Clinico-Hematological Profile of Acute Leukemia Cases in Bihar: A Multiparameter Study in a Tertiary-Care Hospital (original) (raw)
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Curēus, 2024
Objective: This study aimed to examine the impact of leukemia and other cancers in India and to observe any changes over time. Methodology: Detailed estimates of incidence, prevalence, mortality, and disability-adjusted life years (DALYs) for 30 types of cancers in India were analyzed for 29 years from 1990 to 2019 as part of the Global Burden of Diseases (GBD) study. Data from all available sources were used to gather information on the overall burden of disease in India. Results: Cancer is a leading cause of death worldwide, with varying rates of incidence in India, making prevention and treatment a challenge. Because cancer is not a reportable disease in India, the overall burden estimate is still a work in progress. This study analyzed the impact of leukemia and other cancers in India, including trends in incidence, DALYs, and mortality related to all cancers and various malignancies. The causes of leukemia in India were also explored. Conclusions: The study found the trends of cancer types that account for the majority of leukemia-related and cancer-related DALYs, death, prevalence, and incidence in India. Among the four most frequent malignancies, such as leukemia, there was significant variation based on age. Over the last 29 years, mortality from chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) has decreased, while deaths from acute myelogenous leukemia (AML) and chronic lymphocytic leukemia (CLL) have increased steadily.
Spectrum of acute and chronic leukemia at a tertiary care hospital, Haryana, India
International Journal of Research in Medical Sciences, 2016
Leukemia are of two types; acute and chronic. Acute leukemias are; acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). In childhood, ALL is most common type than AML. In India, the incidence of ALL and AML are 35% and 15% of all hematological malignancies respectively. Chronic leukemias are classified into chronic myeloid leukemia (CML) and chronic lypmphocytic leukemia (CLL). 3,4
2018
Introduction: Leukemias are neoplastic proliferations of haematopoietic stem cells and form a major proportion of haematopoietic neoplasms that are diagnosed worldwide. Typing of leukemia is essential for effective therapy because prognosis and survival rate are different for each type and sub-type Aims: To carry out the incidence of acute and chronic leukemias presenting in various departments of GMCH, Guwahati, Assam. Methods: It was a retrospective study of 182 patients carried out in the department of Pathology over a period of one year between February 2017 and January 2018. Diagnosis was based on peripheral blood count, peripheral blood smear and bone marrow examination (as on when availablemarrow sample) for morphology along with cytochemical study whenever possible. Results: In the present study, commonest leukemia was Acute myeloid leukemia (AML) followed by Acute lymphoid leukemia (ALL), chronic myeloid leukemia (CML) and chronic lymphoid leukemia (CLL). Out of total 182 c...
Clinical and Hematological Profile of Acute Myeloid Leukemia (AML) Patients of Sindh
Journal of Hematology & Thromboembolic Diseases, 2016
In Acute Myeloid Leukemia (AML) patients, a diversity of clinical and hematological parameters has been examined for possible value in calculating treatment response and survival. The study was conducted at National Institute of Bone Diseases, Karachi (NIBD), Sind, Pakistan, a tertiary care and teaching hospital, affiliated with
Pattern of occurrence of leukemia at a teaching hospital in eastern region of Nepal-a six year study
JNMA, Journal of the Nepal Medical …, 2009
Introduction: Pattern of leukemia is known to vary widely throughout the world. The characterization of distribution patterns of different subtypes of leukemia in Nepal needs further study. We wanted to study the leukemia pattern in our institute. Methods: A retrospective study of 196 cases of leukemia, diagnosed at BPKIHS, between January 1997 to December 2002 was done. We analyzed the pattern of leukemia at BPKIHS by morphological subtype, gender, age at diagnosis, time period of diagnosis (seasonality), and geographic distribution. Results: Morphological sub typing showed that 121 cases were of acute leukemia and 75 of chronic leukemia. Chronic myeloid leukemia constituted the single largest group comprising 35.2 % of all cases, followed by acute myeloid leukemia (28.57 %) and acute lymphoid leukemia (19.9 %). Maximum numbers of cases were from the lowlands while least number of cases were from the mountain districts. Results were compared with literature from Nepal and other countries. This is the second series of leukemia from Nepal. Conclusions: The data published in this study reflects the leukemia pattern in the eastern region of Nepal. The pattern and distribution of AML, CML, ALL was similar to that in the developed western countries while the lesser frequency of CLL was similar to that in Southeast Asian region.
