Heterologous expression of full-length lanosterol 14α-demethylases of prominent fungal pathogens Candida albicans and Candida glabrata provides tools for antifungal discovery
Mikhail Keniya
Antimicrobial Agents and Chemotherapy, 2018
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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase
Joel Tyndall
Antimicrobial Agents and Chemotherapy, 2015
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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14-Demethylase
Joel Tyndall
2016
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Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14α-Demethylase as a Surrogate
Mikhail Keniya
Journal of Fungi
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Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals
Mikhail Keniya
PloS one, 2016
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Crystal structure of the new investigational drug candidate VT-1598 in complex with Aspergillus fumigatus sterol 14α-demethylase provides insights into its broad-spectrum antifungal activity
Girish Rachakonda
Antimicrobial agents and chemotherapy, 2017
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Three-Dimensional Model of Lanosterol 14 -Demethylase from Cryptococcus neoformans: Active-Site Characterization and Insights into Azole Binding
Guozhu Dong
Antimicrobial Agents and Chemotherapy, 2009
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Sterol 14α-Demethylase Structure-Based Design of VNI ((R)-N-(1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis
Girish Rachakonda
Journal of Medicinal Chemistry, 2018
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Molecular design of two sterol 14α-demethylase homology models and their interactions with the azole antifungals ketoconazole and bifonazole
Bernd Rupp
Journal of Computer-Aided Molecular Design, 2005
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Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors
Livia Uncu
Revista de Chimie
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Thiazolyl-Oxadiazole Derivatives Targeting Lanosterol 14Α-DEMETHYLASE as Potential Antifungal Agents: Design, Synthesis and Molecular Docking Studies
Mariana Palage
2016
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The Mutation T315A in Candida albicans Sterol 14α-Demethylase Causes Reduced Enzyme Activity and Fluconazole Resistance through Reduced Affinity
muhammad saeed Akhtar
Journal of Biological Chemistry, 1997
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Antifungal screening and in silico mechanistic studies of an in-house azole library
ARZU KARAKURT
Chemical Biology & Drug Design, 2019
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Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161
Mikhail Keniya
Antimicrobial Agents and Chemotherapy
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The amino acid substitution N136Y in Candida albicans sterol 14alpha-demethylase is involved in fluconazole resistance
Audrey FLEURY
Medical mycology, 2016
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Molecular Modeling of Azole Antifungal Agents Active against Candida albicans. 1. A Comparative Molecular Field Analysis Study1
Roberto Di Santo
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Probing the Active Site of Candida glabrata Dihydrofolate Reductase with High Resolution Crystal Structures and the Synthesis of New Inhibitors
Dennis Wright
Chemical Biology & Drug Design, 2009
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Relationship of Azole Resistance with the Structural Alteration of the Target Sites: Novel Synthetic Compounds for Better Antifungal Activities
Ram Kumar, Tapan Mukherjee, Parth Malik
The Natural Products Journal, 2014
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Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives
Guozhu Dong
Bioorganic & Medicinal Chemistry Letters, 2010
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Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase
Mikhail Keniya
Antimicrobial Agents and Chemotherapy
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Discovery of new azoles with potent activity against Candida spp. and Candida albicans biofilms through virtual screening
ARZU KARAKURT
European Journal of Medicinal Chemistry, 2019
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Molecular Docking Evaluation of Imidazole Analogues as Potent Candida albicans 14α-Demethylase Inhibitors
Nidhi Rani
Current Computer Aided-Drug Design, 2015
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Structure-Guided Development of Efficacious Antifungal Agents Targeting Candida glabrata Dihydrofolate Reductase
Dennis Wright
Chemistry & Biology, 2008
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Amino Acid Substitutions at the Major Insertion Loop of Candida albicans Sterol 14alpha-Demethylase Are Involved in Fluconazole Resistance
Florent Morio
PLoS ONE, 2011
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Differential Azole Antifungal Efficacies Contrasted Using a Saccharomyces cerevisiae Strain Humanized for Sterol 14α-Demethylase at the Homologous Locus
Denis POMPON
Antimicrobial Agents and Chemotherapy, 2008
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Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells
Yael Roichman
ACS chemical biology, 2017
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Small molecule inhibitors targeting sterol 14α-demethylase (CYP51): synthesis, molecular modeling and evaluation against Candida albicans
Esra Tatar
2020
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Repurposing approach identifies phenylpentanol derivatives as potent azole chemosensitizing agents effective against azole-resistant Candida species
Ehab salama
2019
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Novel nucleosides as potential inhibitors of fungal lanosterol 14α-demethylase: an in vitro and in silico study
pratibha shukla
Future Medicinal Chemistry, 2019
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Identification of 1, 2, 4-Triazine and Its Derivatives against Lanosterol 14 - Demethylase (CYP51) Property of Candida Albicans: Influence on the Development of New Antifungal Therapeutic Strategies
Vijay yadav
2021
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Characterization of a Lanosterol 14α-Demethylase from Pneumocystis carinii
Pawan Vohra
American Journal of Respiratory Cell and Molecular Biology, 2003
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In silico Discovery of a New Potent Inhibitor for Sterol 14-alpha Demethylase as a Promising Antifungal Drug against Aspergillus fumigatus Infection
Hayder O Hashim
Biointerface Research in Applied Chemistry, 2021
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