Applications of green chemistry in the manufacture of oligonucleotide drugs (original) (raw)
UnyLinker: An Efficient and Scaleable Synthesis of Oligonucleotides Utilizing a Universal Linker Molecule: A Novel Approach To Enhance the Purity of Drugs
LUCIO MENDEZ
Organic Process Research & Development, 2008
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Green approaches for the synthesis of nucleotides, their conjugates and analogues
Béatrice Roy
Phosphorus Sulfur and Silicon and The Related Elements, 2020
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Efficient synthesis of antisense phosphorothioate oligonucleotides using a universal solid support
Andrei Guzaev, Vasulinga Ravikumar
Tetrahedron, 2006
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Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry
Thazha Prakash
Bioorganic & Medicinal Chemistry Letters, 2015
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Phosphoramidites and solid supports based on N-substituted 2,4-dihydroxybutyramides: universal reagents for synthesis of modified oligonucleotides
Dmitry Stetsenko
Tetrahedron, 2006
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Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
david butler
Nature biotechnology, 2017
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Solid-Phase Synthesis of Modified Oligonucleotides
Ramon Eritja
International Journal of Peptide Research and Therapeutics, 2006
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Liquid‐Phase Oligonucleotide Synthesis: Past, Present, and Future Predictions
Yogesh Sanghvi
Current protocols in nucleic acid chemistry, 2019
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Modified oligonucleotides: IV solid phase synthesis and preliminary evaluation of phosphorothioate RNA as potential antisense agents
Francois Morvan
Tetrahedron Letters, 1990
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Phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the synthesis of modified oligonucleotides
Sergey Gontarev
Russian Journal of Bioorganic Chemistry, 2017
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An improved synthesis of oligodeoxynucleotide N34∀P54 phosphoramidates and their chimera using hindered phosphoramidite monomers and a novel handle for reverse phase purification
Mark Nguyen
2000
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Large-scale synthesis of high purity “Phos reagent” useful for oligonucleotide therapeutics
Yogesh Sanghvi
Journal of Organometallic Chemistry, 2005
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The pro-oligonucleotide approach: solid phase synthesis and preliminary evaluation of model pro-dodecathymidylates
Francois Morvan
Nucleic Acids Research, 1998
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Prevention of guanine modification and chain cleavage during the solid phase synthesis of oligonucleotides using phosphoramidite derivatives
Nassim Usman
Nucleic Acids Research, 1986
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Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages
sam lee
Nucleic Acids Research, 2014
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Solid-phase synthesis of base-sensitive oligonucleotides
Pasi Virta
Arkivoc, 2008
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Oligonucleotides: Current Trends and Innovative Applications in the Synthesis, Characterization, and Purification
Massimo Morbidelli
Biotechnology Journal, 2020
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Antisense Oligonucleotides Containing Conformationally Constrained 2′,4′-( N Methoxy)aminomethylene and 2′,4′-Aminooxymethylene and 2′- O ,4′- C -Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models
Chris Black
Journal of Medicinal Chemistry, 2010
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Convergent Solution Phase Synthesis of Chimeric Oligonucleotides by a 2+2 and 3+3 Phosphoramidite Strategy
Kaushik Chanda
Australian Journal of Chemistry, 2010
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Mixed-Backbone oligonucleotides as second-generation antisense agents with reduced phosphorothioate-related side effects
Carl Saxinger
Bioorganic & Medicinal Chemistry Letters, 1998
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Synthesis of branched antisense oligonucleotides having multiple specificities
Marvin Rubenstein
Medical Hypotheses, 2006
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An improved synthesis of oligodeoxynucleotide N3'->P5' phosphoramidates and their chimera using hindered phosphoramidite monomers and a novel handle for reverse phase purification
Larry DeDionisio
Nucleic Acids Research, 1998
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Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties
Valentin Vlasov
Proceedings of the National Academy of Sciences of the United States of America, 2019
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3′-3′-linked oligonucleotides: Synthesis and stability studies
Carole Chaix
Bioorganic & Medicinal Chemistry Letters, 1996
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The Dimethoxytrityl Resin Product Anchored Sequential Synthesis Method (DMT PASS): A Conceptually Novel Approach to Oligonucleotide Synthesis
David Sebesta
Organic Process Research & Development, 2000
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Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines
Yogesh Sanghvi
Nucleic Acids Research, 1993
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Antisense Oligonucleotides: An Emerging Area in Drug Discovery and Development
Karishma Dhuri
Journal of Clinical Medicine
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Novel chemoenzymatic protocol for the synthesis of 3′-O- dimethoxytrityl-2′-deoxynucleoside derivatives as building blocks for oligonucleotide synthesis
Yogesh Sanghvi
2006
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Intermolecular radical CC bond formation: Synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides
Dan Cook
Tetrahedron Letters, 1992
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Optimized Automated Solid Phase Synthesis of Oligonucleotides and Derivatives
Gerald Grübler
Zeitschrift für Naturforschung B, 1998
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A new solid-phase synthesis of oligonucleotides 3′-conjugated with peptides
Enrico Bucci
Bioorganic & Medicinal Chemistry, 1999
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Synthesis of 5′-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies
Andrew Rodriguez
Molecules, 2017
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