NMR studies of novel inhibitors bound to farnesyl-protein transferase (original) (raw)
Conformation of a novel tetrapeptide inhibitor NH2-d-Trp-d-Met-Phe(pCl)-Gla-NH2 bound to farnesyl-protein transferase
A. Pessi
Journal of Peptide Research, 1999
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Inhibitors of farnesyl:protein transferase—A possible cancer chemotherapeutic
Daniele Leonard
1996
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Conformation of a heptapeptide substrate bound to protein farnesyltransferase
Lila Gierasch
Biochemistry, 1993
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Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure−Activity Relationships †
Hung Le
Journal of Medicinal Chemistry, 1999
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Farnesyl Diphosphate-Based Inhibitors of Ras Farnesyl Protein Transferase
Veeraswamy Manne
Journal of Medicinal Chemistry, 1995
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Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
Alison Todd
Cancer research, 2001
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Farnesyl Transferase Inhibitors as Potential Anticancer Agents
Sounak Bagchi
Mini Reviews in Medicinal Chemistry, 2018
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A novel class of highly potent, selective, and non-peptidic inhibitor of ras farnesyltransferase (FTase)
Jin-ho Lee
Bioorganic & Medicinal Chemistry Letters, 2001
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Structure−Activity Relationship of 3-Substituted N -(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11 H -benzo[5,6]cyclohepta[1,2- b ]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds
Ming Liu, Amin Nomeir
Journal of Medicinal Chemistry, 1997
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Antitumor Activity of SCH 66336, an Orally Bioavailable Tricyclic Inhibitor of Farnesyl Protein Transferase, in Human Tumor Xenograft Models and Wap-ras Transgenic Mice
Ming Liu
1998
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Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase
Dinesh Patel
Drug Development Research, 1995
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Farnesyl protein transferase inhibitors as targeted therapies for hematologic malignancies
Judith Karp
Seminars in Hematology, 2001
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Sugar-Derived Ras Inhibitors: Group Epitope Mapping by NMR Spectroscopy and Biological Evaluation
Francesco Peri
European Journal of Organic Chemistry, 2006
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CA1A2X-competitive inhibitors of farnesyltransferase as anti-cancer agents
Charles Omer
Trends in Pharmacological Sciences, 1997
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Novel Tricyclic Inhibitors of Farnesyl Protein Transferase
George Njoroge
Journal of Biological Chemistry, 1995
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Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors
Yimin Qian
Bioorganic & Medicinal Chemistry, 1999
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Farnesyltransferase Inhibitors: Overview of their Action and Role in Solid Malignancy Therapy
Alfredo Cesario
Letters in Drug Design & Discovery, 2005
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Novel Conformationally Extended Naphthalene-Based Inhibitors of Farnesyltransferase
Yves Lelievre
Journal of Medicinal Chemistry, 1997
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Potent, non-thiol inhibitors of farnesyltransferase
Scott Mosser
Bioorganic & Medicinal Chemistry Letters, 1998
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Hydrophobicity and functionality maps of farnesyltransferase
Amedeo Caflisch
Journal of Molecular Graphics and Modelling, 2001
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Insights into the structural requirements of farnesyltransferase inhibitors as potential anti-tumor agents based on 3D-QSAR CoMFA and CoMSIA models
Mange Ram Yadav
European Journal of Medicinal Chemistry, 2008
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Potent, Selective, and Orally Bioavailable Tricyclic Pyridyl Acetamide N -Oxide Inhibitors of Farnesyl Protein Transferase with Enhanced in Vivo Antitumor Activity
George Njoroge
Journal of Medicinal Chemistry, 1998
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Novel reverse-turn mimics inhibit farnesyl transferase
Peter Nestler
Bioorganic & Medicinal Chemistry Letters, 1999
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Discovery of a Series of Cyclohexylethylamine-Containing Protein Farnesyltransferase Inhibitors Exhibiting Potent Cellular Activity
James Wasicak
Journal of Medicinal Chemistry, 1999
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Inhibition of human tumor cell growthIn vitro andIn vivo by a specific inhibitor of human farnesyltransferase: BIM-46068
Gilles Favre
International Journal of Cancer, 1999
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Potent and Selective Farnesyl Transferase Inhibitors
Juozas Domarkas, Régis Millet
J Med Chem, 2004
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