Stepwise transformation of rat embryo fibroblasts: c-Jun, JunB, or JunD can cooperate with Ras for focus formation, but a c-Jun-containing heterodimer is required for immortalization (original) (raw)

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

Jean Viallet

Cell, 1989

View PDFchevron_right

Transcription factors junB and c-jun are selectively up-regulated and functionally implicated in fibrosarcoma development

Ella Bossy-wetzel, Rodrigo Bravo

Genes & Development, 1992

View PDFchevron_right

The c-Jun Dimerization Protein 2 Inhibits Cell Transformation and Acts as a Tumor Suppressor Gene

Ronit Heinrich

Journal of Biological Chemistry, 2003

View PDFchevron_right

The defective transforming phenotype of c-Jun Ala63/73 is rescued by mutation of the C-terminal phosphorylation site

Irene Marchetti

Oncogene, 2001

View PDFchevron_right

Overexpression of c-jun, junB, or junD affects cell growth differently

Gilbert Brun

Proceedings of the National Academy of Sciences, 1991

View PDFchevron_right

Mutations in the Jun delta region suggest an inverse correlation between transformation and transcriptional activation

Iain Morgan

Proceedings of the National Academy of Sciences, 1992

View PDFchevron_right

Binétruy B: Rat embryo fibroblasts transformed by c-Jun display highly metastatic and angiogenic activities in vivo and deregulate gene expression of both angiogenic and antiangiogenic factors. Cell Growth and Differentiation 1999, 10(3):193-200. Pre-publ

Michel Kraemer

2013

View PDFchevron_right

JunB inhibits proliferation and transformation in B-lymphoid cells

Veronika Sexl

Blood, 2003

View PDFchevron_right

Heterodimerization with Fra-1 cooperates with the ERK pathway to stabilize c-Jun in response to the RAS oncoprotein

F. Talotta, Laura Casalino

Oncogene, 2010

View PDFchevron_right

c-Jun Activation-dependent Tumorigenic Transformation Induced

Aino Paasinen

2016

View PDFchevron_right

p75-Ras-GRF1 Is a c-Jun/AP-1 Target Protein: Its Up Regulation Results in Increased Ras Activity and Is Necessary for c-Jun-Induced Nonadherent Growth of Rat1a Cells

Geoffrey Clark

Molecular and Cellular Biology, 2005

View PDFchevron_right

Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation

Joël Baguet

Genes & Development, 1998

View PDFchevron_right

Targeting c-Jun and JunB proteins as potential anticancer cell therapy

Juan Alfaro

Oncogene, 2008

View PDFchevron_right

Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts

Tom Kerppola

1992

View PDFchevron_right

JunD Protects Cells from p53Dependent Senescence and Apoptosis

Jonathan Weitzman

Molecular Cell, 2000

View PDFchevron_right

Transcription Factor ATF2 Cooperates with v-Jun To Promote Growth Factor-Independent Proliferation In Vitro and Tumor Formation In Vivo

Joël Baguet

Molecular and Cellular Biology, 1998

View PDFchevron_right

Regulation of the junB gene by v-src

Craig Dobry

Molecular and cellular biology, 1992

View PDFchevron_right

Signal transduction in fibroblasts stably transformed by [Val12]Ras--the activities of extracellular-signal-regulated kinase and Jun N-terminal kinase are only moderately increased, and the activity of the delta-inhibitor of c-Jun is not alleviated

Maria Shoshan

European journal of biochemistry / FEBS, 1997

View PDFchevron_right

JunB does not inhibit the induction of c-Jun during the retinoic acid induced differentiation of F9 cells

Robert Oshima

Developmental Dynamics, 1992

View PDFchevron_right

The Jun and Fos protein families are both required for cell cycle progression in fibroblasts

Karla Kovary

1991

View PDFchevron_right

Conditional Cell Transformation by Doxycycline-Controlled Expression of the ASV17 v-jun Allele

Ralf Weiskirchen

Virology, 2000

View PDFchevron_right

Somatic Excision Demonstrates that c-Jun Induces Cellular Migration and Invasion through Induction of Stem Cell Factor

Richard Pestell

Molecular and Cellular Biology, 2007

View PDFchevron_right

Nuclear Factor of Activated T3 Is a Negative Regulator of Ras-JNK1/2-AP-1–Induced Cell Transformation

Yong Yeon Cho

Cancer Research, 2007

View PDFchevron_right

Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells

Gabriel Gachelin

The EMBO Journal, 1992

View PDFchevron_right

Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation

Peter Sandy

Molecular and Cellular Biology, 2011

View PDFchevron_right

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter

Jonathan Weitzman

Proceedings of the National Academy of Sciences, 2003

View PDFchevron_right

The mammalian Jun proteins: redundancy and specificity

M. Yaniv

Oncogene, 2001

View PDFchevron_right

V-Jun is a Transcriptional Activator, but Not in All Cell-Lines

elias ugarte

Nucleic Acids Research, 1988

View PDFchevron_right

Polyomavirus middle-sized tumor antigen modulates c-Jun phosphorylation and transcriptional activity

Axel Schonthal

Proceedings of the National Academy of Sciences, 1994

View PDFchevron_right

Cyclin-Dependent Kinase-3–Mediated c-Jun Phosphorylation at Ser63 and Ser73 Enhances Cell Transformation

Duo Zheng

Cancer Research, 2009

View PDFchevron_right

Cellular Transformation of Mouse Embryo Fibroblasts in the Absence of Activator E2Fs

Tushar Gupta

Journal of Virology, 2015

View PDFchevron_right