The Tau N279K Exon 10 Splicing Mutation Recapitulates Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 Tauopathy in a Mouse Model (original) (raw)

Differential regulation of microtubule dynamics by three- and four-repeat tau: Implications for the onset of neurodegenerative disease

Jonathan Samuel

Proceedings of the National Academy of Sciences, 2003

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Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders

Max Holzer

Molecular Brain Research, 1999

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Tau with three and four microtubule-binding repeats in human brain of Alzheimer's disease and frontotemporal dementia

Nenad Bogdanovic

Neurobiology of Aging, 2000

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Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17

G. Varani

Proceedings of the National Academy of Sciences, 1999

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victoria makrides

Journal of Biological Chemistry, 2003

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Mary Jordan

Molecular Biology of the Cell, 2004

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Yann Verdier

Scientific Reports, 2015

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Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains

Jennifer Osetek

Acta Neuropathologica, 2007

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FTDP-17 Mutations Compromise the Ability of Tau to Regulate Microtubule Dynamics in Cells

Mary Jordan

Journal of Biological Chemistry, 2006

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Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

Caroline Smet-Nocca

Frontiers in Aging Neuroscience

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Systemic and network functions of the microtubule-associated protein tau: Implications for tau-based therapies

Abdala Ussif

Molecular and Cellular Neuroscience, 2017

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Modulation of Tau Isoforms Imbalance Precludes Tau Pathology and Cognitive Decline in a Mouse Model of Tauopathy

Juan Ferrario

Cell reports, 2018

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Atypical, non-standard functions of the microtubule associated Tau protein

Marie-christine Galas

Acta neuropathologica communications, 2017

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Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects

Bernard Schneider

Scientific reports, 2017

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High Prevalence of Mutations in the Microtubule-Associated Protein Tau in a Population Study of Frontotemporal Dementia in the Netherlands

rivka ravid

American Journal of Human Genetics, 1999

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FTDP-17 Mutations in Tau Alter the Regulation of Microtubule Dynamics

Mary Jordan

Journal of Biological Chemistry, 2008

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Tau protein in neurodegenerative diseases - a review

simona bondari

2017

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Tau mis-splicing correlates with motor impairments and striatal dysfunction in a model of tauopathy

Magdalena De León

Brain, 2021

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Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

Mohamed Senouci

Proceedings of the National Academy of Sciences, 1998

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Oligomerization of the Microtubule Associated Protein Tau is Mediated by its N-Terminal Sequences: Implications for Normal and Pathological Tau Action

Srinivasan Ramachandran

Journal of neurochemistry, 2016

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Three- and Four-repeat Tau Regulate the Dynamic Instability of Two Distinct Microtubule Subpopulations in Qualitatively Different Manners

Mary Jordan

Journal of Biological Chemistry, 2005

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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

Valérie Buée-Scherrer

Brain Research Reviews, 2000

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SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy

Juan Ferrario

Frontiers in Bioengineering and Biotechnology

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A genomic sequence analysis of the mouse and human microtubule-associated protein tau

Yang Zhou

Mammalian Genome, 2001

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Familial FTDP-17 Missense Mutations Inhibit Microtubule Assembly-promoting Activity of Tau by Increasing Phosphorylation at Ser202 in Vitro

Hamid Yaqoob Qureshi

Journal of Biological Chemistry, 2009

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Tau-based treatment strategies in neurodegenerative diseases

Anja Schneider

Neurotherapeutics, 2008

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Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

Katerina Markopoulou

Proceedings of the National Academy of Sciences, 1998

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A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration

Zbigniew Wszolek

Neurology, 1999

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Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability

Frida Kleiman

Frontiers in cellular neuroscience, 2018

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Much More Than a Cytoskeletal Protein: Physiological and Pathological Functions of the Non-microtubule Binding Region of Tau

Lidia Bakota

Frontiers in Neurology, 2020

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