Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage (original) (raw)

The Interglobular Domain of Cartilage Aggrecan Is Cleaved by Hemorrhagic Metalloproteinase HT-d (Atrolysin C) at the Matrix Metalloproteinase and Aggrecanase Sites

Jay Fox

Journal of Biological Chemistry, 1998

View PDFchevron_right

Activation of the Proteolytic Activity of ADAMTS4 (Aggrecanase-1) by C-terminal Truncation

Paul Gottschall

Journal of Biological Chemistry, 2002

View PDFchevron_right

Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins

Jason Duke

Science, 1999

View PDFchevron_right

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage

Peter Roughley

European cells & materials

View PDFchevron_right

Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay

David Buttle

Molecular Pathology, 1997

View PDFchevron_right

Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants

Karena Last

2000

View PDFchevron_right

Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro

Peter Roughley

Biochemical Journal, 1999

View PDFchevron_right

Cloning and Characterization of ADAMTS11, an Aggrecanase from the ADAMTS Family

Yoshifumi Itoh

Journal of Biological Chemistry, 1999

View PDFchevron_right

The cleavage of biglycan by aggrecanases

Peter Roughley

Osteoarthritis and Cartilage, 2006

View PDFchevron_right

Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments1

André Struglics

Osteoarthritis and Cartilage, 2006

View PDFchevron_right

Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation

Robert Newton

Annals of the New York Academy of Sciences, 1999

View PDFchevron_right

Recombinant Human Aggrecan G1-G2 Exhibits Native Binding Properties and Substrate Specificity for Matrix Metalloproteinases and Aggrecanase

Karena Last

Journal of Biological Chemistry, 1999

View PDFchevron_right

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Katrina Lawlor, Clare Meeker, Karena Last

Nature, 2005

View PDFchevron_right

Soluble Recombinant Neprilysin Induces Aggrecanase-Mediated Cleavage of Aggrecan in Cartilage Explant Cultures

Caroline Hoemann

Archives of Biochemistry and Biophysics, 2001

View PDFchevron_right

Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage

Karena Last

Nature Protocols, 2011

View PDFchevron_right

Use of anti-neoepitope antibodies for the analysis of degradative events in cartilage and the molecular basis for neoepitope specificity

Joe Makkerh

Biochemical Society Symposium, 2003

View PDFchevron_right

The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism

John Mort

Biochemical Journal, 2002

View PDFchevron_right

ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures

Matthew Stewart

Osteoarthritis and Cartilage, 2006

View PDFchevron_right

ADAMTS4 Cleaves at the Aggrecanase Site (Glu373-Ala374) and Secondarily at the Matrix Metalloproteinase Site (Asn341-Phe342) in the Aggrecan Interglobular Domain

Karena Last

Journal of Biological Chemistry, 2002

View PDFchevron_right

ADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5

Karena Last

International Journal of Molecular Sciences, 2019

View PDFchevron_right

Chemical and Immunological Assay of the Nonreducing Terminal Residues of Chondroitin Sulfate from Human Aggrecan

Anna Plaas, Peter Roughley, Ronald Midura

Journal of Biological Chemistry, 1997

View PDFchevron_right

The structure of aggrecan fragments in human synovial fluid. evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

John Sandy

Arthritis & Rheumatism, 1993

View PDFchevron_right

Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2)

Priya Chockalingam

Arthritis & Rheumatism, 2004

View PDFchevron_right

Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

Karena Last

FEBS Letters, 1996

View PDFchevron_right

Cleavage of the Carboxyl Tail from the G3 Domain of Aggrecan but Not Versican and Identification of the Amino Acids Involved in the Degradation

Burton Yang

Journal of Biological Chemistry, 2002

View PDFchevron_right

Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein

Peggy Scherle

Arthritis & Rheumatism, 2003

View PDFchevron_right

Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown

Corinne Gendron

Arthritis Research Therapy, 2005

View PDFchevron_right

TIMP-3 Inhibition of ADAMTS-4 (Aggrecanase-1) Is Modulated by Interactions between Aggrecan and the C-terminal Domain of ADAMTS-4

Augustin Amour

Journal of Biological Chemistry, 2007

View PDFchevron_right

MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein

Peter Roughley

Matrix Biology, 2011

View PDFchevron_right

Coincubation of Bovine Synovial or Capsular Tissue with Cartilage Generates a Soluble “Aggrecanase” Activity

David Buttle

Biochemical and Biophysical Research Communications, 1999

View PDFchevron_right

ADAMTS4 (Aggrecanase-1) Activation on the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated Proteinase to Chondroitin Sulfate and Heparan Sulfate on Syndecan-1

John Sandy

Journal of Biological Chemistry, 2004

View PDFchevron_right

A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs

Peter Mitchell

Osteoarthritis and Cartilage, 2010

View PDFchevron_right

Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs

David Buttle

Matrix Biology, 2003

View PDFchevron_right

A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid

André Struglics

Matrix Biology, 2010

View PDFchevron_right