Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. (original) (raw)
- Journal List
- J Clin Invest
- v.87(5); 1991 May
- PMC295273
J Clin Invest. 1991 May; 87(5): 1710–1715.
Department of Medicine, University of California at San Diego, La Jolla 92093.
Abstract
The mechanisms by which HIV-1 infection kills T lymphocytes are not clearly established. Apoptosis is an internally programmed cell death pathway that may regulate both T cell development and senescence, and that is characterized by cleavage of DNA at internucleosomal regions. The present experiments show that acute HIV-1 infection of MT2 lymphoblasts and activated normal peripheral blood mononuclear cells induces apoptosis. The addition of anti-gp120 neutralizing antibody, after HIV-1 infection of MT2 cells, permitted sustained high levels of viral replication, but blocked apoptosis and cell death. Apoptosis may account for the direct cytopathologic effects of HIV-1 in T cells.
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