The Human β Globin Locus Introduced by YAC Transfer Exhibits a Specific and Reproducible Pattern of Developmental Regulation in Transgenic Mice (original ) (raw )Developmental regulation of human gamma- and beta-globin genes in the absence of the locus control region
Ajay Bhargava
Blood, 1994
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An embryonic-specific repressor element located 3′ to the Aγ-globin gene influences transcription of the human β-globin locus in transgenic mice
Eleni Katsantoni
Experimental Hematology, 2004
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Expression of Human Globin Genes in Transgenic Mice Carrying the β‐Globin Gene Cluster with a Mutation Causing Gγβ+ Hereditary Persistence of Fetal Hemoglobina
Ajay Bhargava
Annals of the New York Academy of Sciences, 1990
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Developmental regulation of a complete 70kb human β-globin locus in transgenic mice
Niall Dillon
Genes & Development, 1992
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Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice
Frank Grosveld
Genes & Development, 1992
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Expression of Human Globin Genes in Transgenic Mice Carrying the ?-Globin Gene Cluster with a Mutation Causing G ?? + Hereditary Persistence of Fetal Hemoglobin
Ajay Bhargava
Annals of the New York Academy of Sciences, 1990
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Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes
Michael Antoniou
Genes & Development, 1993
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Promoters of the murine embryonic -like globin genes Ey and h1 do not compete for interaction with the -globin locus control region
Steven Fiering
Proceedings of the National Academy of Sciences, 2003
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Human gamma- to beta-globin gene switching using a mini construct in transgenic mice
Joan Krakowsky
Molecular and Cellular Biology, 1992
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2 The regulation of human globin gene expression
Niall Dillon
1993
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The role of the −50 region of the human γ-globin gene in switching
Dubravka Drabek
The EMBO Journal, 2001
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Globin Gene Switching
Thalia Papayannopoulou
Journal of Biological Chemistry, 1996
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Human gamma- to beta-globin gene switching in transgenic mice
Tim Townes
Genes & Development, 1990
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Position-independent, high-level expression of the human β-globin gene in transgenic mice
David Greaves
Cell, 1987
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Erythroid-specific expression of human beta-globin genes in transgenic mice
Tim Townes
The EMBO Journal, 1985
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Locus control region-A gamma transgenic mice: a new model for studying the induction of fetal hemoglobin in the adult
PANTELIS CONSTANTOULAKIS
Blood, 1991
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Adult and fetal human globin genes are expressed following chromosomal transfer into MEL cells
V. Najfeld
Proceedings of the National Academy of Sciences, 1985
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Extent and high frequency of a short conversion between the human A? and G? fetal globin genes
Francois Morle
Human Genetics, 1990
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Analysis of a 70 kb segment of DNA containing the human ζ and α-globin genes linked to their regulatory element (HS-40) in transgenic mice
Dominic Wells
Nucleic Acids Research, 1994
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Intergenic Transcription and Developmental Remodeling of Chromatin Subdomains in the Human β-globin Locus
Karin Diderich
Molecular Cell, 2000
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Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice
Tim Townes
Proceedings of the National Academy of Sciences, 1987
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Persistent ����-globin expression in adult transgenic mice by HPFH -2, HPFH -3 and HPFH -6 breakpoint sequences
Eleni Katsantoni
2003
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Analysis of the human alpha-globin gene cluster in transgenic mice
Dominic Wells
Proceedings of the National Academy of Sciences, 1993
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Full Activity From Human β-Globin Locus Control Region Transgenes Requires 5′HS1, Distal β-Globin Promoter, and 3′ β-Globin Sequences
Dylan Pannell
Blood, 1998
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Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity
Tim Townes
Nucleic Acids Research, 2000
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Locus control region mediated regulation of adult β-globin gene expression
John Strouboulis , Jörg Bungert
Journal of Cellular Biochemistry, 2008
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Molecular analysis of the human fetal-to-adult globin switching
Suthat Fucharoen
PubMed, 1995
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Developmental and species-divergent globin switching are driven by BCL11A
Philip Tucker , Gregory C Ippolito
Nature, 2009
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Persistent fetal γ-globin expression in adult transgenic mice following deletion of two silencer elements located 3' to the human Aγ-globin gene
Eleni Katsantoni
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A chromosome 11-linked determinant controls fetal globin expression and the fetal-to-adult globin switch
V. Najfeld
Proceedings of the National Academy of Sciences, 1987
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Regulation of the Globin Genes
Paolo Moi
Pediatric Research, 2002
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Developmental regulation of globin gene expression
Mark Minie
Journal of Cell Science, 1992
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Developmental and inducible patterns of human θ1-globin gene expression in embryonic/fetal and adult erythroid cells
Nicholas Moschonas
American Journal of Hematology, 1990
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Intergenic transcription and transinduction of the human beta -globin locus
Peter Fraser
Genes & Development, 1997
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Persistent -globin expression in adult transgenic mice is mediated by HPFH-2, HPFH-3, and HPFH-6 breakpoint sequences
Eleni Katsantoni
2010
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