The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs (original) (raw)

Structures for the Potential Drug Target Purine Nucleoside Phosphorylase from Schistosoma mansoni Causal Agent of Schistosomiasis

Humberto Pereira

Journal of Molecular Biology, 2005

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Purine nucleoside phosphorylase from Schistosoma mansoni in complex with ribose-1-phosphate

Humberto Pereira

Journal of Synchrotron Radiation, 2011

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Structures for the Potential Drug Target Purine Nucleoside Phosphorylase from Causal Agent of Schistosomiasis

Humberto Pereira

J Mol Biol, 2005

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Cloning, expression and preliminary crystallographic studies of the potential drug target purine nucleoside phosphorylase from Schistosoma mansoni

Humberto Pereira

Acta Crystallographica Section D Biological Crystallography, 2003

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Structural basis for selective inhibition of purine nucleoside phosphorylase from Schistosoma mansoni: Kinetic and structural studies

Humberto Pereira

Bioorganic & Medicinal Chemistry, 2010

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Adenosine binding to low-molecular-weight purine nucleoside phosphorylase: the structural basis for recognition based on its complex with the enzyme from Schistosoma mansoni

Humberto Pereira

Acta Crystallographica Section D Biological Crystallography, 2010

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Crystal structure of Schistosoma purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor

Humberto Pereira

Acta Tropica, 2010

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Analysis of two Schistosoma mansoni uridine phosphorylases isoforms suggests the emergence of a protein with a non-canonical function

Antonio Marinho, Larissa Romanello

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Adenosine kinase from Schistosoma mansoni : structural basis for the differential incorporation of nucleoside analogues

Larissa Romanello, Ricardo Demarco, Fernando Bachega

Acta Crystallographica Section D Biological Crystallography, 2013

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Structural bioinformatics study of PNP from Schistosoma mansoni

Augusto Palma

Biochemical and Biophysical Research Communications, 2004

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Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis

Marija Luić

Scientific Reports

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Pathways of nucleotide metabolism in schistosoma mansoni—VI adenosine phosphorylase

Roger Stegman

Biochemical Pharmacology, 1975

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Crystal structure ofEscherichia colipurine nucleoside phosphorylase in complex with 7-deazahypoxanthine

Inna Kuranova

Acta Crystallographica Section F Structural Biology Communications, 2018

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Purine Nucleoside Phosphorylase: A Potential Target for the Development of Drugs to Treat T-Cell- and Apicomplexan Parasite-Mediated Diseases

Luiz Basso

Current Drug Targets, 2007

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Insights into Phosphate Cooperativity and Influence of Substrate Modifications on Binding and Catalysis of Hexameric Purine Nucleoside Phosphorylases

Mario Murakami, P. Giuseppe, Camila Ramos Santos

PLoS ONE, 2012

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Still a Long Way to Fully Understanding the Molecular Mechanism of Escherichia coli Purine Nucleoside Phosphorylase

Beata Wielgus-kutrowska

Croatica Chemica Acta, 2013

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Anopheles gambiae Purine Nucleoside Phosphorylase: Catalysis, Structure, and Inhibition

Mahmoud Ghanem

Biochemistry, 2007

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Crystal structure ofEscherichia colipurine nucleoside phosphorylase in complex with 7-deazahypoxanthine

Ilya Fateev

Acta Crystallographica Section F: Structural Biology Communications, 2018

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Purine Nucleoside Phosphorylase. 2. Catalytic Mechanism †

Wayne C Guida

Biochemistry, 1997

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Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

Gary Evans

Eukaryotic Cell, 2014

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Three-dimensional structure of E. Coli purine nucleoside phosphorylase at 0.99 Å resolution

Inna Kuranova

Crystallography Reports, 2016

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Molecular cloning, overexpression, purification, crystallization and preliminary X-ray diffraction analysis of a purine nucleoside phosphorylase from Bacillus subtilis strain 168

Mario Murakami

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2011

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The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase

Jennifer Arif

Journal of Molecular Biology, 2010

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Inhibition and Structure of Trichomonas vaginalis Purine Nucleoside Phosphorylase with Picomolar Transition State Analogues †

Gary Evans

Biochemistry, 2007

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Homology modeling and docking studies of phosphoenolpyruvate carboxykinase in Schistosoma mansoni

Ananta Swargiary

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Second-Sphere Amino Acids Contribute to Transition-State Structure in Bovine Purine Nucleoside Phosphorylase

Mahmoud Ghanem

Biochemistry, 2008

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Crystal structure of calf spleen purine nucleoside phosphorylase complexed to a novel purine analogue

Valerio Berdini

Febs Letters, 2007

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Crystal structure of human purine nucleoside phosphorylase at 2.3 Å resolution

Rafael Silva

Biochemical and Biophysical Research Communications, 2003

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