The structural basis of cephalosporin formation in a mononuclear ferrous enzyme (original) (raw)

Structure of a cephalosporin synthase

Inger Andersson

Nature, 1998

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Studies on the active site of deacetoxycephalosporin C synthase

Inger Andersson

Journal of Molecular Biology, 1999

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Studies on the active site of deacetoxycephalosporin C synthase 1 1 Edited by D. C. Rees

John Charnock

Journal of Molecular Biology, 1999

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The 2.0 Å Crystal Structure of Cephalosporin Acylase

Ki-Hong Yoon

Structure, 2000

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Structural Basis of Regiospecificity of a Mononuclear Iron Enzyme in Antibiotic Fosfomycin Biosynthesis

Luke Higgins

Journal of The American Chemical Society, 2011

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Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme

Luke Higgins

Nature, 2005

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Crystal Structure of the Non-heme Iron Dioxygenase PtlH in Pentalenolactone Biosynthesis

Haruo Ikeda

Journal of Biological Chemistry, 2007

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Structure of a class III engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity

Elena Rosini

Biochemical Journal, 2013

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Multifunctional Xylooligosaccharide/Cephalosporin C Deacetylase Revealed by the Hexameric Structure of the Bacillus subtilis Enzyme at 1.9Å Resolution

Koen H Verschueren

Journal of Molecular Biology, 2003

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Revealing electronic features governing hydrolysis of cephalosporins in the active site of the L1 metallo-β-lactamase

Vladimir Tsirelson

RSC Advances, 2020

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The crystal structure of the cephalosporin deacetylating enzyme acetyl xylan esterase bound to paraoxon explains the low sensitivity of this serine hydrolase to organophosphate inactivation

Vicente Rubio

Biochemical Journal, 2011

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The N···H hydrogen bond strength in the transition state at the limiting step determines the reactivity of cephalosporins in the active site of L1 metallo-β-lactamase

Vladimir Tsirelson

Mendeleev Communications, 2019

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Structures of FOX-4 Cephamycinase in Complex with Transition-State Analog Inhibitors

Magdalena Taracila

Biomolecules, 2020

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Substrate interactions with human ferrochelatase

Harry Dailey

Proceedings of the National Academy of Sciences, 2007

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Insight into the function of active site residues in the catalytic mechanism of human ferrochelatase

Harry Dailey

Biochemical Journal, 2021

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Human Ferrochelatase: Characterization of Substrate−Iron Binding and Proton-Abstracting Residues †

Harry Dailey

Biochemistry, 2001

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Mutational Analysis of a Key Residue in the Substrate Specificity of a Cephalosporin Acylase

Robbert Cool, Charles F Sio, Linda G Otten

Chembiochem, 2004

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Coupling Reactions of Cephalosporin Sulfones: A Stable 3-Stannylated Cephem

John Buynak

Organic Letters, 2001

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Strategies for the Stereocontrolled Formation of Oxygen Analogues of Penicillins and Cephalosporins

Bartłomiej Furman

Current Medicinal Chemistry, 2004

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Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase

Jean-marie Frère

Proceedings of the National Academy of Sciences, 1993

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Insights into Cephamycin Biosynthesis: the Crystal Structure of CmcI from Streptomyces clavuligerus

Inger Andersson, Linda Öster

Journal of Molecular Biology, 2006

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Structural Insights into the Ferroxidase Site of Ferritins from Higher Eukaryotes

Cecilia Pozzi, Elizabeth Theil

Journal of the American Chemical Society, 2012

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Strategic manipulation of an industrial biocatalyst - evolution of a cephalosporin C acylase

Elena Rosini, Gianluca Conti

FEBS Journal, 2014

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β-Lactamase-catalysed hydrolysis of cephalexin: evolution of the cephalosporoate intermediate

J. Frau, Josefa Donoso

Journal of the Chemical Society, Perkin Transactions 2, 1997

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Biochemical and crystallographic investigations into isonitrile formation by a nonheme iron-dependent oxidase/decarboxylase

Catherine Drennan

Journal of Biological Chemistry, 2021

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Synthesis and biological evaluation of the progenitor of a new class of cephalosporin analogues, with a particular focus on structure-based computational analysis

Giovanni Vigliottá

PLOS ONE, 2017

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Altered Orientation of Active Site Residues in Variants of Human Ferrochelatase. Evidence for a Hydrogen Bond Network Involved in Catalysis †

Harry Dailey

Biochemistry, 2007

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Crystal Structures of the Bacillus licheniformis BS3 Class A β-Lactamase and of the Acyl−Enzyme Adduct Formed with Cefoxitin † , ‡

Jean-marie Frère

Biochemistry, 2002

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Ferritin Structure from Mycobacterium tuberculosis: Comparative Study with Homologues Identifies Extended C-Terminus Involved in Ferroxidase Activity

Vibha Gupta

PLoS ONE, 2011

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Structure-based prediction of modifications in glutarylamidase to allow single-step enzymatic production of 7-aminocephalosporanic acid from cephalosporin C

Herman Schreuder

Protein Science, 2002

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Crystallographic snapshots of the reaction of aromatic C–H with O2 catalysed by a protein-bound iron complex

Christine Cavazza

Nature Chemistry, 2010

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Crystal structures of penicillin acylase enzyme-substrate complexes: structural insights into the catalytic mechanism

Colin McVey

Journal of Molecular Biology, 2001

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