Transformation and transactivation suppressor activity of the c-Jun leucine zipper fused to a bacterial repressor (original) (raw)

Cloning, expression, and spectroscopic studies of the Jun leucine zipper domain

neal williams`

European Journal of Biochemistry, 1994

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jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

Jean Viallet

Cell, 1989

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Role of Interfacial Hydrophobic Residues in the Stabilization of the Leucine Zipper Structures of the Transcription Factors c-Fos and c-Jun

Milton Hearn

Journal of Biological Chemistry, 2001

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Uncoiling c-Jun coiled coils: inhibitory effects of truncated Fos peptides on Jun dimerization and DNA binding in vitro

Elsie Pares

Biopolymers (Peptide Science), 1998

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Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation

James Woodgett

Proceedings of the National Academy of Sciences, 1992

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Transcription activation by the transforming domain of adenovirus E1A is efficiently repressed by the last 44 amino acids of E1A

K. Sollerbrant

Journal of Cancer Research and Clinical Oncology, 1995

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p75-Ras-GRF1 Is a c-Jun/AP-1 Target Protein: Its Up Regulation Results in Increased Ras Activity and Is Necessary for c-Jun-Induced Nonadherent Growth of Rat1a Cells

Geoffrey Clark

Molecular and Cellular Biology, 2005

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The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase

Ronit Heinrich

2001

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Mutations in the Jun delta region suggest an inverse correlation between transformation and transcriptional activation

Iain Morgan

Proceedings of the National Academy of Sciences, 1992

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Dissecting the role of leucine zippers in the binding of bZIP domains of Jun transcription factor to DNA

Amjad Farooq, Caleb McDonald

Biochemical and Biophysical Research Communications, 2010

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TAF7 (TAFII55) plays a role in the transcription activation by c-Jun

László Tora

Journal of Biological …, 2003

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Stepwise transformation of rat embryo fibroblasts: c-Jun, JunB, or JunD can cooperate with Ras for focus formation, but a c-Jun-containing heterodimer is required for immortalization

Laurence Vandel

Molecular and cellular biology, 1996

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Ras-Dependent Regulation of c-Jun Phosphorylation Is Mediated by the Ral Guanine Nucleotide Exchange Factor-Ral Pathway

Rob Wolthuis

Molecular and Cellular Biology, 2000

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Cleavage of the JunB Transcription Factor by Caspases Generates a Carboxyl-terminal Fragment That Inhibits Activator Protein-1 Transcriptional Activity

Brandon Maser

Journal of Biological Chemistry, 2013

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Transformation by ras modifies AP1 composition and activity

Fatima Mechta-Grigoriou

Oncogene, 1997

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Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptional activity by protein kinase A

Masahiko Hibi

The EMBO journal, 1994

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Control of the Orientation of Fos-Jun Binding and the Transcriptional Cooperativity of Fos-Jun-NFAT1 Complexes

Tom Kerppola

Journal of Biological Chemistry, 2001

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Heterodimerization with Fra-1 cooperates with the ERK pathway to stabilize c-Jun in response to the RAS oncoprotein

F. Talotta, Laura Casalino

Oncogene, 2010

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Products of the fos and jun Proto-Oncogenes Bind Cooperatively to the AP1 DNA Recognition Sequence

M. Neuberg

Environmental Health Perspectives, 1990

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Asymmetric Recognition of Nonconsensus AP-1 Sites by Fos-Jun and Jun-Jun Influences Transcriptional Cooperativity with NFAT1

Tom Kerppola

Molecular and Cellular Biology, 2003

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The DNA binding domains of the yeast Ga14 and human c-Jun transcription factors interact through the zinc-finger and bZIP motifs

K. Sollerbrant

Nucleic Acids Research, 1995

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The c-Jun Dimerization Protein 2 Inhibits Cell Transformation and Acts as a Tumor Suppressor Gene

Ronit Heinrich

Journal of Biological Chemistry, 2003

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c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor

Trang Hoang

Journal of Biological Chemistry, 1999

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Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation

Joël Baguet

Genes & Development, 1998

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Structural basis of DNA bending and oriented heterodimer binding by the basic leucine zipper domains of Fos and Jun

Tom Kerppola, N. Rajaram

Proceedings of the National Academy of Sciences, 1997

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Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts

Tom Kerppola

1992

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Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases

Masahiko Hibi

Proceedings of the National Academy of Sciences, 1994

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Evidence that the bZIP domains of the Jun transcription factor bind to DNA as monomers prior to folding and homodimerization

Amjad Farooq, Caleb McDonald

Archives of Biochemistry and Biophysics, 2008

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The cytoskeletal network controls c-Jun translation in a UTR-dependent manner

Pazit Polak

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Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta

Shigeo Ohno

The EMBO Journal, 1994

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Complexes of p21RAS with JUN N-terminal kinase and JUN proteins

Ze'ev Ronai

Proceedings of the National Academy of Sciences, 1995

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The defective transforming phenotype of c-Jun Ala63/73 is rescued by mutation of the C-terminal phosphorylation site

Leslie Caron

Oncogene, 2001

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Thermodynamic analysis of the heterodimerization of leucine zippers of Jun and Fos transcription factors

Amjad Farooq, Caleb McDonald

Biochemical and Biophysical Research Communications, 2008

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Role of the ATFa/JNK2 complex in Jun activation

Bruno Chatton

Oncogene, 1999

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Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region

Tom Kerppola

Molecular and cellular biology, 1994

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