Differential modulation of GABAA receptor function by aryl pyrazoles (original) (raw)
Direct Activation of GABAA Receptors by Loreclezole, an Anticonvulsant Drug with Selectivity for the β-Subunit
Giovanni Biggio
Neuropharmacology, 1996
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Synthesis, Structure−Activity Relationships at the GABA A Receptor in Rat Brain, and Differential Electrophysiological Profile at the Recombinant Human GABA A Receptor of a Series of Substituted 1,2-Diphenylimidazoles
Giovanni Biggio
Journal of Medicinal Chemistry, 2005
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The Anxioselective Agent 7-(2-Chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) Is More Efficacious Than Diazepam at Enhancing GABA-Gated Currents at α1 Subunit-Containing GABAA Receptors
Martyna Krawczyk
Journal of Pharmacology and Experimental Therapeutics, 2006
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Potential anxiolytic agents. 2. Improvement of oral efficacy for the pyrido[1,2-a]benzimidazole (PBI) class of GABA-A receptor modulators
Kris Lulofs
Bioorganic & Medicinal Chemistry Letters
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The Anxioselective Agent 7-(2-Chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) Is More Efficacious Than Diazepam at Enhancing GABA-Gated Currents at 1 Subunit-Containing GABAA Receptors
Phil Skolnick
Journal of Pharmacology and Experimental Therapeutics, 2006
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Common modes of action of γ-butyrolactones and pentylenetetrazol on the GABAA receptor-ionophore complex
Gabor Maksay
European Journal of Pharmacology: Molecular Pharmacology, 1994
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GABAA Receptor Modulators with a Pyrazolo[1,5-a]quinazoline Core: Synthesis, Molecular Modelling Studies and Electrophysiological Assays
Gabriella Guerrini
International Journal of Molecular Sciences
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GABAA receptor pharmacology of fluorinated derivatives of the novel sedative-hypnotic pyrazolopyrimidine indiplon
Alex Hoepping
European Journal of Pharmacology, 2008
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A Behavioural and Neurochemical Study in Rats of the Pharmacology of Loreclezole, a Novel Allosteric Modulator of the GABA A Receptor
Mike Snape
Neuropharmacology, 1996
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molecules Dibenzo[1,2,5]thiadiazepines Are Non-Competitive GABA A Receptor Antagonists
Juan F . Ramírez-Martínez
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In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor 5 Subtype-Selective Inverse Agonist
Ana Lucia Rodrigues
Journal of Pharmacology and Experimental Therapeutics, 2009
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Subtype selectivity of a+b- site ligands of GABAA receptors: identification of the first highly specific positive modulators at a6b2/3g2 receptors
Jie Yang, Isabella Sarto-jackson, Werner Sieghart
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The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit
Alain Hamon
Neuropharmacology, 2003
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Towards Functional Selectivity for α6®3γ2 GABAA Receptors: A Series of Novel Pyrazoloquinolinones
Michael Schnürch
British journal of pharmacology, 2017
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Tricyclic pyridones as functionally selective human GABAAα2/3 receptor-ion channel ligands
Andrew Owens
Bioorganic & Medicinal Chemistry Letters, 2004
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An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA) is a selective and competitive antagonist at the GABAA receptor site
Remy Schlichter
Proceedings of the National Academy of Sciences of the United States of America, 1985
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5-[1‘-(2‘-N-Arylsulfonyl-1‘,2‘,3‘,4‘-tetrahydroisoquinolyl)]-4,5-dihydro-2(3H)-furanones: Positive Allosteric Modulators of the GABAA Receptor with a New Mode of Action
Rodolphe Razet
Journal of Medicinal Chemistry, 2000
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The pharmacology of recombinant GABAA receptors containing bovine α1, β1, γ2L sub-units stably transfected into mouse fibroblast L-cells
John Kemp
British Journal of Pharmacology, 1992
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Gaba agonists and antagonists
Graham Johnston
Biochemical Pharmacology, 1979
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Dibenzo[1,2,5]thiadiazepines Are Non-Competitive GABAA Receptor Antagonists
Juan F . Ramírez-Martínez
2013
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Action of pyrazolopyridines as modulators of [3H]flunitrazepam binding to the GABA/benzodiazepine receptor complex of the cerebellum
Porntip Supavilai
European Journal of Pharmacology, 1981
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Structure and molecular modeling of GABAA receptor antagonists
Daniel Vercauteren
Journal of Medicinal Chemistry, 1992
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Identification of Anxiolytic/Nonsedative Agents among Indol-3-ylglyoxylamides Acting as Functionally Selective Agonists at the γ-Aminobutyric Acid-A (GABA A ) α 2 Benzodiazepine Receptor
Francesca Salvetti
Journal of Medicinal Chemistry, 2009
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New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the γ-aminobutyric acid type A (GABAA) receptor
Gabriella Guerrini
Bioorganic & Medicinal Chemistry, 2011
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Molecular docking analysis of α2-containing GABAA receptors with benzimidazoles derivatives
Aissam El-aliani
2020
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Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans
Bindi Sohal
Journal of Pharmacology and Experimental Therapeutics, 2009
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The effect of cyclopyrrolones on GABAA receptor function is different from that of benzodiazepines
Giovanni Biggio
Naunyn-Schmiedeberg's Archives of Pharmacology, 1994
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Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans
sandra sanabria
Journal of Pharmacology and Experimental Therapeutics, 2010
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Maria Giovannoni
Journal of medicinal chemistry, 2017
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GABA receptors
Wolfgang Froestl
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