original ) (raw )Molecular design of two sterol 14α-demethylase homology models and their interactions with the azole antifungals ketoconazole and bifonazole
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Journal of Computer-Aided Molecular Design, 2005
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Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161
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Azole Resistance Profile of Amino Acid Changes in Aspergillus fumigatus CYP51A Based on Protein Homology Modeling
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Amino Acid Substitutions in the Cytochrome P-450 Lanosterol 14a-Demethylase (CYP51A1) from Azole-Resistant Candida albicans Clinical Isolates Contribute to Resistance to Azole Antifungal Agents
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1998
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PLoS ONE, 2011
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Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature
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Diagnostic microbiology and infectious disease, 2010
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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase
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Antimicrobial Agents and Chemotherapy, 2015
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Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450
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Antimicrobial Agents and Chemotherapy, 1999
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Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives
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Bioorganic & Medicinal Chemistry Letters, 2010
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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14-Demethylase
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Amino Acid Substitutions in the Cytochrome P-450 Lanosterol 14α-Demethylase (CYP51A1) from Azole-Resistant Candida albicans Clinical Isolates Contribute to Resistance to Azole Antifungal Agents
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Antimicrobial Agents and Chemotherapy, 1998
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Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans
Marcel Borgers , Hugo Vanden Bossche
Microbiology (Reading, England), 1999
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Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology
Galina Lepesheva
The Journal of Lipid Research, 2004
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Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1
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Biochimica et biophysica acta, 2016
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Relationship of Azole Resistance with the Structural Alteration of the Target Sites: Novel Synthetic Compounds for Better Antifungal Activities
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The Natural Products Journal, 2014
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Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14α-Demethylase as a Surrogate
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Mechanisms of azole antifungal resistance in clinical isolates of Candida tropicalis
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Cyclic AMP Signaling Pathway Modulates Susceptibility of Candida Species and Saccharomyces cerevisiae to Antifungal Azoles and Other Sterol Biosynthesis Inhibitors
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SpringerPlus, 2014
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The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport
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Molecular docking of azole drugs and their analogs on CYP121 of Mycobacterium tuberculosis
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Bioinformation, 2011
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Amino acid substitutions in the Candida albicans sterol Δ5,6-desaturase (Erg3p) confer azole resistance: characterization of two novel mutants with impaired virulence
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