Involvement of a Specific Metal Ion in the Transition of the Hammerhead Ribozyme to Its Catalytic Conformation
Leonid Beigelman, Alessio Peracchi
Journal of Biological Chemistry, 1997
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Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes
George Slim
1991
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The role of phosphate groups in the VS ribozyme-substrate interaction
Jane Grasby
Nucleic Acids Research, 2004
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Substrate specificity and reaction kinetics of an X-motif ribozyme
Dennis Lazarev
RNA, 2003
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Kinetic Analysis of δ Ribozyme Cleavage†
Stéphane Mercure
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Faculty of 1000 evaluation for Capturing hammerhead ribozyme structures in action by modulating general base catalysis
Pascale Legault
F1000 - Post-publication peer review of the biomedical literature, 2008
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Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme
Timothy D Wilson
Proceedings of the National Academy of Sciences, 2010
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Selected classes of minimised hammerhead ribozyme have very high cleavage rates at low Mg2+ concentration
Trevor Lockett
Nucleic Acids Research, 1999
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Physicochemical Characterization of the Catalytic Unit of Hammerhead Ribozyme and Its Relationship with the Catalytic Activity
Chojiro Kojima
Biophysica
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Functional Group Requirements in the Probable Active Site of the VS Ribozyme
Timothy D Wilson
Journal of Molecular Biology, 2002
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A Kinetic and Thermodynamic Framework for the Hammerhead Ribozyme Reaction
Klemens Hertel
Biochemistry, 1994
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Thio Effects on the Departure of the 3′-Linked Ribonucleoside from Diribonucleoside 3′,3′-Phosphorodithioate Diesters and Triribonucleoside 3′,3′,5′-Phosphoromonothioate Triesters: Implications for Ribozyme Catalysis
Tuomas Lönnberg, Sami Virtanen, Harri Lonnberg
Chemistry - A European Journal, 2007
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Identification and Characterization of a Divalent Metal Ion-Dependent Cleavage Site in the Hammerhead Ribozyme †
Frédéric Godde
Biochemistry, 2001
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Capturing Hammerhead Ribozyme Structures in Action by Modulating General Base Catalysis
Young-In Chi
PLoS Biology, 2008
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Single substitutions of phosphorothioates in the HDV ribozyme G73 define regions necessary for optimal self-cleaving activity
Philip A Gottlieb
Nucleic Acids Research, 1997
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Crucial Roles of Two Hydrated Mg 2+ Ions in Reaction Catalysis of the Pistol Ribozyme
Marianna Teplova
Angewandte Chemie International Edition, 2019
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An oligodeoxyribonucleotide that supports catalytic activity in the hammerhead ribozyme domain
Pascal Chartrand
Nucleic Acids Research, 1995
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Synthesis of 1-deoxy-d-ribofuranose phosphoramidite & the incorporation of abasic nucleotides in stem-loop II of a hammerhead ribozyme
Alexander Karpeisky
Bioorganic & Medicinal Chemistry Letters, 1994
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Structural Variation Induced by Different Nucleotides at the Cleavage Site of the Hammerhead Ribozyme †
Nassim Usman
Biochemistry, 1998
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Model for General Acid−Base Catalysis by the Hammerhead Ribozyme: pH−Activity Relationships of G8 and G12 Variants at the Putative Active Site †
John Burke
Biochemistry, 2005
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Observations on catalysis by hammerhead ribozymes are consistent with a two-divalent-metal-ion mechanism.
Bill Lott
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Chemical models for ribozyme action
Tuomas Lönnberg, Harri Lonnberg
Current Opinion in Chemical Biology, 2005
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The enzymatic hydrolysis of the phosphate ester bond in some thionucleotides
Joseph Nagyvary
Biochimica et biophysica acta, 1979
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Structure–function relationships in the hammerhead ribozyme probed by base rescue
Leonid Beigelman, Alessio Peracchi
RNA, 1998
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Theoretical examination of Mg2+-mediated hydrolysis of a phosphodiester linkage as proposed for the hammerhead ribozyme
Louis Noodleman
Journal of the American Chemical Society, 2003
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Ribozyme Catalysis Revisited: Is Water Involved?
Nils Walter
Molecular Cell, 2007
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Thermodynamic Dissection of the Substrate−Ribozyme Interaction in the Hammerhead Ribozyme †
Klemens Hertel
Biochemistry, 1998
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A two-metal ion mechanism operates in the hammerhead ribozyme-mediated cleavage of an RNA substrate.
Bill Lott
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Using linkers to investigate the spatial separation of the conserved nucleotides A9 and G12 in the hammerhead ribozyme
mohammad reza r. Moghaddam
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1994
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The Structural Basis of Hammerhead Ribozyme Self-Cleavage
Alexander Karpeisky
Cell, 1998
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Thiophilic metal ion rescue of phosphorothioate interference within the Tetrahymena ribozyme P4–P6 domain
Soumitra Basu
RNA, 1999
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Metal ions play a passive role in the hairpin ribozyme catalysed reaction
Jane Grasby
Nucleic acids research, 1997
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The Tetrahymena Ribozyme Cleaves a 5‘-Methylene Phosphonate Monoester ∼102-fold Faster Than a Normal Phosphate Diester: Implications for Enzyme Catalysis of Phosphoryl Transfer Reactions†
Markus Boehringer
2001
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Nature of the Chemical Bond Formed with the Structural Metal Ion at the A9/G10.1 Motif Derived from Hammerhead Ribozymes
Chojiro Kojima
Journal of the American Chemical Society, 2004
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