The role of aggrecan in normal and osteoarthritic cartilage
John Mort
Journal of Experimental Orthopaedics, 2014
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The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism
John Mort
Biochemical Journal, 2002
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Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage
Peter Roughley
Osteoarthritis and Cartilage, 2008
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Molecular manipulation with the arthritogenic epitopes of the G1 domain of human cartilage proteoglycan aggrecan
Tibor Glant
Clinical and Experimental Immunology, 2005
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ADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5
Karena Last
International Journal of Molecular Sciences, 2019
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Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis
William Fisher
BMC musculoskeletal disorders, 2016
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Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage
Demitrios Vynios
The Biochemical journal, 1996
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Modern molecular analysis of a traditional disease: Progression in osteoarthritis
Linda Sandell
Arthritis & Rheumatism, 2007
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The structure of aggrecan fragments in human synovial fluid. evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis
John Sandy
Arthritis & Rheumatism, 1993
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Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis
Ioannis Kanakis
Arthritis & Rheumatology, 2018
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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
Manas Majumdar
Nature, 2007
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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
Katrina Lawlor, Clare Meeker, Karena Last
Nature, 2005
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Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage
Peter Roughley
European cells & materials
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Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2)
Priya Chockalingam
Arthritis & Rheumatism, 2004
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Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants
Karena Last
2000
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Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice
Roger Mason
Arthritis & Rheumatism, 2001
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Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis
Jeffrey Weidner
Osteoarthritis and …, 1997
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Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis
Peter Roughley, Margaret M Smith
Arthritis research & therapy, 2005
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Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity
Paul Salo
Cell Death & Disease
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Proteoglycan Structure and Metabolism in Normal and Osteoarthritic Cartilage of Guinea Pigs
Jeff Stevens
Arthritis & Rheumatism, 1981
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The Proteoglycan Metabolism of Articular Cartilage in Joint-Scale Culture
William Bugbee
Tissue Engineering Part A, 2010
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Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments1
André Struglics
Osteoarthritis and Cartilage, 2006
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ELISA for the core protein of the cartilage large aggregating proteoglycan, aggrecan: Comparison with the concentrations of immunogenic keratan sulphate in synovial fluid, serum and urine
Jens-christian Poulsen
Clinica Chimica Acta, 1994
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Aggrecan Turnover in Human Articular Cartilage: Use of Aspartic Acid Racemization as a Marker of Molecular Age
Nathali Kaushansky
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ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures
Matthew Stewart
Osteoarthritis and Cartilage, 2006
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Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation
Robert Newton
Annals of the New York Academy of Sciences, 1999
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Coincubation of Bovine Synovial or Capsular Tissue with Cartilage Generates a Soluble “Aggrecanase” Activity
David Buttle
Biochemical and Biophysical Research Communications, 1999
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Influence of aging on the synthesis and morphology of the aggrecans synthesized by differentiated human articular chondrocytes
G. Verbruggen
Osteoarthritis and Cartilage, 2000
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ADAMTS5-/- mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes
Stefan Clockaerts
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, 2009
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Proteolytic mechanisms of cartilage breakdown: a target for arthritis therapy?
David Buttle
Molecular Pathology, 1995
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Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay
David Buttle
Molecular Pathology, 1997
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A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid
André Struglics
Matrix Biology, 2010
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In vivo assessment of macromolecular content in articular cartilage of the goat knee
Markus Rudin
Magnetic Resonance in Medicine, 2003
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Topographical investigation of changes in depth-wise proteoglycan distribution in rabbit femoral articular cartilage at 4 weeks after transection of the anterior cruciate ligament
Jukka Jurvelin
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015
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