Narrowing the gap between the promise and reality of polyketide synthases as a synthetic biology platform (original) (raw)

Technical Advances to Accelerate Modular Type I Polyketide Synthase Engineering towards a Retro-biosynthetic Platform

Yao Wan

Biotechnology and Bioprocess Engineering, 2019

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Chemoinformatic-guided engineering of polyketide synthases

Edward Baidoo

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Synthetic biology enabling access to designer polyketides

Lindsay Nichols

Current Opinion in Chemical Biology, 2020

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Steps towards the synthetic biology of polyketide biosynthesis

Rainer Breitling

2014

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ASMPKS: an analysis system for modular polyketide synthases

Kiejung Park

BMC Bioinformatics, 2007

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Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes

Hugo Menzella

Nature Biotechnology, 2005

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Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension

Jesús Mateo Cortés

Chemistry & Biology, 1998

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Minimally Invasive Mutagenesis Gives Rise to a Biosynthetic Polyketide Library

Andreas Brockmeyer

Angewandte Chemie International Edition, 2012

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Engineering polyketide synthases and nonribosomal peptide synthetases

Gavin P Williams

Current Opinion in Structural Biology, 2013

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A comprehensive and engaging overview of the type III family of polyketide synthases

Alex Praseuth

Current Opinion in Chemical Biology, 2007

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Dissecting complex polyketide biosynthesis

Patrick Caffrey

Computational and structural biotechnology journal, 2012

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Rational Design and Assembly of Synthetic Trimodular Polyketide Synthases

Hugo Menzella

Chemistry & Biology, 2007

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Faculty of 1000 evaluation for Structure of a modular polyketide synthase

Sean Lund

F1000 - Post-publication peer review of the biomedical literature, 2014

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Systematic Domain Swaps of Iterative, Nonreducing Polyketide Synthases Provide a Mechanistic Understanding and Rationale For Catalytic Reprogramming

Craig Townsend

Journal of the American Chemical Society, 2014

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Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase

Carlos Olano

Chemical Communications, 2003

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The Assembly Line Enzymology of Polyketide Biosynthesis

Paul Race

Methods in molecular biology (Clifton, N.J.), 2016

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Evidence for Two Catalytically Independent Clusters of Active Sites in a Functional Modular Polyketide Synthase †

Rembert Pieper

Biochemistry, 1996

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Synthetic Polyketide Enzymology: Platform for Biosynthesis of Antimicrobial Polyketides

Jantana Wongsantichon

ACS Catalysis, 2015

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In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

Haruo Ikeda

Nature Communications

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An artificial pathway for polyketide biosynthesis

Lindsay Nichols

Nature Catalysis, 2020

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Insights into Modular Polyketide Synthase Loops Aided by Repetitive Sequences

Samantha Spears

2020

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Recombinatorial biosynthesis of polyketides

Antonio Starcevic

Journal of Industrial Microbiology & Biotechnology, 2011

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Activating Hybrid Modular Interfaces in Synthetic Polyketide Synthases by Cassette Replacement of Ketosynthase Domains

Hugo Menzella

Chemistry & Biology, 2006

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SBSPKS: structure based sequence analysis of polyketide synthases

Zeeshan Ansari

Nucleic Acids Research, 2010

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Structure of a modular polyketide synthase

David Sherman

Nature, 2014

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A bimodular PKS platform that expands the biological design space

luis valencia

2020

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Insights into the stereospecificity of ketoreduction in a modular polyketide synthase

Frank Schulz

Organic & Biomolecular Chemistry, 2011

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Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry

Peter Leadlay

FEBS Journal, 2005

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Polyketide synthesis in vitro on a modular polyketide synthase

Jesús Mateo Cortés

Chemistry & Biology, 1995

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Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase

Peter Leadlay

Chemistry & Biology, 2001

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