Dopamine/serotonin receptor ligands. Part 15: Oxygenation of the benz-indolo-azecine LE 300 leads to novel subnanomolar dopamine D1/D5 antagonists (original) (raw)

Dopamine/Serotonin Receptor Ligands. Part IV [1]: Synthesis and Pharmacology of Novel 3-Benzazecines and 3-Benzazonines as Potential 5-HT2A and Dopamine Receptor Ligands

Hussein El-subbagh

Archiv der Pharmazie, 2002

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Dopamine/Serotonin Receptor Ligands, Part III [1]: Synthesis and Biological Activities of 7, 7′—Alkylene-bis-6, 7, 8, 9, 14, 15-hexahydro-5H-benz[d]indolo[2, 3-g]azecines — Application of the Bivalent Ligand Approach to a Novel Type of Dopamine Receptor Antagonist

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Archiv Der Pharmazie, 2002

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Dopamine/Serotonin Receptor Ligands. 12 1 : SAR Studies on Hexahydro-dibenz[ d , g ]azecines Lead to 4-Chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[ d,g ]azecin-3-ol, the First Picomolar D 5 -Selective Dopamine-Receptor Antagonist

Christoph Enzensperger

Journal of Medicinal Chemistry, 2006

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Dopamine/Serotonin Receptor Ligands. 10: 1 SAR Studies on Azecine-type Dopamine Receptor Ligands by Functional Screening at Human Cloned D 1 , D 2L , and D 5 Receptors with a Microplate Reader Based Calcium Assay Lead to a Novel Potent D 1 /D 5 Selective Antagonist

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Journal of Medicinal Chemistry, 2006

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(.+-.)-(Aminoalkyl)benzazepine Analogs: Novel Dopamine D1 Receptor Antagonists

Jeffrey Witkin

Journal of Medicinal Chemistry, 1995

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Synthesis and receptor affinities of some conformationally restricted analogues of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl- 1H-3-benzazepin-7-ol

R. Chipkin, Donald Hou

Journal of medicinal chemistry, 1989

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Dopamine/serotonin receptor ligands. Part 17: A cross-target SAR approach: Affinities of azecine-styled ligands for 5-HT2A versus D1 and D2 receptors

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Bioorganic & Medicinal Chemistry Letters, 2008

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Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor

martyn wood

Bioorganic & Medicinal Chemistry Letters, 2000

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(±)-3-[4‘-( N , N -Dimethylamino)cinnamyl]benzazepine Analogs: Novel Dopamine D 1 Receptor Antagonists †

Jeffrey Witkin

Journal of Medicinal Chemistry, 1996

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Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626

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Bioorganic & Medicinal Chemistry, 2010

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Dopamine receptor agonists: 3-allyl-6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol and a series of related 3-benzazepines

Robert Demarinis

Journal of Medicinal Chemistry, 1986

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Chiral Indolo[3,2- f ][3]benzazecine-Type Dopamine Receptor Antagonists: Synthesis and Activity of Racemic and Enantiopure Derivatives

Christoph Enzensperger, Hussein El-subbagh

Journal of Medicinal Chemistry, 2011

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Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: A novel series of mixed dopamine D2/D4 receptor antagonist

Xiaoyan Zhang

Bioorganic & Medicinal Chemistry Letters, 2003

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The synthesis, and dopamine D2 and serotonin 5-HT3 receptor affinity of 3-aza analogues (pyridyl) of 4-amino-5-chloro-2-methoxybenzamides

Frank King

Bioorganic & Medicinal Chemistry Letters, 1995

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Structure−Activity Relationships for a Novel Series of Dopamine D2-like Receptor Ligands Based on N-Substituted 3-Aryl-8-azabicyclo[3.2.1]octan-3-ol

Jonathan Katz

Journal of Medicinal Chemistry, 2008

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New generation dopaminergic agents 4. Exploiting the 2-methyl chroman scaffold. Synthesis and evaluation of two novel series of 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano[2,3-e]indole and indol-8-one derivatives

Georgia McGaughey

Tetrahedron, 1998

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Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties

Kjell Svensson

Journal of Medicinal Chemistry, 1989

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(.+-.)-3-Allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines as selective high affinity D1 dopamine receptor antagonists: synthesis and structure-activity relationship

Mai Tran

Journal of Medicinal Chemistry, 1992

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Synthesis, Molecular Properties Estimations, and Dual Dopamine D2 and D3 Receptor Activities of Benzothiazole-Based Ligands

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Further Definition of the D1 Dopamine Receptor Pharmacophore: Synthesis of trans-6,6a,7,8,9,13b-Hexahydro-5H-benzo[d]naphth[2,1-b]azepines as Rigid Analogues of β-Phenyldopamine

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Journal of Medicinal Chemistry, 1997

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Azaindole derivatives with high affinity for the dopamine D4 receptor: Synthesis, ligand binding studies and comparison of molecular electrostatic potential maps

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Bioorganic & Medicinal Chemistry Letters, 1999

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(.+-.)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, a new high affinity D1 dopamine receptor ligand: synthesis and structure-activity relationship

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Journal of Medicinal Chemistry, 1991

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Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands

Ferran Sanz

Bioorganic & Medicinal Chemistry Letters, 2009

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Dopamine receptor binding properties of some 2,3,4,5-tetrahydro-1H-3-benzazepine-7-ols with non-aromatic substituents in the 5-position

Vicki COFFIN

Bioorganic & Medicinal Chemistry Letters, 1992

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Synthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D3 dopamine receptor selective ligands

Robert Mach

MedChemComm, 2013

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Design and discovery of 1,3-benzodiazepines as novel dopamine antagonists

Brian McKittrick

Bioorganic & Medicinal Chemistry Letters, 2009

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Synthesis and dopamine receptor binding of some pyrazolo [3', 4': 6, 7] azepino [5, 4, 3-cd] indoles

Kayed Abu-Safieh

2003

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Dopamine D 3 Receptor Antagonists. 1. Synthesis and Structure−Activity Relationships of 5,6-Dimethoxy- N -alkyl- and N -Alkylaryl-Substituted 2-Aminoindans

Kjell Svensson

Journal of Medicinal Chemistry, 2001

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2-{4-[ω-[4-(2-Methoxyphenyl)-1-piperazinyl]alkoxy]phenyl}-2H-benzotr iazoles and their N-Oxides as Ligands for some 5-Hydroxytryptamine, Dopamine and Adrenergic Receptor Subtypes

Fabio Sparatore

Pharmacy and Pharmacology Communications, 2000

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trans-2,6-, 3,6- and 4,6-Diaza-5,6,6a,7,8,12b-hexahydrobenzo[C]phenanthrene-10,11-diols as dopamine agonists

Yu-Gui Gu

Bioorganic & Medicinal Chemistry Letters, 1999

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2-{4-[ω-[4-(2-Methoxyphenyl)-1-piperazinyl]alkoxy]phenyl}-2 H -benzotr iazoles and their N-Oxides as Ligands for some 5-Hydroxytryptamine, Dopamine and Adrenergic Receptor Subtypes

Fabio Sparatore

Pharmacy and Pharmacology Communications, 2000

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Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity

Diana Canseco

2003

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