Acute myeloid leukaemia: challenges and real world data from India
British journal of haematology, 2015
The management of acute myeloid leukaemia (AML) in India remains a challenge. In a two-year prospective study at our centre there were 380 newly diagnosed AML (excluding acute promyelocytic leukaemia, AML-M3) patients. The median age of newly diagnosed patients was 40 years (range: 1-79; 12·3% were ≤ 15 years, 16·3% were ≥ 60 years old) and there were 244 (64·2%) males. The median duration of symptoms prior to first presentation at our hospital was 4 weeks (range: 1-52). The median distance from home to hospital was 580 km (range: 6-3200 km). 109 (29%) opted for standard of care and were admitted for induction chemotherapy. Of the 271 that did not take treatment the major reason was lack of financial resources in 219 (81%). There were 27 (24·7%) inductions deaths and of these, 12 (44·5%) were due to multidrug-resistant gram-negative bacilli and 12 (44·5%) showed evidence of a fungal infection. The overall survival at 1 year was 70·4% ± 10·7%, 55·6% ± 6·8% and 42·4% ± 15·6% in patien...
Incidence, Mortality, and Epidemiology of Leukemia in South Asia: An Ecological Study
Nowadays cancer is a buzzword in every corner of the world. Among all other Cancer, leukemia is not as familiar as breast cancer or lung cancer. Treat or curing Cancer is challenging, there is still no worthy hope to fight against it. Back a few decades, Cancer was not that much known to the people of South Asia let alone known of Leukemia. Information on the incidence and mortality of Leukemia is paramount to planning health measures and improving the treatment and management of leukemia for general people. Many countries in the South Asian region are designated as developing countries. Hence, the deficiency of diagnosis system, treatment, management, and lack of knowledge about leukemia in this region are major problems. Therefore, the incidence rate, mortality rate, and several deaths are increasing day by day. This study is aimed to investigate the incidence and mortality of leukemia in South Asian Countries for the year 2020 by acquiring data from the global cancer project (GLO...
Changing trends of chronic myeloid leukemia in greater Mumbai, India over a period of 30 years
Indian Journal of Medical and Paediatric Oncology, 2011
Background: Little is known about burden of chronic myeloid leukemia (CML) in India. There is a recent interest to observe incidence and mortality because of advent of new diagnostic and treatment policies for CML. Materials and Methods: We extracted data from the oldest population-based cancer registry of Mumbai for 30 years period from 1976−2005 to observe incidence and mortality rates of CML. We classified the data into four age groups 0−14, 15−29, 30−54 and 55−74 to observe incidence rates in the respective age groups. Results: The age specific rates were highest for the age group of 55−74 years. No significant change in trends of CML was observed for 30 years period. However, there was a significant reduction in incidence rate for recent 15-years period (Estimated average annual percentage change=-3.9). No significant reduction in mortality rate was observed till 2005. Conclusion: The study demonstrates that age-specific rates for CML are highest in age group of 55-74 years, al...
2018
1 M. Sc Medical Lab. Technology, Department of Clinical Haematology, Sher e Kashmir Institute of Medical Sciences, Srinagar, J&K, India 2 Associate Professor, Department of Clinical Haematology, Sher e Kashmir Institute of Medical Sciences, Srinagar, J&K, India 3 Senior resident, Department of Haematopathology, Sher e Kashmir Institute of Medical Sciences, Srinagar, J&K, India 4 Lecturer, Department of pathology, Government Medical College, Srinagar India 5 Assistant professor, Department of Internal Medicine, Sher e Kashmir Institute of Medical Sciences, Srinagar, J&K, India 6 Professor and Head, Department of Clinical Haematology, Sher e Kashmir Institute of Medical Sciences, Srinagar, J&K, India 7 Senior resident, Department of haematology and transfusion medicine, Government Medical College, Srinagar India
2016
Introduction: Leukemias are neoplastic proliferations of haematopoietic cells and form a major proportion of haematopoietic neoplasms that are diagnosed worldwide. Aims: To chart out the incidence of four major types of leukemias presenting for the first time to Hospital located in rural region. Methods: It was a prospective and retrospective study of 156 patients carried out in the department of Pathology located in rural area over a five years period between May 2006 and May 2011. Diagnosis was based on peripheral blood count, peripheral blood smear and bone marrow examination for morphology along with cytochemistry study whenever required. Results: In this study, commonest leukemia was chronic myeloid leukemia (CML) followed by Acute lymphoid leukemia (ALL), Acute myeloid leukemia(AML) and then chronic lymphoid leukemia (CLL). Out of total 156 cases, 90 were male and 66 were females with Male: Female ratio is 1.36:1. Acute lymphoid leukemia was the most common type of leukaemia in the children and adolescents. Myeloid neoplasms were most common in adults. Conclusion: CML was commonest type of leukemia followed by acute lymphoid leukemia. Male predominance was seen in all types of leukemia and age has significant effect on type of leukemia.