraser

Genes & Development, 1997

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Persistent -globin expression in adult transgenic mice is mediated by HPFH-2, HPFH-3, and HPFH-6 breakpoint sequences

Eleni Katsantoni

2010

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