| dbo:abstract |
Inflamm-aging (také známo jako inflammaging či inflamm-ageing) označuje vznik systémového chronického zánětlivého prostředí během stárnutí organismu. Tento jev je úzce spjat s biologickým stárnutím a napomáhá ke vzniku některých chorob. Název Inflamm-aging vzniklo spojením anglických slov inflammation (zánět) a aging (stárnutí). (cs) التهاب الشيخوخة هو التهاب مزمن منخفض الدرجة يتطور مع تقدم العمر. يُعتقد أنه يسرع عملية الشيخوخة البيولوجية ويزيد من تفاقم العديد من الأمراض المرتبطة بالشيخوخة. (ar) Inflammaging (also known as inflamm-aging or inflamm-ageing) is a chronic, sterile low-grade inflammation that develops with advanced age, in the absence of overt infection, and may contribute to clinical manifestations of other age related pathologies. Inflammaging is thought to be caused by a loss of control over systemic inflammation resulting in chronic, overstimulation of the innate immune system. Inflammaging is a significant risk factor in mortality and morbidity in aged individuals Inflammation is essential to protect against viral and bacterial infection, as well as noxious stimuli. It is an integral part of the healing process, though prolonged inflammation can be detrimental. The network dynamics of inflammation changes with age, and factors such as genes, lifestyle, and environment contribute to these changes. Current research studying inflammaging is focused on understanding the interaction of dynamic molecular pathways underlying both aging and inflammation and how they change with chronological age. (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Inflammaging_Schematic_Image.jpg?width=300 |
| dbo:wikiPageID |
59830296 (xsd:integer) |
| dbo:wikiPageLength |
24542 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1088739472 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Overnutrition dbr:Rheumatoid_arthritis dbr:Cytokine dbr:Cytomegalovirus dbr:DNA_repair dbr:Inflammasome dbr:Inflammation dbr:Inflammatory_cytokine dbr:Influenza_A_virus_subtype_H1N1 dbr:Innate_immune_system dbr:Interleukin_6 dbr:Protein_aggregation dbc:Inflammations dbr:Noxious_stimulus dbr:Damage-associated_molecular_pattern dbr:Apoptosis dbr:Leptin dbr:Pathogen-associated_molecular_pattern dbr:Pattern_recognition_receptor dbr:Sensory_overload dbr:Toll-like_receptor dbr:COVID-19 dbr:Adaptive_immune_system dbc:Old_age dbr:Tumor_necrosis_factor-alpha dbr:Gut_microbiome dbr:Systemic_inflammation dbr:Amyotrophic_lateral_sclerosis dbr:Alzheimer's_disease dbr:Parkinson's_disease dbr:Cellular_senescence dbr:Central_nervous_system dbr:Chronic_stress dbr:Severe_acute_respiratory_syndrome_coronavirus_2 dbc:Ageing dbc:Biogerontology dbr:Mitophagy dbr:Autophagy dbr:CD4+/CD8+_ratio dbr:Fibroblast dbr:Interleukin-1_family dbr:Microbiota dbr:Necrosis dbr:Caspase dbr:Cerebrospinal_fluid dbr:Reactive_oxygen_species dbr:Immunosenescence dbr:Lymphatic_system dbr:Lymphocyte dbr:Physical_inactivity dbr:Senescence-associated_secretory_phenotype dbr:Periodontitis dbr:Tumor_necrosis_factor dbr:File:SARS-CoV-2_without_background.png dbr:IL-1B dbr:Il-1a dbr:Pro-inflammatory_cytokine dbr:Insufficient_sleep dbr:Post_prandial dbr:File:3_Models_of_NLRP3_Inflammasome_Activation.png dbr:File:Fimmu-11-01648-g002.jpg dbr:File:Inflammaging_Schematic_Image.jpg dbr:File:TNF-Mediated_Death_and_Survival_Pathways.png dbr:File:TNFa_Crystal_Structure.rsh.png |
| dbp:wikiPageUsesTemplate |
dbt:Short_description |
| dcterms:subject |
dbc:Inflammations dbc:Old_age dbc:Ageing dbc:Biogerontology |
| rdfs:comment |
Inflamm-aging (také známo jako inflammaging či inflamm-ageing) označuje vznik systémového chronického zánětlivého prostředí během stárnutí organismu. Tento jev je úzce spjat s biologickým stárnutím a napomáhá ke vzniku některých chorob. Název Inflamm-aging vzniklo spojením anglických slov inflammation (zánět) a aging (stárnutí). (cs) التهاب الشيخوخة هو التهاب مزمن منخفض الدرجة يتطور مع تقدم العمر. يُعتقد أنه يسرع عملية الشيخوخة البيولوجية ويزيد من تفاقم العديد من الأمراض المرتبطة بالشيخوخة. (ar) Inflammaging (also known as inflamm-aging or inflamm-ageing) is a chronic, sterile low-grade inflammation that develops with advanced age, in the absence of overt infection, and may contribute to clinical manifestations of other age related pathologies. Inflammaging is thought to be caused by a loss of control over systemic inflammation resulting in chronic, overstimulation of the innate immune system. Inflammaging is a significant risk factor in mortality and morbidity in aged individuals (en) |
| rdfs:label |
التهاب الشيخوخة (ar) Inflammaging (cs) Inflammaging (en) |
| owl:sameAs |
wikidata:Inflammaging dbpedia-ar:Inflammaging dbpedia-cs:Inflammaging https://global.dbpedia.org/id/9WBB3 |
| prov:wasDerivedFrom |
wikipedia-en:Inflammaging?oldid=1088739472&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/SARS-CoV-2_without_background.png wiki-commons:Special:FilePath/3_Models_of_NLRP3_Inflammasome_Activation.png wiki-commons:Special:FilePath/Fimmu-11-01648-g002.jpg wiki-commons:Special:FilePath/Inflammaging_Schematic_Image.jpg wiki-commons:Special:FilePath/TNF-Mediated_Death_and_Survival_Pathways.png wiki-commons:Special:FilePath/TNFa_Crystal_Structure.rsh.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:Inflammaging |
| is dbo:wikiPageRedirects of |
dbr:Inflammageing |
| is dbo:wikiPageWikiLink of |
dbr:Cytokine dbr:Induced_stem_cells dbr:Inflammation dbr:Intestinal_permeability dbr:Calorie_restriction dbr:Hallmarks_of_aging dbr:Timeline_of_senescence_research dbr:Systemic_inflammation dbr:BPIFB4 dbr:Effects_of_parasitic_worms_on_the_immune_system dbr:Mitochondrial_theory_of_ageing dbr:Human_betaherpesvirus_5 dbr:Immune_dysregulation dbr:Impact_of_the_COVID-19_pandemic_on_neu...ical_and_other_mental_health_outcomes dbr:Senescence-associated_secretory_phenotype dbr:Inflammageing |
| is rdfs:seeAlso of |
dbr:Life_extension |
| is foaf:primaryTopic of |
wikipedia-en:Inflammaging |
