Significant Role for p 16 INK 4 a in p 53-Independent Telomere-Directed Senescence (original) (raw)
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
Guy Poirier
The EMBO Journal, 1997
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Reversal of human cellular senescence: roles of the p53 and p16 pathways
Paul Yaswen
The EMBO Journal, 2003
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The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo
Gabriele Saretzki
EMBO reports, 2005
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p16INK4a as a Second Effector of the Telomere Damage Pathway
Jacqueline J.l Jacobs
Cell Cycle, 2005
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Loss of p16Ink4a Function Rescues Cellular Senescence Induced by Telomere Dysfunction
Ying Luo
International Journal of Molecular Sciences, 2012
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Inactivation of p16 , with Retention of pRB and p53/p21 Function, in Human MRC5 Fibroblasts That Overcome a Telomere-independent Crisis during Immortalization
Lisa L Prigmore, PharmD
Journal of Biological Chemistry, 2004
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{"__content__"=>"Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16-deficient epithelial cells.", "sup"=>{"__content__"=>"INK4a"}}
laura tusell
Oncotarget, 2018
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p53 Differentially Inhibits Cell Growth Depending on the Mechanism of Telomere Maintenance
Chiara Caslini
Molecular and Cellular Biology, 2004
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Sequential Extension of Proliferative Lifespan In Human Fibroblasts Induced by Over-Expression of CDK4 or 6 and Loss of P53 Function.
Mark Morris
Oncogene, 2002
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p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
Lynda Chin
Cell, 1999
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Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines
Paul Yaswen
Oncogene, 2003
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Loss of p21 promoted tumorigenesis in the background of telomere dysfunctions induced by TRF2 and Wrn deficiency
Ying Luo
International journal of biological sciences, 2018
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Abrogation of Radiation-Inducible Telomerase Upregulation in HPV16 E6 Transfectants of Human Lymphoblasts
Frederik Wenz
Strahlentherapie und Onkologie, 2004
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p53-dependent Down-regulation of Telomerase Is Mediated by p21waf1
Ran Brosh, M. Tzukerman
Journal of Biological Chemistry, 2004
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Reversal of Senescence in Mouse Fibroblasts through Lentiviral Suppression of p53
Rene Bernards
Journal of Biological Chemistry, 2003
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Increased p53 activity does not accelerate telomere-driven ageing
Juana Flores
EMBO reports, 2006
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p53-dependent Down-regulation of Telomerase Is Mediated by p21
Maty Tzukerman
Journal of Biological Chemistry, 2004
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Repression of the Human Papillomavirus E6 Gene Initiates p53Dependent, Telomerase-Independent Senescence and Apoptosis in HeLa Cervical Carcinoma Cells
Stacy Horner
Journal of Virology, 2004
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Comparing the Role of the p53 Gene and Telomerase Enzyme in ‘Accelerated Aging Due to Cancer’: A Literature Review
Raheela Khalid
Cureus, 2020
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Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice
Juana Flores
Genes & Development, 2009
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Soothing the Watchman: Telomerase Reduces the p53-dependent Cellular Stress Response
Paul Yaswen
Cell Cycle, 2007
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Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells
Ahmed Zaid
Oncogene, 2000
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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
Giulia Celi
Nature Cell Biology, 2005
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Relationship between spontaneous or radiation-induced apoptosis and telomere shortening in G0 human lymphocytes
Fabrizio Palitti
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2010
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Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA
Nicola Royle
The Journal of Cell Biology, 2007
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Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence
Olivier Hermine
Blood, 2006
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Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype
Yuval Tabach
2003
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p53 Prevents Entry into Mitosis with Uncapped Telomeres
Maria Thanasoula
Current Biology, 2010
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Involvement of the Cyclin-Dependent Kinase Inhibitor p16 (INK4a) in Replicative Senescence of Normal Human Fibroblasts
David Alcorta
Proceedings of The National Academy of Sciences, 1996
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TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts
Gabriele Saretzki
Mechanisms of ageing …, 2007
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P53-DEPENDENT Integration of Telomere and Growth Factor Deprivation Signals
James Garbe
Proceedings of the National Academy of Sciences, 2007
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Rapid senescence induced by overexpression of p53 in NIH3T3 cells
Jiancheng Hu
Chinese Science Bulletin, 2001
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Contribution of p16INK4a to replicative senescence of human fibroblasts
Ana Gutierrez-Del-Arroyo
Experimental Cell Research, 2004
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