Differential modulation of GABAA receptor function by aryl pyrazoles (original) (raw)

Direct Activation of GABAA Receptors by Loreclezole, an Anticonvulsant Drug with Selectivity for the β-Subunit

Giovanni Biggio

Neuropharmacology, 1996

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Synthesis, Structure−Activity Relationships at the GABA A Receptor in Rat Brain, and Differential Electrophysiological Profile at the Recombinant Human GABA A Receptor of a Series of Substituted 1,2-Diphenylimidazoles

Giovanni Biggio

Journal of Medicinal Chemistry, 2005

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The Anxioselective Agent 7-(2-Chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) Is More Efficacious Than Diazepam at Enhancing GABA-Gated Currents at α1 Subunit-Containing GABAA Receptors

Martyna Krawczyk

Journal of Pharmacology and Experimental Therapeutics, 2006

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Potential anxiolytic agents. 2. Improvement of oral efficacy for the pyrido[1,2-a]benzimidazole (PBI) class of GABA-A receptor modulators

Kris Lulofs

Bioorganic & Medicinal Chemistry Letters

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The Anxioselective Agent 7-(2-Chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) Is More Efficacious Than Diazepam at Enhancing GABA-Gated Currents at 1 Subunit-Containing GABAA Receptors

Phil Skolnick

Journal of Pharmacology and Experimental Therapeutics, 2006

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Common modes of action of γ-butyrolactones and pentylenetetrazol on the GABAA receptor-ionophore complex

Gabor Maksay

European Journal of Pharmacology: Molecular Pharmacology, 1994

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GABAA Receptor Modulators with a Pyrazolo[1,5-a]quinazoline Core: Synthesis, Molecular Modelling Studies and Electrophysiological Assays

Gabriella Guerrini

International Journal of Molecular Sciences

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GABAA receptor pharmacology of fluorinated derivatives of the novel sedative-hypnotic pyrazolopyrimidine indiplon

Alex Hoepping

European Journal of Pharmacology, 2008

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A Behavioural and Neurochemical Study in Rats of the Pharmacology of Loreclezole, a Novel Allosteric Modulator of the GABA A Receptor

Mike Snape

Neuropharmacology, 1996

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molecules Dibenzo[1,2,5]thiadiazepines Are Non-Competitive GABA A Receptor Antagonists

Juan F . Ramírez-Martínez

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In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor 5 Subtype-Selective Inverse Agonist

Ana Lucia Rodrigues

Journal of Pharmacology and Experimental Therapeutics, 2009

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Subtype selectivity of a+b- site ligands of GABAA receptors: identification of the first highly specific positive modulators at a6b2/3g2 receptors

Jie Yang, Isabella Sarto-jackson, Werner Sieghart

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The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit

Alain Hamon

Neuropharmacology, 2003

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Towards Functional Selectivity for α6®3γ2 GABAA Receptors: A Series of Novel Pyrazoloquinolinones

Michael Schnürch

British journal of pharmacology, 2017

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Tricyclic pyridones as functionally selective human GABAAα2/3 receptor-ion channel ligands

Andrew Owens

Bioorganic & Medicinal Chemistry Letters, 2004

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An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA) is a selective and competitive antagonist at the GABAA receptor site

Remy Schlichter

Proceedings of the National Academy of Sciences of the United States of America, 1985

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5-[1‘-(2‘-N-Arylsulfonyl-1‘,2‘,3‘,4‘-tetrahydroisoquinolyl)]-4,5-dihydro-2(3H)-furanones: Positive Allosteric Modulators of the GABAA Receptor with a New Mode of Action

Rodolphe Razet

Journal of Medicinal Chemistry, 2000

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The pharmacology of recombinant GABAA receptors containing bovine α1, β1, γ2L sub-units stably transfected into mouse fibroblast L-cells

John Kemp

British Journal of Pharmacology, 1992

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Gaba agonists and antagonists

Graham Johnston

Biochemical Pharmacology, 1979

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Dibenzo[1,2,5]thiadiazepines Are Non-Competitive GABAA Receptor Antagonists

Juan F . Ramírez-Martínez

2013

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Action of pyrazolopyridines as modulators of [3H]flunitrazepam binding to the GABA/benzodiazepine receptor complex of the cerebellum

Porntip Supavilai

European Journal of Pharmacology, 1981

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Structure and molecular modeling of GABAA receptor antagonists

Daniel Vercauteren

Journal of Medicinal Chemistry, 1992

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Identification of Anxiolytic/Nonsedative Agents among Indol-3-ylglyoxylamides Acting as Functionally Selective Agonists at the γ-Aminobutyric Acid-A (GABA A ) α 2 Benzodiazepine Receptor

Francesca Salvetti

Journal of Medicinal Chemistry, 2009

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New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the γ-aminobutyric acid type A (GABAA) receptor

Gabriella Guerrini

Bioorganic & Medicinal Chemistry, 2011

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Molecular docking analysis of α2-containing GABAA receptors with benzimidazoles derivatives

Aissam El-aliani

2020

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Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans

Bindi Sohal

Journal of Pharmacology and Experimental Therapeutics, 2009

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The effect of cyclopyrrolones on GABAA receptor function is different from that of benzodiazepines

Giovanni Biggio

Naunyn-Schmiedeberg's Archives of Pharmacology, 1994

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Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans

sandra sanabria

Journal of Pharmacology and Experimental Therapeutics, 2010

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{"__content__"=>"Identification of a New Pyrazolo[1,5-a]quinazoline Ligand Highly Affine to γ-Aminobutyric Type A (GABA) Receptor Subtype with Anxiolytic-Like and Antihyperalgesic Activity.", "sub"=>{"__content__"=>"A"}}

Maria Giovannoni

Journal of medicinal chemistry, 2017

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GABA receptors

Wolfgang Froestl

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