Human betaherpesvirus 5 (original) (raw)
Lidský cytomegalovirus je druh viru, patřící mezi cytomegaloviry společně s dalšími viry. Tento druh si jméno vysloužil svojí schopností zvětšovat hostitelské buňky. Daří se mu to zablokováním apoptózy skrze mitochondrie. Společně s dalšími známými lidskými druhy herpesvirů jako jsou HHV-1 a HHV-2 a virem Epstein-Barrové patří do čeledi Herpesviridae.
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| dbo:abstract | Lidský cytomegalovirus je druh viru, patřící mezi cytomegaloviry společně s dalšími viry. Tento druh si jméno vysloužil svojí schopností zvětšovat hostitelské buňky. Daří se mu to zablokováním apoptózy skrze mitochondrie. Společně s dalšími známými lidskými druhy herpesvirů jako jsou HHV-1 a HHV-2 a virem Epstein-Barrové patří do čeledi Herpesviridae. (cs) Das Humane Cytomegalievirus (HCMV) (auch Human betaherpesvirus 5 (HHV-5), Zytomegalievirus (ZMV), Cytomegalievirus (CMV)) ist ein behülltes, doppelsträngiges DNA-Virus (dsDNA), gehört zur Familie der Herpesviridae, Gattung Cytomegalovirus und ist weltweit verbreitet. Die Übertragung erfolgt über Speichel, Urin, Spermasekret sowie bei der Bluttransfusion. (de) فيروس هربس بيتا البشري 5، ويُسمى أحيانًا الفيروس المضخم للخلايا البشرية ( اختصارًا HCMV)، هو نوعٌ نمطيٌ من جنس الفيروس المُضخم للخلايا، والذي يُعد عضوًا ضمن فصيلة الفيروسات الهربسية. (ar) Human betaherpesvirus 5, also called human cytomegalovirus (HCMV), is species of virus in the genus Cytomegalovirus, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. It is also commonly called CMV. Within Herpesviridae, HCMV belongs to the Betaherpesvirinae subfamily, which also includes cytomegaloviruses from other mammals. CMV is a double-stranded DNA virus. Although they may be found throughout the body, HCMV infections are frequently associated with the salivary glands. HCMV infection is typically unnoticed in healthy people, but can be life-threatening for the immunocompromised, such as HIV-infected persons, organ transplant recipients, or newborn infants. Congenital cytomegalovirus infection can lead to significant morbidity and even death. After infection, HCMV remains latent within the body throughout life and can be reactivated at any time. Eventually, it may cause mucoepidermoid carcinoma and possibly other malignancies such as prostate cancer and breast cancer. HCMV is found in all geographic locations and all socioeconomic groups, and infects between 60% and 70% of adults in developed countries and almost 100% in developing countries.Of all herpes viruses, HCMV harbors the most genes dedicated to altering (evading) innate and adaptive host immunity and represents a lifelong burden of antigenic T cell surveillance and immune dysfunction.Commonly it is indicated by the presence of antibodies in the general population. Seroprevalence is age-dependent: 58.9% of individuals aged 6 and older are infected with CMV while 90.8% of individuals aged 80 and older are positive for HCMV. HCMV is also the virus most frequently transmitted to a developing fetus.HCMV infection is more widespread in developing countries and in communities with lower socioeconomic status and represents the most significant viral cause of birth defects in industrialized countries. Congenital HCMV is the leading infectious cause of deafness, learning disabilities, and intellectual disability in children.CMV also "seems to have a large impact on immune parameters in later life and may contribute to increased morbidity and eventual mortality." (en) L'herpesvirus umano 5 o, in inglese, Human herpesvirus 5 (HHV-5, Human betaherpesvirus 5 ) è una specie di virus del genere Cytomegalovirus, della famiglia Herpesviridae alla quale appartiene anche il virus dell'herpes labiale e genitale (Herpes simplex), della varicella (Varicella-zoster), della mononucleosi infettiva (virus di Epstein-Barr). (it) Вирус герпеса человека 5 типа, или цитомегаловирус (человека), или герпесвирус человека тип 5 (ГВЧ-5, англ. Human betaherpesvirus 5, ранее Human herpesvirus 5) — вид герпесвирусов, принадлежащих к роду цитомегаловирус (Cytomegalovirus), способных инфицировать человека наряду с другими видами герпеса человека, такими как HSV-1, HSV-2 и вирус Эпштейна — Барр. Вирус был открыт в 1956 году, в 1979 году зарегистрирован в Международном комитете по таксономии вирусов (ICTV), в 2016 году сменил научное название, как