The Interglobular Domain of Cartilage Aggrecan Is Cleaved by Hemorrhagic Metalloproteinase HT-d (Atrolysin C) at the Matrix Metalloproteinase and Aggrecanase Sites
Jay Fox
Journal of Biological Chemistry, 1998
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Activation of the Proteolytic Activity of ADAMTS4 (Aggrecanase-1) by C-terminal Truncation
Paul Gottschall
Journal of Biological Chemistry, 2002
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Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins
Jason Duke
Science, 1999
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Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage
Peter Roughley
European cells & materials
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Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay
David Buttle
Molecular Pathology, 1997
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Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants
Karena Last
2000
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Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro
Peter Roughley
Biochemical Journal, 1999
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Cloning and Characterization of ADAMTS11, an Aggrecanase from the ADAMTS Family
Yoshifumi Itoh
Journal of Biological Chemistry, 1999
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The cleavage of biglycan by aggrecanases
Peter Roughley
Osteoarthritis and Cartilage, 2006
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Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments1
André Struglics
Osteoarthritis and Cartilage, 2006
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Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation
Robert Newton
Annals of the New York Academy of Sciences, 1999
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Recombinant Human Aggrecan G1-G2 Exhibits Native Binding Properties and Substrate Specificity for Matrix Metalloproteinases and Aggrecanase
Karena Last
Journal of Biological Chemistry, 1999
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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
Katrina Lawlor, Clare Meeker, Karena Last
Nature, 2005
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Soluble Recombinant Neprilysin Induces Aggrecanase-Mediated Cleavage of Aggrecan in Cartilage Explant Cultures
Caroline Hoemann
Archives of Biochemistry and Biophysics, 2001
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Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage
Karena Last
Nature Protocols, 2011
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Use of anti-neoepitope antibodies for the analysis of degradative events in cartilage and the molecular basis for neoepitope specificity
Joe Makkerh
Biochemical Society Symposium, 2003
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The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism
John Mort
Biochemical Journal, 2002
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ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures
Matthew Stewart
Osteoarthritis and Cartilage, 2006
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ADAMTS4 Cleaves at the Aggrecanase Site (Glu373-Ala374) and Secondarily at the Matrix Metalloproteinase Site (Asn341-Phe342) in the Aggrecan Interglobular Domain
Karena Last
Journal of Biological Chemistry, 2002
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ADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5
Karena Last
International Journal of Molecular Sciences, 2019
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Chemical and Immunological Assay of the Nonreducing Terminal Residues of Chondroitin Sulfate from Human Aggrecan
Anna Plaas, Peter Roughley, Ronald Midura
Journal of Biological Chemistry, 1997
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The structure of aggrecan fragments in human synovial fluid. evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis
John Sandy
Arthritis & Rheumatism, 1993
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Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2)
Priya Chockalingam
Arthritis & Rheumatism, 2004
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Degradation of cartilage aggrecan by collagenase-3 (MMP-13)
Karena Last
FEBS Letters, 1996
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Cleavage of the Carboxyl Tail from the G3 Domain of Aggrecan but Not Versican and Identification of the Amino Acids Involved in the Degradation
Burton Yang
Journal of Biological Chemistry, 2002
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Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein
Peggy Scherle
Arthritis & Rheumatism, 2003
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Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown
Corinne Gendron
Arthritis Research Therapy, 2005
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TIMP-3 Inhibition of ADAMTS-4 (Aggrecanase-1) Is Modulated by Interactions between Aggrecan and the C-terminal Domain of ADAMTS-4
Augustin Amour
Journal of Biological Chemistry, 2007
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MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein
Peter Roughley
Matrix Biology, 2011
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Coincubation of Bovine Synovial or Capsular Tissue with Cartilage Generates a Soluble “Aggrecanase” Activity
David Buttle
Biochemical and Biophysical Research Communications, 1999
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ADAMTS4 (Aggrecanase-1) Activation on the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated Proteinase to Chondroitin Sulfate and Heparan Sulfate on Syndecan-1
John Sandy
Journal of Biological Chemistry, 2004
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A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs
Peter Mitchell
Osteoarthritis and Cartilage, 2010
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Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs
David Buttle
Matrix Biology, 2003
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A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid
André Struglics
Matrix Biology, 2010
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