и все герпесвирусы. Является возбудителем цитомегаловирусной инфекции человека. Представляет опасность только для отдельных категорий людей с подавленной или несформированной системой иммунитета, обычно вирусу характерна пожизненная персистенция. В настоящее время известно три штамма цитомегаловируса человека. Развитие вируса происходит в фибробластах человека. Поражённые клетки приобретают гигантские размеры, накапливая скопления частиц возбудителя. Процесс репликации вируса идёт в лейкоцитах, завершается образованием дочерних вирусных частиц, которые, выходя из поражённой клетки, воздействуют на рецепторы ближайших клеток и атакуют их. (ru) 人巨细胞病毒（英語：Human cytomegalovirus，HCMV）或称人类疱疹病毒第五型（英語：Human betaherpesvirus 5，HHV-5），属于β疱疹病毒亚科，是巨细胞病毒（CMV）中以人类为宿主的一种DNA病毒。HCMV因其细胞病变效应而得名，感染后可引发核周和细胞质包涵体的产生以及细胞肿胀。在人类疱疹病毒（HHV）中，HCMV具有最大的基因组长度，约240kbp。尽管HCMV的增殖周期较慢，它的基因表达调控类似于α疱疹病毒，会产生IE、E和L等基因产物呈序列性出现。若基于病毒的基因组或表型进行分析，HCMV中可含有无数独特的毒株。利用限制性酶切分析，可从流行病学角度上区分亚型。在实验室环境中培养的毒株一般会损失10-15kbp的基因，因此对病毒屈性有一定限制作用。 (zh) |
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| dbp:causes | Human betaherpesvirus 5 (en) |
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| dbp:imageAlt | CMV infection of a human lung pneumocyte (en) |
| dbp:imageCaption | CMV infection of a human lung pneumocyte (en) |
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| dbp:name | Human cytomegalovirus (en) |
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| dbp:species | Human betaherpesvirus 5 (en) |
| dbp:synonyms | *Human herpesvirus 5 (en) |
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| rdfs:comment | Lidský cytomegalovirus je druh viru, patřící mezi cytomegaloviry společně s dalšími viry. Tento druh si jméno vysloužil svojí schopností zvětšovat hostitelské buňky. Daří se mu to zablokováním apoptózy skrze mitochondrie. Společně s dalšími známými lidskými druhy herpesvirů jako jsou HHV-1 a HHV-2 a virem Epstein-Barrové patří do čeledi Herpesviridae. (cs) Das Humane Cytomegalievirus (HCMV) (auch Human betaherpesvirus 5 (HHV-5), Zytomegalievirus (ZMV), Cytomegalievirus (CMV)) ist ein behülltes, doppelsträngiges DNA-Virus (dsDNA), gehört zur Familie der Herpesviridae, Gattung Cytomegalovirus und ist weltweit verbreitet. Die Übertragung erfolgt über Speichel, Urin, Spermasekret sowie bei der Bluttransfusion. (de) فيروس هربس بيتا البشري 5، ويُسمى أحيانًا الفيروس المضخم للخلايا البشرية ( اختصارًا HCMV)، هو نوعٌ نمطيٌ من جنس الفيروس المُضخم للخلايا، والذي يُعد عضوًا ضمن فصيلة الفيروسات الهربسية. (ar) L'herpesvirus umano 5 o, in inglese, Human herpesvirus 5 (HHV-5, Human betaherpesvirus 5 ) è una specie di virus del genere Cytomegalovirus, della famiglia Herpesviridae alla quale appartiene anche il virus dell'herpes labiale e genitale (Herpes simplex), della varicella (Varicella-zoster), della mononucleosi infettiva (virus di Epstein-Barr). (it) 人巨细胞病毒（英語：Human cytomegalovirus，HCMV）或称人类疱疹病毒第五型（英語：Human betaherpesvirus 5，HHV-5），属于β疱疹病毒亚科，是巨细胞病毒（CMV）中以人类为宿主的一种DNA病毒。HCMV因其细胞病变效应而得名，感染后可引发核周和细胞质包涵体的产生以及细胞肿胀。在人类疱疹病毒（HHV）中，HCMV具有最大的基因组长度，约240kbp。尽管HCMV的增殖周期较慢，它的基因表达调控类似于α疱疹病毒，会产生IE、E和L等基因产物呈序列性出现。若基于病毒的基因组或表型进行分析，HCMV中可含有无数独特的毒株。利用限制性酶切分析，可从流行病学角度上区分亚型。在实验室环境中培养的毒株一般会损失10-15kbp的基因，因此对病毒屈性有一定限制作用。 (zh) Human betaherpesvirus 5, also called human cytomegalovirus (HCMV), is species of virus in the genus Cytomegalovirus, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. It is also commonly called CMV. Within Herpesviridae, HCMV belongs to the Betaherpesvirinae subfamily, which also includes cytomegaloviruses from other mammals. CMV is a double-stranded DNA virus. (en) Вирус герпеса человека 5 типа, или цитомегаловирус (человека), или герпесвирус человека тип 5 (ГВЧ-5, англ. Human betaherpesvirus 5, ранее Human herpesvirus 5) — вид герпесвирусов, принадлежащих к роду цитомегаловирус (Cytomegalovirus), способных инфицировать человека наряду с другими видами герпеса человека, такими как HSV-1, HSV-2 и вирус Эпштейна — Барр. Вирус был открыт в 1956 году, в 1979 году зарегистрирован в Международном комитете по таксономии вирусов (ICTV), в 2016 году сменил научное название, как и все герпесвирусы. (ru) |
| rdfs:label | فيروس هربس بيتا البشري 5 (ar) Lidský cytomegalovirus (cs) Humanes Cytomegalievirus (de) Human betaherpesvirus 5 (en) Herpesvirus umano 5 (it) Вирус герпеса человека 5 типа (ru) 人巨细胞病毒 (zh) |
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